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The map label for this gene is parE [H]

Identifier: 121998762

GI number: 121998762

Start: 2185927

End: 2187837

Strand: Reverse

Name: parE [H]

Synonym: Hhal_1983

Alternate gene names: 121998762

Gene position: 2187837-2185927 (Counterclockwise)

Preceding gene: 121998772

Following gene: 121998761

Centisome position: 81.68

GC content: 69.28

Gene sequence:

>1911_bases
ATGACAACCAAGACCCAGCAGACCTACGACGCCTCCGACATCGAAGTCCTGACCGGACTGGAGCCGGTACGCCGGCGTCC
CGGTATGTACACCGAAACCAACCGCCCCGACCACCTCGCCCAGGAGGTGATCGACAACAGTGTCGACGAGGCGGTCGCCG
GACACGCCCGGCGCATCGAGGTGACCGTGCACGCTGATGGCTCCCTGGAGGTCAGCGACGACGGCCGCGGCATGCCGGTG
GATATGCATCCCACCGAGGGGGTGCCCGCGGTCGAGGTGATCCTCGGCCGGCTCCACGCCGGCGGCAAGTTCTCGAGCAA
GAGCTACCGCTATTCCGGCGGCCTGCACGGGGTCGGTGTCTCCGTGGTGAACGCGCTATCGACGCGGCTGCAGGTGCATA
TCCGCCGCGACGGCGCCGAGCACACCATCGCCTTCTCGGCGGGGGAGCGGATCGAGCCGCTGGAGCGGGTGGGCAAGACG
CGGGAGACCGGCACCACGCTGCGCTTCTGGCCGGATACCAGCTACTTCGACAGCCCGCGCTTCTCTCGCGCCCGGCTCGA
GCACCTGCTGCGCGCCAAAGCGGTGCTCTGCCCGGGGCTGACGGTCATCCTGCGCGACGCCACCGGGGGCGAGGGGCAGG
AGCCCGAGGTGCTGACCTGGTACTACGAGGATGGGCTGCGCGATTACCTGGCCGGTGCCGTGGCCGACTACGAGCATCTG
CCGGATCCGCCGTTCACTGCCCGGCTCGGCTCCGAGCACGAGGAGATGGAGTGCGCCCTGGTGTGGTTGCCGGAGGGCAG
CGGGCCGGCGGAGAGCTACGTCAACCTCATCCCCACTCCTCAGGGCGGGACCCACGTCAACGGCCTGCGCACCGGCCTGA
CCGAGGCCATGCGCGAGTTCTGCGAGCTGCGTAACCTGCTGCCGCGCGGGGTGCGCATCGCCCCGGAGGACGTCTGGGAG
CACATCAGCTACGTGCTGTCGGTGAAGATGCATGAGCCGCAGTTCGCCGGGCAGACCAAGGAGCGGCTCTCCTCGCGCAA
CTGTGCCGCCTTCGTCTCCGGGGCCGTGAAGGACGCCTTCAGCCTGTGGCTCAACGAGCACACCCAGAGCGCCGAGCAGA
TTGTCGATCTGGTGGTGCGCGCCGCTCAGCGCCGCCAGCGGGCCGCCAAGAAGGTGACGCGCAAGCGGGTGGGCAGTGGG
CCGGCGCTGCCCGGCAAGCTGGCCGACTGCACCGGGCAGGATCCGGCGCGCAGCGAGCTCTTCCTGGTCGAGGGGGATTC
CGCCGGCGGCTCGGCCAAGCAGGCCCGCGAACGGGAATTCCAGGCGGTCATGCCGCTGCGCGGTAAGATCCTCAATACCT
GGGAGGTGGCTCCCGACGAGGTCATGGCCTCCCAGGAGGTCCACGATATCGCCGTGGCCCTGGGGGTCGACCCGGGCAGC
GAGGACCTCTCCGGGCTGCGCTACCACAAGGTCTGCGTCCTGGCCGACGCTGACCCCGACGGCGCGCACATTGCCACGCT
GCTCTGCGCCCTGTTCCAGCGCCACTTCCCGGCCCTGGTGGCCGGCGGCCACGTCTACGTGGCGATGCCGCCGCTGTATC
GCATCGATGTTGGCAAGCAGACCTTCTACGCCCTCGACCGCGACGAGCGCCAGGGTATCCTCGACCGGATCGAGGCCGAG
CGCATCAAGGGCAAGGTGCAGGAGACGCGCTTCAAGGGCCTTGGTGAGATGAACCCGGTCCAGCTGCGCGAGACCACCAT
GGCCCCGGATACCCGCCGCCTGGTTCAGCTCACCGTCGATGACCCCGACGAGACCGAACGCCTGCTCGGCATGCTGCTCG
GCCGTGGCGCCGCAGCCCAGCGCCGCGAGTGGCTGGAGAGCAAGGGCAACCTGGCGGAAATCGTCCTTTGA

Upstream 100 bases:

>100_bases
TCCCGGCGAACGGCTCCCTTGTAACTTGCCTCCGGTAGCCGGAAACTGCTCGCCCCGAGCGCGAACCCTCAATGGCCCGA
TCCGTGACCACCGTGATCCG

Downstream 100 bases:

>100_bases
CCCCCTGACTACTAAGCGCCGAACAGCAAACGACTATGTCCGAAAACGCTGCCTCCGACTTCGAGACGCAACCGCTCCGC
GAGTTCACCGAGCGGGCCTA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MTTKTQQTYDASDIEVLTGLEPVRRRPGMYTETNRPDHLAQEVIDNSVDEAVAGHARRIEVTVHADGSLEVSDDGRGMPV
DMHPTEGVPAVEVILGRLHAGGKFSSKSYRYSGGLHGVGVSVVNALSTRLQVHIRRDGAEHTIAFSAGERIEPLERVGKT
RETGTTLRFWPDTSYFDSPRFSRARLEHLLRAKAVLCPGLTVILRDATGGEGQEPEVLTWYYEDGLRDYLAGAVADYEHL
PDPPFTARLGSEHEEMECALVWLPEGSGPAESYVNLIPTPQGGTHVNGLRTGLTEAMREFCELRNLLPRGVRIAPEDVWE
HISYVLSVKMHEPQFAGQTKERLSSRNCAAFVSGAVKDAFSLWLNEHTQSAEQIVDLVVRAAQRRQRAAKKVTRKRVGSG
PALPGKLADCTGQDPARSELFLVEGDSAGGSAKQAREREFQAVMPLRGKILNTWEVAPDEVMASQEVHDIAVALGVDPGS
EDLSGLRYHKVCVLADADPDGAHIATLLCALFQRHFPALVAGGHVYVAMPPLYRIDVGKQTFYALDRDERQGILDRIEAE
RIKGKVQETRFKGLGEMNPVQLRETTMAPDTRRLVQLTVDDPDETERLLGMLLGRGAAAQRREWLESKGNLAEIVL

Sequences:

>Translated_636_residues
MTTKTQQTYDASDIEVLTGLEPVRRRPGMYTETNRPDHLAQEVIDNSVDEAVAGHARRIEVTVHADGSLEVSDDGRGMPV
DMHPTEGVPAVEVILGRLHAGGKFSSKSYRYSGGLHGVGVSVVNALSTRLQVHIRRDGAEHTIAFSAGERIEPLERVGKT
RETGTTLRFWPDTSYFDSPRFSRARLEHLLRAKAVLCPGLTVILRDATGGEGQEPEVLTWYYEDGLRDYLAGAVADYEHL
PDPPFTARLGSEHEEMECALVWLPEGSGPAESYVNLIPTPQGGTHVNGLRTGLTEAMREFCELRNLLPRGVRIAPEDVWE
HISYVLSVKMHEPQFAGQTKERLSSRNCAAFVSGAVKDAFSLWLNEHTQSAEQIVDLVVRAAQRRQRAAKKVTRKRVGSG
PALPGKLADCTGQDPARSELFLVEGDSAGGSAKQAREREFQAVMPLRGKILNTWEVAPDEVMASQEVHDIAVALGVDPGS
EDLSGLRYHKVCVLADADPDGAHIATLLCALFQRHFPALVAGGHVYVAMPPLYRIDVGKQTFYALDRDERQGILDRIEAE
RIKGKVQETRFKGLGEMNPVQLRETTMAPDTRRLVQLTVDDPDETERLLGMLLGRGAAAQRREWLESKGNLAEIVL
>Mature_635_residues
TTKTQQTYDASDIEVLTGLEPVRRRPGMYTETNRPDHLAQEVIDNSVDEAVAGHARRIEVTVHADGSLEVSDDGRGMPVD
MHPTEGVPAVEVILGRLHAGGKFSSKSYRYSGGLHGVGVSVVNALSTRLQVHIRRDGAEHTIAFSAGERIEPLERVGKTR
ETGTTLRFWPDTSYFDSPRFSRARLEHLLRAKAVLCPGLTVILRDATGGEGQEPEVLTWYYEDGLRDYLAGAVADYEHLP
DPPFTARLGSEHEEMECALVWLPEGSGPAESYVNLIPTPQGGTHVNGLRTGLTEAMREFCELRNLLPRGVRIAPEDVWEH
ISYVLSVKMHEPQFAGQTKERLSSRNCAAFVSGAVKDAFSLWLNEHTQSAEQIVDLVVRAAQRRQRAAKKVTRKRVGSGP
ALPGKLADCTGQDPARSELFLVEGDSAGGSAKQAREREFQAVMPLRGKILNTWEVAPDEVMASQEVHDIAVALGVDPGSE
DLSGLRYHKVCVLADADPDGAHIATLLCALFQRHFPALVAGGHVYVAMPPLYRIDVGKQTFYALDRDERQGILDRIEAER
IKGKVQETRFKGLGEMNPVQLRETTMAPDTRRLVQLTVDDPDETERLLGMLLGRGAAAQRREWLESKGNLAEIVL

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=627, Percent_Identity=24.0829346092504, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI19913406, Length=649, Percent_Identity=24.191063174114, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI1789408, Length=633, Percent_Identity=65.7187993680885, Blast_Score=877, Evalue=0.0,
Organism=Escherichia coli, GI48994957, Length=553, Percent_Identity=40.8679927667269, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645845, Length=590, Percent_Identity=24.7457627118644, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17535065, Length=634, Percent_Identity=23.6593059936909, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324241, Length=381, Percent_Identity=26.246719160105, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136538, Length=625, Percent_Identity=22.88, Blast_Score=129, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 70088; Mature: 69957

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKTQQTYDASDIEVLTGLEPVRRRPGMYTETNRPDHLAQEVIDNSVDEAVAGHARRIE
CCCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHCCCCEEEE
VTVHADGSLEVSDDGRGMPVDMHPTEGVPAVEVILGRLHAGGKFSSKSYRYSGGLHGVGV
EEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCHHHH
SVVNALSTRLQVHIRRDGAEHTIAFSAGERIEPLERVGKTRETGTTLRFWPDTSYFDSPR
HHHHHHHHHEEEEEECCCCCEEEEECCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCC
FSRARLEHLLRAKAVLCPGLTVILRDATGGEGQEPEVLTWYYEDGLRDYLAGAVADYEHL
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHC
PDPPFTARLGSEHEEMECALVWLPEGSGPAESYVNLIPTPQGGTHVNGLRTGLTEAMREF
CCCCCHHHCCCCCCCCEEEEEEEECCCCCHHHHHEEECCCCCCCCCHHHHHHHHHHHHHH
CELRNLLPRGVRIAPEDVWEHISYVLSVKMHEPQFAGQTKERLSSRNCAAFVSGAVKDAF
HHHHHHCCCCCEECHHHHHHHHHHHHEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHH
SLWLNEHTQSAEQIVDLVVRAAQRRQRAAKKVTRKRVGSGPALPGKLADCTGQDPARSEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
FLVEGDSAGGSAKQAREREFQAVMPLRGKILNTWEVAPDEVMASQEVHDIAVALGVDPGS
EEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHEEEEEEECCCCC
EDLSGLRYHKVCVLADADPDGAHIATLLCALFQRHFPALVAGGHVYVAMPPLYRIDVGKQ
HHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCEEEEECCCEEEEECCCC
TFYALDRDERQGILDRIEAERIKGKVQETRFKGLGEMNPVQLRETTMAPDTRRLVQLTVD
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCCCEEEEEEECC
DPDETERLLGMLLGRGAAAQRREWLESKGNLAEIVL
CCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure 
TTKTQQTYDASDIEVLTGLEPVRRRPGMYTETNRPDHLAQEVIDNSVDEAVAGHARRIE
CCCCCCCCCCCCHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHCCCCEEEE
VTVHADGSLEVSDDGRGMPVDMHPTEGVPAVEVILGRLHAGGKFSSKSYRYSGGLHGVGV
EEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCCCHHHH
SVVNALSTRLQVHIRRDGAEHTIAFSAGERIEPLERVGKTRETGTTLRFWPDTSYFDSPR
HHHHHHHHHEEEEEECCCCCEEEEECCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCC
FSRARLEHLLRAKAVLCPGLTVILRDATGGEGQEPEVLTWYYEDGLRDYLAGAVADYEHL
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHC
PDPPFTARLGSEHEEMECALVWLPEGSGPAESYVNLIPTPQGGTHVNGLRTGLTEAMREF
CCCCCHHHCCCCCCCCEEEEEEEECCCCCHHHHHEEECCCCCCCCCHHHHHHHHHHHHHH
CELRNLLPRGVRIAPEDVWEHISYVLSVKMHEPQFAGQTKERLSSRNCAAFVSGAVKDAF
HHHHHHCCCCCEECHHHHHHHHHHHHEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHH
SLWLNEHTQSAEQIVDLVVRAAQRRQRAAKKVTRKRVGSGPALPGKLADCTGQDPARSEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCE
FLVEGDSAGGSAKQAREREFQAVMPLRGKILNTWEVAPDEVMASQEVHDIAVALGVDPGS
EEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHEEEEEEECCCCC
EDLSGLRYHKVCVLADADPDGAHIATLLCALFQRHFPALVAGGHVYVAMPPLYRIDVGKQ
HHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCEEEEECCCEEEEECCCC
TFYALDRDERQGILDRIEAERIKGKVQETRFKGLGEMNPVQLRETTMAPDTRRLVQLTVD
EEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHCCCCCCEEEEEEECC
DPDETERLLGMLLGRGAAAQRREWLESKGNLAEIVL
CCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]