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The map label for this gene is nadC [H]

Identifier: 121998821

GI number: 121998821

Start: 2245149

End: 2246000

Strand: Reverse

Name: nadC [H]

Synonym: Hhal_2042

Alternate gene names: 121998821

Gene position: 2246000-2245149 (Counterclockwise)

Preceding gene: 121998822

Following gene: 121998820

Centisome position: 83.85

GC content: 73.47

Gene sequence:

>852_bases
ATGACCATCTCCTTGCCCCCCCGCGAGACCATCCGTGACGACGTCGCCCGCGCCCTGGCCGAGGACGTGGGTGGCGGCGA
TCTCACCGCCGGCCTGGTGCCGGCCAGCGGCGTCGCCGAGGGGCAGGTGGTGGCCCGTGAGGCGGCGGTGCTCTGCGGCA
CCGCCTGGTTCGACGAGGTCTTCCGCCAGCTCGATCGGGGCGTGGGGGTGCGCTGGCTGTGCAGCGACGGCGAGGCGGTG
GAGCCGGGGGCTGTGGTCTGCCGGATCCAGGGGCCGAGCCGGGCGGTGCTCACCGGCGAGCGTACGGCGCTGAACTTCCT
GCAGTTCCTCTCCGGCACGGCCACCACCGCGCGCCGCTACGCCGACGCCGTGGCGGGGACCGGGGTGCAGCTGCTCGATA
CCCGCAAGACCGTGCCCGGTCTGCGCGCTGCCCAGAAGTACGCGGTGCGTGCCGGCGGGGGCAGCAACCACCGGTTCGGG
CTGTTCGACGCCTACCTGATCAAGGAGAACCACATCGCCGCCTGCGGCGGCCTGACCCCGGCGGTGGAGGTGGCGCGCCT
GCGTGCGGCGGGCACGCCGATCACCGTGGAGATCGAGGACCTGGTCCAGCTCGATGAGGCCATCGCCGCCGGGGCCGATG
TGGTGATGCTCGACAACTTCGACGCCGACGGCATCCGCCAGGCAGTGGACCGGGCCGCCGGCCGCGTCGCCCTGGAGGTC
TCCGGCGGGCTGGATCTGGACGCCGTGCGCGCCCTGGCCGCCACCGGCGTCGACCGCATCTCCGTCGGCGCCCTGACCAA
GCACGTCCACGCCCTGGATCTCTCCCTGCGTTTGACGATCCCCAGCGGCTGA

Upstream 100 bases:

>100_bases
GGGCCGCAGGACGCCGCGGGACCGGCAGCGGCCCTTGCGCGCCACCCCCGGAACCCGGAACACTGCGACACGACCCTGAG
CCATCGACGCTGCATCGACC

Downstream 100 bases:

>100_bases
GCCTGCCGCATTCGCACTCGGTCGGGGCCGCTGAGCGTGCGGTCTTCTGCCCGTTGAGCTGGTTCCGGTCCCGTTGCTAA
CTTCTCGTGAACGGTGGTGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTISLPPRETIRDDVARALAEDVGGGDLTAGLVPASGVAEGQVVAREAAVLCGTAWFDEVFRQLDRGVGVRWLCSDGEAV
EPGAVVCRIQGPSRAVLTGERTALNFLQFLSGTATTARRYADAVAGTGVQLLDTRKTVPGLRAAQKYAVRAGGGSNHRFG
LFDAYLIKENHIAACGGLTPAVEVARLRAAGTPITVEIEDLVQLDEAIAAGADVVMLDNFDADGIRQAVDRAAGRVALEV
SGGLDLDAVRALAATGVDRISVGALTKHVHALDLSLRLTIPSG

Sequences:

>Translated_283_residues
MTISLPPRETIRDDVARALAEDVGGGDLTAGLVPASGVAEGQVVAREAAVLCGTAWFDEVFRQLDRGVGVRWLCSDGEAV
EPGAVVCRIQGPSRAVLTGERTALNFLQFLSGTATTARRYADAVAGTGVQLLDTRKTVPGLRAAQKYAVRAGGGSNHRFG
LFDAYLIKENHIAACGGLTPAVEVARLRAAGTPITVEIEDLVQLDEAIAAGADVVMLDNFDADGIRQAVDRAAGRVALEV
SGGLDLDAVRALAATGVDRISVGALTKHVHALDLSLRLTIPSG
>Mature_282_residues
TISLPPRETIRDDVARALAEDVGGGDLTAGLVPASGVAEGQVVAREAAVLCGTAWFDEVFRQLDRGVGVRWLCSDGEAVE
PGAVVCRIQGPSRAVLTGERTALNFLQFLSGTATTARRYADAVAGTGVQLLDTRKTVPGLRAAQKYAVRAGGGSNHRFGL
FDAYLIKENHIAACGGLTPAVEVARLRAAGTPITVEIEDLVQLDEAIAAGADVVMLDNFDADGIRQAVDRAAGRVALEVS
GGLDLDAVRALAATGVDRISVGALTKHVHALDLSLRLTIPSG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=285, Percent_Identity=36.8421052631579, Blast_Score=145, Evalue=4e-35,
Organism=Escherichia coli, GI1786299, Length=296, Percent_Identity=50, Blast_Score=261, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6321162, Length=290, Percent_Identity=36.2068965517241, Blast_Score=169, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29403; Mature: 29272

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISLPPRETIRDDVARALAEDVGGGDLTAGLVPASGVAEGQVVAREAAVLCGTAWFDEV
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FRQLDRGVGVRWLCSDGEAVEPGAVVCRIQGPSRAVLTGERTALNFLQFLSGTATTARRY
HHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHCCCHHHHHHH
ADAVAGTGVQLLDTRKTVPGLRAAQKYAVRAGGGSNHRFGLFDAYLIKENHIAACGGLTP
HHHHHCCCEEEEECCCCCCCHHHHHHHEEECCCCCCCCEEEEEEEEEECCCEEECCCCCH
AVEVARLRAAGTPITVEIEDLVQLDEAIAAGADVVMLDNFDADGIRQAVDRAAGRVALEV
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCEEEEEE
SGGLDLDAVRALAATGVDRISVGALTKHVHALDLSLRLTIPSG
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEEEEECCCC
>Mature Secondary Structure 
TISLPPRETIRDDVARALAEDVGGGDLTAGLVPASGVAEGQVVAREAAVLCGTAWFDEV
CCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FRQLDRGVGVRWLCSDGEAVEPGAVVCRIQGPSRAVLTGERTALNFLQFLSGTATTARRY
HHHHHCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHCCCHHHHHHH
ADAVAGTGVQLLDTRKTVPGLRAAQKYAVRAGGGSNHRFGLFDAYLIKENHIAACGGLTP
HHHHHCCCEEEEECCCCCCCHHHHHHHEEECCCCCCCCEEEEEEEEEECCCEEECCCCCH
AVEVARLRAAGTPITVEIEDLVQLDEAIAAGADVVMLDNFDADGIRQAVDRAAGRVALEV
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCEEEEEE
SGGLDLDAVRALAATGVDRISVGALTKHVHALDLSLRLTIPSG
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]