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The map label for this gene is trpS [H]

Identifier: 121997385

GI number: 121997385

Start: 660498

End: 661715

Strand: Reverse

Name: trpS [H]

Synonym: Hhal_0584

Alternate gene names: 121997385

Gene position: 661715-660498 (Counterclockwise)

Preceding gene: 121997386

Following gene: 121997384

Centisome position: 24.71

GC content: 66.58

Gene sequence:

>1218_bases
TTGGCTAACATCAACCAACGACCCAGCCGCGTCCTGTCGGGCATGCGCCCGACGGGACGGCTGCATCTGGGCCATTACCA
CGGCGTGCTCAAGAACTGGGTGCGCCTGCAGAACGAGTACGAATGCTTCTTCTTCGTTGCCGACTGGCACGCCCTAACCA
CCCACTACGAGACCCCCTGGGTGGTCGGGGACAATGTCTGGGACATGGTCATCGACTGGCTGGCCTGCGGCGTCAACCCG
AAGCTGGCACGGCTGTTCATCCAGTCCCGGGTGCCCGAGCACGCGGAGCTCCATCTACTGCTGTCGATGATGACCCCGCT
GGGCTGGCTCGAGCGGGTGCCAACGTTCCGTGATCAGCAGGAGCAGCTGAACGACCGCGACCTGTCCACCTACGGTTTCC
TCGGGTACCCGTTGCTTCAATCGGCGGATGTGCTCATCTACAAGGCCACCGAGGTGCCGGTGGGCGAAGACCAGGTGGCC
CACCTGGAGCTCACCCGCGAGGTGGCCCGCCGTTTCAACCACCTCTACGGCGTCGAGCCGGATTTTGAAGAGAAGGCCCA
GGAGGCGGCGCGCAAGATGGGCAAGAAAAACGCCCGCCTCTACCAGGACCTGCGCCGGCGCTACCAGCAGGATGGCGATC
GCGAGGCCCTGGAGGTGGCGCACGCGTTGCTCGAGGGGCAGCCGAACATCACCGTGGCCGACCGCGAGCGCCTCTTCGGC
TACCTCGACGGCACCACACGGGAGCTGCTGCCGGAGCCCGAGGTGCTGCTGACGCCGACGGCGAAGATGCCCGGGCTCGA
TGGCCGTAAGATGTCCAAGTCCTACGACAACACCATTGGCCTGCGTGAGCCCACCGACGACGTGGTCCGCAAGCTGCGCA
CCATGCCCACGGACCCGGCCCGGGTGCGCCGCAATGACCCCGGGAATCCCGAGAAGTGCCCGGTCTGGGACTTCCACCAG
GTCTACTCTGACGAGTCGACCCGTGCGTGGGTGCAGGAGGGCTGCACCACCGCCGGCATCGGCTGCCTGGAGTGCAAGCG
CTGCATCATCGACGCCGTCGAGGCCGAGCTGTCGCCGATCCGCGAGCGGGCGCGGGAGTACGAGGACGATCCCGAGCATG
TGCGCTCGGTCATCGTCGACGGCTGTGAGCAGGCCCGCGAGGAGGCGCGAGAGACCCTTGGCGAGGTGCGCAGTGCCATG
GGCCTGGAGTACCGGTGA

Upstream 100 bases:

>100_bases
GGCCGCCGAGGTCATCCGCGAAGGGGTCGGCGATACCCGCGTCTTCCAGGGCGCTTGAGCGCCCCGGCTCGAATCGCGAA
TCAACGATAAGGAGCGTTGC

Downstream 100 bases:

>100_bases
GCGAGACCGCCGCCGAGGCGACCCCTGCCGAGGATCCAGCCGGCGGCGGCGAGCCGGTGGCCCGCGTCGGCGATGAAGCG
CTGCGGCGGCTGCCGGACGA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MANINQRPSRVLSGMRPTGRLHLGHYHGVLKNWVRLQNEYECFFFVADWHALTTHYETPWVVGDNVWDMVIDWLACGVNP
KLARLFIQSRVPEHAELHLLLSMMTPLGWLERVPTFRDQQEQLNDRDLSTYGFLGYPLLQSADVLIYKATEVPVGEDQVA
HLELTREVARRFNHLYGVEPDFEEKAQEAARKMGKKNARLYQDLRRRYQQDGDREALEVAHALLEGQPNITVADRERLFG
YLDGTTRELLPEPEVLLTPTAKMPGLDGRKMSKSYDNTIGLREPTDDVVRKLRTMPTDPARVRRNDPGNPEKCPVWDFHQ
VYSDESTRAWVQEGCTTAGIGCLECKRCIIDAVEAELSPIRERAREYEDDPEHVRSVIVDGCEQAREEARETLGEVRSAM
GLEYR

Sequences:

>Translated_405_residues
MANINQRPSRVLSGMRPTGRLHLGHYHGVLKNWVRLQNEYECFFFVADWHALTTHYETPWVVGDNVWDMVIDWLACGVNP
KLARLFIQSRVPEHAELHLLLSMMTPLGWLERVPTFRDQQEQLNDRDLSTYGFLGYPLLQSADVLIYKATEVPVGEDQVA
HLELTREVARRFNHLYGVEPDFEEKAQEAARKMGKKNARLYQDLRRRYQQDGDREALEVAHALLEGQPNITVADRERLFG
YLDGTTRELLPEPEVLLTPTAKMPGLDGRKMSKSYDNTIGLREPTDDVVRKLRTMPTDPARVRRNDPGNPEKCPVWDFHQ
VYSDESTRAWVQEGCTTAGIGCLECKRCIIDAVEAELSPIRERAREYEDDPEHVRSVIVDGCEQAREEARETLGEVRSAM
GLEYR
>Mature_404_residues
ANINQRPSRVLSGMRPTGRLHLGHYHGVLKNWVRLQNEYECFFFVADWHALTTHYETPWVVGDNVWDMVIDWLACGVNPK
LARLFIQSRVPEHAELHLLLSMMTPLGWLERVPTFRDQQEQLNDRDLSTYGFLGYPLLQSADVLIYKATEVPVGEDQVAH
LELTREVARRFNHLYGVEPDFEEKAQEAARKMGKKNARLYQDLRRRYQQDGDREALEVAHALLEGQPNITVADRERLFGY
LDGTTRELLPEPEVLLTPTAKMPGLDGRKMSKSYDNTIGLREPTDDVVRKLRTMPTDPARVRRNDPGNPEKCPVWDFHQV
YSDESTRAWVQEGCTTAGIGCLECKRCIIDAVEAELSPIRERAREYEDDPEHVRSVIVDGCEQAREEARETLGEVRSAMG
LEYR

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=170, Percent_Identity=45.2941176470588, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI41352700, Length=170, Percent_Identity=45.2941176470588, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1789786, Length=167, Percent_Identity=40.7185628742515, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71982800, Length=183, Percent_Identity=36.0655737704918, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71982793, Length=183, Percent_Identity=36.0655737704918, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320474, Length=181, Percent_Identity=39.2265193370166, Blast_Score=127, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24666151, Length=400, Percent_Identity=29.75, Blast_Score=167, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 46615; Mature: 46484

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANINQRPSRVLSGMRPTGRLHLGHYHGVLKNWVRLQNEYECFFFVADWHALTTHYETPW
CCCCCCCHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHCCCCCE
VVGDNVWDMVIDWLACGVNPKLARLFIQSRVPEHAELHLLLSMMTPLGWLERVPTFRDQQ
EECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
EQLNDRDLSTYGFLGYPLLQSADVLIYKATEVPVGEDQVAHLELTREVARRFNHLYGVEP
HHCCCCCCCHHCCCCCHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DFEEKAQEAARKMGKKNARLYQDLRRRYQQDGDREALEVAHALLEGQPNITVADRERLFG
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECHHHHHH
YLDGTTRELLPEPEVLLTPTAKMPGLDGRKMSKSYDNTIGLREPTDDVVRKLRTMPTDPA
HHCCCHHHHCCCCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHH
RVRRNDPGNPEKCPVWDFHQVYSDESTRAWVQEGCTTAGIGCLECKRCIIDAVEAELSPI
HHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RERAREYEDDPEHVRSVIVDGCEQAREEARETLGEVRSAMGLEYR
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANINQRPSRVLSGMRPTGRLHLGHYHGVLKNWVRLQNEYECFFFVADWHALTTHYETPW
CCCCCCHHHHHHCCCCCCEEECHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHCCCCCE
VVGDNVWDMVIDWLACGVNPKLARLFIQSRVPEHAELHLLLSMMTPLGWLERVPTFRDQQ
EECCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
EQLNDRDLSTYGFLGYPLLQSADVLIYKATEVPVGEDQVAHLELTREVARRFNHLYGVEP
HHCCCCCCCHHCCCCCHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DFEEKAQEAARKMGKKNARLYQDLRRRYQQDGDREALEVAHALLEGQPNITVADRERLFG
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEECHHHHHH
YLDGTTRELLPEPEVLLTPTAKMPGLDGRKMSKSYDNTIGLREPTDDVVRKLRTMPTDPA
HHCCCHHHHCCCCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHH
RVRRNDPGNPEKCPVWDFHQVYSDESTRAWVQEGCTTAGIGCLECKRCIIDAVEAELSPI
HHCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RERAREYEDDPEHVRSVIVDGCEQAREEARETLGEVRSAMGLEYR
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]