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The map label for this gene is mez [H]

Identifier: 121638219

GI number: 121638219

Start: 2582203

End: 2583849

Strand: Direct

Name: mez [H]

Synonym: BCG_2354

Alternate gene names: 121638219

Gene position: 2582203-2583849 (Clockwise)

Preceding gene: 121638218

Following gene: 121638221

Centisome position: 59.03

GC content: 63.45

Gene sequence:

>1647_bases
ATGAGCGACGCCCGCGTGCCACGGATCCCGGCCGCGTTGTCCGCACCAAGTCTCAACCGTGGAGTCGGCTTCACCCACGC
GCAGCGGCGGCGGCTGGGGCTGACCGGCCGGCTTCCGTCGGCCGTGCTCACGCTCGACCAACAGGCCGAACGCGTATGGC
ATCAGTTGCAGAGCTTGGCCACCGATCTGGGCCGCAACCTGCTTCTCGAACAGCTGCACTACCGCCACGAGGTGCTGTAC
TTCAAGGTGCTGGCCGACCATTTGCCCGAACTGATGCCGGTGGTGTACACGCCCACCGTTGGCGAGGCAATCCAACGCTT
CTCCGACGAATACCGCGGGCAACGCGGACTGTTTCTGAGCATCGACGAACCCGACGAAATCGAGGAAGCCTTCAACACGT
TGGGGCTGGGGCCCGAGGACGTCGACCTGATCGTGTGCACCGATGCCGAGGCGATCCTGGGTATCGGTGACTGGGGTGTG
GGTGGCATCCAGATCGCTGTGGGCAAATTGGCCCTCTACACCGCCGGCGGCGGCGTCGATCCGCGCCGCTGCCTCGCGGT
GTCTCTGGATGTCGGCACCGACAATGAGCAGCTGCTGGCCGATCCGTTCTATCTGGGCAATCGCCACGCCCGGCGGCGCG
GTCGGGAATACGACGAGTTCGTCAGTCGCTATATCGAAACGGCTCAACGGTTATTTCCGCGTGCCATTCTGCATTTCGAG
GACTTCGGGCCGGCGAACGCGCGGAAGATCCTAGACACATACGGCACGGATTACTGCGTGTTCAACGATGACATGCAAGG
AACCGGCGCGGTGGTCTTGGCCGCCGTATACAGCGGTCTGAAGGTTACCGGTATCCCGCTGCGCGATCAGACAATAGTCG
TCTTCGGCGCAGGCACCGCAGGGATGGGGATCGCCGATCAGATCCGGGACGCGATGGTGGCAGACGGTGCCACGCTCGAG
CAGGCGGTGTCCCAGATCTGGCCGCTCGACAGGCCGGGCCTGTTGTTCGACGACATGGATGACCTGCGCGACTTCCAAGT
GCCGTACGCGAAAAACCGCCACCAGCTCGGTGTGGCCGTCGGGGATCGGGTCGGGCTGAGCGACGCGATCAAGATCGCAT
CGCCCACTATCCTGCTCGGCTGCTCAACGGTCTACGGAGCGTTCACCAAAGAGGTGGTCGAGGCGATGACGGCGTCCTGC
AAACACCCGATGATCTTTCCGCTGTCCAACCCGACGTCGCGCATGGAAGCCATCCCCGCCGACGTGCTGGCGTGGTCGAA
TGGCAGGGCGCTGCTTGCCACCGGCAGCCCAGTCGCCCCAGTGGAATTCGACGAAACCACCTACGTCATCGGTCAGGCCA
ACAACGTGTTGGCGTTTCCCGGCATCGGACTGGGCGTCATTGTCGCTGGTGCCCGGTTGATAACCAGGCGCATGCTGCAT
GCAGCAGCGAAGGCCATTGCGCACCAGGCCAATCCGACAAATCCCGGAGACTCGCTGTTGCCGGATGTCCAAAATCTGCG
GGCCATCTCGACAACGGTCGCCGAAGCTGTCTATCGGGCCGCCGTCCAAGACGGGGTGGCTTCCAGGACGCACGACGACG
TCAGGCAGGCCATAGTCGACACCATGTGGCTCCCGGCATATGACTAA

Upstream 100 bases:

>100_bases
ACCTGGACCTGGCCAAAGCCCAAGTCCGGTCGGCGCTCGCCAACCAGCGTTACCATCGCGACGTCCATTAAACCCAGCAC
GGTCACGAACGGAGGTTGTG

Downstream 100 bases:

>100_bases
CCGCGCACTCGACGGTCATCGCTGTAGGCAGCCTCTCGCTTAGCGTCGCTGCCCGCGGTTTGCACGTCACGCGGAAACCA
TCGCCAGCCGGCGAGAAACA

Product: malate dehydrogenase

Products: NA

Alternate protein names: Malic enzyme [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MSDARVPRIPAALSAPSLNRGVGFTHAQRRRLGLTGRLPSAVLTLDQQAERVWHQLQSLATDLGRNLLLEQLHYRHEVLY
FKVLADHLPELMPVVYTPTVGEAIQRFSDEYRGQRGLFLSIDEPDEIEEAFNTLGLGPEDVDLIVCTDAEAILGIGDWGV
GGIQIAVGKLALYTAGGGVDPRRCLAVSLDVGTDNEQLLADPFYLGNRHARRRGREYDEFVSRYIETAQRLFPRAILHFE
DFGPANARKILDTYGTDYCVFNDDMQGTGAVVLAAVYSGLKVTGIPLRDQTIVVFGAGTAGMGIADQIRDAMVADGATLE
QAVSQIWPLDRPGLLFDDMDDLRDFQVPYAKNRHQLGVAVGDRVGLSDAIKIASPTILLGCSTVYGAFTKEVVEAMTASC
KHPMIFPLSNPTSRMEAIPADVLAWSNGRALLATGSPVAPVEFDETTYVIGQANNVLAFPGIGLGVIVAGARLITRRMLH
AAAKAIAHQANPTNPGDSLLPDVQNLRAISTTVAEAVYRAAVQDGVASRTHDDVRQAIVDTMWLPAYD

Sequences:

>Translated_548_residues
MSDARVPRIPAALSAPSLNRGVGFTHAQRRRLGLTGRLPSAVLTLDQQAERVWHQLQSLATDLGRNLLLEQLHYRHEVLY
FKVLADHLPELMPVVYTPTVGEAIQRFSDEYRGQRGLFLSIDEPDEIEEAFNTLGLGPEDVDLIVCTDAEAILGIGDWGV
GGIQIAVGKLALYTAGGGVDPRRCLAVSLDVGTDNEQLLADPFYLGNRHARRRGREYDEFVSRYIETAQRLFPRAILHFE
DFGPANARKILDTYGTDYCVFNDDMQGTGAVVLAAVYSGLKVTGIPLRDQTIVVFGAGTAGMGIADQIRDAMVADGATLE
QAVSQIWPLDRPGLLFDDMDDLRDFQVPYAKNRHQLGVAVGDRVGLSDAIKIASPTILLGCSTVYGAFTKEVVEAMTASC
KHPMIFPLSNPTSRMEAIPADVLAWSNGRALLATGSPVAPVEFDETTYVIGQANNVLAFPGIGLGVIVAGARLITRRMLH
AAAKAIAHQANPTNPGDSLLPDVQNLRAISTTVAEAVYRAAVQDGVASRTHDDVRQAIVDTMWLPAYD
>Mature_547_residues
SDARVPRIPAALSAPSLNRGVGFTHAQRRRLGLTGRLPSAVLTLDQQAERVWHQLQSLATDLGRNLLLEQLHYRHEVLYF
KVLADHLPELMPVVYTPTVGEAIQRFSDEYRGQRGLFLSIDEPDEIEEAFNTLGLGPEDVDLIVCTDAEAILGIGDWGVG
GIQIAVGKLALYTAGGGVDPRRCLAVSLDVGTDNEQLLADPFYLGNRHARRRGREYDEFVSRYIETAQRLFPRAILHFED
FGPANARKILDTYGTDYCVFNDDMQGTGAVVLAAVYSGLKVTGIPLRDQTIVVFGAGTAGMGIADQIRDAMVADGATLEQ
AVSQIWPLDRPGLLFDDMDDLRDFQVPYAKNRHQLGVAVGDRVGLSDAIKIASPTILLGCSTVYGAFTKEVVEAMTASCK
HPMIFPLSNPTSRMEAIPADVLAWSNGRALLATGSPVAPVEFDETTYVIGQANNVLAFPGIGLGVIVAGARLITRRMLHA
AAKAIAHQANPTNPGDSLLPDVQNLRAISTTVAEAVYRAAVQDGVASRTHDDVRQAIVDTMWLPAYD

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=517, Percent_Identity=38.8781431334623, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI62420882, Length=539, Percent_Identity=35.8070500927644, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI62420880, Length=539, Percent_Identity=35.8070500927644, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI239049447, Length=539, Percent_Identity=35.8070500927644, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI4505145, Length=540, Percent_Identity=36.2962962962963, Blast_Score=335, Evalue=9e-92,
Organism=Homo sapiens, GI270265879, Length=450, Percent_Identity=38.6666666666667, Blast_Score=310, Evalue=3e-84,
Organism=Escherichia coli, GI87081919, Length=542, Percent_Identity=41.1439114391144, Blast_Score=418, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17537199, Length=543, Percent_Identity=38.4898710865562, Blast_Score=352, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6322823, Length=557, Percent_Identity=42.7289048473968, Blast_Score=443, Evalue=1e-125,
Organism=Drosophila melanogaster, GI21356279, Length=518, Percent_Identity=38.8030888030888, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI281362674, Length=518, Percent_Identity=38.8030888030888, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI281362672, Length=518, Percent_Identity=38.8030888030888, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24646386, Length=515, Percent_Identity=37.0873786407767, Blast_Score=352, Evalue=4e-97,
Organism=Drosophila melanogaster, GI24646388, Length=515, Percent_Identity=37.0873786407767, Blast_Score=352, Evalue=4e-97,
Organism=Drosophila melanogaster, GI78707232, Length=517, Percent_Identity=34.0425531914894, Blast_Score=316, Evalue=3e-86,
Organism=Drosophila melanogaster, GI281363505, Length=534, Percent_Identity=32.9588014981273, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI78707236, Length=534, Percent_Identity=32.9588014981273, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI281363503, Length=532, Percent_Identity=32.8947368421053, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI78707242, Length=545, Percent_Identity=32.1100917431193, Blast_Score=299, Evalue=4e-81,
Organism=Drosophila melanogaster, GI78707238, Length=545, Percent_Identity=32.1100917431193, Blast_Score=299, Evalue=4e-81,
Organism=Drosophila melanogaster, GI78707240, Length=527, Percent_Identity=32.258064516129, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI19922384, Length=539, Percent_Identity=26.9016697588126, Blast_Score=217, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 59409; Mature: 59278

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDARVPRIPAALSAPSLNRGVGFTHAQRRRLGLTGRLPSAVLTLDQQAERVWHQLQSLA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TDLGRNLLLEQLHYRHEVLYFKVLADHLPELMPVVYTPTVGEAIQRFSDEYRGQRGLFLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHCCCCCEEEE
IDEPDEIEEAFNTLGLGPEDVDLIVCTDAEAILGIGDWGVGGIQIAVGKLALYTAGGGVD
CCCCHHHHHHHHHCCCCCCCCEEEEEECCCCEEECCCCCCCCEEEEEEEEEEEECCCCCC
PRRCLAVSLDVGTDNEQLLADPFYLGNRHARRRGREYDEFVSRYIETAQRLFPRAILHFE
CCCEEEEEEECCCCCCHHEECCHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DFGPANARKILDTYGTDYCVFNDDMQGTGAVVLAAVYSGLKVTGIPLRDQTIVVFGAGTA
CCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEECCCC
GMGIADQIRDAMVADGATLEQAVSQIWPLDRPGLLFDDMDDLRDFQVPYAKNRHQLGVAV
CCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEE
GDRVGLSDAIKIASPTILLGCSTVYGAFTKEVVEAMTASCKHPMIFPLSNPTSRMEAIPA
CCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCH
DVLAWSNGRALLATGSPVAPVEFDETTYVIGQANNVLAFPGIGLGVIVAGARLITRRMLH
HHEEECCCCEEEECCCCCCCEEECCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHH
AAAKAIAHQANPTNPGDSLLPDVQNLRAISTTVAEAVYRAAVQDGVASRTHDDVRQAIVD
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TMWLPAYD
HHCCCCCC
>Mature Secondary Structure 
SDARVPRIPAALSAPSLNRGVGFTHAQRRRLGLTGRLPSAVLTLDQQAERVWHQLQSLA
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TDLGRNLLLEQLHYRHEVLYFKVLADHLPELMPVVYTPTVGEAIQRFSDEYRGQRGLFLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHCCCCCEEEE
IDEPDEIEEAFNTLGLGPEDVDLIVCTDAEAILGIGDWGVGGIQIAVGKLALYTAGGGVD
CCCCHHHHHHHHHCCCCCCCCEEEEEECCCCEEECCCCCCCCEEEEEEEEEEEECCCCCC
PRRCLAVSLDVGTDNEQLLADPFYLGNRHARRRGREYDEFVSRYIETAQRLFPRAILHFE
CCCEEEEEEECCCCCCHHEECCHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DFGPANARKILDTYGTDYCVFNDDMQGTGAVVLAAVYSGLKVTGIPLRDQTIVVFGAGTA
CCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEEECCCC
GMGIADQIRDAMVADGATLEQAVSQIWPLDRPGLLFDDMDDLRDFQVPYAKNRHQLGVAV
CCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEEE
GDRVGLSDAIKIASPTILLGCSTVYGAFTKEVVEAMTASCKHPMIFPLSNPTSRMEAIPA
CCCCCCHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHCCH
DVLAWSNGRALLATGSPVAPVEFDETTYVIGQANNVLAFPGIGLGVIVAGARLITRRMLH
HHEEECCCCEEEECCCCCCCEEECCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHH
AAAKAIAHQANPTNPGDSLLPDVQNLRAISTTVAEAVYRAAVQDGVASRTHDDVRQAIVD
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TMWLPAYD
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]