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The map label for this gene is mutT1

Identifier: 121638866

GI number: 121638866

Start: 3296679

End: 3297632

Strand: Direct

Name: mutT1

Synonym: BCG_3006

Alternate gene names: 121638866

Gene position: 3296679-3297632 (Clockwise)

Preceding gene: 121638865

Following gene: 121638870

Centisome position: 75.36

GC content: 65.41

Gene sequence:

>954_bases
GTGTCGATCCAGAACTCGTCCGCCCGCCGGCGCTCGGCGGGCCGGATTGTGTACGCCGCCGGTGCGGTGCTCTGGCGACC
CGGCAGTGCCGATTCGGAAGGGCCGGTCGAGATCGCTGTCATTCACCGCCCCCGTTACGACGACTGGTCGCTGCCCAAGG
GCAAAGTGGATCCGGGCGAGACCGCACCGGTGGGGGCGGTGCGGGAGATACTCGAGGAGACCGGTCACCGCGCCAACCTG
GGTAGGCGGCTCCTGACGGTGACCTACCCGACCGACTCCCCTTTTCGAGGCGTCAAGAAGGTGCACTACTGGGCAGCGCG
CAGCACCGGTGGGGAATTCACCCCCGGCAGTGAGGTCGACGAGCTGATCTGGTTACCGGTTCCCGACGCGATGAACAAGC
TTGACTACGCCCAGGATCGAAAAGTCCTGTGCCGGTTCGCTAAACACCCGGCGGACACTCAGACGGTGCTGGTGGTGCGG
CATGGCACCGCGGGCAGCAAAGCGCACTTCTCCGGGGACGACAGCAAGCGACCGCTAGACAAGAGGGGTCGTGCGCAGGC
AGAAGCGTTGGTACCACAGCTGCTGGCGTTCGGCGCCACCGATGTTTATGCCGCCGACCGGGTGCGCTGCCACCAGACGA
TGGAGCCACTCGCCGCGGAACTGAACGTGACCATACACAACGAGCCCACCCTGACCGAAGAGTCCTACGCCAACAACCCC
AAACGCGGCCGACACCGAGTGCTGCAGATCGTCGAGCAAGTAGGCACACCCGTGATCTGCACGCAGGGCAAGGTCATTCC
CGATCTGATCACGTGGTGGTGCGAGCGCGACGGTGTGCACCCCGACAAGTCCCGCAATCGCAAAGGCAGCACGTGGGTGT
TGTCGTTGTCAGCCGGCAGGCTTGTGACAGCCGACCACATCGGCGGTGCGCTGGCCGCCAACGTGCGGGCCTAA

Upstream 100 bases:

>100_bases
CGGCACCGCAGCCCCTGACACTGCGTGGTGATTCCCGCTGCTGCACCGACCACATCCACGACCGCGAGCAGCCTGGCCGA
ATTGACCTGCAGGAGTTGAG

Downstream 100 bases:

>100_bases
CACACGGATACCCTTCGTCACATTGCCACCGTGCAAAGGGTATCCGTGTGTCTTGACCTATTTGCGACCCCGCCGAGCGG
TTGCCTTCTTGGCGGGAGCC

Product: putative hydrolase mutT1

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSIQNSSARRRSAGRIVYAAGAVLWRPGSADSEGPVEIAVIHRPRYDDWSLPKGKVDPGETAPVGAVREILEETGHRANL
GRRLLTVTYPTDSPFRGVKKVHYWAARSTGGEFTPGSEVDELIWLPVPDAMNKLDYAQDRKVLCRFAKHPADTQTVLVVR
HGTAGSKAHFSGDDSKRPLDKRGRAQAEALVPQLLAFGATDVYAADRVRCHQTMEPLAAELNVTIHNEPTLTEESYANNP
KRGRHRVLQIVEQVGTPVICTQGKVIPDLITWWCERDGVHPDKSRNRKGSTWVLSLSAGRLVTADHIGGALAANVRA

Sequences:

>Translated_317_residues
MSIQNSSARRRSAGRIVYAAGAVLWRPGSADSEGPVEIAVIHRPRYDDWSLPKGKVDPGETAPVGAVREILEETGHRANL
GRRLLTVTYPTDSPFRGVKKVHYWAARSTGGEFTPGSEVDELIWLPVPDAMNKLDYAQDRKVLCRFAKHPADTQTVLVVR
HGTAGSKAHFSGDDSKRPLDKRGRAQAEALVPQLLAFGATDVYAADRVRCHQTMEPLAAELNVTIHNEPTLTEESYANNP
KRGRHRVLQIVEQVGTPVICTQGKVIPDLITWWCERDGVHPDKSRNRKGSTWVLSLSAGRLVTADHIGGALAANVRA
>Mature_316_residues
SIQNSSARRRSAGRIVYAAGAVLWRPGSADSEGPVEIAVIHRPRYDDWSLPKGKVDPGETAPVGAVREILEETGHRANLG
RRLLTVTYPTDSPFRGVKKVHYWAARSTGGEFTPGSEVDELIWLPVPDAMNKLDYAQDRKVLCRFAKHPADTQTVLVVRH
GTAGSKAHFSGDDSKRPLDKRGRAQAEALVPQLLAFGATDVYAADRVRCHQTMEPLAAELNVTIHNEPTLTEESYANNPK
RGRHRVLQIVEQVGTPVICTQGKVIPDLITWWCERDGVHPDKSRNRKGSTWVLSLSAGRLVTADHIGGALAANVRA

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTT1_MYCTU (P95110)

Other databases:

- EMBL:   AE000516
- EMBL:   BX842581
- PIR:   F70673
- RefSeq:   NP_217501.1
- RefSeq:   NP_337578.1
- HSSP:   Q9U2M7
- ProteinModelPortal:   P95110
- SMR:   P95110
- EnsemblBacteria:   EBMYCT00000002247
- EnsemblBacteria:   EBMYCT00000069472
- GeneID:   888165
- GeneID:   925209
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3063
- KEGG:   mtu:Rv2985
- TIGR:   MT3063
- TubercuList:   Rv2985
- GeneTree:   EBGT00050000015833
- HOGENOM:   HBG430911
- OMA:   RTKVVYY
- ProtClustDB:   CLSK792206
- InterPro:   IPR013078
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502
- SMART:   SM00855

Pfam domain/function: PF00293 NUDIX; PF00300 PGAM; SSF55811 NUDIX_hydrolase

EC number: NA

Molecular weight: Translated: 34781; Mature: 34650

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQNSSARRRSAGRIVYAAGAVLWRPGSADSEGPVEIAVIHRPRYDDWSLPKGKVDPGE
CCCCCCCHHHHHCCCEEEECCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
TAPVGAVREILEETGHRANLGRRLLTVTYPTDSPFRGVKKVHYWAARSTGGEFTPGSEVD
CCCHHHHHHHHHHCCCHHCCCCEEEEEECCCCCCHHHHHHHHEEEECCCCCCCCCCCCCC
ELIWLPVPDAMNKLDYAQDRKVLCRFAKHPADTQTVLVVRHGTAGSKAHFSGDDSKRPLD
CEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEECCCCCCCCHH
KRGRAQAEALVPQLLAFGATDVYAADRVRCHQTMEPLAAELNVTIHNEPTLTEESYANNP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHCCCC
KRGRHRVLQIVEQVGTPVICTQGKVIPDLITWWCERDGVHPDKSRNRKGSTWVLSLSAGR
HHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCC
LVTADHIGGALAANVRA
EEEHHHCCCCCCCCCCC
>Mature Secondary Structure 
SIQNSSARRRSAGRIVYAAGAVLWRPGSADSEGPVEIAVIHRPRYDDWSLPKGKVDPGE
CCCCCCHHHHHCCCEEEECCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
TAPVGAVREILEETGHRANLGRRLLTVTYPTDSPFRGVKKVHYWAARSTGGEFTPGSEVD
CCCHHHHHHHHHHCCCHHCCCCEEEEEECCCCCCHHHHHHHHEEEECCCCCCCCCCCCCC
ELIWLPVPDAMNKLDYAQDRKVLCRFAKHPADTQTVLVVRHGTAGSKAHFSGDDSKRPLD
CEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEECCCCCCCCHH
KRGRAQAEALVPQLLAFGATDVYAADRVRCHQTMEPLAAELNVTIHNEPTLTEESYANNP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHCCCC
KRGRHRVLQIVEQVGTPVICTQGKVIPDLITWWCERDGVHPDKSRNRKGSTWVLSLSAGR
HHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCC
LVTADHIGGALAANVRA
EEEHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036