Click here to switch to the map view.

The map label for this gene is aceE

Identifier: 121997828

GI number: 121997828

Start: 1118262

End: 1120937

Strand: Reverse

Name: aceE

Synonym: Hhal_1037

Alternate gene names: 121997828

Gene position: 1120937-1118262 (Counterclockwise)

Preceding gene: 121997829

Following gene: 121997827

Centisome position: 41.85

GC content: 67.38

Gene sequence:

>2676_bases
ATGCAATCGATACCCGAGTTGCGCGACGATCCGGATCCGGAGGAGATCCAGGAGTGGCTCGACGCCCTGGATGCGGTGAT
CGAACACGAGGGCCCCGAGCGGGCACAGCAGATCCTGGAGCACCTGGTCAGCAAGGGCCGCCGACGCTTGGGGCACCTAC
CATTCAAGGCCACGACCGGCTACATCAACACCATCCCCCGCCACCTGGAGGTCCGTCCGCCGGAGTACACCGATCACCAC
CTGGAGTGGCGCATCCGGGCGCTGGTGCGCTGGAACGCCATCGCCATGGTGGTCGCCGCTAACCGTGAGCACGACGGCAT
CGGTGGGCACATCGCCAGCTACGCCTCGGCCTGCACGCTCTACGAGGTCGGCTTCAACCACTTCTGGCGGGCCCCCAACG
AGGAGCAGGACGGCGATCTGGTCTTCTTCCAGGGCCACTCGGCACCGGGCATCTACGCCCGCGCCTACCTCGAAGGCCGG
CTCAGCGCCGAGCAACTGGCGGGCTTCCGCCAGGATGTCGACGGCGACGGTGTCAGCTCCTACCCGCACCCGTGGCTGAT
GCCCGACTTCTGGCAGTTCCCCACCGTCTCCATGGGCCTCGGCCCCATCCAGGCGGTGCAGCAGGCGCGCATGATGAAGT
ACCTCCACCACCGCGGGATTGAGGACACCAGCGGTCGGAAGGTCTGGTGCTTCATGGGTGATGGCGAGATGGACGAGCCG
GAGTCCATGGGCTCCATCGGCCTCGCCGCCCGCGAGCAGCTCGACAACCTGATCTTCGTGGTCAACTGCAACCTGCAGCG
TCTCGACGGTCCGGTACGTGGCAACGGCAAGATCATCCAGGAACTCGAGGGCGAGTTCCGCGGCGCCGGCTGGAACGTCA
TCAAGGTGATCTGGGGCTCGCGCTGGGACCCACTGCTGGAGCTCGACCACGAGGGGCTCCTGCAGCAGCGCATGGAGGAG
GCCGTCGACGGCGAGTACCAGGCCTTCAAGGCGCGCGGCGGCGATTACACGCGCAAGCACTTCTTCGCCAAGGATCCAGA
GCTGGAGAAGATGGTCGCCGGCATGTCGGACTACGACATCTACCGGCTCAACCGCGGTGGCCACGACCCGCACAAGGTCT
ACGCCGCCTACCACGCCGCGGTGAACCACACCGGGCAGCCCACCGTGATCCTGGCCAAGACGGTCAAGGGCTACGGCATG
GGCGAGGCCGGCGAGGGGCAGAACATCACCCACCAGCAGAAGAAGATGGGCGAGAACGCCCTGCGCCGGTTCCGGGATCA
CTACGAGATCCCCATCCCCGACGAGCAGCTCAAGGAGACGCCCTTCTACAAGCCCGACGACGACGCCCCGGAGATGCGCT
ATCTCCACGAGCGTCGCCAGGCCCTGGGCGGCTATATGCCGGTGCGCTACGAACGGGCCCCGGCGCTCGAGGTGCCGGAG
CTCTCCGCCTTCGACGCCCTGCTCAAAGACAGCGGCGAGCGGGAACTCTCCACCACCATGGCCTTCGTGCGCGCCCTGAC
GGTACTCACCCGCGACAAACAGGTCGGCCAGCGGGTGGTGCCCATCATCCCCGACGAGGCGCGCACCTTCGGCATGGAGG
GGCTGTTCCGTCAGCTCGGCATCTACTCCAACGTCGGCCAGCTCTACGAGCCCGAAGACGCCGACCAGCTGATGTCCTAC
CGCGAGGCGCAGACCGGGCAGATCCTCGAGGAAGGCCTCGACGAGGCCGGGGCCATGTCCTCGTGGATGGCCGCGGCCAC
GTCCTACGCCAACCACGGCGTCAACATGATCCCCTTCTACATCTTCTACTCCATGTTCGGCTTCCAGCGCGTGGGGGATC
TGTGCTGGGCGGCTGGGGATATCCAGGCCCGCGGCTTCCTCATCGGCGGCACCGCTGGCAGGACCACCCTCAACGGCGAG
GGGCTGCAGCACCAGGACGGCCACAGCCACGTCCTCGCCTCGACCATCCCCAACTGCGTCTCCTACGACCCGGCCTTCGA
CTACGAGCTGGCGGTGATCGTCCAAGACGGGCTGCGGCGGATGTACGCCGAGCAGGAGAACTGCTTCTACTACCTGACCG
TCTACAACGAGAACCACACCCACCCGGCGATGCCGGAGGGGGCCGAGGAGGGGATCCGCCGCGGCATGTACCTCTTCCGG
GCCGGGCCCGAGAAGAAGGGGCCGCGGGTGCAGCTGATGGGCTCGGGCAGCATCTTCCGCGAGGTGTTGGCGGCGGCGGA
TCTGCTCGCCAACGACTTCGGCGTCCACGCCGACATCTGGAGCTGCCCCTCGTTCACCGAGTTGGCCCGCGACGGGATGG
TCTGCGCCCGGGCCAATCGGCTCCACCCGGAGGCGGAGCGCCGCCAGTCCTACCTGCAGGCGTGCCTGGAGAGGTACAGC
GGTCCGGCGGTCGCCGCCACGGACTACATGCGCGCCTACCCCGATCAGATCCGCCCCTACATCGGGCGCAAGTTCTGGTC
CCTGGGGACCGACGGTTTTGGCCGCTCGGATACCCGGGAGAAGCTCCGGCGCTTCTTTGAGGTGGACCGCCACCACATCG
CCGCAGCGGCCCTCTACGCCCTCGCCGATGAGGGCACCATCGAGGCCGCGAAGGTCAGCGAGGCCATCGGCAAGTACCAG
CTGGCGGCGGATGCCCCGAACCCGTGGGAGGTGTGA

Upstream 100 bases:

>100_bases
CGGGGAATGCCCGGGGGCCCACAAGGCCGCCGGGTGCGGCCTGGCCACCCGCCGTGTCGCGCCCCGTGGGCCCCGGCGAC
TCTTAACCAGGAGGTAGACC

Downstream 100 bases:

>100_bases
CCGTGGCGGAACAGGAGCTCAAGGTACCGGATATCGGCGGCTTCGAGGAGGTGGAGGTCATCGAGGTCCTGGTTGCGCCC
GGCGACCGGATCGAGGCCGA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 891; Mature: 891

Protein sequence:

>891_residues
MQSIPELRDDPDPEEIQEWLDALDAVIEHEGPERAQQILEHLVSKGRRRLGHLPFKATTGYINTIPRHLEVRPPEYTDHH
LEWRIRALVRWNAIAMVVAANREHDGIGGHIASYASACTLYEVGFNHFWRAPNEEQDGDLVFFQGHSAPGIYARAYLEGR
LSAEQLAGFRQDVDGDGVSSYPHPWLMPDFWQFPTVSMGLGPIQAVQQARMMKYLHHRGIEDTSGRKVWCFMGDGEMDEP
ESMGSIGLAAREQLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWNVIKVIWGSRWDPLLELDHEGLLQQRMEE
AVDGEYQAFKARGGDYTRKHFFAKDPELEKMVAGMSDYDIYRLNRGGHDPHKVYAAYHAAVNHTGQPTVILAKTVKGYGM
GEAGEGQNITHQQKKMGENALRRFRDHYEIPIPDEQLKETPFYKPDDDAPEMRYLHERRQALGGYMPVRYERAPALEVPE
LSAFDALLKDSGERELSTTMAFVRALTVLTRDKQVGQRVVPIIPDEARTFGMEGLFRQLGIYSNVGQLYEPEDADQLMSY
REAQTGQILEEGLDEAGAMSSWMAAATSYANHGVNMIPFYIFYSMFGFQRVGDLCWAAGDIQARGFLIGGTAGRTTLNGE
GLQHQDGHSHVLASTIPNCVSYDPAFDYELAVIVQDGLRRMYAEQENCFYYLTVYNENHTHPAMPEGAEEGIRRGMYLFR
AGPEKKGPRVQLMGSGSIFREVLAAADLLANDFGVHADIWSCPSFTELARDGMVCARANRLHPEAERRQSYLQACLERYS
GPAVAATDYMRAYPDQIRPYIGRKFWSLGTDGFGRSDTREKLRRFFEVDRHHIAAAALYALADEGTIEAAKVSEAIGKYQ
LAADAPNPWEV

Sequences:

>Translated_891_residues
MQSIPELRDDPDPEEIQEWLDALDAVIEHEGPERAQQILEHLVSKGRRRLGHLPFKATTGYINTIPRHLEVRPPEYTDHH
LEWRIRALVRWNAIAMVVAANREHDGIGGHIASYASACTLYEVGFNHFWRAPNEEQDGDLVFFQGHSAPGIYARAYLEGR
LSAEQLAGFRQDVDGDGVSSYPHPWLMPDFWQFPTVSMGLGPIQAVQQARMMKYLHHRGIEDTSGRKVWCFMGDGEMDEP
ESMGSIGLAAREQLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWNVIKVIWGSRWDPLLELDHEGLLQQRMEE
AVDGEYQAFKARGGDYTRKHFFAKDPELEKMVAGMSDYDIYRLNRGGHDPHKVYAAYHAAVNHTGQPTVILAKTVKGYGM
GEAGEGQNITHQQKKMGENALRRFRDHYEIPIPDEQLKETPFYKPDDDAPEMRYLHERRQALGGYMPVRYERAPALEVPE
LSAFDALLKDSGERELSTTMAFVRALTVLTRDKQVGQRVVPIIPDEARTFGMEGLFRQLGIYSNVGQLYEPEDADQLMSY
REAQTGQILEEGLDEAGAMSSWMAAATSYANHGVNMIPFYIFYSMFGFQRVGDLCWAAGDIQARGFLIGGTAGRTTLNGE
GLQHQDGHSHVLASTIPNCVSYDPAFDYELAVIVQDGLRRMYAEQENCFYYLTVYNENHTHPAMPEGAEEGIRRGMYLFR
AGPEKKGPRVQLMGSGSIFREVLAAADLLANDFGVHADIWSCPSFTELARDGMVCARANRLHPEAERRQSYLQACLERYS
GPAVAATDYMRAYPDQIRPYIGRKFWSLGTDGFGRSDTREKLRRFFEVDRHHIAAAALYALADEGTIEAAKVSEAIGKYQ
LAADAPNPWEV
>Mature_891_residues
MQSIPELRDDPDPEEIQEWLDALDAVIEHEGPERAQQILEHLVSKGRRRLGHLPFKATTGYINTIPRHLEVRPPEYTDHH
LEWRIRALVRWNAIAMVVAANREHDGIGGHIASYASACTLYEVGFNHFWRAPNEEQDGDLVFFQGHSAPGIYARAYLEGR
LSAEQLAGFRQDVDGDGVSSYPHPWLMPDFWQFPTVSMGLGPIQAVQQARMMKYLHHRGIEDTSGRKVWCFMGDGEMDEP
ESMGSIGLAAREQLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWNVIKVIWGSRWDPLLELDHEGLLQQRMEE
AVDGEYQAFKARGGDYTRKHFFAKDPELEKMVAGMSDYDIYRLNRGGHDPHKVYAAYHAAVNHTGQPTVILAKTVKGYGM
GEAGEGQNITHQQKKMGENALRRFRDHYEIPIPDEQLKETPFYKPDDDAPEMRYLHERRQALGGYMPVRYERAPALEVPE
LSAFDALLKDSGERELSTTMAFVRALTVLTRDKQVGQRVVPIIPDEARTFGMEGLFRQLGIYSNVGQLYEPEDADQLMSY
REAQTGQILEEGLDEAGAMSSWMAAATSYANHGVNMIPFYIFYSMFGFQRVGDLCWAAGDIQARGFLIGGTAGRTTLNGE
GLQHQDGHSHVLASTIPNCVSYDPAFDYELAVIVQDGLRRMYAEQENCFYYLTVYNENHTHPAMPEGAEEGIRRGMYLFR
AGPEKKGPRVQLMGSGSIFREVLAAADLLANDFGVHADIWSCPSFTELARDGMVCARANRLHPEAERRQSYLQACLERYS
GPAVAATDYMRAYPDQIRPYIGRKFWSLGTDGFGRSDTREKLRRFFEVDRHHIAAAALYALADEGTIEAAKVSEAIGKYQ
LAADAPNPWEV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=886, Percent_Identity=57.2234762979684, Blast_Score=1034, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 100427; Mature: 100427

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSIPELRDDPDPEEIQEWLDALDAVIEHEGPERAQQILEHLVSKGRRRLGHLPFKATTG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
YINTIPRHLEVRPPEYTDHHLEWRIRALVRWNAIAMVVAANREHDGIGGHIASYASACTL
HHHCCCCCEECCCCCCCCCHHHHHHHHHHHHCEEEEEEEECCCCCCCCHHHHHHHHHHHH
YEVGFNHFWRAPNEEQDGDLVFFQGHSAPGIYARAYLEGRLSAEQLAGFRQDVDGDGVSS
HHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
YPHPWLMPDFWQFPTVSMGLGPIQAVQQARMMKYLHHRGIEDTSGRKVWCFMGDGEMDEP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
ESMGSIGLAAREQLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWNVIKVIWGS
HHHCCHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECC
RWDPLLELDHEGLLQQRMEEAVDGEYQAFKARGGDYTRKHFFAKDPELEKMVAGMSDYDI
CCCHHHHCCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHCCCCCCCHHHHHCCCCCCCE
YRLNRGGHDPHKVYAAYHAAVNHTGQPTVILAKTVKGYGMGEAGEGQNITHQQKKMGENA
EEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LRRFRDHYEIPIPDEQLKETPFYKPDDDAPEMRYLHERRQALGGYMPVRYERAPALEVPE
HHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
LSAFDALLKDSGERELSTTMAFVRALTVLTRDKQVGQRVVPIIPDEARTFGMEGLFRQLG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IYSNVGQLYEPEDADQLMSYREAQTGQILEEGLDEAGAMSSWMAAATSYANHGVNMIPFY
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IFYSMFGFQRVGDLCWAAGDIQARGFLIGGTAGRTTLNGEGLQHQDGHSHVLASTIPNCV
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEECCCCCCCCCCCCEEHHHHCCHHH
SYDPAFDYELAVIVQDGLRRMYAEQENCFYYLTVYNENHTHPAMPEGAEEGIRRGMYLFR
CCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCEEEEE
AGPEKKGPRVQLMGSGSIFREVLAAADLLANDFGVHADIWSCPSFTELARDGMVCARANR
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEECCCC
LHPEAERRQSYLQACLERYSGPAVAATDYMRAYPDQIRPYIGRKFWSLGTDGFGRSDTRE
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCHHHH
KLRRFFEVDRHHIAAAALYALADEGTIEAAKVSEAIGKYQLAADAPNPWEV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEECCCCCCCCC
>Mature Secondary Structure
MQSIPELRDDPDPEEIQEWLDALDAVIEHEGPERAQQILEHLVSKGRRRLGHLPFKATTG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
YINTIPRHLEVRPPEYTDHHLEWRIRALVRWNAIAMVVAANREHDGIGGHIASYASACTL
HHHCCCCCEECCCCCCCCCHHHHHHHHHHHHCEEEEEEEECCCCCCCCHHHHHHHHHHHH
YEVGFNHFWRAPNEEQDGDLVFFQGHSAPGIYARAYLEGRLSAEQLAGFRQDVDGDGVSS
HHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
YPHPWLMPDFWQFPTVSMGLGPIQAVQQARMMKYLHHRGIEDTSGRKVWCFMGDGEMDEP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCC
ESMGSIGLAAREQLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGEFRGAGWNVIKVIWGS
HHHCCHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECC
RWDPLLELDHEGLLQQRMEEAVDGEYQAFKARGGDYTRKHFFAKDPELEKMVAGMSDYDI
CCCHHHHCCHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHCCCCCCCHHHHHCCCCCCCE
YRLNRGGHDPHKVYAAYHAAVNHTGQPTVILAKTVKGYGMGEAGEGQNITHQQKKMGENA
EEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
LRRFRDHYEIPIPDEQLKETPFYKPDDDAPEMRYLHERRQALGGYMPVRYERAPALEVPE
HHHHHHCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
LSAFDALLKDSGERELSTTMAFVRALTVLTRDKQVGQRVVPIIPDEARTFGMEGLFRQLG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IYSNVGQLYEPEDADQLMSYREAQTGQILEEGLDEAGAMSSWMAAATSYANHGVNMIPFY
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
IFYSMFGFQRVGDLCWAAGDIQARGFLIGGTAGRTTLNGEGLQHQDGHSHVLASTIPNCV
HHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEECCCCCCCCCCCCEEHHHHCCHHH
SYDPAFDYELAVIVQDGLRRMYAEQENCFYYLTVYNENHTHPAMPEGAEEGIRRGMYLFR
CCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHCEEEEE
AGPEKKGPRVQLMGSGSIFREVLAAADLLANDFGVHADIWSCPSFTELARDGMVCARANR
CCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEECCCC
LHPEAERRQSYLQACLERYSGPAVAATDYMRAYPDQIRPYIGRKFWSLGTDGFGRSDTRE
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCHHHH
KLRRFFEVDRHHIAAAALYALADEGTIEAAKVSEAIGKYQLAADAPNPWEV
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8021225 [H]