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The map label for this gene is moeA1 [H]

Identifier: 121636921

GI number: 121636921

Start: 1140758

End: 1142038

Strand: Direct

Name: moeA1 [H]

Synonym: BCG_1049

Alternate gene names: 121636921

Gene position: 1140758-1142038 (Clockwise)

Preceding gene: 121636920

Following gene: 121636922

Centisome position: 26.08

GC content: 68.23

Gene sequence:

>1281_bases
GTGCGTTCTGTGGAGGAGCAGCAGGCTCGGATATCGGCCGCTGCGGTAGCCCCGAGGCCGATACGCGTTGCGATCGCCGA
GGCGCAGGGATTGATGTGCGCCGAAGAAGTGGTCACCGAACGTCCAATGCCCGGTTTTGATCAGGCCGCCATCGACGGCT
ACGCGGTGCGCAGTGTCGATGTGGCCGGTGTCGGTGATACCGGTGGTGTCCAAGTCTTTGCCGACCACGGCGATCTTGAC
GGTCGCGACGTGCTGACCCTACCGGTGATGGGAACCATCGAAGCCGGAGCGCGCACCCTGAGCAGGTTGCAGCCTCGCCA
AGCGGTCCGGGTGCAGACCGGCGCGCCGCTTCCCACCCTGGCCGATGCGGTCCTGCCGTTGCGGTGGACCGATGGCGGAA
TGTCTCGGGTGCGGGTGCTGCGCGGGGCGCCGTCGGGCGCCTACGTGCGGCGTGCGGGCGACGACGTGCAGCCCGGTGAT
GTGGCGGTGCGCGCGGGGACGATCATCGGCGCAGCCCAGGTGGGGTTGCTGGCGGCGGTCGGCCGTGAACGGGTGCTGGT
GCACCCTCGTCCGCGGCTGTCGGTGATGGCCGTCGGGGGCGAGTTGGTCGACATCTCGCGGACCCCGGGCAACGGGCAGG
TTTATGACGTCAACTCCTATGCCTTGGCTGCGGCGGGCCGGGATGCCGGTGCGGAGGTGAACCGGGTTGGCATCGTCAGC
AACGACCCTACGGAACTTGGCGAAATCGTCGAGGGCCAGCTCAATCGGGCTGAGGTCGTGGTGATCGCCGGCGGGGTGGG
CGGTGCGGCGGCAGAAGCGGTCAGGTCGGTGCTTTCCGAGCTCGGTGAGATGGAGGTCGTGCGGGTCGCCATGCATCCGG
GATCCGTGCAGGGCTTCGGACAGCTCGGCCGTGATGGTGTACCGACCTTTCTGCTGCCGGCCAACCCGGTCAGCGCCCTG
GTGGTCTTCGAGGTGATGGTTCGGCCGCTGATCCGGCTGTCGCTGGGTAAACGGCATCCGATGCGACGGATCGTGTCGGC
GCGCACGCTGTCGCCGATCACGTCGGTGGCCGGGCGCAAGGGCTACCTGCGTGGCCAGTTGATGCGTGATCAGGACAGCG
GCGAGTACCTGGTGCAGGCGCTGGGCGGCGCTCCGGGGGCGTCATCGCACCTGCTCGCGACGCTTGCCGAAGCGAACTGT
CTGGTTGTGGTTCCCACCGGGGCCGAGCAGATTCGCACGGGTGAGATCGTGGATGTCGCCTTCCTGGCTCAGCACGGCTG
A

Upstream 100 bases:

>100_bases
CGACTGGGTCTGACAGAGCAGTAGCCTGGCGACGATACGGCACGGACGGTTCCGGGGTGGGGGATGCCCGGCCCCATGGC
TCGACGGAAAGGCGGGCGCT

Downstream 100 bases:

>100_bases
GCCGAACCACGGCGACTCTGGTGAACTTATGGCGCTCGAATCCCCGGCATCCGGGATGGCCGATGGCCGTCGGGCCGCTG
CGGGTCTCGGCAGGCGTGAT

Product: putative molybdopterin biosynthesis protein moeA1

Products: NA

Alternate protein names: MPT Mo-transferase 1 [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLD
GRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGD
VAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVS
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSAL
VVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANC
LVVVPTGAEQIRTGEIVDVAFLAQHG

Sequences:

>Translated_426_residues
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLD
GRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGD
VAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVS
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSAL
VVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANC
LVVVPTGAEQIRTGEIVDVAFLAQHG
>Mature_426_residues
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLD
GRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGD
VAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVS
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSAL
VVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANC
LVVVPTGAEQIRTGEIVDVAFLAQHG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=411, Percent_Identity=31.3868613138686, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI66932975, Length=411, Percent_Identity=31.3868613138686, Blast_Score=149, Evalue=5e-36,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=31.8537859007833, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI25147659, Length=364, Percent_Identity=28.2967032967033, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136978, Length=303, Percent_Identity=27.3927392739274, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24638841, Length=303, Percent_Identity=27.3927392739274, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44291; Mature: 44291

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVD
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHCCCEEEEEEE
VAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTL
EECCCCCCCEEEEEECCCCCCCEEEEECCEECHHHHHHHHHHCCCCCEEEEECCCCCCHH
ADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAV
HHHEEEEEECCCCHHHHHEEECCCCCCEEECCCCCCCCCCEEEEECEEECHHHHHHHHHC
GRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVS
CCCEEEECCCCCEEEEEECCEEEEEEECCCCCEEEEECCEEEEECCCCCCCCCEEEEEEC
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFG
CCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHH
QLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRK
HCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCC
GYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPTGAEQIRTGEIVDVA
CCEECEEECCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCHHHHCCCCEEEEE
FLAQHG
EEECCC
>Mature Secondary Structure
MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVD
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHHCCCEEEEEEE
VAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTL
EECCCCCCCEEEEEECCCCCCCEEEEECCEECHHHHHHHHHHCCCCCEEEEECCCCCCHH
ADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAV
HHHEEEEEECCCCHHHHHEEECCCCCCEEECCCCCCCCCCEEEEECEEECHHHHHHHHHC
GRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVS
CCCEEEECCCCCEEEEEECCEEEEEEECCCCCEEEEECCEEEEECCCCCCCCCEEEEEEC
NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFG
CCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHH
QLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRK
HCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCC
GYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPTGAEQIRTGEIVDVA
CCEECEEECCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEEECCHHHHCCCCEEEEE
FLAQHG
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]