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The map label for this gene is glyA

Identifier: 121997693

GI number: 121997693

Start: 977238

End: 978488

Strand: Reverse

Name: glyA

Synonym: Hhal_0902

Alternate gene names: 121997693

Gene position: 978488-977238 (Counterclockwise)

Preceding gene: 121997699

Following gene: 121997692

Centisome position: 36.53

GC content: 67.23

Gene sequence:

>1251_bases
ATGTTCTCCCGAGATATGACCATTGCGGGTTACGACCCGGAGCTGGCAGCCGCCATCGAGGACGAGCGCCAGCGCCAGGA
GGATCACATCGAGCTGATCGCCTCCGAGAACTACGCCAGTCCCCGCGTGATGGAAGCGCAGGGCAGCGTGCTGACCAACA
AGTACGCCGAAGGGTACCCGGGCAAGCGCTACTACGGCGGCTGTGAGCACGTCGACGTAGCCGAGCAGCTGGCCATCGAC
CGCGCCAAGCAGCTCTTCGGCGCCGACTACGCCAACGTCCAGCCCCACTCGGGCTCCCAGGCCAACGCCGCCGTCTTCCA
CGCCCTGCTCAAGCCCGGCGACACCATCCTGGGCATGAGCCTCGACCACGGCGGCCACCTGACCCACGGCGCCAAGGTCA
ACTTCTCCGGCAAGCTGTTCAACGCCGTGCAGTACGGCATCAACGACGACGGCCAGATCGACTACGACGAGATCCAGCGC
CTGGCCACCGAACACCAGCCGAAGATGGTCATCGGCGGCTTCTCCGCCTACTCCCAAGTGGTCGATTGGGCGCGCCTGCG
CCAGATCGCCGACTCGGTGGGCGCCTACCTGGTCGTCGATATGGCCCACATCGCCGGCCTGGTGGCCGCCGGGGTCTACC
CCAGCCCGATCCCCCACGCCGACGCGGTGACCTCCACCACCCACAAGACCCTGCGCGGCCCGCGCGGCGGCATCATCCTG
GCCCGCTCCAACCCGGACCTGGAGAAGAAATTCCAGTCGCTGGTCTTCCCGGGGACCCAGGGCGGCCCGCTGATGCACGC
CATCGCCGGCAAGGCCGTGGCCTTCAAGGAGGCCCTCGAGCCCGACTTCAAGCAGTACCAGGAGCAGGTGGTGGCCAACG
CCCGCGCCATGGCCCGGCGCGTCATCGAGCGCGGCTACAACGTCGTCTCCGGCGGTACCGACAACCACCTCTTCCTGATG
GATCTGACCCCCAAGAACCTCACCGGCAAGGATGCGGACGCCGCGCTGGGGCGGGCCAACATCACGGTCAACAAGAACAC
CGTGCCCAACGATCCGCAGTCGCCGTTCGTCACCAGCGGTCTGCGCATCGGCACGCCGGCGATCACCACCCGTGGTTTCA
AGGAGGCCGAGGCCACCCGCCTGGCTGACTGGATCTGTGACGTCCTCGACAACATGGGCGACGAGTCCGTCGTCGAGCGC
GTGCGCGGCGAGGTGGAGCAGATCTGTCGCGAATTCCCCGTCTACGGGTGA

Upstream 100 bases:

>100_bases
GATCCATAAGGCAGCGGGGCGGTGATTCGGAGTTCGGAGGAAGTTCGGTTATACTGGCGGATTGTGCAATGCCGGATCCC
AAGCCGAGCAAGGAGCCTCT

Downstream 100 bases:

>100_bases
CGCGGGACGCCTGATCGACCATGCGCTGCCCGTACTGCCAGAACGCTGACACCCGCGTGGTCGACTCGCGCCTGATCGGC
GAGGGCGAGCAAGTGCGGCG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MFSRDMTIAGYDPELAAAIEDERQRQEDHIELIASENYASPRVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVAEQLAID
RAKQLFGADYANVQPHSGSQANAAVFHALLKPGDTILGMSLDHGGHLTHGAKVNFSGKLFNAVQYGINDDGQIDYDEIQR
LATEHQPKMVIGGFSAYSQVVDWARLRQIADSVGAYLVVDMAHIAGLVAAGVYPSPIPHADAVTSTTHKTLRGPRGGIIL
ARSNPDLEKKFQSLVFPGTQGGPLMHAIAGKAVAFKEALEPDFKQYQEQVVANARAMARRVIERGYNVVSGGTDNHLFLM
DLTPKNLTGKDADAALGRANITVNKNTVPNDPQSPFVTSGLRIGTPAITTRGFKEAEATRLADWICDVLDNMGDESVVER
VRGEVEQICREFPVYG

Sequences:

>Translated_416_residues
MFSRDMTIAGYDPELAAAIEDERQRQEDHIELIASENYASPRVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVAEQLAID
RAKQLFGADYANVQPHSGSQANAAVFHALLKPGDTILGMSLDHGGHLTHGAKVNFSGKLFNAVQYGINDDGQIDYDEIQR
LATEHQPKMVIGGFSAYSQVVDWARLRQIADSVGAYLVVDMAHIAGLVAAGVYPSPIPHADAVTSTTHKTLRGPRGGIIL
ARSNPDLEKKFQSLVFPGTQGGPLMHAIAGKAVAFKEALEPDFKQYQEQVVANARAMARRVIERGYNVVSGGTDNHLFLM
DLTPKNLTGKDADAALGRANITVNKNTVPNDPQSPFVTSGLRIGTPAITTRGFKEAEATRLADWICDVLDNMGDESVVER
VRGEVEQICREFPVYG
>Mature_416_residues
MFSRDMTIAGYDPELAAAIEDERQRQEDHIELIASENYASPRVMEAQGSVLTNKYAEGYPGKRYYGGCEHVDVAEQLAID
RAKQLFGADYANVQPHSGSQANAAVFHALLKPGDTILGMSLDHGGHLTHGAKVNFSGKLFNAVQYGINDDGQIDYDEIQR
LATEHQPKMVIGGFSAYSQVVDWARLRQIADSVGAYLVVDMAHIAGLVAAGVYPSPIPHADAVTSTTHKTLRGPRGGIIL
ARSNPDLEKKFQSLVFPGTQGGPLMHAIAGKAVAFKEALEPDFKQYQEQVVANARAMARRVIERGYNVVSGGTDNHLFLM
DLTPKNLTGKDADAALGRANITVNKNTVPNDPQSPFVTSGLRIGTPAITTRGFKEAEATRLADWICDVLDNMGDESVVER
VRGEVEQICREFPVYG

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=455, Percent_Identity=45.7142857142857, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI261862350, Length=455, Percent_Identity=45.7142857142857, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI261862348, Length=455, Percent_Identity=45.7142857142857, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI19923315, Length=455, Percent_Identity=45.7142857142857, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI261862346, Length=454, Percent_Identity=44.9339207048458, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI22547186, Length=397, Percent_Identity=49.3702770780856, Blast_Score=341, Evalue=9e-94,
Organism=Homo sapiens, GI22547189, Length=384, Percent_Identity=46.875, Blast_Score=309, Evalue=3e-84,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=73.3173076923077, Blast_Score=637, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144732, Length=396, Percent_Identity=47.4747474747475, Blast_Score=356, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=396, Percent_Identity=47.4747474747475, Blast_Score=355, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=397, Percent_Identity=46.8513853904282, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=397, Percent_Identity=45.8438287153652, Blast_Score=343, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24640005, Length=454, Percent_Identity=44.9339207048458, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221329721, Length=454, Percent_Identity=44.9339207048458, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_HALHL (A1WVG6)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002480.1
- ProteinModelPortal:   A1WVG6
- SMR:   A1WVG6
- STRING:   A1WVG6
- GeneID:   4709320
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0902
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   LENEAMI
- PhylomeDB:   A1WVG6
- ProtClustDB:   PRK00011
- BioCyc:   HHAL349124:HHAL_0902-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45196; Mature: 45196

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSRDMTIAGYDPELAAAIEDERQRQEDHIELIASENYASPRVMEAQGSVLTNKYAEGYP
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCEHVDVAEQLAIDRAKQLFGADYANVQPHSGSQANAAVFHALLKPGDTILGMS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEE
LDHGGHLTHGAKVNFSGKLFNAVQYGINDDGQIDYDEIQRLATEHQPKMVIGGFSAYSQV
ECCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHH
VDWARLRQIADSVGAYLVVDMAHIAGLVAAGVYPSPIPHADAVTSTTHKTLRGPRGGIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEE
ARSNPDLEKKFQSLVFPGTQGGPLMHAIAGKAVAFKEALEPDFKQYQEQVVANARAMARR
ECCCCCHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VIERGYNVVSGGTDNHLFLMDLTPKNLTGKDADAALGRANITVNKNTVPNDPQSPFVTSG
HHHCCCEEECCCCCCEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHCC
LRIGTPAITTRGFKEAEATRLADWICDVLDNMGDESVVERVRGEVEQICREFPVYG
CEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFSRDMTIAGYDPELAAAIEDERQRQEDHIELIASENYASPRVMEAQGSVLTNKYAEGYP
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCEHVDVAEQLAIDRAKQLFGADYANVQPHSGSQANAAVFHALLKPGDTILGMS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEE
LDHGGHLTHGAKVNFSGKLFNAVQYGINDDGQIDYDEIQRLATEHQPKMVIGGFSAYSQV
ECCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHH
VDWARLRQIADSVGAYLVVDMAHIAGLVAAGVYPSPIPHADAVTSTTHKTLRGPRGGIIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEE
ARSNPDLEKKFQSLVFPGTQGGPLMHAIAGKAVAFKEALEPDFKQYQEQVVANARAMARR
ECCCCCHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
VIERGYNVVSGGTDNHLFLMDLTPKNLTGKDADAALGRANITVNKNTVPNDPQSPFVTSG
HHHCCCEEECCCCCCEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCHHHCC
LRIGTPAITTRGFKEAEATRLADWICDVLDNMGDESVVERVRGEVEQICREFPVYG
CEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA