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The map label for this gene is nuoN

Identifier: 121998531

GI number: 121998531

Start: 1924762

End: 1926216

Strand: Reverse

Name: nuoN

Synonym: Hhal_1752

Alternate gene names: 121998531

Gene position: 1926216-1924762 (Counterclockwise)

Preceding gene: 121998532

Following gene: 121998530

Centisome position: 71.92

GC content: 66.8

Gene sequence:

>1455_bases
ATGAGCTTCGAGACGCCCGATTTCTCCCTGGCGCTGCCGGAAATCTGGTTGCTGGCGGCCACCTGCGGTGTGCTGGTGGT
GGACCTCTTCTCCAGCGATCCCCGGCGTAGCGCGACCTTTTACCTGACCCAGGGAGCGCTGCTGGTCACCGCAGTGCTGG
CCCTGAGTACCCAGTGGGGCGTGAACGAGGTGACCTTCTCGGGCCACTACATGGCCGATTCGCTGGGTGCCGTGGTGAAG
GCCTCCGTAGCGCTCTTGTCGGTGCTCGCCCTGGCCTATACGCGGCCCTACCTGGGGGACCGCGGCCTGCTCCAGGGGGA
GTTCTACCTGCTGGCGCTGTTCGCCAACCTGGGCATGCTGGTGATCGCCTCCGGGGGGAGTCTGCTGAGCCTTTACCTCG
GCCTGGAGCTGCTGTCGCTGGCGCTCTACGCGCTGGTGGCCTACCACCGTGATTCGCGCCAGGCGGCCGAGGCGGCGATG
AAATATTTCGTCCTCGGTTCGCTGGCCTCGGGGATCCTGCTCTACGGCATGTCGATGGTCTACGGCGCCACGGCGAGCCT
GGAGCTGTCGGTGATCGCCGAGGTGGCCGGCCGTCACTCCGATCCGCTGATGTTGCTCTTCGGCGTGGTGTTCATGCTGG
TGGGCGTGGCCTTCAAGCTCGGGGCCGCGCCGTTCCACGCCTGGGTGCCGGACGTCTATCAGGGCGCCCCGACGCCGGTG
ACGCTGTTCCTGAGCACCGCGCCCAAGGTTGCGGCGGTGGCGCTGTTCATGCGCCTGCTCGTTGACGGGCTGGGGCCGAT
GCACGAGCAGCTCGAGCCGATGCTGATGATCCTGGCCGTCGCCTCGCTGTTGGTTGGCAACCTGATCGCCATCGTGCAGA
CCAACTTCAAGCGCATGCTGGCCTATTCGGCCATCGCCCACGCCGGCTTCATCATGGTTGGGTTCACGGCCGGGACGGAT
GCCGGTCATGCGGCGGCCCTGTTCTACACAATCGCCTACAGCATCATGGCGGCCGGCGCCTTCGGGATGATTACGGTGTT
GGCGCGCTCCGGTTTCGAGGCCGAGGAGATTGCCGATCTGCGCGGGCTCAATGAGCGCCACCCGGTCTACGCCGGCGTGC
TGTTGCTGGTGCTGGTGTCGATGACGGGCATCCCCGGTACCGTGGGCTTCTACGCGAAATACCTGGTCCTCCAGGCCGCC
GTCGAGGCGGGCCATATCCCGCTGGCGATCTTTGCCGTGGTGGCGGCCGTGGTGGGCGCCTTCTACTACCTGCGGGTTCT
CAAGGTCGTCTACTTCGACCGCCCGGAGGCCGAGGTGGATGCGGATACGCTGCCGGCTCCCGGCGCCTCCTCGGCGATCC
GCAGCCTCGTGGTGGTCAACGGCGTCGCGGTCCTGGTGCTGGGGATCTTCCCGGAGCGCCTGATCGCGCTGTGCCAGGCG
GCTTTGGGCCTTTAG

Upstream 100 bases:

>100_bases
TACCCGCAGGCGCTGGTCGCCGTGGCGGAGCCGACCCTGGTCGAGTTGTTGAACGACGTCTCTGCAGCGCTCCCGGCTGC
CCGGTAAGGAAGGAGAGGCA

Downstream 100 bases:

>100_bases
GGGGCCGGGGAGGAGTGGGGGCGCAGCGGCTTGATGTTTGCATAGGGTCCCCGTATAATCCCCTTTAACAGTTGCGGGGT
GGAGCAGTCTGGTAGCTCGT

Product: proton-translocating NADH-quinone oxidoreductase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSFETPDFSLALPEIWLLAATCGVLVVDLFSSDPRRSATFYLTQGALLVTAVLALSTQWGVNEVTFSGHYMADSLGAVVK
ASVALLSVLALAYTRPYLGDRGLLQGEFYLLALFANLGMLVIASGGSLLSLYLGLELLSLALYALVAYHRDSRQAAEAAM
KYFVLGSLASGILLYGMSMVYGATASLELSVIAEVAGRHSDPLMLLFGVVFMLVGVAFKLGAAPFHAWVPDVYQGAPTPV
TLFLSTAPKVAAVALFMRLLVDGLGPMHEQLEPMLMILAVASLLVGNLIAIVQTNFKRMLAYSAIAHAGFIMVGFTAGTD
AGHAAALFYTIAYSIMAAGAFGMITVLARSGFEAEEIADLRGLNERHPVYAGVLLLVLVSMTGIPGTVGFYAKYLVLQAA
VEAGHIPLAIFAVVAAVVGAFYYLRVLKVVYFDRPEAEVDADTLPAPGASSAIRSLVVVNGVAVLVLGIFPERLIALCQA
ALGL

Sequences:

>Translated_484_residues
MSFETPDFSLALPEIWLLAATCGVLVVDLFSSDPRRSATFYLTQGALLVTAVLALSTQWGVNEVTFSGHYMADSLGAVVK
ASVALLSVLALAYTRPYLGDRGLLQGEFYLLALFANLGMLVIASGGSLLSLYLGLELLSLALYALVAYHRDSRQAAEAAM
KYFVLGSLASGILLYGMSMVYGATASLELSVIAEVAGRHSDPLMLLFGVVFMLVGVAFKLGAAPFHAWVPDVYQGAPTPV
TLFLSTAPKVAAVALFMRLLVDGLGPMHEQLEPMLMILAVASLLVGNLIAIVQTNFKRMLAYSAIAHAGFIMVGFTAGTD
AGHAAALFYTIAYSIMAAGAFGMITVLARSGFEAEEIADLRGLNERHPVYAGVLLLVLVSMTGIPGTVGFYAKYLVLQAA
VEAGHIPLAIFAVVAAVVGAFYYLRVLKVVYFDRPEAEVDADTLPAPGASSAIRSLVVVNGVAVLVLGIFPERLIALCQA
ALGL
>Mature_483_residues
SFETPDFSLALPEIWLLAATCGVLVVDLFSSDPRRSATFYLTQGALLVTAVLALSTQWGVNEVTFSGHYMADSLGAVVKA
SVALLSVLALAYTRPYLGDRGLLQGEFYLLALFANLGMLVIASGGSLLSLYLGLELLSLALYALVAYHRDSRQAAEAAMK
YFVLGSLASGILLYGMSMVYGATASLELSVIAEVAGRHSDPLMLLFGVVFMLVGVAFKLGAAPFHAWVPDVYQGAPTPVT
LFLSTAPKVAAVALFMRLLVDGLGPMHEQLEPMLMILAVASLLVGNLIAIVQTNFKRMLAYSAIAHAGFIMVGFTAGTDA
GHAAALFYTIAYSIMAAGAFGMITVLARSGFEAEEIADLRGLNERHPVYAGVLLLVLVSMTGIPGTVGFYAKYLVLQAAV
EAGHIPLAIFAVVAAVVGAFYYLRVLKVVYFDRPEAEVDADTLPAPGASSAIRSLVVVNGVAVLVLGIFPERLIALCQAA
LGL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family

Homologues:

Organism=Homo sapiens, GI251831108, Length=200, Percent_Identity=29.5, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI145693160, Length=418, Percent_Identity=36.8421052631579, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1788614, Length=327, Percent_Identity=26.9113149847095, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788613, Length=503, Percent_Identity=23.4592445328032, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788831, Length=382, Percent_Identity=25.9162303664921, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1788829, Length=394, Percent_Identity=26.3959390862944, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788827, Length=407, Percent_Identity=21.8673218673219, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUON_HALHL (A1WXV4)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003318.1
- STRING:   A1WXV4
- GeneID:   4709423
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1752
- HOGENOM:   HBG747830
- OMA:   ILMTITI
- PhylomeDB:   A1WXV4
- ProtClustDB:   CLSK727517
- BioCyc:   HHAL349124:HHAL_1752-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_00445
- InterPro:   IPR010096
- InterPro:   IPR001750
- TIGRFAMs:   TIGR01770

Pfam domain/function: PF00361 Oxidored_q1

EC number: =1.6.99.5

Molecular weight: Translated: 51074; Mature: 50943

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a3a27b0)-; HASH(0x1b8e324c)-; HASH(0x1b868454)-; HASH(0x1b8e5e5c)-; HASH(0x1b868478)-; HASH(0x1b8597cc)-; HASH(0x1b8e2f7c)-; HASH(0x1b8e5d30)-; HASH(0x1b8e5d48)-; HASH(0x1b8623bc)-; HASH(0x1b86e8a8)-; HASH(0x1b86b7dc)-; HASH(0x1b8e8784)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFETPDFSLALPEIWLLAATCGVLVVDLFSSDPRRSATFYLTQGALLVTAVLALSTQWG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCC
VNEVTFSGHYMADSLGAVVKASVALLSVLALAYTRPYLGDRGLLQGEFYLLALFANLGML
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEE
VIASGGSLLSLYLGLELLSLALYALVAYHRDSRQAAEAAMKYFVLGSLASGILLYGMSMV
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGATASLELSVIAEVAGRHSDPLMLLFGVVFMLVGVAFKLGAAPFHAWVPDVYQGAPTPV
HCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCE
TLFLSTAPKVAAVALFMRLLVDGLGPMHEQLEPMLMILAVASLLVGNLIAIVQTNFKRML
EEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSAIAHAGFIMVGFTAGTDAGHAAALFYTIAYSIMAAGAFGMITVLARSGFEAEEIADL
HHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RGLNERHPVYAGVLLLVLVSMTGIPGTVGFYAKYLVLQAAVEAGHIPLAIFAVVAAVVGA
HCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FYYLRVLKVVYFDRPEAEVDADTLPAPGASSAIRSLVVVNGVAVLVLGIFPERLIALCQA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGL
HHCH
>Mature Secondary Structure 
SFETPDFSLALPEIWLLAATCGVLVVDLFSSDPRRSATFYLTQGALLVTAVLALSTQWG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHCCCC
VNEVTFSGHYMADSLGAVVKASVALLSVLALAYTRPYLGDRGLLQGEFYLLALFANLGML
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEE
VIASGGSLLSLYLGLELLSLALYALVAYHRDSRQAAEAAMKYFVLGSLASGILLYGMSMV
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YGATASLELSVIAEVAGRHSDPLMLLFGVVFMLVGVAFKLGAAPFHAWVPDVYQGAPTPV
HCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCE
TLFLSTAPKVAAVALFMRLLVDGLGPMHEQLEPMLMILAVASLLVGNLIAIVQTNFKRML
EEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSAIAHAGFIMVGFTAGTDAGHAAALFYTIAYSIMAAGAFGMITVLARSGFEAEEIADL
HHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
RGLNERHPVYAGVLLLVLVSMTGIPGTVGFYAKYLVLQAAVEAGHIPLAIFAVVAAVVGA
HCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FYYLRVLKVVYFDRPEAEVDADTLPAPGASSAIRSLVVVNGVAVLVLGIFPERLIALCQA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALGL
HHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA