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The map label for this gene is plsC [C]

Identifier: 121638364

GI number: 121638364

Start: 2753089

End: 2754831

Strand: Reverse

Name: plsC [C]

Synonym: BCG_2501c

Alternate gene names: 121638364

Gene position: 2754831-2753089 (Counterclockwise)

Preceding gene: 121638365

Following gene: 121638363

Centisome position: 62.97

GC content: 63.97

Gene sequence:

>1743_bases
ATGAGCGCCGCTGACGAGCAGGGGGAAGAGCGGGCGACGCGGAAGTCGGCGCCGGATTTGCGCCTACCCGGTTCGGTAGC
CGAGATTCTGGCCAGTCCTGCCGGCCCGAAGGTCGGTGCGTTTTTCGACCTGGACGGCACGCTGGTCGCCGGCTTCACGG
CCGTCATCCTCACCCAGGAGAGGCTGCGGCGCCGCGATATGGGCGTGGGCGAGCTGCTCGGTATGGTTCAGGCCGGCCTG
AATCACACGCTCGGGCGAATCGAGTTCGAAGACCTTATCGGAAAGGCCGCCGCGGCGCTGGCCGGGCGGCTCTTGACCGA
CCTGGAAGAAATCGGCGAGCGGCTATTCGCCCAGCGGATCGAGTCCCGGATCTACCCGGAAATGCGGGAACTGGTCCGGG
CTCACGTGGCCCGCGGCCACACCGTGGTCCTCAGCTCGTCGGCGCTGACCATCCAAGTTGGCCCAGTCGCACGTTTTCTG
GGGATCAACAACATGCTCACCAACAAGTTCGAGACCAACGAGGACGGGATACTCACCGGGGGTGTGCTGAAGCCAATTTT
GTGGGGTCCGGGCAAAGCCACTGCGGTGCAACGCTTTGCGGCCGAGCACGACATCGATCTCAAAGACAGTTACTTCTATG
CCGACGGTGACGAGGACGTCGCCCTGATGTATCTGGTGGGCAATCCGCGACCGACCAATCCGGAAGGAAAGATGGCCGCG
GTCGCCAAGCGACGGGGCTGGCCGATCTTGAAGTTCAACAGTCGCGGCGGTGTGGGCATCCGGCGGCAGTTGCGGACACT
TGCCGGTCTGAGCACCATCGTCCCGGTCGCGGCCGGCGCGGTAGGGATCGGTGTGCTGACCGGTAGCCGGCGCCGCGGCG
TGAATTTCTTTACCTCCACCTTCTCTCAGCTGCTGCTGGCGACCAGCGGCGTGCACCTGAATGTGATCGGAAAAGAGAAT
CTGACCGCCCAGCGGCCCGCCGTCTTTATCTTCAACCACCGCAACCAGGTTGACCCGGTCATTGCCGGTGCGCTGGTGCG
CGACAACTGGGTTGGGGTGGGCAAGAAGGAACTGGCGAGCGACCCGATCATGGGCACGCTGGGGAAGTTGCTGGACGGTG
TGTTCATCGACCGTGATGATCCGGTCGCCGCGGTGGAGACACTGCACACGGTTGAGGAGCGCGCCCGCAATGGACTATCG
ATCGTGATCGCTCCCGAAGGTACCCGGTTGGATACCACCGAAGTCGGGTCATTCAAGAAGGGGCCCTTCCGTATCGCCAT
GGCCGCGAAGATCCCGATCGTGCCGATCGTGATCCGCAATGCGGAGATCGTCGCCTCGCGCAACTCCACCACGATCAATC
CGGGCACGGTCGACGTCGCGGTGTTTCCGCCGATTCCGGTCGATGACTGGACCCTGGACGCCCTGCCGGATCGTATCGCC
GAGGTGCGCCAGCTGTATCTGGACACGCTGGCGGACTGGCCGGTCGATGGGTTGCCCGCGGTCGATCTGTACGCCGAGCA
GAAGGCCGCCAGAAAAGCCAGGGCTCAGGTCGCCAAGGCCACCGCGAAAAGGGTGCCGGCTAAGAAGGCTCCCGCCAAAA
GCGCCGCCAATAAAGGCGCGGCCGCGACGAAGGCGGCTACAAAGAAGGCATCGCCGAAGGCCAAACCCAGCGAATCTAAG
ATCGCTGGCAAGGATGGTGAGGCCTCCGCATCGCCAAGCTCTAGCGCCAAAGGACGGTCGTGA

Upstream 100 bases:

>100_bases
ACGAAATCCTTGCGCTGGCCGGTGATCCGGCACCGCGTGTGCTGCCGGCGTCGTTCGATACTCAAGGAGCCGGTTCAGTG
CCTCGATCGGTGTCGGGCTC

Downstream 100 bases:

>100_bases
CCAAACCGGCGGCCGATGCCAGCGCGGTGCTTACTGCCGAGGACACACTGGTGCTGGCTTCCACGGCGACGCCGGTCGAG
ATGGAGCTGATCATGGGCTG

Product: putative transmembrane phospholipid biosynthesis bifunctionnal enzyme plsC: putative l-3-phosphoserine phosphatase + 1-acyl-SN-glycerol-3-phosphate acyltransferase

Products: CoA; 1,2-diacyl-sn-glycerol 3-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVAGFTAVILTQERLRRRDMGVGELLGMVQAGL
NHTLGRIEFEDLIGKAAAALAGRLLTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALTIQVGPVARFL
GINNMLTNKFETNEDGILTGGVLKPILWGPGKATAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAA
VAKRRGWPILKFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTSTFSQLLLATSGVHLNVIGKEN
LTAQRPAVFIFNHRNQVDPVIAGALVRDNWVGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLS
IVIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNSTTINPGTVDVAVFPPIPVDDWTLDALPDRIA
EVRQLYLDTLADWPVDGLPAVDLYAEQKAARKARAQVAKATAKRVPAKKAPAKSAANKGAAATKAATKKASPKAKPSESK
IAGKDGEASASPSSSAKGRS

Sequences:

>Translated_580_residues
MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVAGFTAVILTQERLRRRDMGVGELLGMVQAGL
NHTLGRIEFEDLIGKAAAALAGRLLTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALTIQVGPVARFL
GINNMLTNKFETNEDGILTGGVLKPILWGPGKATAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAA
VAKRRGWPILKFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTSTFSQLLLATSGVHLNVIGKEN
LTAQRPAVFIFNHRNQVDPVIAGALVRDNWVGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLS
IVIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNSTTINPGTVDVAVFPPIPVDDWTLDALPDRIA
EVRQLYLDTLADWPVDGLPAVDLYAEQKAARKARAQVAKATAKRVPAKKAPAKSAANKGAAATKAATKKASPKAKPSESK
IAGKDGEASASPSSSAKGRS
>Mature_579_residues
SAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVAGFTAVILTQERLRRRDMGVGELLGMVQAGLN
HTLGRIEFEDLIGKAAAALAGRLLTDLEEIGERLFAQRIESRIYPEMRELVRAHVARGHTVVLSSSALTIQVGPVARFLG
INNMLTNKFETNEDGILTGGVLKPILWGPGKATAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAAV
AKRRGWPILKFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTSTFSQLLLATSGVHLNVIGKENL
TAQRPAVFIFNHRNQVDPVIAGALVRDNWVGVGKKELASDPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLSI
VIAPEGTRLDTTEVGSFKKGPFRIAMAAKIPIVPIVIRNAEIVASRNSTTINPGTVDVAVFPPIPVDDWTLDALPDRIAE
VRQLYLDTLADWPVDGLPAVDLYAEQKAARKARAQVAKATAKRVPAKKAPAKSAANKGAAATKAATKKASPKAKPSESKI
AGKDGEASASPSSSAKGRS

Specific function: Converts Lysophosphatidic Acid (Lpa) Into Phosphatidic Acid By Incorporating An Acyl Moiety At The 2 Position. This Enzyme Can Utilize Either Acyl-CoA Or Acyl-Acyl Carrier Protein As The Fatty Acyl Donor. [C]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serB family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI15100175, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI6041665, Length=184, Percent_Identity=28.804347826087, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1789395, Length=167, Percent_Identity=32.3353293413174, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17564032, Length=184, Percent_Identity=30.9782608695652, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17568319, Length=177, Percent_Identity=29.3785310734463, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320151, Length=242, Percent_Identity=30.1652892561983, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641614, Length=199, Percent_Identity=27.1356783919598, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641612, Length=199, Percent_Identity=27.1356783919598, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281364648, Length=218, Percent_Identity=27.5229357798165, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24582856, Length=218, Percent_Identity=27.5229357798165, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24582854, Length=218, Percent_Identity=27.5229357798165, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006383
- InterPro:   IPR006385 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: 2.3.1.51; 3.1.3.3

Molecular weight: Translated: 61743; Mature: 61611

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVAGFTAVILTQE
CCCCCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
RLRRRDMGVGELLGMVQAGLNHTLGRIEFEDLIGKAAAALAGRLLTDLEEIGERLFAQRI
HHHHHCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESRIYPEMRELVRAHVARGHTVVLSSSALTIQVGPVARFLGINNMLTNKFETNEDGILTG
HHHCCHHHHHHHHHHHHCCCEEEEECCEEEEEECCHHHHHCCCHHHHCCCCCCCCCEEEC
GVLKPILWGPGKATAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAA
CHHHHHEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCHHH
VAKRRGWPILKFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTST
HHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCCCCCHHHHHH
FSQLLLATSGVHLNVIGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNWVGVGKKELAS
HHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHCC
DPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLSIVIAPEGTRLDTTEVGSFKK
CCHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCCCC
GPFRIAMAAKIPIVPIVIRNAEIVASRNSTTINPGTVDVAVFPPIPVDDWTLDALPDRIA
CCEEEEEEECCCEEEEEEECCEEEEECCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
EVRQLYLDTLADWPVDGLPAVDLYAEQKAARKARAQVAKATAKRVPAKKAPAKSAANKGA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC
AATKAATKKASPKAKPSESKIAGKDGEASASPSSSAKGRS
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAADEQGEERATRKSAPDLRLPGSVAEILASPAGPKVGAFFDLDGTLVAGFTAVILTQE
CCCCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
RLRRRDMGVGELLGMVQAGLNHTLGRIEFEDLIGKAAAALAGRLLTDLEEIGERLFAQRI
HHHHHCCCHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESRIYPEMRELVRAHVARGHTVVLSSSALTIQVGPVARFLGINNMLTNKFETNEDGILTG
HHHCCHHHHHHHHHHHHCCCEEEEECCEEEEEECCHHHHHCCCHHHHCCCCCCCCCEEEC
GVLKPILWGPGKATAVQRFAAEHDIDLKDSYFYADGDEDVALMYLVGNPRPTNPEGKMAA
CHHHHHEECCCHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEECCCCCCCCCCCHHH
VAKRRGWPILKFNSRGGVGIRRQLRTLAGLSTIVPVAAGAVGIGVLTGSRRRGVNFFTST
HHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCCCCCHHHHHH
FSQLLLATSGVHLNVIGKENLTAQRPAVFIFNHRNQVDPVIAGALVRDNWVGVGKKELAS
HHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHCC
DPIMGTLGKLLDGVFIDRDDPVAAVETLHTVEERARNGLSIVIAPEGTRLDTTEVGSFKK
CCHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHCCCCCC
GPFRIAMAAKIPIVPIVIRNAEIVASRNSTTINPGTVDVAVFPPIPVDDWTLDALPDRIA
CCEEEEEEECCCEEEEEEECCEEEEECCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHH
EVRQLYLDTLADWPVDGLPAVDLYAEQKAARKARAQVAKATAKRVPAKKAPAKSAANKGA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC
AATKAATKKASPKAKPSESKIAGKDGEASASPSSSAKGRS
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; 1-acyl-sn-glycerol 3-phosphate

Specific reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate

General reaction: Acyl group transfer [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]