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The map label for this gene is uvrD [H]

Identifier: 121998487

GI number: 121998487

Start: 1865673

End: 1867760

Strand: Reverse

Name: uvrD [H]

Synonym: Hhal_1708

Alternate gene names: 121998487

Gene position: 1867760-1865673 (Counterclockwise)

Preceding gene: 121998488

Following gene: 121998486

Centisome position: 69.73

GC content: 70.21

Gene sequence:

>2088_bases
GTGGCTTTAACCCCCGAACAGCGGCAGGTCATCGAGCACCCGGGTGGGCACGCCCGGGTCAGTGCTGCGGCCGGTTCCGG
CAAGACAGCGACCCTGGTCGCGCGGGTGGTGGAATTGCTGCGCCGCGGCGCCGATTCGGCGCGCATCCGGGTCCTGATGT
TCAATCGCTCGGCCCGCGAAGATTTCGAGCGGCGATTGGCCGTAGCCATCCGGGAGGCCGGCTGCCAGGCCCGGGTTTCG
GTACAGACATTCCACAGTGCCGGATATCGGCTGTTGCAGCGACTCGAGGCCGAGGGTGTGGTGCCGCGGCGGCGCTTGGA
GAGCGCCGACTGGGTGGCCCGCAAGCTGGCCCGCACGGCGCTGGAGGCGGCGCTGGAGAACCGGGACGAGGCGGAGGCCG
TGGAGGACGAGGCCGTCGACGCGTTCCTGGCCTTCGTCGACGTGGTCAAGGCGGACACCCGCGAGGCGGCCGTCATCCAC
GCCGAGGCGCCCCGCCTGCTGGGAGCGGCACTCCCCGGCCACTACCTGGAGGCGTTCCGCCGCTTCGAGGCGTTGCGCGA
TGATCAAAACGTGCGTCTGCTCAACGATCTGATCCACGAGCCGGTCCAGGCCCTGCTGGCGGATGATGCCCTGGCGCGGC
GGTTCCGGAACCACTTCGACCACGTCATCATCGACGAGTATCAGGACGTTAACGAGGCTCAGCAGCAGCTGATCCGTTGC
ATCGCCGGTGACCGTGCCGCGGTGATGGTCGTCGGGGATCCGGATCAGTGCGTTTACCAGTGGCGGGGGGCGCGACCGGA
GTACATCGTGCGCCGCTTCGACGAGGACTTCCCGGGGGCTGCCAGCTATACCCTGCCGCATACGTTCCGCTTCGGTCATG
CGGTGGCGCTGCTGGGTAATCACACGGTGGTCCGCAATCGGCAGCGGGATGGCAAGCTGTGCCTGGCCGCGCCCCGGAAT
CCGGCCACTGAGGTTCGTCGCTGTACCGACAGCGATCCGGAACTCTATCGGCGCATCCTCGCCGAGCACCGCGCGACCGG
AGGTCGGTTGTCCGATGTGGCGGTGCTGGTGCGCCTCTACAGTCTGGCCGCGCCGCTGGAGCTGGAACTCCTCGAGGCCG
GCGTGCCATTGCGTCTCGAGGGGCGTGCGGGGCTGTTCCAGCGGCGGGAGGTTCGTGCGTTGCTCGGCTATCTGCGCCAT
GCCGCGGGGCTCCTGCGTGACCCCCTGCCGGACGGCGCTGGGCCGGCCGAGCTGCTGACCGAGATGCTGATGCTGCCGGT
AGCCGGCCTGCGCCGGCCCGAGGCACAGGCGGTCGCTCAGGGGTACGCCGATGCACGGCTGCCGCTGATCCGCAGCCTGT
CCCGGGCGGCCGAAGACCTGCCGCGCTGGAAGGGTCGACGGCTGCGCCAACGGGTGGCCTCGCTCGAGTGTCTGGGGGCG
TTCCATGGCGACGATCCGGTGGCGGATGTGCTGGATGAGATCGTCTCGGAACTGTCGCTCTACGAGGCCATCGCCAGTGG
CTCGCCCAGCGCCGAGGCAGCCACGGATCGCAGCATGATGGTCGATGCCCTGCGCCGTTTTGCTGCCAGCGGAGGATGGG
GGCTGACCGAGTTCCTGGAGCGGTGCGACGAACTCATCGCCCGCTCGGCGCAATGGCAGGACGCCCCGCCGGAGCAGGCC
GTGCGCGTGACCTCGATCCACCGGGCCAAGGGGCTGGAGTGGCCGGTCGTCATCGTGCCCGGTCTGGCCGAGGGTACCTT
CCCCTACGGCGTCGGAGAGGCCACCGCGGCGGATCTGGAGGCAGAGCGCCGCCTGTTCTACGTGGCGGTGACCCGCGCGC
AGCACCGGCTGTATCTGGTGCACCCGCAAGATCCGCGGCTGGAGCGGGCCCTGCGCGGTGGGCGGGCCGAGCAGTTTGAT
CCGCACCGGGCGGTGGCCTCGCGCTTTCTGGCCGAGGCGCAGCCGGAGCACTCGATCGCCGCCGGGGCGGCGCTGCATCG
GGGCGAGACGCCCGACAAGCGGCTGCGCACCCGGGTGGTCGGCGACTACCTGGCCGCCTTGCAGGGCCACGAGGTCGTCA
CCGACTGA

Upstream 100 bases:

>100_bases
CGAGATCGAGCGCGAGAGCGCCACCGGACGGGTGCTGGGCCGGGTCCCCGCAGAGGTACGGGTCGAGCCGGGCCGTCTGG
TCCTCAGGCCGCGCTAACCC

Downstream 100 bases:

>100_bases
ATCCGTTTACGCCGCTCGGCGCAGTGCTTAGGCTCAGGGCTCGCGGCGCCGCGTGAAGAGGAGGTGTGGTGGGCAAGCAC
ACAGAGGGTGACCAGGATCC

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MALTPEQRQVIEHPGGHARVSAAAGSGKTATLVARVVELLRRGADSARIRVLMFNRSAREDFERRLAVAIREAGCQARVS
VQTFHSAGYRLLQRLEAEGVVPRRRLESADWVARKLARTALEAALENRDEAEAVEDEAVDAFLAFVDVVKADTREAAVIH
AEAPRLLGAALPGHYLEAFRRFEALRDDQNVRLLNDLIHEPVQALLADDALARRFRNHFDHVIIDEYQDVNEAQQQLIRC
IAGDRAAVMVVGDPDQCVYQWRGARPEYIVRRFDEDFPGAASYTLPHTFRFGHAVALLGNHTVVRNRQRDGKLCLAAPRN
PATEVRRCTDSDPELYRRILAEHRATGGRLSDVAVLVRLYSLAAPLELELLEAGVPLRLEGRAGLFQRREVRALLGYLRH
AAGLLRDPLPDGAGPAELLTEMLMLPVAGLRRPEAQAVAQGYADARLPLIRSLSRAAEDLPRWKGRRLRQRVASLECLGA
FHGDDPVADVLDEIVSELSLYEAIASGSPSAEAATDRSMMVDALRRFAASGGWGLTEFLERCDELIARSAQWQDAPPEQA
VRVTSIHRAKGLEWPVVIVPGLAEGTFPYGVGEATAADLEAERRLFYVAVTRAQHRLYLVHPQDPRLERALRGGRAEQFD
PHRAVASRFLAEAQPEHSIAAGAALHRGETPDKRLRTRVVGDYLAALQGHEVVTD

Sequences:

>Translated_695_residues
MALTPEQRQVIEHPGGHARVSAAAGSGKTATLVARVVELLRRGADSARIRVLMFNRSAREDFERRLAVAIREAGCQARVS
VQTFHSAGYRLLQRLEAEGVVPRRRLESADWVARKLARTALEAALENRDEAEAVEDEAVDAFLAFVDVVKADTREAAVIH
AEAPRLLGAALPGHYLEAFRRFEALRDDQNVRLLNDLIHEPVQALLADDALARRFRNHFDHVIIDEYQDVNEAQQQLIRC
IAGDRAAVMVVGDPDQCVYQWRGARPEYIVRRFDEDFPGAASYTLPHTFRFGHAVALLGNHTVVRNRQRDGKLCLAAPRN
PATEVRRCTDSDPELYRRILAEHRATGGRLSDVAVLVRLYSLAAPLELELLEAGVPLRLEGRAGLFQRREVRALLGYLRH
AAGLLRDPLPDGAGPAELLTEMLMLPVAGLRRPEAQAVAQGYADARLPLIRSLSRAAEDLPRWKGRRLRQRVASLECLGA
FHGDDPVADVLDEIVSELSLYEAIASGSPSAEAATDRSMMVDALRRFAASGGWGLTEFLERCDELIARSAQWQDAPPEQA
VRVTSIHRAKGLEWPVVIVPGLAEGTFPYGVGEATAADLEAERRLFYVAVTRAQHRLYLVHPQDPRLERALRGGRAEQFD
PHRAVASRFLAEAQPEHSIAAGAALHRGETPDKRLRTRVVGDYLAALQGHEVVTD
>Mature_694_residues
ALTPEQRQVIEHPGGHARVSAAAGSGKTATLVARVVELLRRGADSARIRVLMFNRSAREDFERRLAVAIREAGCQARVSV
QTFHSAGYRLLQRLEAEGVVPRRRLESADWVARKLARTALEAALENRDEAEAVEDEAVDAFLAFVDVVKADTREAAVIHA
EAPRLLGAALPGHYLEAFRRFEALRDDQNVRLLNDLIHEPVQALLADDALARRFRNHFDHVIIDEYQDVNEAQQQLIRCI
AGDRAAVMVVGDPDQCVYQWRGARPEYIVRRFDEDFPGAASYTLPHTFRFGHAVALLGNHTVVRNRQRDGKLCLAAPRNP
ATEVRRCTDSDPELYRRILAEHRATGGRLSDVAVLVRLYSLAAPLELELLEAGVPLRLEGRAGLFQRREVRALLGYLRHA
AGLLRDPLPDGAGPAELLTEMLMLPVAGLRRPEAQAVAQGYADARLPLIRSLSRAAEDLPRWKGRRLRQRVASLECLGAF
HGDDPVADVLDEIVSELSLYEAIASGSPSAEAATDRSMMVDALRRFAASGGWGLTEFLERCDELIARSAQWQDAPPEQAV
RVTSIHRAKGLEWPVVIVPGLAEGTFPYGVGEATAADLEAERRLFYVAVTRAQHRLYLVHPQDPRLERALRGGRAEQFDP
HRAVASRFLAEAQPEHSIAAGAALHRGETPDKRLRTRVVGDYLAALQGHEVVTD

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=652, Percent_Identity=26.6871165644172, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI48994965, Length=653, Percent_Identity=28.0245022970904, Blast_Score=156, Evalue=4e-39,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 76961; Mature: 76830

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTPEQRQVIEHPGGHARVSAAAGSGKTATLVARVVELLRRGADSARIRVLMFNRSARE
CCCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
DFERRLAVAIREAGCQARVSVQTFHSAGYRLLQRLEAEGVVPRRRLESADWVARKLARTA
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHH
LEAALENRDEAEAVEDEAVDAFLAFVDVVKADTREAAVIHAEAPRLLGAALPGHYLEAFR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHCCHHHHHHHH
RFEALRDDQNVRLLNDLIHEPVQALLADDALARRFRNHFDHVIIDEYQDVNEAQQQLIRC
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHHHHHHHHH
IAGDRAAVMVVGDPDQCVYQWRGARPEYIVRRFDEDFPGAASYTLPHTFRFGHAVALLGN
HCCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC
HTVVRNRQRDGKLCLAAPRNPATEVRRCTDSDPELYRRILAEHRATGGRLSDVAVLVRLY
CHHEECCCCCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLAAPLELELLEAGVPLRLEGRAGLFQRREVRALLGYLRHAAGLLRDPLPDGAGPAELLT
HHCCCCHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EMLMLPVAGLRRPEAQAVAQGYADARLPLIRSLSRAAEDLPRWKGRRLRQRVASLECLGA
HHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHGDDPVADVLDEIVSELSLYEAIASGSPSAEAATDRSMMVDALRRFAASGGWGLTEFLE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RCDELIARSAQWQDAPPEQAVRVTSIHRAKGLEWPVVIVPGLAEGTFPYGVGEATAADLE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHH
AERRLFYVAVTRAQHRLYLVHPQDPRLERALRGGRAEQFDPHRAVASRFLAEAQPEHSIA
HHHEEEEEEEECCCCEEEEECCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
AGAALHRGETPDKRLRTRVVGDYLAALQGHEVVTD
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ALTPEQRQVIEHPGGHARVSAAAGSGKTATLVARVVELLRRGADSARIRVLMFNRSARE
CCCCHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
DFERRLAVAIREAGCQARVSVQTFHSAGYRLLQRLEAEGVVPRRRLESADWVARKLARTA
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHH
LEAALENRDEAEAVEDEAVDAFLAFVDVVKADTREAAVIHAEAPRLLGAALPGHYLEAFR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHCCHHHHHHHH
RFEALRDDQNVRLLNDLIHEPVQALLADDALARRFRNHFDHVIIDEYQDVNEAQQQLIRC
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHCCHHHHHHHHHHH
IAGDRAAVMVVGDPDQCVYQWRGARPEYIVRRFDEDFPGAASYTLPHTFRFGHAVALLGN
HCCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCC
HTVVRNRQRDGKLCLAAPRNPATEVRRCTDSDPELYRRILAEHRATGGRLSDVAVLVRLY
CHHEECCCCCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SLAAPLELELLEAGVPLRLEGRAGLFQRREVRALLGYLRHAAGLLRDPLPDGAGPAELLT
HHCCCCHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EMLMLPVAGLRRPEAQAVAQGYADARLPLIRSLSRAAEDLPRWKGRRLRQRVASLECLGA
HHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHGDDPVADVLDEIVSELSLYEAIASGSPSAEAATDRSMMVDALRRFAASGGWGLTEFLE
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
RCDELIARSAQWQDAPPEQAVRVTSIHRAKGLEWPVVIVPGLAEGTFPYGVGEATAADLE
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCHHHHHHH
AERRLFYVAVTRAQHRLYLVHPQDPRLERALRGGRAEQFDPHRAVASRFLAEAQPEHSIA
HHHEEEEEEEECCCCEEEEECCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
AGAALHRGETPDKRLRTRVVGDYLAALQGHEVVTD
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]