Click here to switch to the map view.

The map label for this gene is macA [H]

Identifier: 121998656

GI number: 121998656

Start: 2053891

End: 2055108

Strand: Reverse

Name: macA [H]

Synonym: Hhal_1877

Alternate gene names: 121998656

Gene position: 2055108-2053891 (Counterclockwise)

Preceding gene: 121998657

Following gene: 121998655

Centisome position: 76.73

GC content: 72.0

Gene sequence:

>1218_bases
ATGCCCTCCAGACCGCGTACCCGCCTCCAGACCGTCCTCCTGTGGGTTGCCAGTGCCCTGATCCTCCTCGGGGCGGTGGC
CCTGTTTCGTGCCGATCTCGGCACCGGCCCCACCGGCGAGGGGCGGGAGACCGCCGCCGTGGCCGTCGAGGTCGACGCCG
TCGAGCGCCGCGATCTGGCGGATGTTCGTCGGTTCGACGGCAATCTCGAGGCTGCGGTGCGCTACGAGCTGGCCCCCAAG
GTCACCGGCGAGCTGCGCAGCCTGGAGGTGCGCATCGGTGACACCCTCGAGCCCGGGGATCTGATCGCCCGGCTCGACGA
CCAAGAGGTGGCGCAGGAGGTGGCCGAGGCCGAGGCGGGGCTCGAGGTGGCCCGGGCGCAGCTTGCCGAGAGCCAGGCCG
CCCTGGAGTCTGCTGAGCGGGATCTGAATCGCACCCGCGAGCTTCGCGAGCGCCAGATCGCCTCGGCGGCGGAACTGGAG
GCCGCCGAGGCGCAAGTGGCCGCCGAGCGCAGCCGGGTGCAGCTGGCCCGGGCGCAGATTGCGCAGCAGCAGGCGACGCT
GAGCGCCGCGCAGATCCGCCGCTCCTTCACCGAGATCCGCGCCGACTGGGACGAGGGCGAGCGGGTGGTCGGCGAGCGGT
TCAAGGACCCCGGCGCTACGGTCAGCGCTGGTGAGGCGATGCTGACCTTGCTCGACATTTCCGAACTGCGAGCCGAGGCG
TTCGTTACCGAGCGAGAGTACGCCCGTCTGATGCCCGGGCAGTCGGCACGCTTGCGCGTCGAGGGGTACCCGGACACCGA
GTTCGAGGCCGAGGTGGCCCGGCTGGCCCCGCTTTTCAGCGCCACCCTGCGCCAGGCCCGGGTCGAGTTCACCGTGCCCA
ACCCGGAGGGCCAACTGCGTCCGGGGATGTTCGCCCGTCTGGCCGTGGAGGTTGGCCGGGCCGAGGATGTTCGCACCGTT
CCCCGCGAGGCGGTGGTGCAGCGTGGCGGACAACCCTCGGTCTTCCTGCTTGAAGAGGGAGAAGACGCCCCGCGGGTGCG
CCTGATGCCGGTGGAGACCGGGCTGCGTGCCGAAGGGCGGATCGAGGTGCGCCCGCGTGACGAGGAGGACGGCGAGGCCC
TCACGGGCCACGTGGTGACCCTGGGCCAGCATCTGCTCGCCGATGGCAGCCGGGTCGAGGTGGTGGGAGAGCAGGCCGCC
GAGGTGGCCGCACCGTGA

Upstream 100 bases:

>100_bases
CCGTGACCGCAGCCGGTCTCGGCCCGTATCCACCCGGAGTGGCGGAGGGGGTTGGTATACTTTGCCGCAGCTCCAGACCA
GGTAAGTCGACCGATATTCC

Downstream 100 bases:

>100_bases
GGATCGCCGCCTTCTGTGCCCGACGGCCGGTGTTCACCGTCATGGTGACGCTGATCGCCGTGACCCTGGGGCTCAATGCC
CTCGATCGTCTGCCGGTAGA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPSRPRTRLQTVLLWVASALILLGAVALFRADLGTGPTGEGRETAAVAVEVDAVERRDLADVRRFDGNLEAAVRYELAPK
VTGELRSLEVRIGDTLEPGDLIARLDDQEVAQEVAEAEAGLEVARAQLAESQAALESAERDLNRTRELRERQIASAAELE
AAEAQVAAERSRVQLARAQIAQQQATLSAAQIRRSFTEIRADWDEGERVVGERFKDPGATVSAGEAMLTLLDISELRAEA
FVTEREYARLMPGQSARLRVEGYPDTEFEAEVARLAPLFSATLRQARVEFTVPNPEGQLRPGMFARLAVEVGRAEDVRTV
PREAVVQRGGQPSVFLLEEGEDAPRVRLMPVETGLRAEGRIEVRPRDEEDGEALTGHVVTLGQHLLADGSRVEVVGEQAA
EVAAP

Sequences:

>Translated_405_residues
MPSRPRTRLQTVLLWVASALILLGAVALFRADLGTGPTGEGRETAAVAVEVDAVERRDLADVRRFDGNLEAAVRYELAPK
VTGELRSLEVRIGDTLEPGDLIARLDDQEVAQEVAEAEAGLEVARAQLAESQAALESAERDLNRTRELRERQIASAAELE
AAEAQVAAERSRVQLARAQIAQQQATLSAAQIRRSFTEIRADWDEGERVVGERFKDPGATVSAGEAMLTLLDISELRAEA
FVTEREYARLMPGQSARLRVEGYPDTEFEAEVARLAPLFSATLRQARVEFTVPNPEGQLRPGMFARLAVEVGRAEDVRTV
PREAVVQRGGQPSVFLLEEGEDAPRVRLMPVETGLRAEGRIEVRPRDEEDGEALTGHVVTLGQHLLADGSRVEVVGEQAA
EVAAP
>Mature_404_residues
PSRPRTRLQTVLLWVASALILLGAVALFRADLGTGPTGEGRETAAVAVEVDAVERRDLADVRRFDGNLEAAVRYELAPKV
TGELRSLEVRIGDTLEPGDLIARLDDQEVAQEVAEAEAGLEVARAQLAESQAALESAERDLNRTRELRERQIASAAELEA
AEAQVAAERSRVQLARAQIAQQQATLSAAQIRRSFTEIRADWDEGERVVGERFKDPGATVSAGEAMLTLLDISELRAEAF
VTEREYARLMPGQSARLRVEGYPDTEFEAEVARLAPLFSATLRQARVEFTVPNPEGQLRPGMFARLAVEVGRAEDVRTVP
REAVVQRGGQPSVFLLEEGEDAPRVRLMPVETGLRAEGRIEVRPRDEEDGEALTGHVVTLGQHLLADGSRVEVVGEQAAE
VAAP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=317, Percent_Identity=29.3375394321767, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87082036, Length=342, Percent_Identity=25.1461988304094, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44144; Mature: 44013

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRPRTRLQTVLLWVASALILLGAVALFRADLGTGPTGEGRETAAVAVEVDAVERRDLA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHH
DVRRFDGNLEAAVRYELAPKVTGELRSLEVRIGDTLEPGDLIARLDDQEVAQEVAEAEAG
HHHHHCCCCEEEEEEEECCCHHCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHH
LEVARAQLAESQAALESAERDLNRTRELRERQIASAAELEAAEAQVAAERSRVQLARAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQQQATLSAAQIRRSFTEIRADWDEGERVVGERFKDPGATVSAGEAMLTLLDISELRAEA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHH
FVTEREYARLMPGQSARLRVEGYPDTEFEAEVARLAPLFSATLRQARVEFTVPNPEGQLR
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCC
PGMFARLAVEVGRAEDVRTVPREAVVQRGGQPSVFLLEEGEDAPRVRLMPVETGLRAEGR
CCHHHHHHHHHCCCCHHHHCCHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCE
IEVRPRDEEDGEALTGHVVTLGQHLLADGSRVEVVGEQAAEVAAP
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCC
>Mature Secondary Structure 
PSRPRTRLQTVLLWVASALILLGAVALFRADLGTGPTGEGRETAAVAVEVDAVERRDLA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCHHHHHHH
DVRRFDGNLEAAVRYELAPKVTGELRSLEVRIGDTLEPGDLIARLDDQEVAQEVAEAEAG
HHHHHCCCCEEEEEEEECCCHHCCCEEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHH
LEVARAQLAESQAALESAERDLNRTRELRERQIASAAELEAAEAQVAAERSRVQLARAQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQQQATLSAAQIRRSFTEIRADWDEGERVVGERFKDPGATVSAGEAMLTLLDISELRAEA
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHH
FVTEREYARLMPGQSARLRVEGYPDTEFEAEVARLAPLFSATLRQARVEFTVPNPEGQLR
HHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCC
PGMFARLAVEVGRAEDVRTVPREAVVQRGGQPSVFLLEEGEDAPRVRLMPVETGLRAEGR
CCHHHHHHHHHCCCCHHHHCCHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCE
IEVRPRDEEDGEALTGHVVTLGQHLLADGSRVEVVGEQAAEVAAP
EEECCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]