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The map label for this gene is lpxA

Identifier: 121998238

GI number: 121998238

Start: 1571166

End: 1571942

Strand: Reverse

Name: lpxA

Synonym: Hhal_1456

Alternate gene names: 121998238

Gene position: 1571942-1571166 (Counterclockwise)

Preceding gene: 121998239

Following gene: 121998237

Centisome position: 58.69

GC content: 65.51

Gene sequence:

>777_bases
TTGACGCGAATCCACCCGAACGCCCTGGTCGATCCCAAGGCTCGCCTCGGTGAAGAGGTCGAGGTGGGGCCGTTCAGCGT
CATCGGTCCGGATGTGGAGATCGACGAGGGGACCTGGATCGGCCCCCACGCGGTTATTCAGGGCCCGACCCGCATCGGTC
GGGACAATCGGATCTATCAATTCGCTGCGCTCGGTGAGGCCCCCCAGCACAAGGGGTACCAGGGGGAACCCACCGAGCTG
GTGATCGGTGACGGCAACACCATCCGCGAGTTTGTTACCTGCCACCGCGGTACCGCTCAGGGGCGGGGCGAGACCCGGAT
CGGGGATCACAACTGGCTGATGGCCTACTGCCACATCGCCCACGATTGCCGCCTGGGCAATCACCTGCTGTTCGCCAACT
CCGCCTCGCTGGCTGGACACGTGGACGTCGGCGATCACGCAACCCTGGGCGGCTTCGCGTTGGTTCACCAGTTCTGCCGC
ATCGGCCCCTACGCCTTCTGCGGGTTCGGCAGCGGCATCAACCGGGACGTGCCGCCGTTCGTCACGGTCTCCGGGCAGAT
GGCTGTCCCCCACGGCATCAACTCGGTCGGGCTGCGTCGGCACGGCTTCTCGCGGGAGCGTATTCGGGATATCAAGCGTG
CCTACCGCACGATCTACCGCCAGGGTCTTCGGCTTGACGACGCCCGCGAGGCGTTGTGTCAGCAGCTCAGTCACTCCGCG
GACGTGCAGGGCATGGTCGATTTCATCGACAACAGTCAGCGCGGCCTGTTGCGCTGA

Upstream 100 bases:

>100_bases
TGCGCCGGGTGACGCGGGGCATCTGGATCTTCGAGGCCCGTGGCAGCGTCGACGGTGAGCTGGCTGCCGAGTGCGAGATC
CGCTGCACGGTGCGTACGGT

Downstream 100 bases:

>100_bases
GGCCACCATCCGCCGGCGTAGGGGGGTCTGATCATGGCCAGTCCCAGGGTGGCGATCCTCGCCGGTGAGCTCTCCGGCGA
TGTCCTCGGCGCCGGGCTGA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTRIHPNALVDPKARLGEEVEVGPFSVIGPDVEIDEGTWIGPHAVIQGPTRIGRDNRIYQFAALGEAPQHKGYQGEPTEL
VIGDGNTIREFVTCHRGTAQGRGETRIGDHNWLMAYCHIAHDCRLGNHLLFANSASLAGHVDVGDHATLGGFALVHQFCR
IGPYAFCGFGSGINRDVPPFVTVSGQMAVPHGINSVGLRRHGFSRERIRDIKRAYRTIYRQGLRLDDAREALCQQLSHSA
DVQGMVDFIDNSQRGLLR

Sequences:

>Translated_258_residues
MTRIHPNALVDPKARLGEEVEVGPFSVIGPDVEIDEGTWIGPHAVIQGPTRIGRDNRIYQFAALGEAPQHKGYQGEPTEL
VIGDGNTIREFVTCHRGTAQGRGETRIGDHNWLMAYCHIAHDCRLGNHLLFANSASLAGHVDVGDHATLGGFALVHQFCR
IGPYAFCGFGSGINRDVPPFVTVSGQMAVPHGINSVGLRRHGFSRERIRDIKRAYRTIYRQGLRLDDAREALCQQLSHSA
DVQGMVDFIDNSQRGLLR
>Mature_257_residues
TRIHPNALVDPKARLGEEVEVGPFSVIGPDVEIDEGTWIGPHAVIQGPTRIGRDNRIYQFAALGEAPQHKGYQGEPTELV
IGDGNTIREFVTCHRGTAQGRGETRIGDHNWLMAYCHIAHDCRLGNHLLFANSASLAGHVDVGDHATLGGFALVHQFCRI
GPYAFCGFGSGINRDVPPFVTVSGQMAVPHGINSVGLRRHGFSRERIRDIKRAYRTIYRQGLRLDDAREALCQQLSHSAD
VQGMVDFIDNSQRGLLR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=255, Percent_Identity=49.8039215686275, Blast_Score=261, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_HALHL (A1WX11)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003025.1
- ProteinModelPortal:   A1WX11
- SMR:   A1WX11
- STRING:   A1WX11
- GeneID:   4709179
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1456
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   GHTSIGE
- PhylomeDB:   A1WX11
- ProtClustDB:   PRK05289
- BioCyc:   HHAL349124:HHAL_1456-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28394; Mature: 28263

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIHPNALVDPKARLGEEVEVGPFSVIGPDVEIDEGTWIGPHAVIQGPTRIGRDNRIYQ
CCCCCCCCCCCCHHHCCCCCCCCCEEEECCCEEECCCCEECCHHEEECCHHCCCCCCEEE
FAALGEAPQHKGYQGEPTELVIGDGNTIREFVTCHRGTAQGRGETRIGDHNWLMAYCHIA
EEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEHEEHHH
HDCRLGNHLLFANSASLAGHVDVGDHATLGGFALVHQFCRIGPYAFCGFGSGINRDVPPF
HHCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCE
VTVSGQMAVPHGINSVGLRRHGFSRERIRDIKRAYRTIYRQGLRLDDAREALCQQLSHSA
EEECCCEECCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
DVQGMVDFIDNSQRGLLR
CHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TRIHPNALVDPKARLGEEVEVGPFSVIGPDVEIDEGTWIGPHAVIQGPTRIGRDNRIYQ
CCCCCCCCCCCHHHCCCCCCCCCEEEECCCEEECCCCEECCHHEEECCHHCCCCCCEEE
FAALGEAPQHKGYQGEPTELVIGDGNTIREFVTCHRGTAQGRGETRIGDHNWLMAYCHIA
EEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEHEEHHH
HDCRLGNHLLFANSASLAGHVDVGDHATLGGFALVHQFCRIGPYAFCGFGSGINRDVPPF
HHCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCE
VTVSGQMAVPHGINSVGLRRHGFSRERIRDIKRAYRTIYRQGLRLDDAREALCQQLSHSA
EEECCCEECCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
DVQGMVDFIDNSQRGLLR
CHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA