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The map label for this gene is alr

Identifier: 121997449

GI number: 121997449

Start: 732390

End: 733484

Strand: Reverse

Name: alr

Synonym: Hhal_0652

Alternate gene names: 121997449

Gene position: 733484-732390 (Counterclockwise)

Preceding gene: 121997450

Following gene: 121997448

Centisome position: 27.38

GC content: 72.33

Gene sequence:

>1095_bases
GTGAGTCGGGCGGCGCGGGCCACGGTGAACCTCAGCGCGCTGCGTGCCAATCTCCGGACCGCCCGTGCGGCGGCCCCGCA
GCAGCGGATCATGGCGGTCATCAAGTCCGACGGCTACGGCCACGGCCTGGCCGTCGTGGCCGGGGCGTTGACCGGCCACG
CCGAGGCCTTCGCCGTCACCGACGCCGATGAGGCCGAAGCCCTCCGGGCCGCCGGGTTCCGGGAGCGGATCGTCTTGCTC
CAGGGACCGTTCGCGGTCGACGACCTGGCCCGGGCGGCAGCCGCGGATCTGGAACTGGTCATTCATGCCCACTGGCAGGT
GGAGGCGCTGGCACAGGCGCAGCTGGCCTCGCCGGTGACGGTCTGGCTGAAGGTCGATAGCGGCATGCACCGGCTCGGCT
TTCCGCCGGAGGAGGTTCAGGATGCCTGGCGTCGCCTCACGGAGGCCTCCTGCGTTCGGGCCGATATCGGCTTCCTGACC
CACCTGGCCTGCGCTGATGATCGCGACGATCCCGCCACCGAGCGCCAGCTGGAGACCTTCCAGGCGGCCTGTGACGGTTT
GCCGGGGCCGCGGTCGGCGGCCAACTCGGCCGGTGTGCTCGGTTGGCCGGCGAGCCATTACGACTGGGTGCGCCCAGGGA
TCATGCTCTACGGGGCCTCGCCCTTCGTGGACGGTCGCGACGAGCAGCCGGCGCTCCAGCCGGCCATGGCCTTCCAGGGG
CGAGTGGTGGCGGTGCGCCATCTGCGCGCCGGGGATCCGGTCGGCTACGGGGCGACCTGGTCGTGTCCGGAGGCGATGCC
GGTTGGGGTGGTGTCCATCGGCTACGGAGACGGGTACCCCCGCCACGCGCCGAGCGGCACGCCGGTGGAGGTGGCCGGCC
AGCGGACCCGGCTGGTCGGGCGGATCTCCATGGATATGTTGGCGGTGGATCTGCGTGGCCTCGATCCGGTGGCGGAGGGG
GACCCGGCCATCCTCTGGGGAGGAGCAGTGCGCGCCGAAGAGGTGGCGGGTGCCTGCGGGACCATCGCCTACGAGCTGTT
CTGTCGGATGCCGCCGCGGGTCCGGCGGGAGCCGGTGGACGGGGAGACGCTCTGA

Upstream 100 bases:

>100_bases
AGCGGCAGGGGCCGATCGGGACGGTCAAGCTCACCTTCCTGGGTGAATACACCCGGTTCGAGAACTACATCGAAGACGTC
TACGGCGGAGGGATCCCGGG

Downstream 100 bases:

>100_bases
TGGCCCGGGCCCGGCGACGGTTTGTCTGCTCGGCCTGTGGCGCAGAGCAACCGCAGTGGGCTGGGCAGTGCCCGGAGTGC
GGCGCCTGGAACACGCTGGA

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSRAARATVNLSALRANLRTARAAAPQQRIMAVIKSDGYGHGLAVVAGALTGHAEAFAVTDADEAEALRAAGFRERIVLL
QGPFAVDDLARAAAADLELVIHAHWQVEALAQAQLASPVTVWLKVDSGMHRLGFPPEEVQDAWRRLTEASCVRADIGFLT
HLACADDRDDPATERQLETFQAACDGLPGPRSAANSAGVLGWPASHYDWVRPGIMLYGASPFVDGRDEQPALQPAMAFQG
RVVAVRHLRAGDPVGYGATWSCPEAMPVGVVSIGYGDGYPRHAPSGTPVEVAGQRTRLVGRISMDMLAVDLRGLDPVAEG
DPAILWGGAVRAEEVAGACGTIAYELFCRMPPRVRREPVDGETL

Sequences:

>Translated_364_residues
MSRAARATVNLSALRANLRTARAAAPQQRIMAVIKSDGYGHGLAVVAGALTGHAEAFAVTDADEAEALRAAGFRERIVLL
QGPFAVDDLARAAAADLELVIHAHWQVEALAQAQLASPVTVWLKVDSGMHRLGFPPEEVQDAWRRLTEASCVRADIGFLT
HLACADDRDDPATERQLETFQAACDGLPGPRSAANSAGVLGWPASHYDWVRPGIMLYGASPFVDGRDEQPALQPAMAFQG
RVVAVRHLRAGDPVGYGATWSCPEAMPVGVVSIGYGDGYPRHAPSGTPVEVAGQRTRLVGRISMDMLAVDLRGLDPVAEG
DPAILWGGAVRAEEVAGACGTIAYELFCRMPPRVRREPVDGETL
>Mature_363_residues
SRAARATVNLSALRANLRTARAAAPQQRIMAVIKSDGYGHGLAVVAGALTGHAEAFAVTDADEAEALRAAGFRERIVLLQ
GPFAVDDLARAAAADLELVIHAHWQVEALAQAQLASPVTVWLKVDSGMHRLGFPPEEVQDAWRRLTEASCVRADIGFLTH
LACADDRDDPATERQLETFQAACDGLPGPRSAANSAGVLGWPASHYDWVRPGIMLYGASPFVDGRDEQPALQPAMAFQGR
VVAVRHLRAGDPVGYGATWSCPEAMPVGVVSIGYGDGYPRHAPSGTPVEVAGQRTRLVGRISMDMLAVDLRGLDPVAEGD
PAILWGGAVRAEEVAGACGTIAYELFCRMPPRVRREPVDGETL

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=359, Percent_Identity=45.4038997214485, Blast_Score=305, Evalue=3e-84,
Organism=Escherichia coli, GI1787439, Length=355, Percent_Identity=40.8450704225352, Blast_Score=273, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_HALHL (A1WUS2)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001002236.1
- ProteinModelPortal:   A1WUS2
- SMR:   A1WUS2
- STRING:   A1WUS2
- GeneID:   4709796
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_0652
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   WGKQVLA
- PhylomeDB:   A1WUS2
- ProtClustDB:   CLSK727178
- BioCyc:   HHAL349124:HHAL_0652-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 38709; Mature: 38578

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 35-35 ACT_SITE 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAARATVNLSALRANLRTARAAAPQQRIMAVIKSDGYGHGLAVVAGALTGHAEAFAVT
CCCCHHHEEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEC
DADEAEALRAAGFRERIVLLQGPFAVDDLARAAAADLELVIHAHWQVEALAQAQLASPVT
CCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCCCEE
VWLKVDSGMHRLGFPPEEVQDAWRRLTEASCVRADIGFLTHLACADDRDDPATERQLETF
EEEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QAACDGLPGPRSAANSAGVLGWPASHYDWVRPGIMLYGASPFVDGRDEQPALQPAMAFQG
HHHHCCCCCCCCCCCCCCEECCCCCCCCHHCCCEEEEECCCCCCCCCCCCCHHHHHHHCC
RVVAVRHLRAGDPVGYGATWSCPEAMPVGVVSIGYGDGYPRHAPSGTPVEVAGQRTRLVG
CEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEECCCHHHEEH
RISMDMLAVDLRGLDPVAEGDPAILWGGAVRAEEVAGACGTIAYELFCRMPPRVRREPVD
HHHHHHHEEHHCCCCCCCCCCCEEEECCCCCHHHHHCHHHHHHHHHHHCCCHHHCCCCCC
GETL
CCCC
>Mature Secondary Structure 
SRAARATVNLSALRANLRTARAAAPQQRIMAVIKSDGYGHGLAVVAGALTGHAEAFAVT
CCCHHHEEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEC
DADEAEALRAAGFRERIVLLQGPFAVDDLARAAAADLELVIHAHWQVEALAQAQLASPVT
CCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCEEEEEEECCHHHHHHHHHHCCCEE
VWLKVDSGMHRLGFPPEEVQDAWRRLTEASCVRADIGFLTHLACADDRDDPATERQLETF
EEEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
QAACDGLPGPRSAANSAGVLGWPASHYDWVRPGIMLYGASPFVDGRDEQPALQPAMAFQG
HHHHCCCCCCCCCCCCCCEECCCCCCCCHHCCCEEEEECCCCCCCCCCCCCHHHHHHHCC
RVVAVRHLRAGDPVGYGATWSCPEAMPVGVVSIGYGDGYPRHAPSGTPVEVAGQRTRLVG
CEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCEEECCCHHHEEH
RISMDMLAVDLRGLDPVAEGDPAILWGGAVRAEEVAGACGTIAYELFCRMPPRVRREPVD
HHHHHHHEEHHCCCCCCCCCCCEEEECCCCCHHHHHCHHHHHHHHHHHCCCHHHCCCCCC
GETL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA