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The map label for this gene is algA [H]

Identifier: 121998320

GI number: 121998320

Start: 1672416

End: 1673903

Strand: Reverse

Name: algA [H]

Synonym: Hhal_1538

Alternate gene names: 121998320

Gene position: 1673903-1672416 (Counterclockwise)

Preceding gene: 121998321

Following gene: 121998318

Centisome position: 62.5

GC content: 65.79

Gene sequence:

>1488_bases
ATGGCCGATGATGCCTACACCCCGTCGCAAGCAGCGCCTGATTCGCAAGACGTGTTCGAGCGTGCCGCCCGCCGCCACGC
GGTGATCCTTGCCGGCGGGTCCGGGACCCGTCTGTGGCCGCTGTCCCGGCGCAACATGCCCAAGCAGCTGCTGGCCCTGA
CCAGTGCCGACACGCTTCTCCAGGAGACGGCGGCGCGGTTGCTACCGGCCTTGCCGGCCCAGCGGATGAGCACGGTCACG
CACGTGGACCACCGCTTCGAGGTCAAGGGCCAGCTGCATGAGGTTGATCCGCAGCTGGCCGAGGGCGTGTTGGTGGAGCC
GTCAGCCCGCAATACCCTGCCGGCCATCGCCTGGGCGGTGGCCCGTATCGCCCACGAGCGGCCCGATGCGCTCGTCGGGG
TCTTCCCCTCCGACCACCAGATCGCCGACGCCGAGGCATTGCGCGGGGCCTGGGCCCGGGCTGAGGTGGCGGCGGACGCC
GGCAAGCTGGTGCTCTTCGGCATCCAGCCCACCGAGCCGGCCACCGGTTTCGGCTACATCCAGGCCGGCCCTGCGCTGGA
GGTCGGCGTGGAGCAGGTCCAGCGCTTCGTGGAGAAACCCGATGGGCAGACGGCTCAGCGCTACCTCGAGCAGGGCGGTT
ACTACTGGAACAGCGGCATGTTCGTCTTTCGGGCGGATCGTTTTCTGGAGCTACTCGCCGCACATCAGCCGGAGATTGCC
GACGCCGTAGCCGAGTGGGCTGAGCCGGATTGCCCGCCGGACTCTGATCGCTACGGCCAGCTGCCCGAACTCTCCATTGA
TTACGGCCTGCTGGAGAGGGCCGACTCGGTAGCGGTGGTCCCGGTGGACCTGGGCTGGAGCGATCTGGGCAGTTGGGAGG
CGCTCTATCAAGAGCGGATCAAGGATGATCACGGCAATGTCTGCCAAGGACCTGCGCTACCTGTCGATAGTCAGGACAAC
CTCCTTTGGAGTGCCGACGGCGGTCTGCTCGCTGCCTACGGCGTGGAAAACTTGGCACTGGTTCAGACTCGCGATGCCAC
CCTGGTCTGCCCGCGGGATCGCCTGGGCGACCTCAAGCCGCTCGTCGCCGAGGTCGCTGCGTACAAACCGGAGCTTGCCG
AGTACCACGTCACCGTGGCACGCCCCTGGGGGAGCTACACCACGCTGGAGAGCGGTCACCGCTACAAGCTCAAGCGGATC
GTGGTGAAACCCGGTTGTCAGCTCTCGTTACAGATGCACTACCACCGCTCGGAGCACTGGGTGGTGATCGCTGGTACCGC
CAAGGTGGTCAATGGGGACGAAGAGATCTACCTCGAGGAGAACCAGTCGACGTACGTGCCGGCCACTCGACCGCACCGTC
TGTCGAATCCGGGGCGAATCCCGCTGCAGATCATCGAGATCCAGACCGGTCCCTATCTGGAGGAGGACGATCTGGTCCGT
TTCGAGGACCTCTACGGCCGTATGGATGATGCTTCCGAATCCCGATAG

Upstream 100 bases:

>100_bases
CTACTGGTTCGTCACCTGTTCTACAAGGCCTTCCGCGCACCCCGGGATCTGGATGCCGAGGCGGCGCAGATGGATCCACA
ACAGCACGGATGATGCCCCT

Downstream 100 bases:

>100_bases
CCGAGCCCCTGTATAGGGGTGATCATGCCCCGTATAGGGGTAATCATGCCCCTGTCGATTCAGGAAGCTGTCTCGGTATC
CGAGCCCTGACGCTGCCAGC

Product: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MADDAYTPSQAAPDSQDVFERAARRHAVILAGGSGTRLWPLSRRNMPKQLLALTSADTLLQETAARLLPALPAQRMSTVT
HVDHRFEVKGQLHEVDPQLAEGVLVEPSARNTLPAIAWAVARIAHERPDALVGVFPSDHQIADAEALRGAWARAEVAADA
GKLVLFGIQPTEPATGFGYIQAGPALEVGVEQVQRFVEKPDGQTAQRYLEQGGYYWNSGMFVFRADRFLELLAAHQPEIA
DAVAEWAEPDCPPDSDRYGQLPELSIDYGLLERADSVAVVPVDLGWSDLGSWEALYQERIKDDHGNVCQGPALPVDSQDN
LLWSADGGLLAAYGVENLALVQTRDATLVCPRDRLGDLKPLVAEVAAYKPELAEYHVTVARPWGSYTTLESGHRYKLKRI
VVKPGCQLSLQMHYHRSEHWVVIAGTAKVVNGDEEIYLEENQSTYVPATRPHRLSNPGRIPLQIIEIQTGPYLEEDDLVR
FEDLYGRMDDASESR

Sequences:

>Translated_495_residues
MADDAYTPSQAAPDSQDVFERAARRHAVILAGGSGTRLWPLSRRNMPKQLLALTSADTLLQETAARLLPALPAQRMSTVT
HVDHRFEVKGQLHEVDPQLAEGVLVEPSARNTLPAIAWAVARIAHERPDALVGVFPSDHQIADAEALRGAWARAEVAADA
GKLVLFGIQPTEPATGFGYIQAGPALEVGVEQVQRFVEKPDGQTAQRYLEQGGYYWNSGMFVFRADRFLELLAAHQPEIA
DAVAEWAEPDCPPDSDRYGQLPELSIDYGLLERADSVAVVPVDLGWSDLGSWEALYQERIKDDHGNVCQGPALPVDSQDN
LLWSADGGLLAAYGVENLALVQTRDATLVCPRDRLGDLKPLVAEVAAYKPELAEYHVTVARPWGSYTTLESGHRYKLKRI
VVKPGCQLSLQMHYHRSEHWVVIAGTAKVVNGDEEIYLEENQSTYVPATRPHRLSNPGRIPLQIIEIQTGPYLEEDDLVR
FEDLYGRMDDASESR
>Mature_494_residues
ADDAYTPSQAAPDSQDVFERAARRHAVILAGGSGTRLWPLSRRNMPKQLLALTSADTLLQETAARLLPALPAQRMSTVTH
VDHRFEVKGQLHEVDPQLAEGVLVEPSARNTLPAIAWAVARIAHERPDALVGVFPSDHQIADAEALRGAWARAEVAADAG
KLVLFGIQPTEPATGFGYIQAGPALEVGVEQVQRFVEKPDGQTAQRYLEQGGYYWNSGMFVFRADRFLELLAAHQPEIAD
AVAEWAEPDCPPDSDRYGQLPELSIDYGLLERADSVAVVPVDLGWSDLGSWEALYQERIKDDHGNVCQGPALPVDSQDNL
LWSADGGLLAAYGVENLALVQTRDATLVCPRDRLGDLKPLVAEVAAYKPELAEYHVTVARPWGSYTTLESGHRYKLKRIV
VKPGCQLSLQMHYHRSEHWVVIAGTAKVVNGDEEIYLEENQSTYVPATRPHRLSNPGRIPLQIIEIQTGPYLEEDDLVRF
EDLYGRMDDASESR

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=479, Percent_Identity=44.4676409185804, Blast_Score=385, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 54645; Mature: 54514

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDAYTPSQAAPDSQDVFERAARRHAVILAGGSGTRLWPLSRRNMPKQLLALTSADTLL
CCCCCCCCCCCCCCHHHHHHHHHHCEEEEEECCCCCEEEECHHCCCCHHHHHHHHHHHHH
QETAARLLPALPAQRMSTVTHVDHRFEVKGQLHEVDPQLAEGVLVEPSARNTLPAIAWAV
HHHHHHHHHCCCHHHHHHHHHCCCEEEECCCHHHCCHHHHCCEEECCCCCCCHHHHHHHH
ARIAHERPDALVGVFPSDHQIADAEALRGAWARAEVAADAGKLVLFGIQPTEPATGFGYI
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEE
QAGPALEVGVEQVQRFVEKPDGQTAQRYLEQGGYYWNSGMFVFRADRFLELLAAHQPEIA
ECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCCEEEEEHHHHHHHHHHCCCHHH
DAVAEWAEPDCPPDSDRYGQLPELSIDYGLLERADSVAVVPVDLGWSDLGSWEALYQERI
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHH
KDDHGNVCQGPALPVDSQDNLLWSADGGLLAAYGVENLALVQTRDATLVCPRDRLGDLKP
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCEEEEEECCCEEECCHHHCCCHHH
LVAEVAAYKPELAEYHVTVARPWGSYTTLESGHRYKLKRIVVKPGCQLSLQMHYHRSEHW
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCE
VVIAGTAKVVNGDEEIYLEENQSTYVPATRPHRLSNPGRIPLQIIEIQTGPYLEEDDLVR
EEEECCEEEECCCCEEEEECCCCEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCH
FEDLYGRMDDASESR
HHHHHCCCCCCCCCC
>Mature Secondary Structure 
ADDAYTPSQAAPDSQDVFERAARRHAVILAGGSGTRLWPLSRRNMPKQLLALTSADTLL
CCCCCCCCCCCCCHHHHHHHHHHCEEEEEECCCCCEEEECHHCCCCHHHHHHHHHHHHH
QETAARLLPALPAQRMSTVTHVDHRFEVKGQLHEVDPQLAEGVLVEPSARNTLPAIAWAV
HHHHHHHHHCCCHHHHHHHHHCCCEEEECCCHHHCCHHHHCCEEECCCCCCCHHHHHHHH
ARIAHERPDALVGVFPSDHQIADAEALRGAWARAEVAADAGKLVLFGIQPTEPATGFGYI
HHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCEE
QAGPALEVGVEQVQRFVEKPDGQTAQRYLEQGGYYWNSGMFVFRADRFLELLAAHQPEIA
ECCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCCEEEEEHHHHHHHHHHCCCHHH
DAVAEWAEPDCPPDSDRYGQLPELSIDYGLLERADSVAVVPVDLGWSDLGSWEALYQERI
HHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHH
KDDHGNVCQGPALPVDSQDNLLWSADGGLLAAYGVENLALVQTRDATLVCPRDRLGDLKP
CCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCEEEEEECCCEEECCHHHCCCHHH
LVAEVAAYKPELAEYHVTVARPWGSYTTLESGHRYKLKRIVVKPGCQLSLQMHYHRSEHW
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCE
VVIAGTAKVVNGDEEIYLEENQSTYVPATRPHRLSNPGRIPLQIIEIQTGPYLEEDDLVR
EEEECCEEEECCCCEEEEECCCCEECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCH
FEDLYGRMDDASESR
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]