Click here to switch to the map view.

The map label for this gene is furB [H]

Identifier: 121638238

GI number: 121638238

Start: 2606672

End: 2607064

Strand: Direct

Name: furB [H]

Synonym: BCG_2373

Alternate gene names: 121638238

Gene position: 2606672-2607064 (Clockwise)

Preceding gene: 121638237

Following gene: 121638242

Centisome position: 59.59

GC content: 62.85

Gene sequence:

>393_bases
ATGAGTGCAGCCGGTGTCCGCTCTACCCGCCAGCGGGCAGCCATCTCGACACTGTTAGAGACGCTCGACGACTTTCGTTC
GGCCCAGGAACTGCACGACGAACTGCGCCGGCGCGGCGAGAACATCGGTCTGACCACCGTCTACCGCACACTGCAGTCGA
TGGCATCCTCCGGACTGGTGGACACACTGCGCACCGACACCGGTGAATCGGTCTACCGCAGATGCTCGGAGCACCATCAC
CACCATCTGGTGTGCCGCAGCTGCGGTTCCACCATCGAAGTAGGTGACCACGAGGTGGAGGCGTGGGCGGCGGAGGTGGC
CACCAAACATGGATTCTCTGACGTCAGCCACACCATCGAGATCTTCGGCACCTGCTCAGACTGCCGGAGCTAG

Upstream 100 bases:

>100_bases
CCGGGGAGCGATCGGGCCGAGAAGTGCTGTACCGACTTGCTGACCACCACCTCGCGCACATTGTGCTCGACGCCGTCGCG
CACGCCGGTGAGGACGCAAT

Downstream 100 bases:

>100_bases
GACACCACCGAGGTCGAGCGACCCCACACGCCGAACGTGCAACCATGGCGGCTCCGCCCGGCGTGTCGCCGCCACCAGGG
CACGTTCGGCGCACAGCGAG

Product: putative ferric uptake regulation protein furB

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MSAAGVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSMASSGLVDTLRTDTGESVYRRCSEHHH
HHLVCRSCGSTIEVGDHEVEAWAAEVATKHGFSDVSHTIEIFGTCSDCRS

Sequences:

>Translated_130_residues
MSAAGVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSMASSGLVDTLRTDTGESVYRRCSEHHH
HHLVCRSCGSTIEVGDHEVEAWAAEVATKHGFSDVSHTIEIFGTCSDCRS
>Mature_129_residues
SAAGVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSMASSGLVDTLRTDTGESVYRRCSEHHHH
HLVCRSCGSTIEVGDHEVEAWAAEVATKHGFSDVSHTIEIFGTCSDCRS

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=132, Percent_Identity=37.8787878787879, Blast_Score=96, Evalue=6e-22,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 14417; Mature: 14286

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAGVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSMASSGLV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHH
DTLRTDTGESVYRRCSEHHHHHLVCRSCGSTIEVGDHEVEAWAAEVATKHGFSDVSHTIE
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
IFGTCSDCRS
HHHCHHHHCC
>Mature Secondary Structure 
SAAGVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSMASSGLV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHH
DTLRTDTGESVYRRCSEHHHHHLVCRSCGSTIEVGDHEVEAWAAEVATKHGFSDVSHTIE
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
IFGTCSDCRS
HHHCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9055816 [H]