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The map label for this gene is crtE [H]

Identifier: 121998392

GI number: 121998392

Start: 1754465

End: 1755340

Strand: Reverse

Name: crtE [H]

Synonym: Hhal_1613

Alternate gene names: 121998392

Gene position: 1755340-1754465 (Counterclockwise)

Preceding gene: 121998395

Following gene: 121998391

Centisome position: 65.54

GC content: 72.03

Gene sequence:

>876_bases
ATGGAACCGAGCAAGAGAATCGAAAGCGCCCTAGAGGCTGCAGTGGCCCGGGCAACGGCGGCCCCTGCCCCGCCGCAGCT
AGCGCACGCCGTCCGCCACGCCGTGTTCGCTGGCGGTGCCCGGGTGCGGCCGCGCCTGTGCCTGACGGTCGCCGCCGCCT
GCGGCGACGATCATCCCGAGCTGGCCGACGCGGCGGCCACCGCCATCGAGCTGATGCATTGTGCCTCGCTGGTCCACGAC
GACCTGCCGTGTTTCGACGACGCGGCGACCCGGCGCGGGCAGCCTTCGGTACACGCCGCTTACGGCGAGCGGTTGGCCGT
GCTGGCTGGCGATGCGCTCATCGTCCACGCGCTGGAGACGCTGGCGTTGACGGTGCCGCAGGCCCCGCAGCGGGCCGGCG
CCCTGCTGACCACGGTGACCCGAGCGACCGGCATGCCCTACGGCATTACCGCCGGACAGGCCTGGGAGTCCGAGCCGGAG
ATCCCGGTGGCGGAGTACCATCAGGCCAAGACCGGGTCGCTGTTTGCCGCCGCGACCGTCGCGGGCGCCATCGCCGCGGG
CGCCGAGGACCAGGCGGACCGTTGGCGGATCGTGGGTGAGCGGCTGGGCGAGGCGTACCAGGTTGCCGACGACCTGCGCG
ACGCCGTTGGCGCAGAGGATGAGTTGGGCAAGCCCACTGGTCAGGACTCCTCCCACGGCCTTGCCAATGCGGTCTCCGAG
CACGGTCTGCAGGGTGCCAAGGAGCGCCTGGATCGGCTGGTTCAGGAAGCCGTCGATGCCGTGCCGGAATGCGCCGGGGC
CGAGCAGCTGCGCGCGGGGATCCTCCAGGAGATGGAACGGGTGCTGCCCGAGAGCTTGGGCCGTAGCGCGGCGTGA

Upstream 100 bases:

>100_bases
GCAGCGACGTTGACATGGGGTGGGTCCCTGACTAGCGTACTCGACGACTCATATCTTCCCTGGAACGCAAGCCTACACGC
CGCCGGCGGGAGGGGGCTAC

Downstream 100 bases:

>100_bases
TCCGCACCTGGCGAAATAGTCCGTGGCGGGACCGCCTGCACGACTGGCGGGACCGCCTGCTGGCTAGCTCCCGCTTCCAC
CGGCTGGCCGCGCGCTTCCC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: GGPP synthase; Farnesyltranstransferase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MEPSKRIESALEAAVARATAAPAPPQLAHAVRHAVFAGGARVRPRLCLTVAAACGDDHPELADAAATAIELMHCASLVHD
DLPCFDDAATRRGQPSVHAAYGERLAVLAGDALIVHALETLALTVPQAPQRAGALLTTVTRATGMPYGITAGQAWESEPE
IPVAEYHQAKTGSLFAAATVAGAIAAGAEDQADRWRIVGERLGEAYQVADDLRDAVGAEDELGKPTGQDSSHGLANAVSE
HGLQGAKERLDRLVQEAVDAVPECAGAEQLRAGILQEMERVLPESLGRSAA

Sequences:

>Translated_291_residues
MEPSKRIESALEAAVARATAAPAPPQLAHAVRHAVFAGGARVRPRLCLTVAAACGDDHPELADAAATAIELMHCASLVHD
DLPCFDDAATRRGQPSVHAAYGERLAVLAGDALIVHALETLALTVPQAPQRAGALLTTVTRATGMPYGITAGQAWESEPE
IPVAEYHQAKTGSLFAAATVAGAIAAGAEDQADRWRIVGERLGEAYQVADDLRDAVGAEDELGKPTGQDSSHGLANAVSE
HGLQGAKERLDRLVQEAVDAVPECAGAEQLRAGILQEMERVLPESLGRSAA
>Mature_291_residues
MEPSKRIESALEAAVARATAAPAPPQLAHAVRHAVFAGGARVRPRLCLTVAAACGDDHPELADAAATAIELMHCASLVHD
DLPCFDDAATRRGQPSVHAAYGERLAVLAGDALIVHALETLALTVPQAPQRAGALLTTVTRATGMPYGITAGQAWESEPE
IPVAEYHQAKTGSLFAAATVAGAIAAGAEDQADRWRIVGERLGEAYQVADDLRDAVGAEDELGKPTGQDSSHGLANAVSE
HGLQGAKERLDRLVQEAVDAVPECAGAEQLRAGILQEMERVLPESLGRSAA

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=211, Percent_Identity=33.175355450237, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1786623, Length=277, Percent_Identity=33.2129963898917, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789578, Length=211, Percent_Identity=30.3317535545024, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17505681, Length=171, Percent_Identity=35.0877192982456, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24651612, Length=225, Percent_Identity=31.1111111111111, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.29 [H]

Molecular weight: Translated: 30227; Mature: 30227

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPSKRIESALEAAVARATAAPAPPQLAHAVRHAVFAGGARVRPRLCLTVAAACGDDHPE
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHH
LADAAATAIELMHCASLVHDDLPCFDDAATRRGQPSVHAAYGERLAVLAGDALIVHALET
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHCCHHHHHCHHHHHHHHHH
LALTVPQAPQRAGALLTTVTRATGMPYGITAGQAWESEPEIPVAEYHQAKTGSLFAAATV
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHH
AGAIAAGAEDQADRWRIVGERLGEAYQVADDLRDAVGAEDELGKPTGQDSSHGLANAVSE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHH
HGLQGAKERLDRLVQEAVDAVPECAGAEQLRAGILQEMERVLPESLGRSAA
HCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEPSKRIESALEAAVARATAAPAPPQLAHAVRHAVFAGGARVRPRLCLTVAAACGDDHPE
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHH
LADAAATAIELMHCASLVHDDLPCFDDAATRRGQPSVHAAYGERLAVLAGDALIVHALET
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHCCHHHHHCHHHHHHHHHH
LALTVPQAPQRAGALLTTVTRATGMPYGITAGQAWESEPEIPVAEYHQAKTGSLFAAATV
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHH
AGAIAAGAEDQADRWRIVGERLGEAYQVADDLRDAVGAEDELGKPTGQDSSHGLANAVSE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCHHHHHHHH
HGLQGAKERLDRLVQEAVDAVPECAGAEQLRAGILQEMERVLPESLGRSAA
HCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721699; 10648776 [H]