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The map label for this gene is pdhA [H]

Identifier: 121638379

GI number: 121638379

Start: 2774789

End: 2775892

Strand: Reverse

Name: pdhA [H]

Synonym: BCG_2517c

Alternate gene names: 121638379

Gene position: 2775892-2774789 (Counterclockwise)

Preceding gene: 121638380

Following gene: 121638378

Centisome position: 63.46

GC content: 64.4

Gene sequence:

>1104_bases
ATGGGGGAGGGTTCTCGGAGGCCATCTGGGATGTTGATGTCTGTCGATCTTGAGCCGGTGCAACTCGTCGGCCCGGACGG
TACGCCGACGGCCGAACGCCGCTACCACCGTGACCTTCCTGAGGAAACGCTGCGTTGGCTCTACGAGATGATGGTGGTCA
CCCGCGAGCTGGATACCGAATTCGTCAATCTGCAGCGCCAGGGGGAGCTGGCGTTGTACACGCCCTGTCGCGGGCAGGAA
GCCGCGCAGGTGGGTGCGGCGGCTTGCCTACGCAAAACCGACTGGTTGTTCCCCCAATACCGAGAATTGGGCGTCTACCT
AGTGCGTGGCATCCCGCCTGGACATGTTGGGGTCGCGTGGCGTGGAACCTGGCACGGCGGGCTGCAATTCACCACGAAGT
GCTGTGCACCGATGTCGGTTCCCATCGGCACCCAGACCTTGCACGCGGTGGGCGCGGCGATGGCCGCGCAACGCCTGGAC
GAGGACTCCGTGACGGTGGCCTTTCTGGGCGACGGCGCCACCAGCGAGGGCGACGTACATGAGGCGCTCAATTTCGCGGC
GGTGTTCACCACACCGTGCGTGTTCTACGTGCAGAACAACCAGTGGGCAATCTCGATGCCGGTATCCAGGCAGACCGCCG
CACCATCTATCGCGCACAAGGCGATTGGCTACGGGATGCCAGGCATCCGGGTGGACGGCAACGACGTGCTGGCATGCTAT
GCGGTGATGGCCGAAGCTGCCGCTCGGGCTCGGGCCGGCGACGGTCCAACGCTGATCGAGGCGGTCACTTACCGTCTTGG
TCCGCACACCACCGCCGATGATCCAACCCGGTACCGCAGCCAGGAGGAGGTGGACCGCTGGGCGACGCTGGACCCGATTC
CGCGCTATCGCACTTACTTACAAGATCAGGGCCTGTGGTCGCAACGCCTCGAGGAACAGGTGACGGCTCGGGCAAAACAC
GTGCGGTCCGAGCTACGCGACGCGGTCTTTGATGCGCCTGACTTCGACGTCGATGAGGTGTTCACCACGGTGTACGCCGA
AATCACACCCGGGTTGCAGGCGCAGCGCGAACAGCTGCGTGCCGAACTGGCGCGGACTGACTGA

Upstream 100 bases:

>100_bases
TGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCACGGCATCTTCTGACGCGTAACCGCGTTGTGA
TCGCGAGCTGAGGAGACGGT

Downstream 100 bases:

>100_bases
GGAGGCGGGCATGACTCAAATCGCAGACCGTCCGGCCAGGCCGGATGAGACGCTTGCGGTAGCGGTGAGCGACATCACGC
AGTCGTTGACCATGGTCCAG

Product: putative pyruvate dehydrogenase E1 component subunit alpha pdhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQE
AAQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLD
EDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACY
AVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQVTARAKH
VRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELARTD

Sequences:

>Translated_367_residues
MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQE
AAQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLD
EDSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACY
AVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQVTARAKH
VRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELARTD
>Mature_366_residues
GEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTEFVNLQRQGELALYTPCRGQEA
AQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAWRGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLDE
DSVTVAFLGDGATSEGDVHEALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACYA
VMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYLQDQGLWSQRLEEQVTARAKHV
RSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLRAELARTD

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=358, Percent_Identity=38.8268156424581, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI258645172, Length=358, Percent_Identity=38.8268156424581, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI4885543, Length=304, Percent_Identity=30.5921052631579, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI291084742, Length=304, Percent_Identity=30.5921052631579, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI4505685, Length=304, Percent_Identity=30.5921052631579, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI291084744, Length=311, Percent_Identity=29.903536977492, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI291084757, Length=298, Percent_Identity=28.5234899328859, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=389, Percent_Identity=35.2185089974293, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI86563357, Length=389, Percent_Identity=35.2185089974293, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17536047, Length=329, Percent_Identity=28.8753799392097, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI32564172, Length=329, Percent_Identity=28.8753799392097, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=28.7925696594427, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21355903, Length=345, Percent_Identity=34.2028985507246, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24639740, Length=345, Percent_Identity=29.2753623188406, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24639744, Length=345, Percent_Identity=29.2753623188406, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28571106, Length=345, Percent_Identity=29.2753623188406, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24639746, Length=313, Percent_Identity=29.7124600638978, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24639748, Length=332, Percent_Identity=29.5180722891566, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40616; Mature: 40485

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTE
CCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
FVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAW
HHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCEEEEECCCCCCEEEEE
RGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVH
ECCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHH
EALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACY
HHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCCHHHHHHHHCCCCCEEECCCCHHHHH
AVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYL
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHCCCCCCHHHHHHH
QDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AELARTD
HHHHCCC
>Mature Secondary Structure 
GEGSRRPSGMLMSVDLEPVQLVGPDGTPTAERRYHRDLPEETLRWLYEMMVVTRELDTE
CCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
FVNLQRQGELALYTPCRGQEAAQVGAAACLRKTDWLFPQYRELGVYLVRGIPPGHVGVAW
HHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCEEEEECCCCCCEEEEE
RGTWHGGLQFTTKCCAPMSVPIGTQTLHAVGAAMAAQRLDEDSVTVAFLGDGATSEGDVH
ECCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHH
EALNFAAVFTTPCVFYVQNNQWAISMPVSRQTAAPSIAHKAIGYGMPGIRVDGNDVLACY
HHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCCHHHHHHHHCCCCCEEECCCCHHHHH
AVMAEAAARARAGDGPTLIEAVTYRLGPHTTADDPTRYRSQEEVDRWATLDPIPRYRTYL
HHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHCCCCCCHHHHHHH
QDQGLWSQRLEEQVTARAKHVRSELRDAVFDAPDFDVDEVFTTVYAEITPGLQAQREQLR
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHH
AELARTD
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]