Click here to switch to the map view.

The map label for this gene is hemF [H]

Identifier: 121999098

GI number: 121999098

Start: 2545632

End: 2546552

Strand: Reverse

Name: hemF [H]

Synonym: Hhal_2320

Alternate gene names: 121999098

Gene position: 2546552-2545632 (Counterclockwise)

Preceding gene: 121999099

Following gene: 121999096

Centisome position: 95.08

GC content: 67.75

Gene sequence:

>921_bases
ATGACGGATGCGATGCCGGTCGACGGGATCCAGCGCGTCCACGACTGGCTGTTGACCTGGCAGGAGCGTGTCTGCCGGTT
CGTTGAAGGTTGGGACGGTGGCGGTGCCTTCCAGGCGGATCGCTGGGACCGTCCTGGCGGGGGCGGCGGCGAGAGCCGTG
TACTTCAAGGTGGTCGGGTGATCGAGCAGGGCGGTGTGAACTTCTCCCACGTCCGTGGTGAGGCGCTGCCCGAGGCGGCC
ACCGAGCGGCGGGCCGAGCTGGCCGGGCAGCCCTTCGAGGCGGTGGGCGTGTCCCTGGTGCTGCACCCGTGGAACCCGTA
CGTTCCGATCACCCACGCCAACCTGCGGTTGTTTGTGGCCGGTGAGCCGGGTCGCGGCGCCCAGTGGTGGTTCGGCGGCG
GGTTCGATCTGACCCCTTGCTACCCCTTCGACGACGATTGTTACCATTTCCATCGCTGTGCCCGGGCGGCCTGCGCGCCG
TTCGGAGAGACGGTCTATCCGGTGTTTAAACGCTGGTGTGACGACTACTTCCGCCTGCCCCACCGCGATGAGCAACGCGG
CATCGGCGGGCTGTTCTTCGACGATCTCAACGACTGGGGGTTCGAGACGACCTTCCGGTTCGTCCAGAGGGTGGGGCGGG
CCTTCCTCGATGCCTACGGCCCCATCATCGAGTCTCGCCGGGATCACGCCTACGGCGACCGCGAGCGGGAGTTCCAGCTC
TACCGGCGCGGCCGGTATGTGGAGTTCAACCTCCTGCAGGATCGCGGGACCCGGTTCGGCATCCAGTCGGAGGGGCGGAC
CGAATCAATCCTGATGTCGCTGCCACCCCGGGTGCGCTGGGAGTACGGCTACCAGCCCGAGCCCGGCAGCCCGGAGGCCC
GCCTGACCGAGGTGTATCTCATCCCCCGCGACTGGGTCTGA

Upstream 100 bases:

>100_bases
TGGCGCCGGTGGGCCGCTGCACCGGGTCCGGGTGCCAGATCCTGCCCGGCGAGCACGGGATGGATGGGTTCTTCTACGCC
TGCCTCGAGCGGAGTGCCGC

Downstream 100 bases:

>100_bases
ACACCCCGCGCCCGGCGGGGTGCGGGGTCGTCCGAGTCCCGAGCGCCTCAGCCCTCCTGATGGTAGCGGGCGATCCGCTC
GACCTCGTTCCTGGAGCCGA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTDAMPVDGIQRVHDWLLTWQERVCRFVEGWDGGGAFQADRWDRPGGGGGESRVLQGGRVIEQGGVNFSHVRGEALPEAA
TERRAELAGQPFEAVGVSLVLHPWNPYVPITHANLRLFVAGEPGRGAQWWFGGGFDLTPCYPFDDDCYHFHRCARAACAP
FGETVYPVFKRWCDDYFRLPHRDEQRGIGGLFFDDLNDWGFETTFRFVQRVGRAFLDAYGPIIESRRDHAYGDREREFQL
YRRGRYVEFNLLQDRGTRFGIQSEGRTESILMSLPPRVRWEYGYQPEPGSPEARLTEVYLIPRDWV

Sequences:

>Translated_306_residues
MTDAMPVDGIQRVHDWLLTWQERVCRFVEGWDGGGAFQADRWDRPGGGGGESRVLQGGRVIEQGGVNFSHVRGEALPEAA
TERRAELAGQPFEAVGVSLVLHPWNPYVPITHANLRLFVAGEPGRGAQWWFGGGFDLTPCYPFDDDCYHFHRCARAACAP
FGETVYPVFKRWCDDYFRLPHRDEQRGIGGLFFDDLNDWGFETTFRFVQRVGRAFLDAYGPIIESRRDHAYGDREREFQL
YRRGRYVEFNLLQDRGTRFGIQSEGRTESILMSLPPRVRWEYGYQPEPGSPEARLTEVYLIPRDWV
>Mature_305_residues
TDAMPVDGIQRVHDWLLTWQERVCRFVEGWDGGGAFQADRWDRPGGGGGESRVLQGGRVIEQGGVNFSHVRGEALPEAAT
ERRAELAGQPFEAVGVSLVLHPWNPYVPITHANLRLFVAGEPGRGAQWWFGGGFDLTPCYPFDDDCYHFHRCARAACAPF
GETVYPVFKRWCDDYFRLPHRDEQRGIGGLFFDDLNDWGFETTFRFVQRVGRAFLDAYGPIIESRRDHAYGDREREFQLY
RRGRYVEFNLLQDRGTRFGIQSEGRTESILMSLPPRVRWEYGYQPEPGSPEARLTEVYLIPRDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=309, Percent_Identity=48.2200647249191, Blast_Score=279, Evalue=2e-75,
Organism=Escherichia coli, GI1788777, Length=296, Percent_Identity=62.1621621621622, Blast_Score=373, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6320249, Length=305, Percent_Identity=43.2786885245902, Blast_Score=241, Evalue=9e-65,
Organism=Drosophila melanogaster, GI17864388, Length=304, Percent_Identity=48.0263157894737, Blast_Score=286, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 35203; Mature: 35072

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAMPVDGIQRVHDWLLTWQERVCRFVEGWDGGGAFQADRWDRPGGGGGESRVLQGGRV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEE
IEQGGVNFSHVRGEALPEAATERRAELAGQPFEAVGVSLVLHPWNPYVPITHANLRLFVA
EECCCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHCCEEEEEECCCCCCEEEECCEEEEEE
GEPGRGAQWWFGGGFDLTPCYPFDDDCYHFHRCARAACAPFGETVYPVFKRWCDDYFRLP
CCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
HRDEQRGIGGLFFDDLNDWGFETTFRFVQRVGRAFLDAYGPIIESRRDHAYGDREREFQL
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YRRGRYVEFNLLQDRGTRFGIQSEGRTESILMSLPPRVRWEYGYQPEPGSPEARLTEVYL
HHCCCEEEEEEECCCCCCCCCCCCCCCHHHEEECCCCCEECCCCCCCCCCCCCEEEEEEE
IPRDWV
ECCCCC
>Mature Secondary Structure 
TDAMPVDGIQRVHDWLLTWQERVCRFVEGWDGGGAFQADRWDRPGGGGGESRVLQGGRV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEE
IEQGGVNFSHVRGEALPEAATERRAELAGQPFEAVGVSLVLHPWNPYVPITHANLRLFVA
EECCCCCHHHHCCCCCHHHHHHHHHHHCCCCHHHCCEEEEEECCCCCCEEEECCEEEEEE
GEPGRGAQWWFGGGFDLTPCYPFDDDCYHFHRCARAACAPFGETVYPVFKRWCDDYFRLP
CCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
HRDEQRGIGGLFFDDLNDWGFETTFRFVQRVGRAFLDAYGPIIESRRDHAYGDREREFQL
CCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YRRGRYVEFNLLQDRGTRFGIQSEGRTESILMSLPPRVRWEYGYQPEPGSPEARLTEVYL
HHCCCEEEEEEECCCCCCCCCCCCCCCHHHEEECCCCCEECCCCCCCCCCCCCEEEEEEE
IPRDWV
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA