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The map label for this gene is adk

Identifier: 121998563

GI number: 121998563

Start: 1958517

End: 1959176

Strand: Reverse

Name: adk

Synonym: Hhal_1784

Alternate gene names: 121998563

Gene position: 1959176-1958517 (Counterclockwise)

Preceding gene: 121998565

Following gene: 121998562

Centisome position: 73.15

GC content: 65.15

Gene sequence:

>660_bases
ATGCGGCTCATTCTATTAGGCCCCCCGGGCGCCGGGAAAGGTACGCAGGCCGCCCATATCTGTGAGGCCTTCGGTATCCC
CCAGATCTCCACCGGCGACATGCTGCGTGCCGCCGTCAAGGCGGGTACCCCGTTGGGGCAGCAGGCCAAGAAGATCATGG
ATGAGGGTGGCCTCGTCTCCGACGATATCATCCTGGGGCTGATCGAGGAGCGCGTTGCCCAGGCGGATTGTGCCAATGGC
TTCCTGTTTGACGGTTTTCCGCGCACCATCGCGCAGGCGGACGGTCTCAACGATCAGGGGATCCGCATCGACGCGGTGGT
CGAGATCCAGGTGCCGGACGAGGAGATCGTCGACCGTATGGCTGGGCGCCGCGTCCATCCGGGGTCCGGGCGTGTCTACC
ACGTGACGCACAACCCGCCCCGGCAAGAGGGCAAGGACGACGTGACCGGCGAGGATCTGGTCCAGCGTGAGGACGATCGT
GAGGAGACGGTTCGCCACCGGCTTGGCGTCTATCACGAACAGACCCGGCCGCTGGTCGACTACTATTCCCAGTGGGCGCA
GAAGGGTGGTGCCGATGCGCCCGCCTACATCACCGTCGACGGTCAGCGTCCCGTCGAGACGGTGCGAGACGAGATCCTCG
CTGCGCTGAAGGCGCGTTAA

Upstream 100 bases:

>100_bases
CCGTCTCATTAGCCTTTCGTCTTCTTGTTCGTTTGCGTTCGTGTCGCAGGCCCCGTGGCCTCGACGGCATATCCCACTAA
ACGATATACGAGGTGAATCA

Downstream 100 bases:

>100_bases
CCGGGCACGCGGCGGGGGCTTGTCGTCGGCCCTCGCCGTTTTTTGGAGGTGTGCCTGACCATGTGGATTCGACGTCTGCT
CGCCGTCCTTCTTGCCTACT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MRLILLGPPGAGKGTQAAHICEAFGIPQISTGDMLRAAVKAGTPLGQQAKKIMDEGGLVSDDIILGLIEERVAQADCANG
FLFDGFPRTIAQADGLNDQGIRIDAVVEIQVPDEEIVDRMAGRRVHPGSGRVYHVTHNPPRQEGKDDVTGEDLVQREDDR
EETVRHRLGVYHEQTRPLVDYYSQWAQKGGADAPAYITVDGQRPVETVRDEILAALKAR

Sequences:

>Translated_219_residues
MRLILLGPPGAGKGTQAAHICEAFGIPQISTGDMLRAAVKAGTPLGQQAKKIMDEGGLVSDDIILGLIEERVAQADCANG
FLFDGFPRTIAQADGLNDQGIRIDAVVEIQVPDEEIVDRMAGRRVHPGSGRVYHVTHNPPRQEGKDDVTGEDLVQREDDR
EETVRHRLGVYHEQTRPLVDYYSQWAQKGGADAPAYITVDGQRPVETVRDEILAALKAR
>Mature_219_residues
MRLILLGPPGAGKGTQAAHICEAFGIPQISTGDMLRAAVKAGTPLGQQAKKIMDEGGLVSDDIILGLIEERVAQADCANG
FLFDGFPRTIAQADGLNDQGIRIDAVVEIQVPDEEIVDRMAGRRVHPGSGRVYHVTHNPPRQEGKDDVTGEDLVQREDDR
EETVRHRLGVYHEQTRPLVDYYSQWAQKGGADAPAYITVDGQRPVETVRDEILAALKAR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=197, Percent_Identity=47.7157360406091, Blast_Score=204, Evalue=4e-53,
Organism=Homo sapiens, GI4502013, Length=220, Percent_Identity=45.9090909090909, Blast_Score=204, Evalue=5e-53,
Organism=Homo sapiens, GI19923437, Length=188, Percent_Identity=43.0851063829787, Blast_Score=167, Evalue=8e-42,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=41.7582417582418, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=41.7582417582418, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=41.7582417582418, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=41.7582417582418, Blast_Score=154, Evalue=8e-38,
Organism=Homo sapiens, GI22749187, Length=182, Percent_Identity=29.1208791208791, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI4502011, Length=183, Percent_Identity=28.9617486338798, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=26.9406392694064, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=26.0869565217391, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21450759, Length=259, Percent_Identity=20.4633204633205, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=62.7358490566038, Blast_Score=274, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17552384, Length=216, Percent_Identity=42.1296296296296, Blast_Score=186, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=186, Percent_Identity=36.0215053763441, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=31.8681318681319, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=220, Percent_Identity=27.7272727272727, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17533833, Length=220, Percent_Identity=27.7272727272727, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320432, Length=208, Percent_Identity=49.0384615384615, Blast_Score=213, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6321018, Length=188, Percent_Identity=40.9574468085106, Blast_Score=141, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=218, Percent_Identity=25.2293577981651, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=49.7267759562842, Blast_Score=196, Evalue=7e-51,
Organism=Drosophila melanogaster, GI17737899, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645822, Length=184, Percent_Identity=42.3913043478261, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24663208, Length=213, Percent_Identity=29.5774647887324, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI17647141, Length=213, Percent_Identity=29.5774647887324, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI221459597, Length=195, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356893, Length=195, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_HALHL (A1WXY6)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003350.1
- ProteinModelPortal:   A1WXY6
- SMR:   A1WXY6
- STRING:   A1WXY6
- GeneID:   4710893
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1784
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   A1WXY6
- ProtClustDB:   PRK00279
- BioCyc:   HHAL349124:HHAL_1784-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23883; Mature: 23883

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQAAHICEAFGIPQISTGDMLRAAVKAGTPLGQQAKKIMDEGGLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
DDIILGLIEERVAQADCANGFLFDGFPRTIAQADGLNDQGIRIDAVVEIQVPDEEIVDRM
HHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHH
AGRRVHPGSGRVYHVTHNPPRQEGKDDVTGEDLVQREDDREETVRHRLGVYHEQTRPLVD
HCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCHHHHCCCHHH
YYSQWAQKGGADAPAYITVDGQRPVETVRDEILAALKAR
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQAAHICEAFGIPQISTGDMLRAAVKAGTPLGQQAKKIMDEGGLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
DDIILGLIEERVAQADCANGFLFDGFPRTIAQADGLNDQGIRIDAVVEIQVPDEEIVDRM
HHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHH
AGRRVHPGSGRVYHVTHNPPRQEGKDDVTGEDLVQREDDREETVRHRLGVYHEQTRPLVD
HCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCHHHHCCCHHH
YYSQWAQKGGADAPAYITVDGQRPVETVRDEILAALKAR
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA