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The map label for this gene is clpB [H]

Identifier: 121999011

GI number: 121999011

Start: 2445600

End: 2448212

Strand: Reverse

Name: clpB [H]

Synonym: Hhal_2232

Alternate gene names: 121999011

Gene position: 2448212-2445600 (Counterclockwise)

Preceding gene: 121999012

Following gene: 121999009

Centisome position: 91.4

GC content: 66.44

Gene sequence:

>2613_bases
ATGCGGATGGACAAGCTGACCACCAAATTCCAGATGGCCATCGCCGAGGCGCAGAGCCTGGCGGTGGGCCGTGACCACCA
GTTCATCGAGCCGGTTCACCTGATGATGGCCATGCTCGATCAGGAGGGCGGCGGCGTTCGTCCGCTGCTCCAGCAGGCCG
GGGTCAACCTCAACAAGCTCCGCTCCCAGCTCGGGGAGGCCCTGGAGCACATGCCGCAGGTCACGGGGACCGGCGGGGAG
GTGCACCTCTCCAACGAGCTGGGGCGCCTGCTCAACCTCACCGACAAGCTGGCGCAGAAGCGCAAGGACCAATACCTCTC
CAGTGAGCTGTTCATACTCGCCGTGCTCGAGGATGGCAAGAGCCGCTTGGCGCAGATCCTCGAGCAGGCCGGCGCGGCCA
AGGCGCCGGTGGAGCAGGCCGTCGAGCAGGTGCGTGGCGGTCAGGCTGTGGACGATCCCAACGCGGAGGAGCAGCGCCAG
GCGCTGGAGAAGTACACCATCGACCTGACCGAGCGCGCTGAGCAGGGCAAGCTCGACCCGGTGATCGGCCGCGACGACGA
GATCCGGCGCACGGTGCAGGTCCTTCAGCGCCGGACCAAGAACAACCCGGTGCTCATCGGCGAGCCGGGTACCGGCAAGA
CGGCCATCGTCGAGGGCCTGGCCCAGCGCATCGTCAACGCCGAGGTGCCGGAGGGCCTCAAGAACAAGCGCGTCCTCTCC
CTCGATCTGGGCGCACTGCTCGCCGGGGCCAAGTACCGCGGCGATTTCGAGGAGCGCCTCAAGGCGCTGCTCAAGGAGCT
CGGCCAGCAGGAGGGGCAGATCATCCTCTTCATCGACGAGCTCCATACCATCGTCGGTGCCGGCAAGGCCGAGGGCGCCA
TGGACGCCGGCAATATGCTCAAGCCGGCCCTGGCCCGGGGCGAGCTCCACTGCATCGGTGCGACCACCCTCAACGAGTAC
CGGGAGAACATCGAGAAGGACGCCGCCCTGGAGCGCCGCTTCCAGACGGTGCTGGTGGATGAGCCCAGCGTCGAGGATAC
GGTGGCCATCCTGCGCGGGCTCAAGGAGCGTTACGAGGTTCACCACGGCGTCGAGATCACCGACCCGGCCATCGTCTCGG
CGGCGACGCTGTCGCACCGTTACATCACGGACCGCAACCTGCCGGACAAGGCCATCGATCTGGTCGACGAGGCGGCGTCG
CGGATCCGGATGGAGATCGACTCCAAGCCGGAGTCCATGGATCGGCTTGAGCGCCGACTGATCCAGCTGAAGATCGAGCG
TGAGGCACTCAAGAACGAAAACGACGACGCCTCCCGGAAGCGGCTGGCGACCCTCGAGGATGAGATCAGCGAGCTGGAGC
AGGAGTACCAGAGCCTCGAGGAGATCTGGAACTCCGAGAAGGCGGCCGTCGAGGGCACGCAATCGATCAAGGAGGAGCTC
GAGCGCGCCCGCCAGGAGGTCGAGACCGCCCGTCGGGCCGGTGACCTGCAGCGCATGTCCGAACTCCAGTACGGCCGCAT
CCCCGAGCTGGAGCGGCAGCTGGACATGGCCGCCCAGGCGGACATGTACGACATGAAGCTGCTGCGGAACCGGGTTACCG
AGGAGGAAGTCGCCGAGGTGGTCTCCAAGTGGACCGGCATCCCGGTCTCCAAGATGCTCGAGGGCGAACGGGACAAGCTC
CTGCGCATGGAAGAGGCGCTGCACGAGCGAGTGGTTGGTCAGGACGAGGCCATCGGCGCAGTGGCCAACGCCATCCGTCG
CTCCCGGGCCGGGCTGTCGGATCCGAATCGGCCCAACGGCTCGTTCCTCTTCCTCGGTCCGACCGGCGTGGGCAAGACCG
AGCTGTGCAAGGCGCTGGCTGAATTCCTCTTCGATACCCAAGAGGCCATGGTGCGCATCGACATGTCCGAGTTCATGGAG
AAGCACTCCGTGGCCCGGCTGATCGGCGCCCCCCCGGGGTACGTCGGCTATGAGGAGGGCGGCTACCTGACCGAGCATGT
GCGGCGCAAGCCGTACTCGGTGATCCTCCTCGACGAGGTGGAGAAGGCCCACGCAGACGTGTTCAACGTCCTGCTGCAGG
TGCTCGACGACGGCCGCCTGACCGACAGCCACGGCCGTACCGTGGACTTCCGCAACACGGTCATCGTCATGACCTCGAAC
CTCGGCTCCGAGGTCATCCAGACCATGGCCGGTGAGGAAGAGGAGAGCTACCAGCGGATGAAGAGCTCGGTGATGGACAT
CGTCGGGACCCAGTTCCGCCCCGAGTTCATCAACCGCATCGACGAGGTGGTGGTCTTCCGGCCGCTGTCCCGGGAGCAGA
TCCGGGCCATTACCAGCATCCAGGTCCGCTATCTCAGTGAGCGGCTGGCCGAGCGCGACATGGCCCTGGAGCTCAGTGAG
GTGGCCCTGGACCGGATCGGTGAAGCGGGCTTCGACCCGGTCTACGGTGCCCGCCCGCTCAAGCGGGTCCTGCAGCACGA
GGTGGAGAACCCGCTGGCCCGGGAGATGTTGCAGGGCAACTTCGGGCAGGGCGATCGCATCCGTGTCGACGTGCAGGACG
GCGAGTTCCGCTTCGAACGCGGCGAGCCGGTGATCGAGGGCGAGGTGGTCTGA

Upstream 100 bases:

>100_bases
CCCATCCTCGCCGCCCCATCTATCCTGACAAGGGTCAAGCCATCGCCAACGTGCGGTGAACCGGATCGTCGGCCCGACAT
GCGGCCAAGGGGGTAGAGCA

Downstream 100 bases:

>100_bases
GAGCCGACCGCCGCCCGCGGTCACGCCCGAGCGGTGCCGGACTGTGCCCGGAGGAGGCCCTCCGGGCACAGTCGTGTCGG
ATTAGCCGGGGCGGCGTTCC

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 870; Mature: 870

Protein sequence:

>870_residues
MRMDKLTTKFQMAIAEAQSLAVGRDHQFIEPVHLMMAMLDQEGGGVRPLLQQAGVNLNKLRSQLGEALEHMPQVTGTGGE
VHLSNELGRLLNLTDKLAQKRKDQYLSSELFILAVLEDGKSRLAQILEQAGAAKAPVEQAVEQVRGGQAVDDPNAEEQRQ
ALEKYTIDLTERAEQGKLDPVIGRDDEIRRTVQVLQRRTKNNPVLIGEPGTGKTAIVEGLAQRIVNAEVPEGLKNKRVLS
LDLGALLAGAKYRGDFEERLKALLKELGQQEGQIILFIDELHTIVGAGKAEGAMDAGNMLKPALARGELHCIGATTLNEY
RENIEKDAALERRFQTVLVDEPSVEDTVAILRGLKERYEVHHGVEITDPAIVSAATLSHRYITDRNLPDKAIDLVDEAAS
RIRMEIDSKPESMDRLERRLIQLKIEREALKNENDDASRKRLATLEDEISELEQEYQSLEEIWNSEKAAVEGTQSIKEEL
ERARQEVETARRAGDLQRMSELQYGRIPELERQLDMAAQADMYDMKLLRNRVTEEEVAEVVSKWTGIPVSKMLEGERDKL
LRMEEALHERVVGQDEAIGAVANAIRRSRAGLSDPNRPNGSFLFLGPTGVGKTELCKALAEFLFDTQEAMVRIDMSEFME
KHSVARLIGAPPGYVGYEEGGYLTEHVRRKPYSVILLDEVEKAHADVFNVLLQVLDDGRLTDSHGRTVDFRNTVIVMTSN
LGSEVIQTMAGEEEESYQRMKSSVMDIVGTQFRPEFINRIDEVVVFRPLSREQIRAITSIQVRYLSERLAERDMALELSE
VALDRIGEAGFDPVYGARPLKRVLQHEVENPLAREMLQGNFGQGDRIRVDVQDGEFRFERGEPVIEGEVV

Sequences:

>Translated_870_residues
MRMDKLTTKFQMAIAEAQSLAVGRDHQFIEPVHLMMAMLDQEGGGVRPLLQQAGVNLNKLRSQLGEALEHMPQVTGTGGE
VHLSNELGRLLNLTDKLAQKRKDQYLSSELFILAVLEDGKSRLAQILEQAGAAKAPVEQAVEQVRGGQAVDDPNAEEQRQ
ALEKYTIDLTERAEQGKLDPVIGRDDEIRRTVQVLQRRTKNNPVLIGEPGTGKTAIVEGLAQRIVNAEVPEGLKNKRVLS
LDLGALLAGAKYRGDFEERLKALLKELGQQEGQIILFIDELHTIVGAGKAEGAMDAGNMLKPALARGELHCIGATTLNEY
RENIEKDAALERRFQTVLVDEPSVEDTVAILRGLKERYEVHHGVEITDPAIVSAATLSHRYITDRNLPDKAIDLVDEAAS
RIRMEIDSKPESMDRLERRLIQLKIEREALKNENDDASRKRLATLEDEISELEQEYQSLEEIWNSEKAAVEGTQSIKEEL
ERARQEVETARRAGDLQRMSELQYGRIPELERQLDMAAQADMYDMKLLRNRVTEEEVAEVVSKWTGIPVSKMLEGERDKL
LRMEEALHERVVGQDEAIGAVANAIRRSRAGLSDPNRPNGSFLFLGPTGVGKTELCKALAEFLFDTQEAMVRIDMSEFME
KHSVARLIGAPPGYVGYEEGGYLTEHVRRKPYSVILLDEVEKAHADVFNVLLQVLDDGRLTDSHGRTVDFRNTVIVMTSN
LGSEVIQTMAGEEEESYQRMKSSVMDIVGTQFRPEFINRIDEVVVFRPLSREQIRAITSIQVRYLSERLAERDMALELSE
VALDRIGEAGFDPVYGARPLKRVLQHEVENPLAREMLQGNFGQGDRIRVDVQDGEFRFERGEPVIEGEVV
>Mature_870_residues
MRMDKLTTKFQMAIAEAQSLAVGRDHQFIEPVHLMMAMLDQEGGGVRPLLQQAGVNLNKLRSQLGEALEHMPQVTGTGGE
VHLSNELGRLLNLTDKLAQKRKDQYLSSELFILAVLEDGKSRLAQILEQAGAAKAPVEQAVEQVRGGQAVDDPNAEEQRQ
ALEKYTIDLTERAEQGKLDPVIGRDDEIRRTVQVLQRRTKNNPVLIGEPGTGKTAIVEGLAQRIVNAEVPEGLKNKRVLS
LDLGALLAGAKYRGDFEERLKALLKELGQQEGQIILFIDELHTIVGAGKAEGAMDAGNMLKPALARGELHCIGATTLNEY
RENIEKDAALERRFQTVLVDEPSVEDTVAILRGLKERYEVHHGVEITDPAIVSAATLSHRYITDRNLPDKAIDLVDEAAS
RIRMEIDSKPESMDRLERRLIQLKIEREALKNENDDASRKRLATLEDEISELEQEYQSLEEIWNSEKAAVEGTQSIKEEL
ERARQEVETARRAGDLQRMSELQYGRIPELERQLDMAAQADMYDMKLLRNRVTEEEVAEVVSKWTGIPVSKMLEGERDKL
LRMEEALHERVVGQDEAIGAVANAIRRSRAGLSDPNRPNGSFLFLGPTGVGKTELCKALAEFLFDTQEAMVRIDMSEFME
KHSVARLIGAPPGYVGYEEGGYLTEHVRRKPYSVILLDEVEKAHADVFNVLLQVLDDGRLTDSHGRTVDFRNTVIVMTSN
LGSEVIQTMAGEEEESYQRMKSSVMDIVGTQFRPEFINRIDEVVVFRPLSREQIRAITSIQVRYLSERLAERDMALELSE
VALDRIGEAGFDPVYGARPLKRVLQHEVENPLAREMLQGNFGQGDRIRVDVQDGEFRFERGEPVIEGEVV

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=325, Percent_Identity=36, Blast_Score=206, Evalue=8e-53,
Organism=Escherichia coli, GI1788943, Length=853, Percent_Identity=69.9882766705745, Blast_Score=1238, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=423, Percent_Identity=40.4255319148936, Blast_Score=289, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6320464, Length=708, Percent_Identity=53.2485875706215, Blast_Score=775, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=859, Percent_Identity=42.7240977881257, Blast_Score=677, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 97594; Mature: 97594

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMDKLTTKFQMAIAEAQSLAVGRDHQFIEPVHLMMAMLDQEGGGVRPLLQQAGVNLNKL
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHH
RSQLGEALEHMPQVTGTGGEVHLSNELGRLLNLTDKLAQKRKDQYLSSELFILAVLEDGK
HHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCH
SRLAQILEQAGAAKAPVEQAVEQVRGGQAVDDPNAEEQRQALEKYTIDLTERAEQGKLDP
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
VIGRDDEIRRTVQVLQRRTKNNPVLIGEPGTGKTAIVEGLAQRIVNAEVPEGLKNKRVLS
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEE
LDLGALLAGAKYRGDFEERLKALLKELGQQEGQIILFIDELHTIVGAGKAEGAMDAGNML
EEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHH
KPALARGELHCIGATTLNEYRENIEKDAALERRFQTVLVDEPSVEDTVAILRGLKERYEV
HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HHGVEITDPAIVSAATLSHRYITDRNLPDKAIDLVDEAASRIRMEIDSKPESMDRLERRL
HCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IQLKIEREALKNENDDASRKRLATLEDEISELEQEYQSLEEIWNSEKAAVEGTQSIKEEL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ERARQEVETARRAGDLQRMSELQYGRIPELERQLDMAAQADMYDMKLLRNRVTEEEVAEV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VSKWTGIPVSKMLEGERDKLLRMEEALHERVVGQDEAIGAVANAIRRSRAGLSDPNRPNG
HHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SFLFLGPTGVGKTELCKALAEFLFDTQEAMVRIDMSEFMEKHSVARLIGAPPGYVGYEEG
CEEEECCCCCCHHHHHHHHHHHHHCHHHHHHEECHHHHHHHHHHHHHHCCCCCCCCCCCC
GYLTEHVRRKPYSVILLDEVEKAHADVFNVLLQVLDDGRLTDSHGRTVDFRNTVIVMTSN
CHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECC
LGSEVIQTMAGEEEESYQRMKSSVMDIVGTQFRPEFINRIDEVVVFRPLSREQIRAITSI
CCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
QVRYLSERLAERDMALELSEVALDRIGEAGFDPVYGARPLKRVLQHEVENPLAREMLQGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCC
FGQGDRIRVDVQDGEFRFERGEPVIEGEVV
CCCCCEEEEEECCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MRMDKLTTKFQMAIAEAQSLAVGRDHQFIEPVHLMMAMLDQEGGGVRPLLQQAGVNLNKL
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHH
RSQLGEALEHMPQVTGTGGEVHLSNELGRLLNLTDKLAQKRKDQYLSSELFILAVLEDGK
HHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCH
SRLAQILEQAGAAKAPVEQAVEQVRGGQAVDDPNAEEQRQALEKYTIDLTERAEQGKLDP
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
VIGRDDEIRRTVQVLQRRTKNNPVLIGEPGTGKTAIVEGLAQRIVNAEVPEGLKNKRVLS
CCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEE
LDLGALLAGAKYRGDFEERLKALLKELGQQEGQIILFIDELHTIVGAGKAEGAMDAGNML
EEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHH
KPALARGELHCIGATTLNEYRENIEKDAALERRFQTVLVDEPSVEDTVAILRGLKERYEV
HHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HHGVEITDPAIVSAATLSHRYITDRNLPDKAIDLVDEAASRIRMEIDSKPESMDRLERRL
HCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IQLKIEREALKNENDDASRKRLATLEDEISELEQEYQSLEEIWNSEKAAVEGTQSIKEEL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ERARQEVETARRAGDLQRMSELQYGRIPELERQLDMAAQADMYDMKLLRNRVTEEEVAEV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VSKWTGIPVSKMLEGERDKLLRMEEALHERVVGQDEAIGAVANAIRRSRAGLSDPNRPNG
HHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
SFLFLGPTGVGKTELCKALAEFLFDTQEAMVRIDMSEFMEKHSVARLIGAPPGYVGYEEG
CEEEECCCCCCHHHHHHHHHHHHHCHHHHHHEECHHHHHHHHHHHHHHCCCCCCCCCCCC
GYLTEHVRRKPYSVILLDEVEKAHADVFNVLLQVLDDGRLTDSHGRTVDFRNTVIVMTSN
CHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECC
LGSEVIQTMAGEEEESYQRMKSSVMDIVGTQFRPEFINRIDEVVVFRPLSREQIRAITSI
CCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
QVRYLSERLAERDMALELSEVALDRIGEAGFDPVYGARPLKRVLQHEVENPLAREMLQGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCC
FGQGDRIRVDVQDGEFRFERGEPVIEGEVV
CCCCCEEEEEECCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]