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The map label for this gene is pdhB [H]

Identifier: 121638378

GI number: 121638378

Start: 2773732

End: 2774778

Strand: Reverse

Name: pdhB [H]

Synonym: BCG_2516c

Alternate gene names: 121638378

Gene position: 2774778-2773732 (Counterclockwise)

Preceding gene: 121638379

Following gene: 121638377

Centisome position: 63.43

GC content: 63.8

Gene sequence:

>1047_bases
ATGACTCAAATCGCAGACCGTCCGGCCAGGCCGGATGAGACGCTTGCGGTAGCGGTGAGCGACATCACGCAGTCGTTGAC
CATGGTCCAGGCGATCAACCGCGCCCTGTACGACGCGATGGCCGCCGACGAGCGGGTATTGGTGTTTGGCGAGGATGTCG
CGGTCGAGGGTGGGGTGTTTCGGGTGACCGAGGGACTGGCCGATACGTTCGGTGCAGACCGGTGCTTCGACACGCCACTG
GCGGAGTCCGCGATCATCGGAATAGCCGTCGGGTTGGCACTACGTGGCTTTGTGCCGGTGCCAGAAATCCAGTTCGACGG
CTTTTCCTATCCGGCTTTCGACCAAGTGGTGAGCCATCTGGCCAAGTACCGGACTCGCACCCGCGGTGAGGTGGACATGC
CGGTGACCGTCCGGATCCCCTCGTTTGGCGGTATCGGTGCGGCCGAACATCATTCGGACTCCACGGAGTCCTACTGGGTG
CACACCGCGGGCCTCAAGGTGGTGGTGCCGTCGACACCCGGTGACGCTTACTGGCTGCTGCGGCACGCTATCGCCTGCCC
GGACCCCGTGATGTATCTGGAGCCCAAACGCCGCTACCACAGCCGCGGGATGGTCGACACTAGCCGGCCGGAACCGCCGA
TCGGGCACGCGATGGTGCGCCGGTCCGGCACCGATGTGACCGTGGTAACGTACGGAAACCTGGTGAGCACCGCCCTGTCT
AGCGCGGATACTGCAGAGCAGCAACATGATTGGAGTCTGGAGGTTATCGATCTGCGGTCGTTGGCGCCGCTGGACTTCGA
CACCATTGCTGCGTCGATCCAGCGCACCGGGCGTTGCGTGGTGATGCACGAAGGGCCGCGCAGCCTCGGCTATGGTGCCG
GTCTGGCCGCGCGCATCCAGGAAGAGATGTTCTACCAATTGGAGGCTCCGGTGTTGCGTGCCTGCGGTTTTGACACACCC
TACCCGCCTGCGCGGTTGGAAAAATTGTGGTTACCCGGCCCCGACCGGCTGTTGGACTGCGTCGAACGTGTGCTGCGTCA
GCCATGA

Upstream 100 bases:

>100_bases
GAGGTGTTCACCACGGTGTACGCCGAAATCACACCCGGGTTGCAGGCGCAGCGCGAACAGCTGCGTGCCGAACTGGCGCG
GACTGACTGAGGAGGCGGGC

Downstream 100 bases:

>100_bases
GCGGTGAGGACAGCATCAGGTCTTTCCCGGTGCCCGACCTCGGCGAGGGACTGCAGGAAGTGACGGTGACGTGTTGGAGC
GTCGCCGTCGGCGACGATGT

Product: putative pyruvate dehydrogenase E1 component subunit beta pdhB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPL
AESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWV
HTAGLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHSRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALS
SADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTP
YPPARLEKLWLPGPDRLLDCVERVLRQP

Sequences:

>Translated_348_residues
MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPL
AESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWV
HTAGLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHSRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALS
SADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTP
YPPARLEKLWLPGPDRLLDCVERVLRQP
>Mature_347_residues
TQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVFRVTEGLADTFGADRCFDTPLA
ESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHLAKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVH
TAGLKVVVPSTPGDAYWLLRHAIACPDPVMYLEPKRRYHSRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALSS
ADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQEEMFYQLEAPVLRACGFDTPY
PPARLEKLWLPGPDRLLDCVERVLRQP

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=329, Percent_Identity=39.209726443769, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI34101272, Length=329, Percent_Identity=39.209726443769, Blast_Score=239, Evalue=3e-63,
Organism=Homo sapiens, GI156564403, Length=331, Percent_Identity=34.1389728096677, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI291084858, Length=331, Percent_Identity=32.9305135951662, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17506935, Length=338, Percent_Identity=39.6449704142012, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17538422, Length=328, Percent_Identity=35.6707317073171, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6319698, Length=341, Percent_Identity=33.4310850439883, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI160714832, Length=328, Percent_Identity=40.2439024390244, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI160714828, Length=328, Percent_Identity=40.2439024390244, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI21358145, Length=330, Percent_Identity=38.4848484848485, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24650940, Length=330, Percent_Identity=38.4848484848485, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=41.7582417582418, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=41.7582417582418, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38095; Mature: 37963

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVF
CCCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCEE
RVTEGLADTFGADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHL
EEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHH
AKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLL
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCEEEEEECCCCCHHHHH
RHAIACPDPVMYLEPKRRYHSRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALS
HHHHCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECHHHHHHHH
SADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQ
HHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHH
EEMFYQLEAPVLRACGFDTPYPPARLEKLWLPGPDRLLDCVERVLRQP
HHHHHHHCCHHHHHCCCCCCCCHHHHHEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQIADRPARPDETLAVAVSDITQSLTMVQAINRALYDAMAADERVLVFGEDVAVEGGVF
CCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEECCCEE
RVTEGLADTFGADRCFDTPLAESAIIGIAVGLALRGFVPVPEIQFDGFSYPAFDQVVSHL
EEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHH
AKYRTRTRGEVDMPVTVRIPSFGGIGAAEHHSDSTESYWVHTAGLKVVVPSTPGDAYWLL
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEECCEEEEEECCCCCHHHHH
RHAIACPDPVMYLEPKRRYHSRGMVDTSRPEPPIGHAMVRRSGTDVTVVTYGNLVSTALS
HHHHCCCCCEEEECCHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECHHHHHHHH
SADTAEQQHDWSLEVIDLRSLAPLDFDTIAASIQRTGRCVVMHEGPRSLGYGAGLAARIQ
HHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHH
EEMFYQLEAPVLRACGFDTPYPPARLEKLWLPGPDRLLDCVERVLRQP
HHHHHHHCCHHHHHCCCCCCCCHHHHHEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA