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The map label for this gene is lipH [H]

Identifier: 121637329

GI number: 121637329

Start: 1599638

End: 1600597

Strand: Reverse

Name: lipH [H]

Synonym: BCG_1460c

Alternate gene names: 121637329

Gene position: 1600597-1599638 (Counterclockwise)

Preceding gene: 121637330

Following gene: 121637328

Centisome position: 36.59

GC content: 67.92

Gene sequence:

>960_bases
ATGACAGAGCCGACCGTCGCCCGGCCTGATATCGATCCCGTGCTGAAGATGCTGCTCGATACCTTTCCGGTGACCTTCAC
CGCGGCCGACGGTGTCGAAGTCGCCCGCGCGCGGCTCCGCCAGCTGAAGACACCCGCGGAGTTGCTGCCGGAGCTACGGA
TCGAGGAACGGACCGTTGGCTACGACGGGCTCACCGACATTCCGGTCCGCGTCTACTGGCCGCCGGTCGTTCGCGACAAC
CTGCCCGTGGTTGTCTACTACCACGGTGGCGGCTGGTCGCTCGGCGGTCTGGACACCCACGACCCCGTCGCCCGCGCCCA
CGCCGTCGGCGCGCAGGCCATCGTGGTGTCCGTCGACTACCGGCTTGCCCCGGAACATCCCTACCCGGCCGGGATCGACG
ACAGCTGGGCGGCATTGCGCTGGGTCGGCGAAAACGCCGCCGAACTGGGCGGTGACCCGAGCCGGATCGCCGTGGCCGGT
GACTCTGCGGGCGGCAACATCTCGGCGGTCATGGCGCAGTTGGCCCGGGATGTCGGCGGACCGCCGCTGGTGTTCCAGCT
GCTGTGGTACCCGACGACCATGGCCGACCTGTCGCTGCCGTCTTTCACCGAAAATGCCGATGCGCCAATCCTGGACCGTG
ACGTCATCGACGCGTTCCTGGCCTGGTATGTGCCGGGGCTGGACATCAGTGATCACACGATGCTGCCCACGACACTGGCC
CCGGGAAACGCTGACCTGTCCGGCCTGCCTCCCGCCTTCATCGGCACCGCCGAGCATGATCCGCTGCGCGACGACGGTGC
TTGCTACGCCGAATTGCTCACGGCCGCAGGGGTTTCCGTAGAGCTAAGCAACGAGCCCACCATGGTGCACGGCTACGTCA
ACTTCGCCCTGGTGGTGCCCGCCGCGGCCGAAGCCACCGGCCGCGGCTTGGCGGCGCTGAAGAGGGCGTTGCACGCATAA

Upstream 100 bases:

>100_bases
TGCCGGTGTGGTGCCCGCCGCCACCGAGGCCACCAACCGTGGGCTGGTGGCGCTACGGGTTGTGCTACACGGATAGGCCT
GGCGGTCGTACGGTAGGCCC

Downstream 100 bases:

>100_bases
CGTCGGCGGCATGCCCGGTCGGCTGAATCGCCGCCCGCCGCGGTGCCGCCCGGGCCGCACATTGTGATGTATGATATGGT
GTATGAAGCGGACCAACATC

Product: putative lipase lipH

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MTEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTPAELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDN
LPVVVYYHGGGWSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAG
DSAGGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPTTLA
PGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA

Sequences:

>Translated_319_residues
MTEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTPAELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDN
LPVVVYYHGGGWSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAG
DSAGGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPTTLA
PGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA
>Mature_318_residues
TEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTPAELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDNL
PVVVYYHGGGWSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAGD
SAGGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPTTLAP
GNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI206597554, Length=304, Percent_Identity=31.25, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI68051721, Length=300, Percent_Identity=32, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI68299767, Length=302, Percent_Identity=30.4635761589404, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI226423947, Length=308, Percent_Identity=31.1688311688312, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI226423952, Length=244, Percent_Identity=31.1475409836066, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI226423950, Length=244, Percent_Identity=31.1475409836066, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI157041239, Length=282, Percent_Identity=27.3049645390071, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI61966717, Length=327, Percent_Identity=25.9938837920489, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI21328446, Length=152, Percent_Identity=32.2368421052632, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI68508957, Length=103, Percent_Identity=36.8932038834951, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI68508967, Length=103, Percent_Identity=36.8932038834951, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI68508965, Length=103, Percent_Identity=36.8932038834951, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1786682, Length=248, Percent_Identity=30.241935483871, Blast_Score=95, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI72001146, Length=140, Percent_Identity=35.7142857142857, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996133, Length=140, Percent_Identity=39.2857142857143, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17540028, Length=195, Percent_Identity=30.2564102564103, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17567059, Length=160, Percent_Identity=33.75, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115533410, Length=144, Percent_Identity=29.8611111111111, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533412, Length=144, Percent_Identity=29.8611111111111, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656084, Length=86, Percent_Identity=37.2093023255814, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24656076, Length=86, Percent_Identity=37.2093023255814, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20130169, Length=86, Percent_Identity=37.2093023255814, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 33881; Mature: 33750

Theoretical pI: Translated: 4.32; Mature: 4.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTPAELLPELRIEERTVG
CCCCCCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCHHHHHHCCCHHHCCC
YDGLTDIPVRVYWPPVVRDNLPVVVYYHGGGWSLGGLDTHDPVARAHAVGAQAIVVSVDY
CCCCCCCCEEEEECCHHCCCCCEEEEEECCCEECCCCCCCCHHHHHHHCCCEEEEEEEEE
RLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGG
EECCCCCCCCCCCCCCHHEEEECCCHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCC
PPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPTTLA
CHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCEEEC
PGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALVVP
CCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEEEEEC
AAAEATGRGLAALKRALHA
CCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TEPTVARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTPAELLPELRIEERTVG
CCCCCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCHHHHHHCCCHHHCCC
YDGLTDIPVRVYWPPVVRDNLPVVVYYHGGGWSLGGLDTHDPVARAHAVGAQAIVVSVDY
CCCCCCCCEEEEECCHHCCCCCEEEEEECCCEECCCCCCCCHHHHHHHCCCEEEEEEEEE
RLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGG
EECCCCCCCCCCCCCCHHEEEECCCHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCC
PPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPTTLA
CHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCEEEC
PGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALVVP
CCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEEEEEC
AAAEATGRGLAALKRALHA
CCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]