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The map label for this gene is uvrD [H]

Identifier: 121999202

GI number: 121999202

Start: 2662401

End: 2664578

Strand: Reverse

Name: uvrD [H]

Synonym: Hhal_2424

Alternate gene names: 121999202

Gene position: 2664578-2662401 (Counterclockwise)

Preceding gene: 121999203

Following gene: 121999199

Centisome position: 99.48

GC content: 69.93

Gene sequence:

>2178_bases
ATGCCCATCGATGCCCTGACCGCGGATCTCAACGATGCCCAGCGCGAGGCCGTGTGCCTGCCTCCGGGCCGCGCCCTGGT
GTTGGCCGGGGCCGGCAGTGGCAAGACCCGCGTGCTCACCCGGCGCGCCGCCTACCTGGTGCAGGTCGAGGGGGCTTCGC
CGTTCGCCATCCTGGCGGTCACCTTCACCAACAAGGCGGCCGGCGAGATGCGCGGGCGCATCGGCGAACTCCTCGGCATC
GCTACCGCCGGCATGTGGGTCGGCACCTTCCACGGCATCGCCCACCGTCTGTTGCGTCAGCACGCCCAGCGCGCTGGGCT
CCCCGAAGGTTTCCAGATCCTCGATGCCGATGACCAGCTGCGCGTGGTCAAGCGGGTCCTGCGCGCCCGGGGCAACGACG
AGTCCCGCTTCCCGCCGCGCCAGGTGCGGGGATTCATCAGCGCGCGCAAGGAGGAGGGGGAGCGTCCCAGCGACGTGACC
GAGGCCGGGGGCGATTATCAGCAGGAGCTGCTGGCCGTCTACCACGATTACGAGCAGGCGTGCCGTCGTGGTGGCTTGGT
GGATTTCTCCGAGTTGCTGCTGCGCGCCTACGAGCTGCTGCGCGACGACCCCGAGCTCCTTGGCCACTACCAGCGGCGCT
TTGCCCACATCCTGGTCGACGAGTTCCAGGACACCAATGCCCTGCAGTATCGCTGGCTGAAGCTGCTCGGCGGCGAGCAG
TCGGAGCTGTTTGTTGTCGGCGACGACGACCAGTCCATCTACGGCTGGCGGGGTGCCCGGGTGGAGAACATCGAGCACTT
CCGGCGGGAGATGGGCGACGTCCGGGTGGTCCGCCTGGAGCAGAACTACCGCTCCACCGGCACCATCCTCGACGCTGCCA
ACCGGCTGATCGAGCACAACAGCGGCCGGCTGGGCAAGCAGCTGTGGACCGACGGCTGGAGCGGCGAGCCGATCACCCTC
TACGCCGCGTTCAACGAGGTCGACGAGGCGCGCTGGGTGGTCGATCGTATTCGCCAGCTGAGCGAGGAGGGCGGCTACGG
CCATGCCGACTTCGCCATCCTCTACCGCTCCAACGCCCAGTCCCGCGCCCTCGAGCACGAACTCCACGCCGCCCGGCTGC
CGTTCCGCGTCTACGGGGGGCTGCGCTTCTTCGAACGCGCCGAGGTCAAGGATGCCCTGGCCTACCTGCGCCTGGTGGCC
AATCGCCACGACGACGCCAGCTTCGAACGGGTGGTCAACACCCCGCCGCGCGGCATCGGCGCCAAGACCGTCGACGCGGT
CCGCTACGCCGCCCGGGAGGCCGACGTTTCGATGTGGCGGGCCGCCCGGGAGCTGACCGGCAGCCGGGCCCTGGCCGCCC
GGGCGCGCAACGCCTTGGCCAGCTTCCTGGAACGCATCGACGCCCTGGACAGTGAGCTCACCGACCGACCGCTCCACGAT
CAGGTGGAGCAGGTGATCGCCCGCACCGACTTGCGCCGCCACCACGAGCGAGACGAGGCCCGTCTGGAGAACCTCGACGA
GCTGGTGACCGCCGCGCGCACCTTCGCCCAGCGCGATGAGCCGGAAGATGATCTGGACCCCCTGGCGGCCTTTCTCACCC
ACGCCGCCCTGGAGGCCGGCGAGGGGCAGGCCGACGACTGGGAGCACTCGGTGCAGCTGATGACCCTGCACTCGGCCAAG
GGGCTGGAGTTCCCGGTGGTCTTTTTAGTAGGGATGGAGGAGGGGTTGTTCCCCCACCGCATGTCCGTCGAGGAGCCCGG
CCGTCTGGAGGAGGAGCGCAGGCTGTGCTATGTCGGCATGACCCGGGCCAGGCAGCGGCTGATCCTGACCCACGCCGAGA
AGCGGCGCCTGCACGGCATGGATCAGTTGGCCCGGCCATCGCGCTTTCTCACCGAGATACCCGGTGAGCATCTCGAGGAG
GTCCGTCCACGCATGTCCGTACGGCGGGGGCCCCCGTCGGTGCCTGCGTCCGGCGGGAGCGGCTCGTCGCTGCCGGCCGA
CGCCCCGCCCGAGGGGTTGAGTCTGGGCAGCCGTGTCCACCACCCGCGGTTCGGCGACGGCGTGCTCCTTCACTGTGAGG
GCAGCGGCCCCAATGCCCGCCTGCAGGTCCGGTTCGATAGCGCCGGGACCAAGTGGCTGATCGCCGGCCGCGCCGGCCTG
GAACCGGCTACCAGCTGA

Upstream 100 bases:

>100_bases
GTGGGCACCGCCCGCGAACCCACCTTCCGCGAGCTGGTCGAACGGATGCGCAGTGCCGCGGTGCTTCAAGACCCGACCCA
GACCCTGCCGGCAGCCTGAT

Downstream 100 bases:

>100_bases
ACAGCCGCCATAGCGGTGTGCGCGGCGGGTCGTGGGCGTGGTAGTCGCCCCCGCTGCCGTCGAGGACGCCGTCTCCGGTC
GTGTCGTAGAGCAGGTACGG

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 725; Mature: 724

Protein sequence:

>725_residues
MPIDALTADLNDAQREAVCLPPGRALVLAGAGSGKTRVLTRRAAYLVQVEGASPFAILAVTFTNKAAGEMRGRIGELLGI
ATAGMWVGTFHGIAHRLLRQHAQRAGLPEGFQILDADDQLRVVKRVLRARGNDESRFPPRQVRGFISARKEEGERPSDVT
EAGGDYQQELLAVYHDYEQACRRGGLVDFSELLLRAYELLRDDPELLGHYQRRFAHILVDEFQDTNALQYRWLKLLGGEQ
SELFVVGDDDQSIYGWRGARVENIEHFRREMGDVRVVRLEQNYRSTGTILDAANRLIEHNSGRLGKQLWTDGWSGEPITL
YAAFNEVDEARWVVDRIRQLSEEGGYGHADFAILYRSNAQSRALEHELHAARLPFRVYGGLRFFERAEVKDALAYLRLVA
NRHDDASFERVVNTPPRGIGAKTVDAVRYAAREADVSMWRAARELTGSRALAARARNALASFLERIDALDSELTDRPLHD
QVEQVIARTDLRRHHERDEARLENLDELVTAARTFAQRDEPEDDLDPLAAFLTHAALEAGEGQADDWEHSVQLMTLHSAK
GLEFPVVFLVGMEEGLFPHRMSVEEPGRLEEERRLCYVGMTRARQRLILTHAEKRRLHGMDQLARPSRFLTEIPGEHLEE
VRPRMSVRRGPPSVPASGGSGSSLPADAPPEGLSLGSRVHHPRFGDGVLLHCEGSGPNARLQVRFDSAGTKWLIAGRAGL
EPATS

Sequences:

>Translated_725_residues
MPIDALTADLNDAQREAVCLPPGRALVLAGAGSGKTRVLTRRAAYLVQVEGASPFAILAVTFTNKAAGEMRGRIGELLGI
ATAGMWVGTFHGIAHRLLRQHAQRAGLPEGFQILDADDQLRVVKRVLRARGNDESRFPPRQVRGFISARKEEGERPSDVT
EAGGDYQQELLAVYHDYEQACRRGGLVDFSELLLRAYELLRDDPELLGHYQRRFAHILVDEFQDTNALQYRWLKLLGGEQ
SELFVVGDDDQSIYGWRGARVENIEHFRREMGDVRVVRLEQNYRSTGTILDAANRLIEHNSGRLGKQLWTDGWSGEPITL
YAAFNEVDEARWVVDRIRQLSEEGGYGHADFAILYRSNAQSRALEHELHAARLPFRVYGGLRFFERAEVKDALAYLRLVA
NRHDDASFERVVNTPPRGIGAKTVDAVRYAAREADVSMWRAARELTGSRALAARARNALASFLERIDALDSELTDRPLHD
QVEQVIARTDLRRHHERDEARLENLDELVTAARTFAQRDEPEDDLDPLAAFLTHAALEAGEGQADDWEHSVQLMTLHSAK
GLEFPVVFLVGMEEGLFPHRMSVEEPGRLEEERRLCYVGMTRARQRLILTHAEKRRLHGMDQLARPSRFLTEIPGEHLEE
VRPRMSVRRGPPSVPASGGSGSSLPADAPPEGLSLGSRVHHPRFGDGVLLHCEGSGPNARLQVRFDSAGTKWLIAGRAGL
EPATS
>Mature_724_residues
PIDALTADLNDAQREAVCLPPGRALVLAGAGSGKTRVLTRRAAYLVQVEGASPFAILAVTFTNKAAGEMRGRIGELLGIA
TAGMWVGTFHGIAHRLLRQHAQRAGLPEGFQILDADDQLRVVKRVLRARGNDESRFPPRQVRGFISARKEEGERPSDVTE
AGGDYQQELLAVYHDYEQACRRGGLVDFSELLLRAYELLRDDPELLGHYQRRFAHILVDEFQDTNALQYRWLKLLGGEQS
ELFVVGDDDQSIYGWRGARVENIEHFRREMGDVRVVRLEQNYRSTGTILDAANRLIEHNSGRLGKQLWTDGWSGEPITLY
AAFNEVDEARWVVDRIRQLSEEGGYGHADFAILYRSNAQSRALEHELHAARLPFRVYGGLRFFERAEVKDALAYLRLVAN
RHDDASFERVVNTPPRGIGAKTVDAVRYAAREADVSMWRAARELTGSRALAARARNALASFLERIDALDSELTDRPLHDQ
VEQVIARTDLRRHHERDEARLENLDELVTAARTFAQRDEPEDDLDPLAAFLTHAALEAGEGQADDWEHSVQLMTLHSAKG
LEFPVVFLVGMEEGLFPHRMSVEEPGRLEEERRLCYVGMTRARQRLILTHAEKRRLHGMDQLARPSRFLTEIPGEHLEEV
RPRMSVRRGPPSVPASGGSGSSLPADAPPEGLSLGSRVHHPRFGDGVLLHCEGSGPNARLQVRFDSAGTKWLIAGRAGLE
PATS

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=726, Percent_Identity=57.9889807162534, Blast_Score=838, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=641, Percent_Identity=37.597503900156, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI1787196, Length=341, Percent_Identity=29.6187683284457, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=501, Percent_Identity=28.3433133732535, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324477, Length=663, Percent_Identity=22.473604826546, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81097; Mature: 80966

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIDALTADLNDAQREAVCLPPGRALVLAGAGSGKTRVLTRRAAYLVQVEGASPFAILAV
CCCCHHCCCCCHHCCCEEECCCCCEEEEEECCCCCHHHHEEEEEEEEEECCCCCEEEEEE
TFTNKAAGEMRGRIGELLGIATAGMWVGTFHGIAHRLLRQHAQRAGLPEGFQILDADDQL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHH
RVVKRVLRARGNDESRFPPRQVRGFISARKEEGERPSDVTEAGGDYQQELLAVYHDYEQA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHH
CRRGGLVDFSELLLRAYELLRDDPELLGHYQRRFAHILVDEFQDTNALQYRWLKLLGGEQ
HHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
SELFVVGDDDQSIYGWRGARVENIEHFRREMGDVRVVRLEQNYRSTGTILDAANRLIEHN
CCEEEEECCCCCEECCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCC
SGRLGKQLWTDGWSGEPITLYAAFNEVDEARWVVDRIRQLSEEGGYGHADFAILYRSNAQ
CCCHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCH
SRALEHELHAARLPFRVYGGLRFFERAEVKDALAYLRLVANRHDDASFERVVNTPPRGIG
HHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC
AKTVDAVRYAAREADVSMWRAARELTGSRALAARARNALASFLERIDALDSELTDRPLHD
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
QVEQVIARTDLRRHHERDEARLENLDELVTAARTFAQRDEPEDDLDPLAAFLTHAALEAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
EGQADDWEHSVQLMTLHSAKGLEFPVVFLVGMEEGLFPHRMSVEEPGRLEEERRLCYVGM
CCCCCCHHCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHEEHEEH
TRARQRLILTHAEKRRLHGMDQLARPSRFLTEIPGEHLEEVRPRMSVRRGPPSVPASGGS
HHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCC
GSSLPADAPPEGLSLGSRVHHPRFGDGVLLHCEGSGPNARLQVRFDSAGTKWLIAGRAGL
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCC
EPATS
CCCCC
>Mature Secondary Structure 
PIDALTADLNDAQREAVCLPPGRALVLAGAGSGKTRVLTRRAAYLVQVEGASPFAILAV
CCCHHCCCCCHHCCCEEECCCCCEEEEEECCCCCHHHHEEEEEEEEEECCCCCEEEEEE
TFTNKAAGEMRGRIGELLGIATAGMWVGTFHGIAHRLLRQHAQRAGLPEGFQILDADDQL
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHH
RVVKRVLRARGNDESRFPPRQVRGFISARKEEGERPSDVTEAGGDYQQELLAVYHDYEQA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHH
CRRGGLVDFSELLLRAYELLRDDPELLGHYQRRFAHILVDEFQDTNALQYRWLKLLGGEQ
HHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
SELFVVGDDDQSIYGWRGARVENIEHFRREMGDVRVVRLEQNYRSTGTILDAANRLIEHN
CCEEEEECCCCCEECCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHCC
SGRLGKQLWTDGWSGEPITLYAAFNEVDEARWVVDRIRQLSEEGGYGHADFAILYRSNAQ
CCCHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCH
SRALEHELHAARLPFRVYGGLRFFERAEVKDALAYLRLVANRHDDASFERVVNTPPRGIG
HHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCC
AKTVDAVRYAAREADVSMWRAARELTGSRALAARARNALASFLERIDALDSELTDRPLHD
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
QVEQVIARTDLRRHHERDEARLENLDELVTAARTFAQRDEPEDDLDPLAAFLTHAALEAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
EGQADDWEHSVQLMTLHSAKGLEFPVVFLVGMEEGLFPHRMSVEEPGRLEEERRLCYVGM
CCCCCCHHCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHEEHEEH
TRARQRLILTHAEKRRLHGMDQLARPSRFLTEIPGEHLEEVRPRMSVRRGPPSVPASGGS
HHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCC
GSSLPADAPPEGLSLGSRVHHPRFGDGVLLHCEGSGPNARLQVRFDSAGTKWLIAGRAGL
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCCEEEEECCCCC
EPATS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]