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The map label for this gene is echA7 [C]

Identifier: 121636897

GI number: 121636897

Start: 1112251

End: 1113060

Strand: Reverse

Name: echA7 [C]

Synonym: BCG_1025c

Alternate gene names: 121636897

Gene position: 1113060-1112251 (Counterclockwise)

Preceding gene: 121636898

Following gene: 121636892

Centisome position: 25.44

GC content: 71.48

Gene sequence:

>810_bases
ATGGACAGCCCCGTCGACTACGCTGGCCCGGCCGCCTGCGGCGGCCCCTTCGCCAGGCTGACACTGAACTCTCCGCACAA
CCGCAACGCGCTGTCGAGCACGCTGGTCAGCCAACTACATCAAGGGCTGAGTGCGGCCGAAGCAGATCCGGCGGTGCGGC
TGGTCGTGCTGGGGCATACCGGCGGAACGTTCTGCGCCGGCGCGGACCTCAGCGAGGCCGGCGGTGGTGGTGGTGATCCG
TACCGGATGGCGGTGGCGCGGGCGCGGGAAATGACGGCGCTGTTGCGCGCCATCGTCGAGTCGCCGCTGCCGGTGGTCGG
CGCCATCAACGGGCATGTGCGGGCCGGCGGGTTCGGCCTGGTCGGTGCGTGCGACATGGTGGTCGCCGGACCGGAAAGCA
CGTTCGCGCTGACCGAGGCACGGATCGGGGTGGCACCGGCGATCATCTCGCTGACGCTGCTGCCCAAGCTTTCGCCGCGC
GCCGCGGCCCGCTATTACCTGACCGGCGAGAAGTTCGGCGCCCGCGAAGCCGCCGACATCGGACTGATCACCATGGCGGC
CGACGACGTGGACGCCGCGGTGGCCGCGCTGGTCGCCGACGTGGGCCGCGGCTCGCCACAAGGCCTGGCCGCGTCGAAGG
CGCTGACCACGGCCGCCGTGCTCGAAGGGTTCGACCGCGACGCCGAACGCCTGACCGAGGAGTCGGCCAGGCTGTTCGTC
TCCGACGAAGCGCGCGAAGGGATGCTGGCCTTCCTGCAGAAACGTCCGCCCCGCTGGGTCCAGCCGGCGACGATGCGGGC
CGCTGACTAG

Upstream 100 bases:

>100_bases
TGATGACCTCGGCCCGCTTGGCGCGGATCGCCCCGATCAGCCGCGAGATGGTGCTGAACTTCGTTGCGCAGACATCGCTG
GGTCTGCCCCGGTCCTACTG

Downstream 100 bases:

>100_bases
GCCCGCCGGGCCCCCGCCTACGACGCAGGAGGTTGGGAACAGCCTATTCCGAATTACCTTGCGGTTCGGACACACAGGCG
GCGAACTGCCTCAGACCGGA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDSPVDYAGPAACGGPFARLTLNSPHNRNALSSTLVSQLHQGLSAAEADPAVRLVVLGHTGGTFCAGADLSEAGGGGGDP
YRMAVARAREMTALLRAIVESPLPVVGAINGHVRAGGFGLVGACDMVVAGPESTFALTEARIGVAPAIISLTLLPKLSPR
AAARYYLTGEKFGAREAADIGLITMAADDVDAAVAALVADVGRGSPQGLAASKALTTAAVLEGFDRDAERLTEESARLFV
SDEAREGMLAFLQKRPPRWVQPATMRAAD

Sequences:

>Translated_269_residues
MDSPVDYAGPAACGGPFARLTLNSPHNRNALSSTLVSQLHQGLSAAEADPAVRLVVLGHTGGTFCAGADLSEAGGGGGDP
YRMAVARAREMTALLRAIVESPLPVVGAINGHVRAGGFGLVGACDMVVAGPESTFALTEARIGVAPAIISLTLLPKLSPR
AAARYYLTGEKFGAREAADIGLITMAADDVDAAVAALVADVGRGSPQGLAASKALTTAAVLEGFDRDAERLTEESARLFV
SDEAREGMLAFLQKRPPRWVQPATMRAAD
>Mature_269_residues
MDSPVDYAGPAACGGPFARLTLNSPHNRNALSSTLVSQLHQGLSAAEADPAVRLVVLGHTGGTFCAGADLSEAGGGGGDP
YRMAVARAREMTALLRAIVESPLPVVGAINGHVRAGGFGLVGACDMVVAGPESTFALTEARIGVAPAIISLTLLPKLSPR
AAARYYLTGEKFGAREAADIGLITMAADDVDAAVAALVADVGRGSPQGLAASKALTTAAVLEGFDRDAERLTEESARLFV
SDEAREGMLAFLQKRPPRWVQPATMRAAD

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=250, Percent_Identity=28, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI31542718, Length=258, Percent_Identity=25.1937984496124, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4502327, Length=249, Percent_Identity=28.9156626506024, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI37594471, Length=222, Percent_Identity=28.8288288288288, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI37594469, Length=222, Percent_Identity=28.8288288288288, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI221136756, Length=246, Percent_Identity=26.4227642276423, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI221136753, Length=246, Percent_Identity=26.4227642276423, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI221307494, Length=249, Percent_Identity=26.5060240963855, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI25453481, Length=253, Percent_Identity=23.7154150197628, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI51538573, Length=253, Percent_Identity=23.7154150197628, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI70995211, Length=179, Percent_Identity=27.9329608938547, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=31.5789473684211, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI221142681, Length=260, Percent_Identity=28.8461538461538, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787660, Length=251, Percent_Identity=29.8804780876494, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082183, Length=250, Percent_Identity=24.8, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788597, Length=249, Percent_Identity=26.1044176706827, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=248, Percent_Identity=30.241935483871, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17540306, Length=252, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=255, Percent_Identity=24.3137254901961, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=251, Percent_Identity=27.8884462151394, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=187, Percent_Identity=25.668449197861, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=252, Percent_Identity=24.6031746031746, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=200, Percent_Identity=28, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540714, Length=178, Percent_Identity=26.9662921348315, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19922422, Length=247, Percent_Identity=27.5303643724696, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24653139, Length=250, Percent_Identity=29.6, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI20129971, Length=253, Percent_Identity=28.4584980237154, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24653477, Length=253, Percent_Identity=28.4584980237154, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583165, Length=187, Percent_Identity=31.0160427807487, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921018, Length=191, Percent_Identity=30.3664921465969, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357171, Length=214, Percent_Identity=29.9065420560748, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27605; Mature: 27605

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSPVDYAGPAACGGPFARLTLNSPHNRNALSSTLVSQLHQGLSAAEADPAVRLVVLGHT
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECC
GGTFCAGADLSEAGGGGGDPYRMAVARAREMTALLRAIVESPLPVVGAINGHVRAGGFGL
CCCEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCCE
VGACDMVVAGPESTFALTEARIGVAPAIISLTLLPKLSPRAAARYYLTGEKFGAREAADI
EECCCEEEECCCCCEEEHHHHHCHHHHHHHHHHCCCCCCHHHEEEEEECCCCCCCCCCCC
GLITMAADDVDAAVAALVADVGRGSPQGLAASKALTTAAVLEGFDRDAERLTEESARLFV
EEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEE
SDEAREGMLAFLQKRPPRWVQPATMRAAD
CCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDSPVDYAGPAACGGPFARLTLNSPHNRNALSSTLVSQLHQGLSAAEADPAVRLVVLGHT
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECC
GGTFCAGADLSEAGGGGGDPYRMAVARAREMTALLRAIVESPLPVVGAINGHVRAGGFGL
CCCEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCCE
VGACDMVVAGPESTFALTEARIGVAPAIISLTLLPKLSPRAAARYYLTGEKFGAREAADI
EECCCEEEECCCCCEEEHHHHHCHHHHHHHHHHCCCCCCHHHEEEEEECCCCCCCCCCCC
GLITMAADDVDAAVAALVADVGRGSPQGLAASKALTTAAVLEGFDRDAERLTEESARLFV
EEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEE
SDEAREGMLAFLQKRPPRWVQPATMRAAD
CCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA