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The map label for this gene is uppS [H]

Identifier: 121998244

GI number: 121998244

Start: 1578399

End: 1579178

Strand: Reverse

Name: uppS [H]

Synonym: Hhal_1462

Alternate gene names: 121998244

Gene position: 1579178-1578399 (Counterclockwise)

Preceding gene: 121998245

Following gene: 121998243

Centisome position: 58.96

GC content: 67.56

Gene sequence:

>780_bases
ATGGCGGATACGAATGGGCCAGCCCAGATCAGTGAGCGGCTAGCCGGTGTCGAGTTGCCGCGCCATATCGCCATCGTCAT
GGATGGCAACGGGCGCTGGGCACAGCGGCAAGGGCAGCCGCGCTACGCCGGCCACCGTGCCGGGGCGCGCTCGGTTCGCG
AGGTGGTGGAGGCGTGTGGCCGCCTTGAGCTGGAGGCGCTGACGCTGTTCGCCTTCAGCAGCGAGAACTGGCGCCGTCCG
CGGGGCGAGGTCCGCGTGCTGATGCAGCTGTTCCGGACCACCCTGGATCAGGAGCTGCAACGGCTCCACGAGAACGATGT
GCGCCTGAGCTTCATCGGCGACCGGACTCAGTTCGAAGCAGGTCTGCAGCGGCGGCTGACCGATGCCGAGGCGCTTACCG
CGGAGAACACCGGACTGCAGCTGATCGTCGCGACCAGCTACGGCGGGCGCTGGGAGATCGCTGAGGCCGCCCGCCGTTTG
GCCGCGTCGGCGGCTCGGGGCGAGGTCGATCCGCAGTCCATCGATGAGGACGCCTTCCGCGGCGCGCTGTCCCTTCCGGA
TGTCGTCGATCCCGATCTGTTCATCCGCACCGGGGGCGAGCGGCGCATCTCCAACTTCCTGCTCTGGCAGATGGCCTATA
CCGAGCTCCACTTTGCCGAGACCCTGTGGCCGGACTTCGGTACCGAGGGGTTGGCCCGCGCCATCGAAGACTATGCCGCG
CGGGATCGTCGATTCGGTGCGGTCACCTCCTATCCGCTGAAGTCGGTGCGCCATGCTTAA

Upstream 100 bases:

>100_bases
CCAGGAGGCCATCCAGAAGCTCACCGACCGGTATGTGGCGCAAGTCGACGACCTGCTCGAGGAGAAAGAACGCGAGCTCA
TGGAGGTCTGAGCGGGTCGT

Downstream 100 bases:

>100_bases
GGCACGGGTGCTGACCGCGCTGGCGCTGGGGCCGCTGCTTCTTGCCGCAATCTGGTTGTTGCCTACCCCGGTGCTGGCGT
TGGCGCTGGGGGGGGTCGCG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MADTNGPAQISERLAGVELPRHIAIVMDGNGRWAQRQGQPRYAGHRAGARSVREVVEACGRLELEALTLFAFSSENWRRP
RGEVRVLMQLFRTTLDQELQRLHENDVRLSFIGDRTQFEAGLQRRLTDAEALTAENTGLQLIVATSYGGRWEIAEAARRL
AASAARGEVDPQSIDEDAFRGALSLPDVVDPDLFIRTGGERRISNFLLWQMAYTELHFAETLWPDFGTEGLARAIEDYAA
RDRRFGAVTSYPLKSVRHA

Sequences:

>Translated_259_residues
MADTNGPAQISERLAGVELPRHIAIVMDGNGRWAQRQGQPRYAGHRAGARSVREVVEACGRLELEALTLFAFSSENWRRP
RGEVRVLMQLFRTTLDQELQRLHENDVRLSFIGDRTQFEAGLQRRLTDAEALTAENTGLQLIVATSYGGRWEIAEAARRL
AASAARGEVDPQSIDEDAFRGALSLPDVVDPDLFIRTGGERRISNFLLWQMAYTELHFAETLWPDFGTEGLARAIEDYAA
RDRRFGAVTSYPLKSVRHA
>Mature_258_residues
ADTNGPAQISERLAGVELPRHIAIVMDGNGRWAQRQGQPRYAGHRAGARSVREVVEACGRLELEALTLFAFSSENWRRPR
GEVRVLMQLFRTTLDQELQRLHENDVRLSFIGDRTQFEAGLQRRLTDAEALTAENTGLQLIVATSYGGRWEIAEAARRLA
ASAARGEVDPQSIDEDAFRGALSLPDVVDPDLFIRTGGERRISNFLLWQMAYTELHFAETLWPDFGTEGLARAIEDYAAR
DRRFGAVTSYPLKSVRHA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=34.5291479820628, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=34.5291479820628, Blast_Score=133, Evalue=1e-31,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=51.7543859649123, Blast_Score=249, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=231, Percent_Identity=35.0649350649351, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=222, Percent_Identity=28.3783783783784, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6319474, Length=214, Percent_Identity=33.1775700934579, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=32.8947368421053, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29066; Mature: 28935

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTNGPAQISERLAGVELPRHIAIVMDGNGRWAQRQGQPRYAGHRAGARSVREVVEACG
CCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RLELEALTLFAFSSENWRRPRGEVRVLMQLFRTTLDQELQRLHENDVRLSFIGDRTQFEA
CCEEEHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
GLQRRLTDAEALTAENTGLQLIVATSYGGRWEIAEAARRLAASAARGEVDPQSIDEDAFR
HHHHHHHHHHHHEECCCCEEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCHHHCCHHHHH
GALSLPDVVDPDLFIRTGGERRISNFLLWQMAYTELHFAETLWPDFGTEGLARAIEDYAA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RDRRFGAVTSYPLKSVRHA
HHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure 
ADTNGPAQISERLAGVELPRHIAIVMDGNGRWAQRQGQPRYAGHRAGARSVREVVEACG
CCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
RLELEALTLFAFSSENWRRPRGEVRVLMQLFRTTLDQELQRLHENDVRLSFIGDRTQFEA
CCEEEHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
GLQRRLTDAEALTAENTGLQLIVATSYGGRWEIAEAARRLAASAARGEVDPQSIDEDAFR
HHHHHHHHHHHHEECCCCEEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCHHHCCHHHHH
GALSLPDVVDPDLFIRTGGERRISNFLLWQMAYTELHFAETLWPDFGTEGLARAIEDYAA
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
RDRRFGAVTSYPLKSVRHA
HHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA