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The map label for this gene is zwf1

Identifier: 121637053

GI number: 121637053

Start: 1275122

End: 1276522

Strand: Direct

Name: zwf1

Synonym: BCG_1182

Alternate gene names: 121637053

Gene position: 1275122-1276522 (Clockwise)

Preceding gene: 121637049

Following gene: 121637054

Centisome position: 29.15

GC content: 63.81

Gene sequence:

>1401_bases
TTGGTTGACGGCGGAGGTGGCGCGTCAGATCTGTTGGTGATCTTCGGAATTACCGGTGACCTGGCCCGCAAGATGACCTT
CCGCGCGTTGTATCGGCTCGAGCGCCACCAGTTGCTGGACTGCCCCATCCTGGGTGTGGCCAGTGACGACATGTCCGTCG
GGCAGTTGGTCAAGTGGGCTCGCGAGTCCATCGGTCGTACCGAAAAGATCGACGATGCGGTGTTCGACCGGTTGGCGGGC
CGGTTGTCCTACCTGCACGGTGACGTCACCGACAGCCAGCTCTACGATTCGCTGGCCGAACTGATTGGCTCGGCCTGTCG
GCCGCTGTATTACCTGGAAATGCCGCCGGCGCTGTTCGCGCCGATTGTCGAAAATCTCGCGAACGTGCGGCTGTTGGAGC
GCGCACGCGTTGCCGTGGAAAAGCCGTTCGGCCACGACCTGGCCTCCGCGCTCGAACTCAACGCCCGGCTGCGAGCGGTG
TTGGGCGAAGACCAAATCCTGCGTGTGGACCACTTTCTGGGCAAGCAGCCCGTCGTCGAGCTGGAGTACCTGAGGTTCGC
CAATCAGGCGTTAGCCGAGCTCTGGGATCGCAACAGCATCTCCGAGATCCACATCACCATGGCCGAGGACTTCGGGGTGG
AGGACCGCGGCAAGTTTTACGACGCCGTCGGTGCCCTGCGTGACGTGGTGCAAAACCATCTGCTGCAGGTGCTGGCGCTG
GTGACGATGGAACCGCCGGTCGGTTCCAGCGCCGATGACCTCAACGACAAGAAGGCCGAGGTCTTCCGGGCGATGGCGCC
GCTGGATCCCGATCGGTGCGTGCGTGGGCAGTACCTCGGCTACACCGAAGTTGCGGGCGTAGCAAGCGATTCGGCGACCG
AAACGTATGTCGCGCTGCGAACCGAGATCGACAACTGGCGCTGGGCCGGGGTGCCGATCTTCGTGCGGGCCGGAAAAGAG
CTGCCCGCGAAGGTCACCGAAGTACGGCTATTTCTACGCCGAGTTCCGGCATTGGCCTTTCTGCCCAACCGCCGACCGGC
CGAGCCCAACCAGATTGTGCTGCGTATCGACCCCGATCCGGGTATGCGACTGCAGATTTCGGCCCACACCGACGACTCGT
GGCGAGATATCCACCTGGACTCCTCGTTCGCGGTGGACCTCGGTGAACCGATACGACCCTATGAGCGGCTGCTGTATGCC
GGATTGGTCGGCGATCACCAGTTGTTCGCCCGCGAGGACAGCATCGAGCAGACGTGGCGGATCGTGCAGCCGCTGCTCGA
CAACCCGGGTGAAATCCATCGGTACGATCGCGGTTCCTGGGGTCCGGAAGCCGCGCAGTCGTTGCTGCGCGGTCACCGCG
GTTGGCAGTCGCCGTGGCTGCCCCGCGGCACGGACGCATGA

Upstream 100 bases:

>100_bases
CGGCCAGGATGTAGACCGCGATCTGCAGCGTCGGGTTGTCGGGCCAATGGGCTAGGGTTGAGTTCGGCCGCCGCGGGAAA
GCAAGTCTGGAGGTGCGGGT

Downstream 100 bases:

>100_bases
GTTCAAGGAGACGAAAAGGCGATGCAACTAGGAATGATCGGTCTGGGCCGGATGGGTGCGAATATCGTCCGCCGCTTGGC
CAAAGGTGGACACGACTGCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWARESIGRTEKIDDAVFDRLAG
RLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFAPIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAV
LGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLAL
VTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRAGKE
LPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYA
GLVGDHQLFAREDSIEQTWRIVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA

Sequences:

>Translated_466_residues
MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWARESIGRTEKIDDAVFDRLAG
RLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFAPIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAV
LGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLAL
VTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRAGKE
LPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYA
GLVGDHQLFAREDSIEQTWRIVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA
>Mature_466_residues
MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWARESIGRTEKIDDAVFDRLAG
RLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFAPIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAV
LGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLAL
VTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRAGKE
LPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYA
GLVGDHQLFAREDSIEQTWRIVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI109389365, Length=487, Percent_Identity=31.8275154004107, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI108773793, Length=487, Percent_Identity=31.8275154004107, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI52145310, Length=347, Percent_Identity=32.8530259365994, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1788158, Length=478, Percent_Identity=35.1464435146443, Blast_Score=290, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17538218, Length=494, Percent_Identity=32.7935222672065, Blast_Score=254, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=34.8547717842324, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24643352, Length=472, Percent_Identity=33.6864406779661, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24643350, Length=472, Percent_Identity=33.6864406779661, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI221513548, Length=465, Percent_Identity=27.0967741935484, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PD2_MYCBO (P0A587)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854808.1
- ProteinModelPortal:   P0A587
- SMR:   P0A587
- EnsemblBacteria:   EBMYCT00000016348
- GeneID:   1090448
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1152
- GeneTree:   EBGT00050000015853
- HOGENOM:   HBG322449
- OMA:   TGDLAFK
- ProtClustDB:   PRK12853
- BioCyc:   MBOV233413:MB1152-MONOMER
- BRENDA:   1.1.1.49
- GO:   GO:0005488
- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR23429
- PIRSF:   PIRSF000110
- PRINTS:   PR00079
- TIGRFAMs:   TIGR00871

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N

EC number: =1.1.1.49

Molecular weight: Translated: 52174; Mature: 52174

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: ACT_SITE 233-233 BINDING 18-18 BINDING 48-48 BINDING 171-171 BINDING 175-175 BINDING 324-324

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWA
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHH
RESIGRTEKIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFA
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHH
PIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAVLGEDQILRVDHFLGKQPVVE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCHH
LEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLAL
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALR
HHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEE
TEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDP
EECCCEEECCCEEEEECCCCCCHHHHHHHHHHHHCCHHEECCCCCCCCCCEEEEEECCCC
GMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYAGLVGDHQLFAREDSIEQTWR
CCEEEEEECCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHCHHHHHHHHH
IVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA
HHHHHHCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWA
CCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHH
RESIGRTEKIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFA
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHH
PIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAVLGEDQILRVDHFLGKQPVVE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHCCCCCCHH
LEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLAL
HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALR
HHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHCCCCCCCCCEEEEEE
TEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDP
EECCCEEECCCEEEEECCCCCCHHHHHHHHHHHHCCHHEECCCCCCCCCCEEEEEECCCC
GMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYAGLVGDHQLFAREDSIEQTWR
CCEEEEEECCCCCCEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCHHHHCHHHHHHHHH
IVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA
HHHHHHCCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972