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The map label for this gene is gnd2 [H]

Identifier: 121637054

GI number: 121637054

Start: 1276544

End: 1277566

Strand: Direct

Name: gnd2 [H]

Synonym: BCG_1183

Alternate gene names: 121637054

Gene position: 1276544-1277566 (Clockwise)

Preceding gene: 121637053

Following gene: 121637056

Centisome position: 29.18

GC content: 65.69

Gene sequence:

>1023_bases
ATGCAACTAGGAATGATCGGTCTGGGCCGGATGGGTGCGAATATCGTCCGCCGCTTGGCCAAAGGTGGACACGACTGCGT
GGTCTACGACCACGACCCCGACGCGGTCAAGGCGATGGCCGGGGAGGACCGGACCACCGGGGTGGCCTCGTTGCGTGAGT
TGTCTCAGCGGCTCTCCGCCCCGCGAGTTGTCTGGGTGATGGTGCCCGCGGGGAACATCACCACCGCGGTGATCGAAGAG
CTGGCCAACACGCTCGAGGCCGGCGACATTGTGATCGACGGTGGCAACACCTATTATCGCGACGATCTGCGGCACGAAAA
GCTGTTGTTCAAGAAGGGAATTCACCTACTCGACTGTGGCACCAGCGGCGGTGTGTGGGGTCGGGAACGTGGCTACTGCC
TGATGATCGGCGGGGATGGCGACGCGTTCGCGCGCGCGGAGCCGATCTTCGCCACCGTCGCGCCGGGGGTGGCGGCCGCC
CCGCGCACCCCGGGCCGAGACGGTGAGGTCGCGCCATCGGAACAAGGCTATTTGCATTGTGGGCCTTGCGGTTCGGGTCA
CTTCGTGAAGATGGTCCACAACGGCATCGAATACGGGATGATGGCCTCCTTGGCGGAGGGATTGAACATCCTGCGCAATG
CCGACGTCGGCACCCGCGTGCAACACGGTGACGCCGAAACCGCGCCGCTGCCGAATCCCGAGTGCTACCAGTACGACTTC
GACATCCCGGAGGTCGCCGAGGTATGGCGGCGGGGCAGCGTGATCGGCTCCTGGCTGCTGGATTTGACCGCGATCGCGCT
GCGCGAATCACCTGACCTAGCGGAATTCTCCGGACGGGTCTCCGACTCTGGCGAGGGCCGGTGGACCGCCATCGCGGCGA
TCGACGAGGGCGTGCCCGCGCCGGTGCTGACCACCGCGCTGCAGTCCCGCTTCGCCTCGCGTGACCTCGACGACTTCGCC
AACAAGGCGCTGTCGGCGATGCGCAAGCAGTTCGGCGGACACGCCGAGAAACCGGCTAACTAA

Upstream 100 bases:

>100_bases
TCCGGAAGCCGCGCAGTCGTTGCTGCGCGGTCACCGCGGTTGGCAGTCGCCGTGGCTGCCCCGCGGCACGGACGCATGAG
TTCAAGGAGACGAAAAGGCG

Downstream 100 bases:

>100_bases
GTCGCCTGACGAAGTCCACCACGACGTCGGTGAACGCGTCGTTGTCGTCGCCGGCGGCGGTGCGCCCCGCGTTGGACAAT
TCGACGAACTCCGCGTTGGG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEE
LANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAA
PRTPGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDF
DIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPAPVLTTALQSRFASRDLDDFA
NKALSAMRKQFGGHAEKPAN

Sequences:

>Translated_340_residues
MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEE
LANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAA
PRTPGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDF
DIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPAPVLTTALQSRFASRDLDDFA
NKALSAMRKQFGGHAEKPAN
>Mature_340_residues
MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEE
LANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAA
PRTPGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDF
DIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPAPVLTTALQSRFASRDLDDFA
NKALSAMRKQFGGHAEKPAN

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=343, Percent_Identity=31.4868804664723, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1788341, Length=337, Percent_Identity=29.3768545994065, Blast_Score=144, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17542558, Length=325, Percent_Identity=31.6923076923077, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321695, Length=325, Percent_Identity=31.3846153846154, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6321977, Length=320, Percent_Identity=31.875, Blast_Score=124, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24639279, Length=319, Percent_Identity=30.7210031347962, Blast_Score=117, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 36359; Mature: 36359

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSA
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHCC
PRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCG
CEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHHHCCCEEEECC
TSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPSEQGYLHC
CCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
GPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDF
CCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEECC
DIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCH
PVLTTALQSRFASRDLDDFANKALSAMRKQFGGHAEKPAN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSA
CCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCHHHHHHHHHHHHHHCC
PRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCG
CEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHHHCCCEEEECC
TSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPSEQGYLHC
CCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
GPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDF
CCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEECC
DIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCH
PVLTTALQSRFASRDLDDFANKALSAMRKQFGGHAEKPAN
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]