Click here to switch to the map view.

The map label for this gene is grxD [H]

Identifier: 121997526

GI number: 121997526

Start: 814734

End: 815069

Strand: Reverse

Name: grxD [H]

Synonym: Hhal_0729

Alternate gene names: 121997526

Gene position: 815069-814734 (Counterclockwise)

Preceding gene: 121997527

Following gene: 121997525

Centisome position: 30.43

GC content: 67.26

Gene sequence:

>336_bases
ATGAGCGACGAATCGGTTCAGCAGACCATTGCCCGCCAGGTGTCGGAGAACCCGATCCTGCTGTACATGAAGGGCAGCCC
GGAGCAGCCCATGTGCGGCTTCTCGCAGCGGGCGGCCCAGGCCCTGGCCGGCTGCGGGCGGGAGTTCGCCTACGTGGATG
TGCTCCAGGATGAGCGCATCCGTCAGGGGATCAAGGACTACGGCGACTGGCCGACCATCCCGCAGCTCTACATCGACGGC
GAGCTGGTCGGCGGCTGCGATATCATCATGGAGATGTTCGACTCCGGCGAGCTGCAGCAGCTGGTCGACGCCGCCGGGGC
GGGCGCCAGCGGCTGA

Upstream 100 bases:

>100_bases
TGGGTGGGATGAGCGCGCCGGAGTGGCGTTTTACGATGCCCGCCAGGCGGTGGCCGGAAGCGGGCCCCGCCGCGGATCTG
CCGCAGAGGATGGAGACGCA

Downstream 100 bases:

>100_bases
GGGCCGGGCGGCTTGCTCGCGCTCACGGGGCGCCGTAGCATGCGGCACCCGAATCCAGTTACGGCAGCCCCATGACCGAG
CAGAACCCCGCGCAGTCGTC

Product: glutaredoxin-like protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 111; Mature: 110

Protein sequence:

>111_residues
MSDESVQQTIARQVSENPILLYMKGSPEQPMCGFSQRAAQALAGCGREFAYVDVLQDERIRQGIKDYGDWPTIPQLYIDG
ELVGGCDIIMEMFDSGELQQLVDAAGAGASG

Sequences:

>Translated_111_residues
MSDESVQQTIARQVSENPILLYMKGSPEQPMCGFSQRAAQALAGCGREFAYVDVLQDERIRQGIKDYGDWPTIPQLYIDG
ELVGGCDIIMEMFDSGELQQLVDAAGAGASG
>Mature_110_residues
SDESVQQTIARQVSENPILLYMKGSPEQPMCGFSQRAAQALAGCGREFAYVDVLQDERIRQGIKDYGDWPTIPQLYIDGE
LVGGCDIIMEMFDSGELQQLVDAAGAGASG

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42516576, Length=86, Percent_Identity=51.1627906976744, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI95113651, Length=88, Percent_Identity=46.5909090909091, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787943, Length=100, Percent_Identity=62, Blast_Score=142, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17556042, Length=103, Percent_Identity=37.8640776699029, Blast_Score=94, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71988159, Length=108, Percent_Identity=36.1111111111111, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71988153, Length=108, Percent_Identity=36.1111111111111, Blast_Score=92, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325198, Length=105, Percent_Identity=43.8095238095238, Blast_Score=102, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321022, Length=86, Percent_Identity=45.3488372093023, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320303, Length=86, Percent_Identity=44.1860465116279, Blast_Score=94, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24642023, Length=98, Percent_Identity=47.9591836734694, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19921242, Length=96, Percent_Identity=37.5, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 12049; Mature: 11917

Theoretical pI: Translated: 3.87; Mature: 3.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDESVQQTIARQVSENPILLYMKGSPEQPMCGFSQRAAQALAGCGREFAYVDVLQDERI
CCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
RQGIKDYGDWPTIPQLYIDGELVGGCDIIMEMFDSGELQQLVDAAGAGASG
HHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDESVQQTIARQVSENPILLYMKGSPEQPMCGFSQRAAQALAGCGREFAYVDVLQDERI
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
RQGIKDYGDWPTIPQLYIDGELVGGCDIIMEMFDSGELQQLVDAAGAGASG
HHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]