Click here to switch to the map view.

The map label for this gene is mtnP [H]

Identifier: 121998049

GI number: 121998049

Start: 1367593

End: 1368324

Strand: Reverse

Name: mtnP [H]

Synonym: Hhal_1259

Alternate gene names: 121998049

Gene position: 1368324-1367593 (Counterclockwise)

Preceding gene: 121998050

Following gene: 121998043

Centisome position: 51.09

GC content: 66.39

Gene sequence:

>732_bases
ATGAGTGTCGGCATTATCGGCGGGACGGGGCTGACGTCCCTGGAAGGGCTGGAAATTACCCGCCGCGAGGTGGTCCGGAC
CCCGTTCGGCGAGCCTTCGGCCCCCCTGATTCACGGTACGTTCCGGGGCCACAATATCACCTTCCTGGCCCGCCACGGTC
ATAGTCACAACATTCCTCCGCATCAGGTCAATTACCGGGCCAACATCTGGGCCCTGCGTCATGTCGGGGTCGATCGTGTG
ATCGCCGTGGCTGCCGTCGGCGGCCTCGGGGAGGCCTACGCGCCGCGCCGGATCGCCATCCCGGACCAGATCATCGATTA
CACCCACTCGCGCATCTCGACGTTCCACGATCAGGATCTGGAGCACGTCACCCACATCGACTTTACCTATCCCTACGACG
CCACGGTGCGGGAGTGGCTGCTCTGTGCTGCCCGCGACGCCGGTATCGACGCGGTGGACGGGGGGACCTACGGCGCGACC
CAGGGCCCGCGCCTGGAGACCGCTGCGGAGATTCGCCGGATGCGGCAGGACGGCTGCGACCTGGTGGGGATGACCGGGAT
GCCGGAGGCAGCGTTGGCCCGCGAGGCCGAGTTGCGCTACGCCCACTGTGCCGTAGTGGCCAACTGGGCGGCTGGCATGG
GGGATGGCGAAGAACTCTCCATGGACGAGATCCGCGAGCACCTGATCCACGGCATGGAGGCGGTGCGGAAGATGATCGCC
TCACTGAGCTAG

Upstream 100 bases:

>100_bases
GTCGGGGCCTCGGCCGCAACGCGGACGGCATCTACGCCATCGATCAGCGCATCGAACAGGCGGCGAAAACCCAGCAAGAA
CCGGATACGGAGGAGCGTTG

Downstream 100 bases:

>100_bases
GCGGGGCGCCCAGCCCCGCTTCTCCCGGCGCCACCCGCCGACGCGGCCTCAGATCGGTGCCCCGAAACCGGGTGCACCTC
AGTCCTCCGGAGGGCGGTCG

Product: purine phosphorylase family 2

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSVGIIGGTGLTSLEGLEITRREVVRTPFGEPSAPLIHGTFRGHNITFLARHGHSHNIPPHQVNYRANIWALRHVGVDRV
IAVAAVGGLGEAYAPRRIAIPDQIIDYTHSRISTFHDQDLEHVTHIDFTYPYDATVREWLLCAARDAGIDAVDGGTYGAT
QGPRLETAAEIRRMRQDGCDLVGMTGMPEAALAREAELRYAHCAVVANWAAGMGDGEELSMDEIREHLIHGMEAVRKMIA
SLS

Sequences:

>Translated_243_residues
MSVGIIGGTGLTSLEGLEITRREVVRTPFGEPSAPLIHGTFRGHNITFLARHGHSHNIPPHQVNYRANIWALRHVGVDRV
IAVAAVGGLGEAYAPRRIAIPDQIIDYTHSRISTFHDQDLEHVTHIDFTYPYDATVREWLLCAARDAGIDAVDGGTYGAT
QGPRLETAAEIRRMRQDGCDLVGMTGMPEAALAREAELRYAHCAVVANWAAGMGDGEELSMDEIREHLIHGMEAVRKMIA
SLS
>Mature_242_residues
SVGIIGGTGLTSLEGLEITRREVVRTPFGEPSAPLIHGTFRGHNITFLARHGHSHNIPPHQVNYRANIWALRHVGVDRVI
AVAAVGGLGEAYAPRRIAIPDQIIDYTHSRISTFHDQDLEHVTHIDFTYPYDATVREWLLCAARDAGIDAVDGGTYGATQ
GPRLETAAEIRRMRQDGCDLVGMTGMPEAALAREAELRYAHCAVVANWAAGMGDGEELSMDEIREHLIHGMEAVRKMIAS
LS

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=244, Percent_Identity=36.8852459016393, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71980569, Length=212, Percent_Identity=38.6792452830189, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6323045, Length=247, Percent_Identity=32.3886639676113, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI20130079, Length=244, Percent_Identity=37.2950819672131, Blast_Score=161, Evalue=4e-40,
Organism=Drosophila melanogaster, GI221459247, Length=217, Percent_Identity=35.9447004608295, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 26578; Mature: 26447

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVGIIGGTGLTSLEGLEITRREVVRTPFGEPSAPLIHGTFRGHNITFLARHGHSHNIPP
CCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCC
HQVNYRANIWALRHVGVDRVIAVAAVGGLGEAYAPRRIAIPDQIIDYTHSRISTFHDQDL
CEECCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCH
EHVTHIDFTYPYDATVREWLLCAARDAGIDAVDGGTYGATQGPRLETAAEIRRMRQDGCD
HHHEEEEEECCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCC
LVGMTGMPEAALAREAELRYAHCAVVANWAAGMGDGEELSMDEIREHLIHGMEAVRKMIA
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SLS
HCC
>Mature Secondary Structure 
SVGIIGGTGLTSLEGLEITRREVVRTPFGEPSAPLIHGTFRGHNITFLARHGHSHNIPP
CEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCC
HQVNYRANIWALRHVGVDRVIAVAAVGGLGEAYAPRRIAIPDQIIDYTHSRISTFHDQDL
CEECCEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCH
EHVTHIDFTYPYDATVREWLLCAARDAGIDAVDGGTYGATQGPRLETAAEIRRMRQDGCD
HHHEEEEEECCCCHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCC
LVGMTGMPEAALAREAELRYAHCAVVANWAAGMGDGEELSMDEIREHLIHGMEAVRKMIA
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
SLS
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12533478 [H]