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The map label for this gene is cobQ

Identifier: 121998686

GI number: 121998686

Start: 2102513

End: 2103964

Strand: Reverse

Name: cobQ

Synonym: Hhal_1907

Alternate gene names: 121998686

Gene position: 2103964-2102513 (Counterclockwise)

Preceding gene: 121998687

Following gene: 121998685

Centisome position: 78.55

GC content: 73.14

Gene sequence:

>1452_bases
GTGGTGAGAGCCCGCACCCTGATGCTCCAGGGCACCTGCTCCGGCGCCGGCAAGACGGCGCTGGTGGCGGGGCTGTGCCG
GCTGCTCGCCCGCCACGGCGTCCGCGTGGCGCCGTTCAAGCCGCAGAACATGAGCAACAATGCGGCGGTCACCGCCGACG
GTGGCGAGATCGGGCGCGGTCAGTGGCTTCAGGCCCTGGCTGCTGGGCTGCCGGCGCACACCGACATGAACCCGGTGCTA
CTCAAGCCCGAGGCCGAGCGCACCGCCCAGGTGGTGGTCCAGGGCCACGTCACCGGGCGGCTGGAGGCGCGCGCCTTCCG
CGAGGCCCGCCAGCCGCTGCTGCCGCCGGTGCTCGAGTCCTTCCAGCGCCTGTGCGCCGCCTACGACGTGGTGCTGGTGG
AGGGGGCGGGTTCGCCGGCGGAGCCCAACCTGCGCCAGGGGGATATCGCCAACATGGGCTTTGCCGAGGCGGCCGATGTG
CCGGTCTGGCTGGTCGGCGACATCGATCGCGGCGGGGTCTTCGCCTCCCTGCTCGGCACCCTGGAGTGGCTCGACGACGC
CGACCGGCGCCGGGTGGAGGCGCTGATCATCAACCGTTTCCGCGGTAGCCCCGAACTCCTCGGCGAGGCGCCAGCCCAGC
TGGAGGCCCGGGGCGGGGTGCCGGTGATCGGCGTCGTCCCCGCCGTGCCCGATCTGCACTTGCCCGAGGAGGATGCCCCG
TACCGGATGGCCGGGCCGCGCGGCTCCGGCGGCGCCCTGCAAGTGGTGGCGGTGGCCTATCCGCGGATGAGCAACCACGA
CGATCTCGACGCCCTGGACGCCGAGTCCGGGGTGCACGTTCGCTTCGCCCGCCAGCCCCGGGAGCTCGACGGCGCCGATC
TCATCGTCCTGCCCGGGTCCAAGCACGTCTTCTCGGATCTGGCCTGGCTGCGCGAGTCGGGCATGGCCGAGGCGCTCTAT
CGCCACTGCCGCTATGGGGGTCGGGTGGTCGGCCTCTGCGGCGGGCTGCAGATGCTCGGCGAGGGCATCGAAGACCCGGA
AGGCGTCGAGGGCGGCGGCAGCGCACCGGGGCTGGGTCTGCTGCCGGTGCACACCCGTCTGGCGCCGACCAAGCAGCTCG
CCGAGGTGCACGGCCACGCCGAGTGGCCGGCGCCCGTGGCGGTCACCGGCTACGAGATCCACCACGGCGTAACCGGCGCC
CAAGAGGGGCTCTTCCCCTTCGTGGCGCGCTCCGATGACGGTCGCGTGCTCGGCAGCTACCTCCACCGGCTGTTCGACAG
CGGACCGTTCCGCCGTGCCCTGCTGGTGGAGTGGTTCGCCCTGGAGGGCGAGGGCGGCGACGAGCAGGCGCGCATCGAGG
CGGAGCTGGACCGGCTCGCCGACACCCTGGAGCAGGCCCTCGAGCCGGGCTGGTTAAAGGCGCTGGGCGTACCTGCGCGG
CCGTCGACCTAG

Upstream 100 bases:

>100_bases
ACGCCCCGCAGCCGCTGATCGACGCCGCGGATACGGTCAGCGAGATCGCCTCGGCCCGTCACGCCTTCGAGGCCGGGGTC
CGCGCCCAGCCGGGGATCGA

Downstream 100 bases:

>100_bases
GCGCTCGTCCCGTCCGTGGTTCCTCCCCGACGGGGGTACGAGGACTGTCTGCTGCGACGAACTGTCCGGCTCATCGATTT
GCAACCGCCCGTTCGGCCCG

Product: cobyric acid synthase CobQ

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MVRARTLMLQGTCSGAGKTALVAGLCRLLARHGVRVAPFKPQNMSNNAAVTADGGEIGRGQWLQALAAGLPAHTDMNPVL
LKPEAERTAQVVVQGHVTGRLEARAFREARQPLLPPVLESFQRLCAAYDVVLVEGAGSPAEPNLRQGDIANMGFAEAADV
PVWLVGDIDRGGVFASLLGTLEWLDDADRRRVEALIINRFRGSPELLGEAPAQLEARGGVPVIGVVPAVPDLHLPEEDAP
YRMAGPRGSGGALQVVAVAYPRMSNHDDLDALDAESGVHVRFARQPRELDGADLIVLPGSKHVFSDLAWLRESGMAEALY
RHCRYGGRVVGLCGGLQMLGEGIEDPEGVEGGGSAPGLGLLPVHTRLAPTKQLAEVHGHAEWPAPVAVTGYEIHHGVTGA
QEGLFPFVARSDDGRVLGSYLHRLFDSGPFRRALLVEWFALEGEGGDEQARIEAELDRLADTLEQALEPGWLKALGVPAR
PST

Sequences:

>Translated_483_residues
MVRARTLMLQGTCSGAGKTALVAGLCRLLARHGVRVAPFKPQNMSNNAAVTADGGEIGRGQWLQALAAGLPAHTDMNPVL
LKPEAERTAQVVVQGHVTGRLEARAFREARQPLLPPVLESFQRLCAAYDVVLVEGAGSPAEPNLRQGDIANMGFAEAADV
PVWLVGDIDRGGVFASLLGTLEWLDDADRRRVEALIINRFRGSPELLGEAPAQLEARGGVPVIGVVPAVPDLHLPEEDAP
YRMAGPRGSGGALQVVAVAYPRMSNHDDLDALDAESGVHVRFARQPRELDGADLIVLPGSKHVFSDLAWLRESGMAEALY
RHCRYGGRVVGLCGGLQMLGEGIEDPEGVEGGGSAPGLGLLPVHTRLAPTKQLAEVHGHAEWPAPVAVTGYEIHHGVTGA
QEGLFPFVARSDDGRVLGSYLHRLFDSGPFRRALLVEWFALEGEGGDEQARIEAELDRLADTLEQALEPGWLKALGVPAR
PST
>Mature_483_residues
MVRARTLMLQGTCSGAGKTALVAGLCRLLARHGVRVAPFKPQNMSNNAAVTADGGEIGRGQWLQALAAGLPAHTDMNPVL
LKPEAERTAQVVVQGHVTGRLEARAFREARQPLLPPVLESFQRLCAAYDVVLVEGAGSPAEPNLRQGDIANMGFAEAADV
PVWLVGDIDRGGVFASLLGTLEWLDDADRRRVEALIINRFRGSPELLGEAPAQLEARGGVPVIGVVPAVPDLHLPEEDAP
YRMAGPRGSGGALQVVAVAYPRMSNHDDLDALDAESGVHVRFARQPRELDGADLIVLPGSKHVFSDLAWLRESGMAEALY
RHCRYGGRVVGLCGGLQMLGEGIEDPEGVEGGGSAPGLGLLPVHTRLAPTKQLAEVHGHAEWPAPVAVTGYEIHHGVTGA
QEGLFPFVARSDDGRVLGSYLHRLFDSGPFRRALLVEWFALEGEGGDEQARIEAELDRLADTLEQALEPGWLKALGVPAR
PST

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_HALHL (A1WYA9)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003473.1
- ProteinModelPortal:   A1WYA9
- STRING:   A1WYA9
- GeneID:   4710653
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1907
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   AMSYRER
- BioCyc:   HHAL349124:HHAL_1907-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 51459; Mature: 51459

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 333-333 ACT_SITE 422-422

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRARTLMLQGTCSGAGKTALVAGLCRLLARHGVRVAPFKPQNMSNNAAVTADGGEIGRG
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCHH
QWLQALAAGLPAHTDMNPVLLKPEAERTAQVVVQGHVTGRLEARAFREARQPLLPPVLES
HHHHHHHHCCCCCCCCCCEEECCCHHCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHH
FQRLCAAYDVVLVEGAGSPAEPNLRQGDIANMGFAEAADVPVWLVGDIDRGGVFASLLGT
HHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH
LEWLDDADRRRVEALIINRFRGSPELLGEAPAQLEARGGVPVIGVVPAVPDLHLPEEDAP
HHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCC
YRMAGPRGSGGALQVVAVAYPRMSNHDDLDALDAESGVHVRFARQPRELDGADLIVLPGS
EEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCC
KHVFSDLAWLRESGMAEALYRHCRYGGRVVGLCGGLQMLGEGIEDPEGVEGGGSAPGLGL
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
LPVHTRLAPTKQLAEVHGHAEWPAPVAVTGYEIHHGVTGAQEGLFPFVARSDDGRVLGSY
ECCCCCCCCHHHHHHHCCCCCCCCCEEEECEEEECCCCCCCCCCCEEEEECCCCHHHHHH
LHRLFDSGPFRRALLVEWFALEGEGGDEQARIEAELDRLADTLEQALEPGWLKALGVPAR
HHHHHCCCCCHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
PST
CCC
>Mature Secondary Structure
MVRARTLMLQGTCSGAGKTALVAGLCRLLARHGVRVAPFKPQNMSNNAAVTADGGEIGRG
CCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCCCHH
QWLQALAAGLPAHTDMNPVLLKPEAERTAQVVVQGHVTGRLEARAFREARQPLLPPVLES
HHHHHHHHCCCCCCCCCCEEECCCHHCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHH
FQRLCAAYDVVLVEGAGSPAEPNLRQGDIANMGFAEAADVPVWLVGDIDRGGVFASLLGT
HHHHHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHH
LEWLDDADRRRVEALIINRFRGSPELLGEAPAQLEARGGVPVIGVVPAVPDLHLPEEDAP
HHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCC
YRMAGPRGSGGALQVVAVAYPRMSNHDDLDALDAESGVHVRFARQPRELDGADLIVLPGS
EEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEECCC
KHVFSDLAWLRESGMAEALYRHCRYGGRVVGLCGGLQMLGEGIEDPEGVEGGGSAPGLGL
HHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCE
LPVHTRLAPTKQLAEVHGHAEWPAPVAVTGYEIHHGVTGAQEGLFPFVARSDDGRVLGSY
ECCCCCCCCHHHHHHHCCCCCCCCCEEEECEEEECCCCCCCCCCCEEEEECCCCHHHHHH
LHRLFDSGPFRRALLVEWFALEGEGGDEQARIEAELDRLADTLEQALEPGWLKALGVPAR
HHHHHCCCCCHHHHEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
PST
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA