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The map label for this gene is lpxB

Identifier: 121998237

GI number: 121998237

Start: 1569993

End: 1571132

Strand: Reverse

Name: lpxB

Synonym: Hhal_1455

Alternate gene names: 121998237

Gene position: 1571132-1569993 (Counterclockwise)

Preceding gene: 121998238

Following gene: 121998236

Centisome position: 58.66

GC content: 70.79

Gene sequence:

>1140_bases
ATGGCCAGTCCCAGGGTGGCGATCCTCGCCGGTGAGCTCTCCGGCGATGTCCTCGGCGCCGGGCTGATGCGCGAGCTCCG
TCGCCGGTCGCCCGGTGTGCAGTTCGAGGGCATCGGCGGGCCGGCCATGGCAGCCGAGGGGCTCGAGTCCCTGGTCCCCA
TGGAGCGGCTCTCGCTGATGGGCGTGACCGAGATCGTCCGGCATCTGCCGGGGCTGCTGCGGCTGCGTGCCGATCTCGCC
AGGCGGTGGCGCGAGGCCCCGCCGGACTGCTTCATCGGCGTCGATCTGCCCGACTTCAATCTGGGTCTGGAGCGGCGCTT
GCGCGCCGCCGGCATCCCCACCGTCCACTACGTCAGCCCAACGATCTGGGCCTGGCGTCCCGGGCGGGTCAAGGGGGTCC
GGCAGTCGGTGGACCGGATGCTGACCCTTTACCCCTTCGAGGAGAAGTTCTACGCCGAAAGCGGCGTGGATGCCGTGTGT
GTCGGCCATCCGGCCGCCGACCGCTACCCGATGCAGCCCGATACCGGGGCAGCGCGCCGGACGCTGGGCCTGGCCGAGGA
CGCCACGGTGGTGGCGTTGCTCCCCGGCAGCCGGAGCAGCGAGATCGATCGCCTGCTGGAGCCCTTCCTGGGCGCCGCGG
CGCTGCTGGCGCAACGGCCGGATGCGCCGGATTTCGTCATCCCCGTCGCTGCACCGCGGTTGCGCGAGCGGATCGAGGCA
GCGGTGGCCCGTCACGATATCCGCCTGCGGACCCGTCTACTCGAAGGCGATACAGCCACGGCGGTCACGGCGGCGGATGT
GGCATTGACCGCCTCGGGGACGGCAACCCTGGAGGTCATGCTGGCCAAACGGCCCATGGTGGTGGCCTATCGTCTGTCGC
CGCTGAGCTACCAGATCATTCGCCGCCTGATCCGCGTGCCCTGGGTGTCGCAGCCCAATCTGCTGGCGGGCGAACCGCTG
GTGCCGGAGTACTTCCAGTCTGACGTCGATCCGCAGATCCTTGCTGAGGCAGCGGCGTACTGGCTCGACGACGCCCCCGC
CCGCCTGCAGCTGGTGGGCCGTTTTCGCCACCTCCACGAGACGCTGGCCCGGGGCGCCGATGCGCGGGCGGCGGAGGCGG
TTCTCGAGGTGCTGCAGTGA

Upstream 100 bases:

>100_bases
TCACTCCGCGGACGTGCAGGGCATGGTCGATTTCATCGACAACAGTCAGCGCGGCCTGTTGCGCTGAGGCCACCATCCGC
CGGCGTAGGGGGGTCTGATC

Downstream 100 bases:

>100_bases
CCCCCTCGCGCGGTGCATGGGGGGTGGTGGGCGTTGACGAGGCCGGACGCGGACCCTGGGCAGGGCCGGTGGTTGCCGCG
GCGGTGGTCCTGGCGGAACC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MASPRVAILAGELSGDVLGAGLMRELRRRSPGVQFEGIGGPAMAAEGLESLVPMERLSLMGVTEIVRHLPGLLRLRADLA
RRWREAPPDCFIGVDLPDFNLGLERRLRAAGIPTVHYVSPTIWAWRPGRVKGVRQSVDRMLTLYPFEEKFYAESGVDAVC
VGHPAADRYPMQPDTGAARRTLGLAEDATVVALLPGSRSSEIDRLLEPFLGAAALLAQRPDAPDFVIPVAAPRLRERIEA
AVARHDIRLRTRLLEGDTATAVTAADVALTASGTATLEVMLAKRPMVVAYRLSPLSYQIIRRLIRVPWVSQPNLLAGEPL
VPEYFQSDVDPQILAEAAAYWLDDAPARLQLVGRFRHLHETLARGADARAAEAVLEVLQ

Sequences:

>Translated_379_residues
MASPRVAILAGELSGDVLGAGLMRELRRRSPGVQFEGIGGPAMAAEGLESLVPMERLSLMGVTEIVRHLPGLLRLRADLA
RRWREAPPDCFIGVDLPDFNLGLERRLRAAGIPTVHYVSPTIWAWRPGRVKGVRQSVDRMLTLYPFEEKFYAESGVDAVC
VGHPAADRYPMQPDTGAARRTLGLAEDATVVALLPGSRSSEIDRLLEPFLGAAALLAQRPDAPDFVIPVAAPRLRERIEA
AVARHDIRLRTRLLEGDTATAVTAADVALTASGTATLEVMLAKRPMVVAYRLSPLSYQIIRRLIRVPWVSQPNLLAGEPL
VPEYFQSDVDPQILAEAAAYWLDDAPARLQLVGRFRHLHETLARGADARAAEAVLEVLQ
>Mature_378_residues
ASPRVAILAGELSGDVLGAGLMRELRRRSPGVQFEGIGGPAMAAEGLESLVPMERLSLMGVTEIVRHLPGLLRLRADLAR
RWREAPPDCFIGVDLPDFNLGLERRLRAAGIPTVHYVSPTIWAWRPGRVKGVRQSVDRMLTLYPFEEKFYAESGVDAVCV
GHPAADRYPMQPDTGAARRTLGLAEDATVVALLPGSRSSEIDRLLEPFLGAAALLAQRPDAPDFVIPVAAPRLRERIEAA
VARHDIRLRTRLLEGDTATAVTAADVALTASGTATLEVMLAKRPMVVAYRLSPLSYQIIRRLIRVPWVSQPNLLAGEPLV
PEYFQSDVDPQILAEAAAYWLDDAPARLQLVGRFRHLHETLARGADARAAEAVLEVLQ

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=374, Percent_Identity=44.9197860962567, Blast_Score=315, Evalue=2e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41407; Mature: 41276

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPRVAILAGELSGDVLGAGLMRELRRRSPGVQFEGIGGPAMAAEGLESLVPMERLSLM
CCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHH
GVTEIVRHLPGLLRLRADLARRWREAPPDCFIGVDLPDFNLGLERRLRAAGIPTVHYVSP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCCEEEECCC
TIWAWRPGRVKGVRQSVDRMLTLYPFEEKFYAESGVDAVCVGHPAADRYPMQPDTGAARR
CEEECCCCCHHHHHHHHHHHEEECCCHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHH
TLGLAEDATVVALLPGSRSSEIDRLLEPFLGAAALLAQRPDAPDFVIPVAAPRLRERIEA
HCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHH
AVARHDIRLRTRLLEGDTATAVTAADVALTASGTATLEVMLAKRPMVVAYRLSPLSYQII
HHHHHHHHHHHHHHCCCCCCEEEEHHEEEECCCCCEEEEEECCCCEEEEEEECCCHHHHH
RRLIRVPWVSQPNLLAGEPLVPEYFQSDVDPQILAEAAAYWLDDAPARLQLVGRFRHLHE
HHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TLARGADARAAEAVLEVLQ
HHHCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
ASPRVAILAGELSGDVLGAGLMRELRRRSPGVQFEGIGGPAMAAEGLESLVPMERLSLM
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHH
GVTEIVRHLPGLLRLRADLARRWREAPPDCFIGVDLPDFNLGLERRLRAAGIPTVHYVSP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHCCCCEEEECCC
TIWAWRPGRVKGVRQSVDRMLTLYPFEEKFYAESGVDAVCVGHPAADRYPMQPDTGAARR
CEEECCCCCHHHHHHHHHHHEEECCCHHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHH
TLGLAEDATVVALLPGSRSSEIDRLLEPFLGAAALLAQRPDAPDFVIPVAAPRLRERIEA
HCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHH
AVARHDIRLRTRLLEGDTATAVTAADVALTASGTATLEVMLAKRPMVVAYRLSPLSYQII
HHHHHHHHHHHHHHCCCCCCEEEEHHEEEECCCCCEEEEEECCCCEEEEEEECCCHHHHH
RRLIRVPWVSQPNLLAGEPLVPEYFQSDVDPQILAEAAAYWLDDAPARLQLVGRFRHLHE
HHHHHCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
TLARGADARAAEAVLEVLQ
HHHCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA