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The map label for this gene is fadE25 [H]

Identifier: 121998275

GI number: 121998275

Start: 1613414

End: 1615195

Strand: Reverse

Name: fadE25 [H]

Synonym: Hhal_1493

Alternate gene names: 121998275

Gene position: 1615195-1613414 (Counterclockwise)

Preceding gene: 121998276

Following gene: 121998274

Centisome position: 60.3

GC content: 68.97

Gene sequence:

>1782_bases
ATGAGCATGTACCGCGCACCGACTCGCGATCTGCGTTTCGTCATCGAAGAACTGATCGGCCTGGAGCGTTTTTCCGGGCT
GCAGGATCTGGAAGAGATCACCCCGGATCTGCTGGAGGCGGTCCTCGAGGAGGCCGATCGGCTGGCCAGTGAGGTTTGGG
CTCCGCTGAACCAGGTCGGCGACCGCCAAGGGTGCCGGATGGAGGGGGGCGAGATGCGTTTGCCCGAGGGCTTCACCGAG
GCCTACCAGGCGTTTGTCGAGGGGGGGTGGAACGGCATCAACGCCCATCCGGAGCACGGCGGCCAGGGATTGCCCGAGGT
CGTCGCTACGGCGACCCAAGAGATGTGGCACGGCGCCAATATGGCGTTGGCCCTGGCCCCCATGCTCTCGGCGGGGGCGA
CCGAACTGCTCCACCGCCACGGGGACGAGGCCCTGCGCGCTCGCTATCTGGGCAAGCTGGTCAGCGGGGAGTGGACCGGT
ACCATGGACCTGACCGAGCCCCAGGCCGGTTCCGATCTGGGGCAGGTCAAGTGCCGTGCGGTACCGGACGGCGACGCCTA
TCGCCTCTACGGTCAGAAGACCTACATCACCTGGGGGGAGCACGAGGCCGCCGAGAACATCATCCACCTGGTCTTGGCCC
GGACCCCGGATGCCCCCGAGGGGCATCGCGGCATCTCCTTGTTCCTGGTGCCCAAGTACCGGGTGGCCGAGGACGGTTCC
CTGGGGGTGCGCAACGACGTCCACTGCACCGCGCTGGAGCACAAGCTCGGCATCCACGGTTCGCCGACCTGCACCATCAG
CTACGGGGACAGCGAGGGGGCGGTGGGCTACCTCGTCGGTGAGCCCTGCCGCGGCCTCAACCACATGTTCACGATGATGA
ACGAGGCGCGCCACAAGGTCGGGGTACAAAGCGTCGGCGTGGCCGAGCGGGCCTATCAGCAGGCGCTGGCCTTCGCCCGG
GACCGAGTGCAGGGCCGCCGCCCCGGGGGCAAGGCGTCGGTGCCGATCCTCCAGCACCCGGATGTCCGCCGCAGCCTGAT
GACCATGCGGGCTCAGACCGAGGCCATGCGCGCGCTGGCGCTGCTGACCGCGGCAGAGATGGACGTTGCCGGGCACGCCG
CCGACGCGGCGGCGCGCCAGAGCGCCCAGCGCCGGGTGGATCTGTTCACGCCGGTGGTCAAGGCGGTTGCCAGCGATCAG
GCCGTGGAGATCACCTCGGTGGGCATTCAGGTCCACGGCGGTATGGGGTATATCGAGGAGGTGGAGGCCCCGCAGCTGTT
GCGCGACGTGCGTGTTGCGGCGATTTACGAGGGCACCAACGGCATCCAGGCGCAAGACTTCACGCTGCGCAAGGTGCTCA
AGGATGGCGGTGAAACCCTGGAAGCGGTGCTCGGCGAGGCCGACGAAACCGTTGAGGCGTTGCGTCGCGACCCCGACGTC
GCCCCCCTGGCCGACGGGCTGGCGGAGGGGGTCGCCACGCTGCGGGAGAGTACGGCGCGGCTCCTGCAAGACGGCGCCGA
GGATCCGCTGGTGCCCTTGACGGCGGCCACACCCTACCTGATGCAGGCGGGCTTGGTGCTGGGCGGCTGGCTGATGGGCC
GGGCCGCCCTGGCGGCCCAGGCGGGGATCCGTGCGGGCTCCGGCGACGCCGACTTCTATGCAGGCAAGCTGCACACCGCG
CGCTTCTACATGCGCCACATCCTGCCGCGGCTCCACGGCTATACACCGGCCATCCGGGGTGGCAGCGATGAGCTCGAGGC
GATTGACGACGGCCATTGGTGA

Upstream 100 bases:

>100_bases
ACAAGGATCCCGAGGCGCCCATCTTCGAGGTGGCCGACTACGGCCTGGTTGCCGACCTGCGGGAAGCCCTTCCCGCGCTG
CGCACTGCACTGGAGCAGGC

Downstream 100 bases:

>100_bases
GGAGGCTCCGGTTTGGATCAGGAGGAACTTGAGCGCGAAACGCTGACCTACGACGTTGTCGTGGTCGGTGCCGGGCCGGC
GGGGTTGGCGGCCGCCCTGG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MSMYRAPTRDLRFVIEELIGLERFSGLQDLEEITPDLLEAVLEEADRLASEVWAPLNQVGDRQGCRMEGGEMRLPEGFTE
AYQAFVEGGWNGINAHPEHGGQGLPEVVATATQEMWHGANMALALAPMLSAGATELLHRHGDEALRARYLGKLVSGEWTG
TMDLTEPQAGSDLGQVKCRAVPDGDAYRLYGQKTYITWGEHEAAENIIHLVLARTPDAPEGHRGISLFLVPKYRVAEDGS
LGVRNDVHCTALEHKLGIHGSPTCTISYGDSEGAVGYLVGEPCRGLNHMFTMMNEARHKVGVQSVGVAERAYQQALAFAR
DRVQGRRPGGKASVPILQHPDVRRSLMTMRAQTEAMRALALLTAAEMDVAGHAADAAARQSAQRRVDLFTPVVKAVASDQ
AVEITSVGIQVHGGMGYIEEVEAPQLLRDVRVAAIYEGTNGIQAQDFTLRKVLKDGGETLEAVLGEADETVEALRRDPDV
APLADGLAEGVATLRESTARLLQDGAEDPLVPLTAATPYLMQAGLVLGGWLMGRAALAAQAGIRAGSGDADFYAGKLHTA
RFYMRHILPRLHGYTPAIRGGSDELEAIDDGHW

Sequences:

>Translated_593_residues
MSMYRAPTRDLRFVIEELIGLERFSGLQDLEEITPDLLEAVLEEADRLASEVWAPLNQVGDRQGCRMEGGEMRLPEGFTE
AYQAFVEGGWNGINAHPEHGGQGLPEVVATATQEMWHGANMALALAPMLSAGATELLHRHGDEALRARYLGKLVSGEWTG
TMDLTEPQAGSDLGQVKCRAVPDGDAYRLYGQKTYITWGEHEAAENIIHLVLARTPDAPEGHRGISLFLVPKYRVAEDGS
LGVRNDVHCTALEHKLGIHGSPTCTISYGDSEGAVGYLVGEPCRGLNHMFTMMNEARHKVGVQSVGVAERAYQQALAFAR
DRVQGRRPGGKASVPILQHPDVRRSLMTMRAQTEAMRALALLTAAEMDVAGHAADAAARQSAQRRVDLFTPVVKAVASDQ
AVEITSVGIQVHGGMGYIEEVEAPQLLRDVRVAAIYEGTNGIQAQDFTLRKVLKDGGETLEAVLGEADETVEALRRDPDV
APLADGLAEGVATLRESTARLLQDGAEDPLVPLTAATPYLMQAGLVLGGWLMGRAALAAQAGIRAGSGDADFYAGKLHTA
RFYMRHILPRLHGYTPAIRGGSDELEAIDDGHW
>Mature_592_residues
SMYRAPTRDLRFVIEELIGLERFSGLQDLEEITPDLLEAVLEEADRLASEVWAPLNQVGDRQGCRMEGGEMRLPEGFTEA
YQAFVEGGWNGINAHPEHGGQGLPEVVATATQEMWHGANMALALAPMLSAGATELLHRHGDEALRARYLGKLVSGEWTGT
MDLTEPQAGSDLGQVKCRAVPDGDAYRLYGQKTYITWGEHEAAENIIHLVLARTPDAPEGHRGISLFLVPKYRVAEDGSL
GVRNDVHCTALEHKLGIHGSPTCTISYGDSEGAVGYLVGEPCRGLNHMFTMMNEARHKVGVQSVGVAERAYQQALAFARD
RVQGRRPGGKASVPILQHPDVRRSLMTMRAQTEAMRALALLTAAEMDVAGHAADAAARQSAQRRVDLFTPVVKAVASDQA
VEITSVGIQVHGGMGYIEEVEAPQLLRDVRVAAIYEGTNGIQAQDFTLRKVLKDGGETLEAVLGEADETVEALRRDPDVA
PLADGLAEGVATLRESTARLLQDGAEDPLVPLTAATPYLMQAGLVLGGWLMGRAALAAQAGIRAGSGDADFYAGKLHTAR
FYMRHILPRLHGYTPAIRGGSDELEAIDDGHW

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=399, Percent_Identity=26.5664160401003, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI4557233, Length=357, Percent_Identity=30.5322128851541, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI21361497, Length=415, Percent_Identity=26.0240963855422, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI4501857, Length=318, Percent_Identity=25.7861635220126, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=28.051948051948, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4557235, Length=444, Percent_Identity=26.8018018018018, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI7656849, Length=354, Percent_Identity=24.8587570621469, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI226958412, Length=356, Percent_Identity=25.8426966292135, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI226958414, Length=356, Percent_Identity=25.8426966292135, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4557231, Length=307, Percent_Identity=27.0358306188925, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI187960098, Length=307, Percent_Identity=27.0358306188925, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI87082384, Length=299, Percent_Identity=31.438127090301, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87081958, Length=345, Percent_Identity=27.8260869565217, Blast_Score=86, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=342, Percent_Identity=32.4561403508772, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI86563383, Length=342, Percent_Identity=32.4561403508772, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17508101, Length=359, Percent_Identity=27.5766016713092, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17533517, Length=403, Percent_Identity=24.317617866005, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17534899, Length=352, Percent_Identity=27.8409090909091, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17570075, Length=367, Percent_Identity=27.5204359673025, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=25.6, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17538396, Length=358, Percent_Identity=28.2122905027933, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71985184, Length=367, Percent_Identity=25.0681198910082, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17569725, Length=351, Percent_Identity=25.3561253561254, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=363, Percent_Identity=25.6198347107438, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71990804, Length=288, Percent_Identity=26.3888888888889, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=24, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71982178, Length=234, Percent_Identity=28.2051282051282, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32563615, Length=238, Percent_Identity=26.0504201680672, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356377, Length=357, Percent_Identity=31.0924369747899, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24660351, Length=306, Percent_Identity=29.7385620915033, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI281363737, Length=310, Percent_Identity=27.741935483871, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=27.0053475935829, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355753, Length=360, Percent_Identity=28.6111111111111, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646207, Length=363, Percent_Identity=27.2727272727273, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 64022; Mature: 63891

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMYRAPTRDLRFVIEELIGLERFSGLQDLEEITPDLLEAVLEEADRLASEVWAPLNQVG
CCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHC
DRQGCRMEGGEMRLPEGFTEAYQAFVEGGWNGINAHPEHGGQGLPEVVATATQEMWHGAN
CCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
MALALAPMLSAGATELLHRHGDEALRARYLGKLVSGEWTGTMDLTEPQAGSDLGQVKCRA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
VPDGDAYRLYGQKTYITWGEHEAAENIIHLVLARTPDAPEGHRGISLFLVPKYRVAEDGS
CCCCCCEEEECCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEECCCCC
LGVRNDVHCTALEHKLGIHGSPTCTISYGDSEGAVGYLVGEPCRGLNHMFTMMNEARHKV
CCCCCCCEEEEHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
GVQSVGVAERAYQQALAFARDRVQGRRPGGKASVPILQHPDVRRSLMTMRAQTEAMRALA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLTAAEMDVAGHAADAAARQSAQRRVDLFTPVVKAVASDQAVEITSVGIQVHGGMGYIEE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHH
VEAPQLLRDVRVAAIYEGTNGIQAQDFTLRKVLKDGGETLEAVLGEADETVEALRRDPDV
CCHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCC
APLADGLAEGVATLRESTARLLQDGAEDPLVPLTAATPYLMQAGLVLGGWLMGRAALAAQ
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
AGIRAGSGDADFYAGKLHTARFYMRHILPRLHGYTPAIRGGSDELEAIDDGHW
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
SMYRAPTRDLRFVIEELIGLERFSGLQDLEEITPDLLEAVLEEADRLASEVWAPLNQVG
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHC
DRQGCRMEGGEMRLPEGFTEAYQAFVEGGWNGINAHPEHGGQGLPEVVATATQEMWHGAN
CCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
MALALAPMLSAGATELLHRHGDEALRARYLGKLVSGEWTGTMDLTEPQAGSDLGQVKCRA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
VPDGDAYRLYGQKTYITWGEHEAAENIIHLVLARTPDAPEGHRGISLFLVPKYRVAEDGS
CCCCCCEEEECCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEEECCCCC
LGVRNDVHCTALEHKLGIHGSPTCTISYGDSEGAVGYLVGEPCRGLNHMFTMMNEARHKV
CCCCCCCEEEEHHHHCCCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
GVQSVGVAERAYQQALAFARDRVQGRRPGGKASVPILQHPDVRRSLMTMRAQTEAMRALA
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLTAAEMDVAGHAADAAARQSAQRRVDLFTPVVKAVASDQAVEITSVGIQVHGGMGYIEE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHH
VEAPQLLRDVRVAAIYEGTNGIQAQDFTLRKVLKDGGETLEAVLGEADETVEALRRDPDV
CCHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCC
APLADGLAEGVATLRESTARLLQDGAEDPLVPLTAATPYLMQAGLVLGGWLMGRAALAAQ
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
AGIRAGSGDADFYAGKLHTARFYMRHILPRLHGYTPAIRGGSDELEAIDDGHW
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]