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The map label for this gene is 121999110

Identifier: 121999110

GI number: 121999110

Start: 2558341

End: 2559303

Strand: Reverse

Name: 121999110

Synonym: Hhal_2332

Alternate gene names: NA

Gene position: 2559303-2558341 (Counterclockwise)

Preceding gene: 121999112

Following gene: 121999109

Centisome position: 95.55

GC content: 71.34

Gene sequence:

>963_bases
ATGGAGGCGAAGACCGTCTGTGTCGTCGGCGGAACCGGTTTTGTTGGGATGCACGTGGCCAACCGGCTCGCCGACCGGGG
ATACCGGATACGGGCGCTGACCCGCCGTTCCCATCGTGGCCGCGACCTGCTGCTCTTTCCCGGGCTGCGCCTGTTCGAGG
CCGATGTCCACGACGAGCGGGAGCTGGTGCGCCACTTCAGCGGCTGTCACGCCGTGATCAACCTGGCCGGTGCGCACACC
GGGCGGGGCGGGCCGCGGGAGGACGCCTACCACGAGGTCCATGTCGATCTGCCGCGCCGCGTGCTGGCCGCTGCGCGCCG
GGCAAGCGTGCCGCGCCTGGTCCACATGAGCGCCCTCGGCGCGCACCCCGATGCGGTCAGCCGGTTCCTGCGCACCAAGG
GCGAGGGCGAGCAGTTGGTCCTGGCAGCCGATCCGGATGAGATCGGCGCCACCGTGCTGCAGCCTTCAGTGATCTTCGGT
GCCGGTGACCGGTTCCTGAATCGCTTCGCCGGGCTGCTGCGCTTTGCCCCCGGGGTCTTCTTCCTGCCTACCCCGGATGC
CCGCCTCCAGCCGGTCTTCGGTGGCGACGTGGCTCAGGCGGTGATCAACGCGACGGAAGACCCCCGGACGGCGGGGCAGA
CCTACCAGCTCTGCGGGCCGCAGATCTACACCCTGCGCGAGCTGGTGGAGTACGTGGCAGAACTGCGCGGCCTGCGCCGG
CGGGTGGTCGGTCTCCCCGACAGCCTGTCGCAGCTCAGCGGCCGCCTGCTCGGGCTCGCTCCCGGGCGGCCTTACACCCT
GGACGAGTACCGCTTCACCGCCACCCCTAACTGCTGTGCCGAGGATGGCCTGGCAGCGCTGGGGATCCGCGCCAACGCCC
TGGAGGCGATCACCCCCGGGTACCTGGGTGCGGCCGGGCGGCAGGCGCAGTACCAGCAGGCCCGGCGCGAGGCCGGTCGC
TAG

Upstream 100 bases:

>100_bases
CGCGGCGCAAGGGGTGGTGCGGCGTCGTTGAAAAGTTGCGCATAAAAGGCCACGGTATCGCTCCGTAACGATCGTATTTC
GGTTCTTCAGGAGACCGTTC

Downstream 100 bases:

>100_bases
GCCGTGGAACGCTACCGGGTCGGCGGCGCGGTGCGTGATCGCCTCCTCGGGCGGCCCGTGGATGAGGTCGACTGGGTGGT
GGTCGGGGCGACGCCGGAGG

Product: NAD-dependent epimerase/dehydratase

Products: NAD+; ubiquinol

Alternate protein names: NADH Dehydrogenase; NADH-Ubiquinone Oxidoreductase; 3-Beta Hydroxysteroid Dehydrogenase/Isomerase; Nucleoside-Diphosphate-Sugar Epimerase; Oxidoreductase; NADH-Ubiquinone Oxidoreductase Subunit; 3-Beta Hydroxysteroid Dehydrogenase/Isomerase Family; NADH Dehydrogenase/Oxidoreductase-Like Protein; NAD-Dependent Epimerase/Dehydratase Family Protein; NAD Dependent Epimerase/Dehydratase Family Protein; 3-Beta-Hydroxy-Delta(5)-Steroid Dehydrogenase; NADH Ubiquinone Oxidoreductase; Nucleoside-Diphosphate-Sugar Epimerases; NADH Dehydrogenase 1 Alpha Subcomplex; Dehydrogenase; NADH Dehydrogenase/NADH Dehydrogenase Protein; Ubiquinone Dependent NADH Dehydrogenase; NADH Dehydrogenase Subunit; NADH-Ubiquinone Oxidoreductase Family Protein; NADH Dehydrogenase-Like Protein; NAD Dependent Epimerase; Nucleoside-Diphosphate Sugar Epimerase; NAD Dependent Epimerase/Dehydratase Family; NADH-Ubiquinone Oxidoreductase -Like Protein; NADH-Ubiquinone Oxidoreductase Putativ; NADH-Quinone Oxidoreductase

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MEAKTVCVVGGTGFVGMHVANRLADRGYRIRALTRRSHRGRDLLLFPGLRLFEADVHDERELVRHFSGCHAVINLAGAHT
GRGGPREDAYHEVHVDLPRRVLAAARRASVPRLVHMSALGAHPDAVSRFLRTKGEGEQLVLAADPDEIGATVLQPSVIFG
AGDRFLNRFAGLLRFAPGVFFLPTPDARLQPVFGGDVAQAVINATEDPRTAGQTYQLCGPQIYTLRELVEYVAELRGLRR
RVVGLPDSLSQLSGRLLGLAPGRPYTLDEYRFTATPNCCAEDGLAALGIRANALEAITPGYLGAAGRQAQYQQARREAGR

Sequences:

>Translated_320_residues
MEAKTVCVVGGTGFVGMHVANRLADRGYRIRALTRRSHRGRDLLLFPGLRLFEADVHDERELVRHFSGCHAVINLAGAHT
GRGGPREDAYHEVHVDLPRRVLAAARRASVPRLVHMSALGAHPDAVSRFLRTKGEGEQLVLAADPDEIGATVLQPSVIFG
AGDRFLNRFAGLLRFAPGVFFLPTPDARLQPVFGGDVAQAVINATEDPRTAGQTYQLCGPQIYTLRELVEYVAELRGLRR
RVVGLPDSLSQLSGRLLGLAPGRPYTLDEYRFTATPNCCAEDGLAALGIRANALEAITPGYLGAAGRQAQYQQARREAGR
>Mature_320_residues
MEAKTVCVVGGTGFVGMHVANRLADRGYRIRALTRRSHRGRDLLLFPGLRLFEADVHDERELVRHFSGCHAVINLAGAHT
GRGGPREDAYHEVHVDLPRRVLAAARRASVPRLVHMSALGAHPDAVSRFLRTKGEGEQLVLAADPDEIGATVLQPSVIFG
AGDRFLNRFAGLLRFAPGVFFLPTPDARLQPVFGGDVAQAVINATEDPRTAGQTYQLCGPQIYTLRELVEYVAELRGLRR
RVVGLPDSLSQLSGRLLGLAPGRPYTLDEYRFTATPNCCAEDGLAALGIRANALEAITPGYLGAAGRQAQYQQARREAGR

Specific function: Unknown

COG id: COG0702

COG function: function code MG; Predicted nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6681764, Length=297, Percent_Identity=30.3030303030303, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI239745448, Length=287, Percent_Identity=27.1777003484321, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310132178, Length=287, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI310113012, Length=287, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17556106, Length=323, Percent_Identity=28.4829721362229, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24667554, Length=249, Percent_Identity=35.3413654618474, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 1.6.5.3; 1.6.99.3

Molecular weight: Translated: 34774; Mature: 34774

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAKTVCVVGGTGFVGMHVANRLADRGYRIRALTRRSHRGRDLLLFPGLRLFEADVHDER
CCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEHHHCCCCCEEEEECCCCEEECCCCHHH
ELVRHFSGCHAVINLAGAHTGRGGPREDAYHEVHVDLPRRVLAAARRASVPRLVHMSALG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHC
AHPDAVSRFLRTKGEGEQLVLAADPDEIGATVLQPSVIFGAGDRFLNRFAGLLRFAPGVF
CCHHHHHHHHHCCCCCCEEEEEECCHHHCHHHHCCCEEEECCHHHHHHHHHHHHHCCCEE
FLPTPDARLQPVFGGDVAQAVINATEDPRTAGQTYQLCGPQIYTLRELVEYVAELRGLRR
EECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEHHCCCHHHHHHHHHHHHHHHHHHHH
RVVGLPDSLSQLSGRLLGLAPGRPYTLDEYRFTATPNCCAEDGLAALGIRANALEAITPG
HHCCCCHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCHHHCCCEEECCCCCHHHHCCCC
YLGAAGRQAQYQQARREAGR
HHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MEAKTVCVVGGTGFVGMHVANRLADRGYRIRALTRRSHRGRDLLLFPGLRLFEADVHDER
CCCCEEEEECCCCHHHHHHHHHHHHCCEEEEEEHHHCCCCCEEEEECCCCEEECCCCHHH
ELVRHFSGCHAVINLAGAHTGRGGPREDAYHEVHVDLPRRVLAAARRASVPRLVHMSALG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHC
AHPDAVSRFLRTKGEGEQLVLAADPDEIGATVLQPSVIFGAGDRFLNRFAGLLRFAPGVF
CCHHHHHHHHHCCCCCCEEEEEECCHHHCHHHHCCCEEEECCHHHHHHHHHHHHHCCCEE
FLPTPDARLQPVFGGDVAQAVINATEDPRTAGQTYQLCGPQIYTLRELVEYVAELRGLRR
EECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEHHCCCHHHHHHHHHHHHHHHHHHHH
RVVGLPDSLSQLSGRLLGLAPGRPYTLDEYRFTATPNCCAEDGLAALGIRANALEAITPG
HHCCCCHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCHHHCCCEEECCCCCHHHHCCCC
YLGAAGRQAQYQQARREAGR
HHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA