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The map label for this gene is lspA [H]

Identifier: 121998614

GI number: 121998614

Start: 2005876

End: 2006349

Strand: Reverse

Name: lspA [H]

Synonym: Hhal_1835

Alternate gene names: 121998614

Gene position: 2006349-2005876 (Counterclockwise)

Preceding gene: 121998615

Following gene: 121998613

Centisome position: 74.91

GC content: 67.72

Gene sequence:

>474_bases
ATGGGCTACCGGCTCTGGATGCTGCTTGCTGTCGCCATCGCGGCACTGGATCAGGCCACCAAGGTCTGGGCCCAGGCGGC
GCTGCGGCCCTACGAGTCGGTGGAGCTGCTGCCGGTCCTCAGCCTGACCCTGGGCTACAATCCCGGGGCTGCCTTCAGCC
TGCTGGGCGACGCTGGCGGCTGGCAGCGCTGGCTCCTGGCCGGGGTGGCCGCTGCGGTCGGGGTGTACCTGGCCTATTGG
CTGCGGCGCATCGGCGCGTCGCAGCCCTGGCTCTCCGCAGGGCTGGCGTTGATCCTCGCCGGGGCCCTGGGCAACCTGGT
GGATCGCCTGCGGCTGGGGCAGGTGGTGGACTTCATCCACCTGCACTACGCCGGTTTCCACTGGCCGATCTTCAACGTCG
CCGATATCGCCATCACGGTCGGTGCAGGGCTCGTGATCGTGATCCTTCTCTTTTTTGATCGGTCGAACCTGTAG

Upstream 100 bases:

>100_bases
ATATCGGCGCCAGCGATGAGCACCCGGAGCTGTGCGGCCGCTGCGTCGAGAACGTGGCCGGGTCCGGCGAGTACCGGGCC
ACGGCCTGACGGGGGAGGGC

Downstream 100 bases:

>100_bases
GGAAGAGCGAACGGAGGTCCCCGTGCCCAAGATCCACCTTGCCAACCCTCGCGGTTTCTGTGCCGGCGTGGACCGCGCCA
TTGCCATTGTCGATCGAGCC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MGYRLWMLLAVAIAALDQATKVWAQAALRPYESVELLPVLSLTLGYNPGAAFSLLGDAGGWQRWLLAGVAAAVGVYLAYW
LRRIGASQPWLSAGLALILAGALGNLVDRLRLGQVVDFIHLHYAGFHWPIFNVADIAITVGAGLVIVILLFFDRSNL

Sequences:

>Translated_157_residues
MGYRLWMLLAVAIAALDQATKVWAQAALRPYESVELLPVLSLTLGYNPGAAFSLLGDAGGWQRWLLAGVAAAVGVYLAYW
LRRIGASQPWLSAGLALILAGALGNLVDRLRLGQVVDFIHLHYAGFHWPIFNVADIAITVGAGLVIVILLFFDRSNL
>Mature_156_residues
GYRLWMLLAVAIAALDQATKVWAQAALRPYESVELLPVLSLTLGYNPGAAFSLLGDAGGWQRWLLAGVAAAVGVYLAYWL
RRIGASQPWLSAGLALILAGALGNLVDRLRLGQVVDFIHLHYAGFHWPIFNVADIAITVGAGLVIVILLFFDRSNL

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=142, Percent_Identity=42.9577464788732, Blast_Score=107, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 16970; Mature: 16839

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYRLWMLLAVAIAALDQATKVWAQAALRPYESVELLPVLSLTLGYNPGAAFSLLGDAGG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
WQRWLLAGVAAAVGVYLAYWLRRIGASQPWLSAGLALILAGALGNLVDRLRLGQVVDFIH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHYAGFHWPIFNVADIAITVGAGLVIVILLFFDRSNL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GYRLWMLLAVAIAALDQATKVWAQAALRPYESVELLPVLSLTLGYNPGAAFSLLGDAGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
WQRWLLAGVAAAVGVYLAYWLRRIGASQPWLSAGLALILAGALGNLVDRLRLGQVVDFIH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHYAGFHWPIFNVADIAITVGAGLVIVILLFFDRSNL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA