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The map label for this gene is holB [H]

Identifier: 123965392

GI number: 123965392

Start: 143476

End: 144435

Strand: Reverse

Name: holB [H]

Synonym: P9515_01571

Alternate gene names: 123965392

Gene position: 144435-143476 (Counterclockwise)

Preceding gene: 123965393

Following gene: 123965390

Centisome position: 8.48

GC content: 25.73

Gene sequence:

>960_bases
ATGATTAATCTTGAAAATGATAATCTTTTGATTAATAAAGAAGTCAATCAAATTTTAGAAAATATACTTCAAACAAAAGT
ATTTTCTAACGGTTATATTTTTTATGGCCCTGAAGGTATTGGAAAAAAACAAACAGCTATTGAATTTATTAAAGAAATTT
TTATTCAAGATTCTTCTAATTCAAATATTCAAGAAAAAATTATAGATAATAACCATCCAGATTTTTTATTAATAGAGCCA
ACATATGTTTTCAAGGGTAATCTTATAAATAGTTCAGAAGCCGATTCTTCAAAAAACAAAAAAGCAACAATAAGAATTGA
GCAAATAAGGAATATAAAAAATTTTTTGGCTCAAAAATCTATTGAATCAGGAAAAAAGATTGTCTTAATTATTGATGCAG
ACCTTTTAAATGAAGCTGCATCCAATTGCCTTTTAAAAACACTTGAAGAGCCCACTAATGGTCTGTTTATTCTTTTAACA
TCAAGATTAAGTTCACTTTTAGGTACTATTATCTCAAGATGTCAACTCATTAGATTTAAATCTTTTTCATACAAACAACT
TGAGATTTTTATAAAAAATAATACAGATGATTCAATATTAAACAATGAAGAAAAAGTGAATTTAGAAGATTTAATTTATT
CAGCGAATGGCTCTCCAGGGAAAATACTGAAAAATATAAAAATGTGGAACGAATTACCTAACGAGATAAAAGATAATTTA
AGCTTCCCATTGATGAATAATCTAGAAATACTAAAAGTTTCAAAAATAATTGCTGAGGAACTAGTGTTAGATCAACAGAT
ATTCTTAGTAAACCTTATGCAAAAAAAATGTTGGGAAACAGCTAAAAATAAAAAGATAATTAAAACATTAGAAAAATTGA
AAATTCATCTCATGAATTTTACCCAACCAAGGCTAGCTTGGGAAGTGAGCTTATTAAAAATAGCTAATGAAGATTTATAA

Upstream 100 bases:

>100_bases
TAAAGAAAAAAAGTGGAAAGTAATATCTGCGACCCAAAATATTACTGCTATTTCTAATGAAATTAAAGAAACGTTACTAA
AAACTTTTCGTAACTAAAGA

Downstream 100 bases:

>100_bases
AAATTACTCAATCACTGTATTAATTAAACTTGAATTTCTAGATTCTGTAAATTTTTGACTTGCAACGTCAACTTTTGCTT
CATCAGGTAATTCAAGGCAA

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MINLENDNLLINKEVNQILENILQTKVFSNGYIFYGPEGIGKKQTAIEFIKEIFIQDSSNSNIQEKIIDNNHPDFLLIEP
TYVFKGNLINSSEADSSKNKKATIRIEQIRNIKNFLAQKSIESGKKIVLIIDADLLNEAASNCLLKTLEEPTNGLFILLT
SRLSSLLGTIISRCQLIRFKSFSYKQLEIFIKNNTDDSILNNEEKVNLEDLIYSANGSPGKILKNIKMWNELPNEIKDNL
SFPLMNNLEILKVSKIIAEELVLDQQIFLVNLMQKKCWETAKNKKIIKTLEKLKIHLMNFTQPRLAWEVSLLKIANEDL

Sequences:

>Translated_319_residues
MINLENDNLLINKEVNQILENILQTKVFSNGYIFYGPEGIGKKQTAIEFIKEIFIQDSSNSNIQEKIIDNNHPDFLLIEP
TYVFKGNLINSSEADSSKNKKATIRIEQIRNIKNFLAQKSIESGKKIVLIIDADLLNEAASNCLLKTLEEPTNGLFILLT
SRLSSLLGTIISRCQLIRFKSFSYKQLEIFIKNNTDDSILNNEEKVNLEDLIYSANGSPGKILKNIKMWNELPNEIKDNL
SFPLMNNLEILKVSKIIAEELVLDQQIFLVNLMQKKCWETAKNKKIIKTLEKLKIHLMNFTQPRLAWEVSLLKIANEDL
>Mature_319_residues
MINLENDNLLINKEVNQILENILQTKVFSNGYIFYGPEGIGKKQTAIEFIKEIFIQDSSNSNIQEKIIDNNHPDFLLIEP
TYVFKGNLINSSEADSSKNKKATIRIEQIRNIKNFLAQKSIESGKKIVLIIDADLLNEAASNCLLKTLEEPTNGLFILLT
SRLSSLLGTIISRCQLIRFKSFSYKQLEIFIKNNTDDSILNNEEKVNLEDLIYSANGSPGKILKNIKMWNELPNEIKDNL
SFPLMNNLEILKVSKIIAEELVLDQQIFLVNLMQKKCWETAKNKKIIKTLEKLKIHLMNFTQPRLAWEVSLLKIANEDL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003959
- InterPro:   IPR004622 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36557; Mature: 36557

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINLENDNLLINKEVNQILENILQTKVFSNGYIFYGPEGIGKKQTAIEFIKEIFIQDSSN
CCEECCCCEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
SNIQEKIIDNNHPDFLLIEPTYVFKGNLINSSEADSSKNKKATIRIEQIRNIKNFLAQKS
CCHHHHHCCCCCCCEEEEECEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
IESGKKIVLIIDADLLNEAASNCLLKTLEEPTNGLFILLTSRLSSLLGTIISRCQLIRFK
HHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHC
SFSYKQLEIFIKNNTDDSILNNEEKVNLEDLIYSANGSPGKILKNIKMWNELPNEIKDNL
CCCCEEEEEEEECCCCCHHCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHCHHHHHHCC
SFPLMNNLEILKVSKIIAEELVLDQQIFLVNLMQKKCWETAKNKKIIKTLEKLKIHLMNF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
TQPRLAWEVSLLKIANEDL
CCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MINLENDNLLINKEVNQILENILQTKVFSNGYIFYGPEGIGKKQTAIEFIKEIFIQDSSN
CCEECCCCEEEEHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCC
SNIQEKIIDNNHPDFLLIEPTYVFKGNLINSSEADSSKNKKATIRIEQIRNIKNFLAQKS
CCHHHHHCCCCCCCEEEEECEEEEECCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
IESGKKIVLIIDADLLNEAASNCLLKTLEEPTNGLFILLTSRLSSLLGTIISRCQLIRFK
HHCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHC
SFSYKQLEIFIKNNTDDSILNNEEKVNLEDLIYSANGSPGKILKNIKMWNELPNEIKDNL
CCCCEEEEEEEECCCCCHHCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHCHHHHHHCC
SFPLMNNLEILKVSKIIAEELVLDQQIFLVNLMQKKCWETAKNKKIIKTLEKLKIHLMNF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
TQPRLAWEVSLLKIANEDL
CCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550441; 10984043 [H]