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The map label for this gene is ftsI [H]

Identifier: 121998876

GI number: 121998876

Start: 2302731

End: 2304458

Strand: Reverse

Name: ftsI [H]

Synonym: Hhal_2097

Alternate gene names: 121998876

Gene position: 2304458-2302731 (Counterclockwise)

Preceding gene: 121998877

Following gene: 121998875

Centisome position: 86.04

GC content: 70.37

Gene sequence:

>1728_bases
GTGAGCAGGAATACGCGCCGACAACCCGCGCTCAATGGGCCGCCGCGCTGGCGGCTCTACAGCGTGGTGGCGGTGATGGC
CATCGCCGCCGGCGCGGTGATCCTGCGCGCTCTGGATCTGCAGGTGATCAACAGCGAATTCCTCCGCGACGAGGCCGATG
CCCGCCACCTGCGCACGGTGAGCATGCCGGCGCACCGGGGCGTGATCACCGACCGCAACGGTGAGCCGCTGGCAATCAGC
TCGCCGGTTAAGTCGGCCTGGGCCAACCCGGGGGAGTTGCTTGAGGACGGCGCGGCGGTCGCCGCCGTGGCCGAGGTGCT
GGAGCGCTCTCCGGCGGAACTGCGCGATTTCCTGAAGGCGCGGGAGGGGCGGCATTTCGTCTACCTGCGTCGCCACCTGT
CGCCGCAGGTGGCGACGCGCATGCGCGAACTGGACGCCCCGGGGGTGCAGCTGCAGCAGGAGTTCCGCCGCTTCTATCCG
GCCGGCGAGGTGGCGGCTCAGCTGGTCGGTTTTACCGACATCGATGGCCAGGGGCTGGCCGGTGTCGAGCGCGCCTTCGA
GGATCCGCTGAGTGGGCGCAGTGGCGCCAAGCGCGTCATCCGCGACCCGTTCGGGCGCACCATCGAGGATGTGGAGCTGC
TGCGCGAGCCGCGCCCTGGTGAAGATGTCCACCTGTCGCTGGATCGGCGCATCCAGTACGTGGCCTACCGCGAGCTCAAG
CGAGCCGTTCGCGGTCACGACGCCGAGGGAGGCGCGGCGGTCGTGCTGGATGCAACGAGCGGGGAGGTCCTGGCAATGGT
CAGCCAGCCCTCGTTCAACCCCCATCGCCGCGCCGGCGTCGAGCCTGAGCAGCGCCGCAACCGGGCGGTGAGCTGGGCCC
AGGAGCCGGGCTCCGTGATCAAGCCGTTCACCATTGCCGCAGCGCTCTCCAGCGGCGCGGTGCGCAGTGGGCAGGCGTTC
GACACGGCCCCGGGGACCATGCGCGTCGGACGGCACACCGTCCGTGATTTCCTCGATTACGGTGAGCTCGATATCGCCGG
CGTGCTGCAGAAGTCCAGCAACGTGGGCACCGTGAAGATGGCCCTGGAGACCGAGCCGCGGGCCCTATGGAACACCCTGG
AGGACATCGGCTTCGGCGAGCGTACGCGCAGCGGCCTGCGGGACGAGGTGGCCGGGCAGTTTCTGCCGGCGCCGCCCCGC
GGCGACGTGCAGCGCGCGACGCTCTCCTACGGCTACGGCGTCACCGCTACGCCGTTGCAGCTGGCGCGGGCCTACGCCGC
GCTGGCCCGGGACGGCGTCATTCGCCCGATCTCCATCCAGGCGGTGGAGGAGCCGCCGGAGGGCCGGCAGGTGCTCGATC
CGGAGCTGGCAGCCGAGATCCGCGGCATGCTCGAGGCGGTGGTCGAGCCCGGCGGCACCGGGACCCGTGCTGCTATCTCC
GGTTATCGAGTAGCCGGCAAGACCGGCACGGTCCTCAAGAGCGGCCCCAGTGGCTACGCCGAGGAGGACTACCTCGCCTC
TTTCATTGGTTTCGCCCCGGCGTCGGACCCGCGCCTGGTCATGGCCGTGACCATCGATCAGCCGCGCGGCGATCTCTACT
ACGGCGGCCAGGTGGCCGCGCCGGTCTTCTCCCGGGTGATGGGCAACGCGCTGCGCATGCTCAATGTGCCGCCCGACGAT
CTCCCGGAGCTTGAAGTGCCGGTCGTCGCCGAGAGGGAGGGGTCATGA

Upstream 100 bases:

>100_bases
GGGCACAGCCGCCTGGAGCGCGTCGCCGGCGAGGAGCTGGGGATGGCGCTGCCCGAGCGCGACGAGATCATCATCCTGAG
GCGCCCTTAAGGTGGCGAGA

Downstream 100 bases:

>100_bases
CTGCTGCGGCCCTCCCCGAAGTGACCCTGCGCTGGCTGCTTGAGCCGTGGGTCGACGAGGCGTTGCCTGCCGCGTCGATC
CAGGGGCTGACCCCCGATAC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 575; Mature: 574

Protein sequence:

>575_residues
MSRNTRRQPALNGPPRWRLYSVVAVMAIAAGAVILRALDLQVINSEFLRDEADARHLRTVSMPAHRGVITDRNGEPLAIS
SPVKSAWANPGELLEDGAAVAAVAEVLERSPAELRDFLKAREGRHFVYLRRHLSPQVATRMRELDAPGVQLQQEFRRFYP
AGEVAAQLVGFTDIDGQGLAGVERAFEDPLSGRSGAKRVIRDPFGRTIEDVELLREPRPGEDVHLSLDRRIQYVAYRELK
RAVRGHDAEGGAAVVLDATSGEVLAMVSQPSFNPHRRAGVEPEQRRNRAVSWAQEPGSVIKPFTIAAALSSGAVRSGQAF
DTAPGTMRVGRHTVRDFLDYGELDIAGVLQKSSNVGTVKMALETEPRALWNTLEDIGFGERTRSGLRDEVAGQFLPAPPR
GDVQRATLSYGYGVTATPLQLARAYAALARDGVIRPISIQAVEEPPEGRQVLDPELAAEIRGMLEAVVEPGGTGTRAAIS
GYRVAGKTGTVLKSGPSGYAEEDYLASFIGFAPASDPRLVMAVTIDQPRGDLYYGGQVAAPVFSRVMGNALRMLNVPPDD
LPELEVPVVAEREGS

Sequences:

>Translated_575_residues
MSRNTRRQPALNGPPRWRLYSVVAVMAIAAGAVILRALDLQVINSEFLRDEADARHLRTVSMPAHRGVITDRNGEPLAIS
SPVKSAWANPGELLEDGAAVAAVAEVLERSPAELRDFLKAREGRHFVYLRRHLSPQVATRMRELDAPGVQLQQEFRRFYP
AGEVAAQLVGFTDIDGQGLAGVERAFEDPLSGRSGAKRVIRDPFGRTIEDVELLREPRPGEDVHLSLDRRIQYVAYRELK
RAVRGHDAEGGAAVVLDATSGEVLAMVSQPSFNPHRRAGVEPEQRRNRAVSWAQEPGSVIKPFTIAAALSSGAVRSGQAF
DTAPGTMRVGRHTVRDFLDYGELDIAGVLQKSSNVGTVKMALETEPRALWNTLEDIGFGERTRSGLRDEVAGQFLPAPPR
GDVQRATLSYGYGVTATPLQLARAYAALARDGVIRPISIQAVEEPPEGRQVLDPELAAEIRGMLEAVVEPGGTGTRAAIS
GYRVAGKTGTVLKSGPSGYAEEDYLASFIGFAPASDPRLVMAVTIDQPRGDLYYGGQVAAPVFSRVMGNALRMLNVPPDD
LPELEVPVVAEREGS
>Mature_574_residues
SRNTRRQPALNGPPRWRLYSVVAVMAIAAGAVILRALDLQVINSEFLRDEADARHLRTVSMPAHRGVITDRNGEPLAISS
PVKSAWANPGELLEDGAAVAAVAEVLERSPAELRDFLKAREGRHFVYLRRHLSPQVATRMRELDAPGVQLQQEFRRFYPA
GEVAAQLVGFTDIDGQGLAGVERAFEDPLSGRSGAKRVIRDPFGRTIEDVELLREPRPGEDVHLSLDRRIQYVAYRELKR
AVRGHDAEGGAAVVLDATSGEVLAMVSQPSFNPHRRAGVEPEQRRNRAVSWAQEPGSVIKPFTIAAALSSGAVRSGQAFD
TAPGTMRVGRHTVRDFLDYGELDIAGVLQKSSNVGTVKMALETEPRALWNTLEDIGFGERTRSGLRDEVAGQFLPAPPRG
DVQRATLSYGYGVTATPLQLARAYAALARDGVIRPISIQAVEEPPEGRQVLDPELAAEIRGMLEAVVEPGGTGTRAAISG
YRVAGKTGTVLKSGPSGYAEEDYLASFIGFAPASDPRLVMAVTIDQPRGDLYYGGQVAAPVFSRVMGNALRMLNVPPDDL
PELEVPVVAEREGS

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=550, Percent_Identity=41.6363636363636, Blast_Score=434, Evalue=1e-123,
Organism=Escherichia coli, GI1786854, Length=641, Percent_Identity=25.8970358814353, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 62263; Mature: 62132

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRNTRRQPALNGPPRWRLYSVVAVMAIAAGAVILRALDLQVINSEFLRDEADARHLRTV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
SMPAHRGVITDRNGEPLAISSPVKSAWANPGELLEDGAAVAAVAEVLERSPAELRDFLKA
CCCCCCCEEECCCCCCEEECCCHHHHCCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHH
REGRHFVYLRRHLSPQVATRMRELDAPGVQLQQEFRRFYPAGEVAAQLVGFTDIDGQGLA
HCCCEEEEHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCH
GVERAFEDPLSGRSGAKRVIRDPFGRTIEDVELLREPRPGEDVHLSLDRRIQYVAYRELK
HHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHH
RAVRGHDAEGGAAVVLDATSGEVLAMVSQPSFNPHRRAGVEPEQRRNRAVSWAQEPGSVI
HHHCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCC
KPFTIAAALSSGAVRSGQAFDTAPGTMRVGRHTVRDFLDYGELDIAGVLQKSSNVGTVKM
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEE
ALETEPRALWNTLEDIGFGERTRSGLRDEVAGQFLPAPPRGDVQRATLSYGYGVTATPLQ
EEECCHHHHHHHHHHCCCCHHHHHCHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHH
LARAYAALARDGVIRPISIQAVEEPPEGRQVLDPELAAEIRGMLEAVVEPGGTGTRAAIS
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHC
GYRVAGKTGTVLKSGPSGYAEEDYLASFIGFAPASDPRLVMAVTIDQPRGDLYYGGQVAA
CEEEECCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEECCEEHH
PVFSRVMGNALRMLNVPPDDLPELEVPVVAEREGS
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCC
>Mature Secondary Structure 
SRNTRRQPALNGPPRWRLYSVVAVMAIAAGAVILRALDLQVINSEFLRDEADARHLRTV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
SMPAHRGVITDRNGEPLAISSPVKSAWANPGELLEDGAAVAAVAEVLERSPAELRDFLKA
CCCCCCCEEECCCCCCEEECCCHHHHCCCCHHHHHCCHHHHHHHHHHHCCHHHHHHHHHH
REGRHFVYLRRHLSPQVATRMRELDAPGVQLQQEFRRFYPAGEVAAQLVGFTDIDGQGLA
HCCCEEEEHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCH
GVERAFEDPLSGRSGAKRVIRDPFGRTIEDVELLREPRPGEDVHLSLDRRIQYVAYRELK
HHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHH
RAVRGHDAEGGAAVVLDATSGEVLAMVSQPSFNPHRRAGVEPEQRRNRAVSWAQEPGSVI
HHHCCCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCC
KPFTIAAALSSGAVRSGQAFDTAPGTMRVGRHTVRDFLDYGELDIAGVLQKSSNVGTVKM
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCEEEE
ALETEPRALWNTLEDIGFGERTRSGLRDEVAGQFLPAPPRGDVQRATLSYGYGVTATPLQ
EEECCHHHHHHHHHHCCCCHHHHHCHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCHHHH
LARAYAALARDGVIRPISIQAVEEPPEGRQVLDPELAAEIRGMLEAVVEPGGTGTRAAIS
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHC
GYRVAGKTGTVLKSGPSGYAEEDYLASFIGFAPASDPRLVMAVTIDQPRGDLYYGGQVAA
CEEEECCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCEEECCEEHH
PVFSRVMGNALRMLNVPPDDLPELEVPVVAEREGS
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]