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The map label for this gene is pyrC

Identifier: 121997527

GI number: 121997527

Start: 815172

End: 816209

Strand: Reverse

Name: pyrC

Synonym: Hhal_0730

Alternate gene names: 121997527

Gene position: 816209-815172 (Counterclockwise)

Preceding gene: 121997531

Following gene: 121997526

Centisome position: 30.47

GC content: 71.97

Gene sequence:

>1038_bases
ATGGATACCCTGACCCTGCCCCGGCCCGACGACTGGCACCTGCACCTGCGCGACGGTGCCCTCATGCAGGCCGTGGCCCC
CCAGGCCGCGGCGGTCTTCTCGCGGGCGATCATCATGCCCAACCTGCAGCCGCCGGTGACCACGGTGGAGCAGGCGGCGG
CCTACCGCCAGCGCATCCTCGGCGCGCTGCCGGCGGGCTCGACCTTCGAGCCGCTGATGACGCTCTACCTCACCGACAAG
ACCTCGCCCGAGGAGATCGTCCGTGCGGCGGCCAGCGGTTTCGTGCACGCCGTCAAGCTCTACCCGGCGGGGGCCACCAC
GCACTCGGATGCCGGCGTCACCGATCTGCTGCTCTGCTACGATGCCCTCGCCGCCATGGAGGAGCAGGGCCTGCCGCTGC
TGATCCACGGCGAGCGCACGGGCCCGGAGCTGGATATCTTCGAGCGCGAGACGGCCTTCATCGACGATGTGCTCCAGCCG
CTGCTCGACCGGCACCCGCGGCTGAAGGTGGTGCTCGAGCACGTCACCACCGCCGTCGGCGCCGAGCTGGTGACCGGCGA
CGACCCGCGTCTGGCCGGGACCTTCACACCGCAGCACCTGCTCTACAACCGCAACGATCTGCTCGTCGGCGGGCTCAAAC
CGCACTACTACTGCATGCCGATCCTCAAGCGCGAGGCCGACCGCGAGGCGCTGCTCGAGGCCGCCACCTCCGGCCACCCG
CGGGTCTTCCTGGGCACCGACTCCGCCCCGCACCCCCGGGGGGCCAAGGAGTCGGCGTGTGGCTGTGCCGGCTGCTATAC
GGCGCCCATCGCGCTATCGCTCTACGCCGAGGCCTTCGAGGCGGCCGGTGCGCTGGAGCGGCTGGCCGATTTCGCCGGGC
GCAACGGCCCGGCCTTCTACGGCCTGCCGGTCAACCCGGAGACGGTTACCCTGGAGCGGGCCCCGCTGGAGGTGCCGGCC
AGCTACCCCGGCGGCGATGAGCCGGTGGTGCCCCTGCGCGCCGGCGAGAGCCTGGCCTGGCGGTTGCACCAACCCTAG

Upstream 100 bases:

>100_bases
CGGCCCCATCGATCAGTTGCGCACTCTACCACAAGCCGACGCCCTGCAAAACCCCGGCCGCCCCTTGCAACTGGCCGGCA
GCGCTTGGAAACTCCTCTCC

Downstream 100 bases:

>100_bases
GGTGGGTGGGATGAGCGCGCCGGAGTGGCGTTTTACGATGCCCGCCAGGCGGTGGCCGGAAGCGGGCCCCGCCGCGGATC
TGCCGCAGAGGATGGAGACG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MDTLTLPRPDDWHLHLRDGALMQAVAPQAAAVFSRAIIMPNLQPPVTTVEQAAAYRQRILGALPAGSTFEPLMTLYLTDK
TSPEEIVRAAASGFVHAVKLYPAGATTHSDAGVTDLLLCYDALAAMEEQGLPLLIHGERTGPELDIFERETAFIDDVLQP
LLDRHPRLKVVLEHVTTAVGAELVTGDDPRLAGTFTPQHLLYNRNDLLVGGLKPHYYCMPILKREADREALLEAATSGHP
RVFLGTDSAPHPRGAKESACGCAGCYTAPIALSLYAEAFEAAGALERLADFAGRNGPAFYGLPVNPETVTLERAPLEVPA
SYPGGDEPVVPLRAGESLAWRLHQP

Sequences:

>Translated_345_residues
MDTLTLPRPDDWHLHLRDGALMQAVAPQAAAVFSRAIIMPNLQPPVTTVEQAAAYRQRILGALPAGSTFEPLMTLYLTDK
TSPEEIVRAAASGFVHAVKLYPAGATTHSDAGVTDLLLCYDALAAMEEQGLPLLIHGERTGPELDIFERETAFIDDVLQP
LLDRHPRLKVVLEHVTTAVGAELVTGDDPRLAGTFTPQHLLYNRNDLLVGGLKPHYYCMPILKREADREALLEAATSGHP
RVFLGTDSAPHPRGAKESACGCAGCYTAPIALSLYAEAFEAAGALERLADFAGRNGPAFYGLPVNPETVTLERAPLEVPA
SYPGGDEPVVPLRAGESLAWRLHQP
>Mature_345_residues
MDTLTLPRPDDWHLHLRDGALMQAVAPQAAAVFSRAIIMPNLQPPVTTVEQAAAYRQRILGALPAGSTFEPLMTLYLTDK
TSPEEIVRAAASGFVHAVKLYPAGATTHSDAGVTDLLLCYDALAAMEEQGLPLLIHGERTGPELDIFERETAFIDDVLQP
LLDRHPRLKVVLEHVTTAVGAELVTGDDPRLAGTFTPQHLLYNRNDLLVGGLKPHYYCMPILKREADREALLEAATSGHP
RVFLGTDSAPHPRGAKESACGCAGCYTAPIALSLYAEAFEAAGALERLADFAGRNGPAFYGLPVNPETVTLERAPLEVPA
SYPGGDEPVVPLRAGESLAWRLHQP

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1787301, Length=341, Percent_Identity=53.6656891495601, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=34.5505617977528, Blast_Score=188, Evalue=1e-48,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRC_HALHL (A1WV00)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002314.1
- ProteinModelPortal:   A1WV00
- SMR:   A1WV00
- STRING:   A1WV00
- GeneID:   4711119
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0730
- eggNOG:   COG0418
- HOGENOM:   HBG628648
- OMA:   KESACGC
- PhylomeDB:   A1WV00
- ProtClustDB:   PRK05451
- BioCyc:   HHAL349124:HHAL_0730-MONOMER
- HAMAP:   MF_00219
- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195
- PIRSF:   PIRSF001237
- TIGRFAMs:   TIGR00856

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.3

Molecular weight: Translated: 37159; Mature: 37159

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLTLPRPDDWHLHLRDGALMQAVAPQAAAVFSRAIIMPNLQPPVTTVEQAAAYRQRIL
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GALPAGSTFEPLMTLYLTDKTSPEEIVRAAASGFVHAVKLYPAGATTHSDAGVTDLLLCY
HCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHH
DALAAMEEQGLPLLIHGERTGPELDIFERETAFIDDVLQPLLDRHPRLKVVLEHVTTAVG
HHHHHHHHCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
AELVTGDDPRLAGTFTPQHLLYNRNDLLVGGLKPHYYCMPILKREADREALLEAATSGHP
CEEEECCCCCEEECCCHHHHEECCCCEEEECCCCCEEEHHHHHHCCHHHHHHHHHCCCCC
RVFLGTDSAPHPRGAKESACGCAGCYTAPIALSLYAEAFEAAGALERLADFAGRNGPAFY
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
GLPVNPETVTLERAPLEVPASYPGGDEPVVPLRAGESLAWRLHQP
ECCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEECCC
>Mature Secondary Structure
MDTLTLPRPDDWHLHLRDGALMQAVAPQAAAVFSRAIIMPNLQPPVTTVEQAAAYRQRIL
CCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GALPAGSTFEPLMTLYLTDKTSPEEIVRAAASGFVHAVKLYPAGATTHSDAGVTDLLLCY
HCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHH
DALAAMEEQGLPLLIHGERTGPELDIFERETAFIDDVLQPLLDRHPRLKVVLEHVTTAVG
HHHHHHHHCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
AELVTGDDPRLAGTFTPQHLLYNRNDLLVGGLKPHYYCMPILKREADREALLEAATSGHP
CEEEECCCCCEEECCCHHHHEECCCCEEEECCCCCEEEHHHHHHCCHHHHHHHHHCCCCC
RVFLGTDSAPHPRGAKESACGCAGCYTAPIALSLYAEAFEAAGALERLADFAGRNGPAFY
EEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
GLPVNPETVTLERAPLEVPASYPGGDEPVVPLRAGESLAWRLHQP
ECCCCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA