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The map label for this gene is csd [H]

Identifier: 123965314

GI number: 123965314

Start: 83993

End: 85270

Strand: Reverse

Name: csd [H]

Synonym: P9515_00791

Alternate gene names: 123965314

Gene position: 85270-83993 (Counterclockwise)

Preceding gene: 123965315

Following gene: 123965312

Centisome position: 5.0

GC content: 31.69

Gene sequence:

>1278_bases
ATGGAAACAATTAAAAATTTCCCGCAAATAGTCAAAAAAAACTTTAATTTGGTAGATAAAAAAGATTTTCCTTTATTAGA
GAATAATTTTAAAAGCAAAAATAAAATTATTTATCTAGATCACGCTGCAACAACACAAAAGCCAAGCCAAGTTCTAGAAA
AAATTGAAGAATATTATAAAAAATTCAATGCAAACGTTCATAGGGGTGCTCATCAATTAAGTGCGAAAGCAACAGAAGAA
TTTGAGAATTCAAGATCTTTAGTTGCTAAATACATTAATGCAAATTCAACGCAAGAAATAATCTTTACAAGAAATGCAAC
TGAAGCTATCAATCTAGTTGCAAGATCATGGGGAGAATTCACGTTAAAAGAGAATGATGAAATTATTTTGTCAGTAATGG
AGCATCATAGTAATATTGTTCCTTGGCAAATGGTAGCTGCTAAAAACCAATGCAAACTGAAATTTGTCGGAATTGATCAA
GACGGAAAATTAGATATAAATGATTTCAAGTCCAAATTAACAAATAAAACAAAACTAGTCAGTTTATTGCACATAAGCAA
TACCTTAGGTTGCTGTAATCCAATAAAAGAAATAACCAAATTAGCTAAGGTTAAGGGTTCTTTAGTTCTGCTTGATGCTT
GTCAAAGTTTAGCTCATCAAAAGTTAGATATTGATGAATTAGGTATAGATTTTTTAGCAGGTTCAGGACATAAATTATGT
GGACCAACAGGTATAGGTTTCTTATGGGCAAAGAAAGAGATATTAGAGGAAATTCCTCCTTTTTTTGGTGGAGGTGAAAT
GATTCAAGATGTTTTTGAAGATACAAGTACTTGGGCAGAGCTTCCTCACAAATTTGAAGCAGGTACTCCTGCTATTGCAG
AGGCTATAGGATTAGCGGAAGCAATTAAATATATCAACAATATTGGCTTAGATCGTATCAGTGAATACGAAAAGCAAATT
ACAAAATATTTATTTGAACAACTAAGTCAAATTAAAGATCTTGTAATAATAGGACCTCCACCAAAGATAGACCCTAATAG
AGCTTCACTAGCAACGTTTTATATAAAGGGAATACATTCAAACGATATCGCTGAGATTCTGGATTCAAAAGGTATTTGTA
TAAGAAGCGGACATCACTGTTGTCAACCATTGCATAGACATATCGGAGTTAATTCAACAGCAAGAGTTAGCATGAACTTC
ACAACTACGAAAGACGATATAAATGCTTTTATCGAAAAACTGAAAGAAACTATTAGTTTTTTAAGACTTAATTCTTAA

Upstream 100 bases:

>100_bases
GTAAACTACAATTAAGTTCTTACATTCAAGAAATAATCTCAAGTATTCCTATTTCTAAAGATAGATGGGATTTACTTGAT
AAACTTTTAAAAGAAAATTA

Downstream 100 bases:

>100_bases
ATATTTAAAGTTCTCTCTAAAAATTTCTGAGTTTTTATAAGAACCTGTTGCTTATTATCTAAATTTTTAAAACCATGCCC
TTCATTATCAAAAAATATAA

Product: putative cysteine desulfurase or selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
METIKNFPQIVKKNFNLVDKKDFPLLENNFKSKNKIIYLDHAATTQKPSQVLEKIEEYYKKFNANVHRGAHQLSAKATEE
FENSRSLVAKYINANSTQEIIFTRNATEAINLVARSWGEFTLKENDEIILSVMEHHSNIVPWQMVAAKNQCKLKFVGIDQ
DGKLDINDFKSKLTNKTKLVSLLHISNTLGCCNPIKEITKLAKVKGSLVLLDACQSLAHQKLDIDELGIDFLAGSGHKLC
GPTGIGFLWAKKEILEEIPPFFGGGEMIQDVFEDTSTWAELPHKFEAGTPAIAEAIGLAEAIKYINNIGLDRISEYEKQI
TKYLFEQLSQIKDLVIIGPPPKIDPNRASLATFYIKGIHSNDIAEILDSKGICIRSGHHCCQPLHRHIGVNSTARVSMNF
TTTKDDINAFIEKLKETISFLRLNS

Sequences:

>Translated_425_residues
METIKNFPQIVKKNFNLVDKKDFPLLENNFKSKNKIIYLDHAATTQKPSQVLEKIEEYYKKFNANVHRGAHQLSAKATEE
FENSRSLVAKYINANSTQEIIFTRNATEAINLVARSWGEFTLKENDEIILSVMEHHSNIVPWQMVAAKNQCKLKFVGIDQ
DGKLDINDFKSKLTNKTKLVSLLHISNTLGCCNPIKEITKLAKVKGSLVLLDACQSLAHQKLDIDELGIDFLAGSGHKLC
GPTGIGFLWAKKEILEEIPPFFGGGEMIQDVFEDTSTWAELPHKFEAGTPAIAEAIGLAEAIKYINNIGLDRISEYEKQI
TKYLFEQLSQIKDLVIIGPPPKIDPNRASLATFYIKGIHSNDIAEILDSKGICIRSGHHCCQPLHRHIGVNSTARVSMNF
TTTKDDINAFIEKLKETISFLRLNS
>Mature_425_residues
METIKNFPQIVKKNFNLVDKKDFPLLENNFKSKNKIIYLDHAATTQKPSQVLEKIEEYYKKFNANVHRGAHQLSAKATEE
FENSRSLVAKYINANSTQEIIFTRNATEAINLVARSWGEFTLKENDEIILSVMEHHSNIVPWQMVAAKNQCKLKFVGIDQ
DGKLDINDFKSKLTNKTKLVSLLHISNTLGCCNPIKEITKLAKVKGSLVLLDACQSLAHQKLDIDELGIDFLAGSGHKLC
GPTGIGFLWAKKEILEEIPPFFGGGEMIQDVFEDTSTWAELPHKFEAGTPAIAEAIGLAEAIKYINNIGLDRISEYEKQI
TKYLFEQLSQIKDLVIIGPPPKIDPNRASLATFYIKGIHSNDIAEILDSKGICIRSGHHCCQPLHRHIGVNSTARVSMNF
TTTKDDINAFIEKLKETISFLRLNS

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=399, Percent_Identity=23.5588972431078, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI156713448, Length=265, Percent_Identity=27.1698113207547, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1787970, Length=398, Percent_Identity=40.9547738693467, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=33.5802469135802, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI48994898, Length=402, Percent_Identity=24.8756218905473, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25143064, Length=295, Percent_Identity=28.4745762711864, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI193211090, Length=376, Percent_Identity=25.2659574468085, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319831, Length=397, Percent_Identity=25.9445843828715, Blast_Score=137, Evalue=5e-33,
Organism=Drosophila melanogaster, GI20129463, Length=293, Percent_Identity=28.3276450511945, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 47723; Mature: 47723

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIKNFPQIVKKNFNLVDKKDFPLLENNFKSKNKIIYLDHAATTQKPSQVLEKIEEYYK
CCHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
KFNANVHRGAHQLSAKATEEFENSRSLVAKYINANSTQEIIFTRNATEAINLVARSWGEF
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCE
TLKENDEIILSVMEHHSNIVPWQMVAAKNQCKLKFVGIDQDGKLDINDFKSKLTNKTKLV
EECCCCHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHH
SLLHISNTLGCCNPIKEITKLAKVKGSLVLLDACQSLAHQKLDIDELGIDFLAGSGHKLC
HHHHHHHHHHCCHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCHHHHCHHHCCCCCCCCC
GPTGIGFLWAKKEILEEIPPFFGGGEMIQDVFEDTSTWAELPHKFEAGTPAIAEAIGLAE
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
AIKYINNIGLDRISEYEKQITKYLFEQLSQIKDLVIIGPPPKIDPNRASLATFYIKGIHS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHEEEEEEECCCC
NDIAEILDSKGICIRSGHHCCQPLHRHIGVNSTARVSMNFTTTKDDINAFIEKLKETISF
CHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
LRLNS
HHCCC
>Mature Secondary Structure
METIKNFPQIVKKNFNLVDKKDFPLLENNFKSKNKIIYLDHAATTQKPSQVLEKIEEYYK
CCHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
KFNANVHRGAHQLSAKATEEFENSRSLVAKYINANSTQEIIFTRNATEAINLVARSWGEF
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCE
TLKENDEIILSVMEHHSNIVPWQMVAAKNQCKLKFVGIDQDGKLDINDFKSKLTNKTKLV
EECCCCHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHH
SLLHISNTLGCCNPIKEITKLAKVKGSLVLLDACQSLAHQKLDIDELGIDFLAGSGHKLC
HHHHHHHHHHCCHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCHHHHCHHHCCCCCCCCC
GPTGIGFLWAKKEILEEIPPFFGGGEMIQDVFEDTSTWAELPHKFEAGTPAIAEAIGLAE
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
AIKYINNIGLDRISEYEKQITKYLFEQLSQIKDLVIIGPPPKIDPNRASLATFYIKGIHS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCHHHEEEEEEECCCC
NDIAEILDSKGICIRSGHHCCQPLHRHIGVNSTARVSMNFTTTKDDINAFIEKLKETISF
CHHHHHHCCCCCEEECCCHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHH
LRLNS
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]