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The map label for this gene is uvrD1

Identifier: 121636874

GI number: 121636874

Start: 1088737

End: 1091052

Strand: Direct

Name: uvrD1

Synonym: BCG_1003

Alternate gene names: 121636874

Gene position: 1088737-1091052 (Clockwise)

Preceding gene: 121636870

Following gene: 121636876

Centisome position: 24.89

GC content: 65.2

Gene sequence:

>2316_bases
ATGAGTGTGCACGCGACCGACGCCAAGCCTCCCGGTCCATCCCCAGCGGACCAACTGCTCGACGGCCTCAACCCGCAACA
GCGCCAGGCGGTCGTGCATGAGGGTTCGCCGCTGCTGATCGTCGCGGGCGCGGGTTCGGGTAAGACCGCGGTGTTGACCC
GCCGCATTGCCTATCTGATGGCGGCCCGCGGCGTCGGGGTGGGCCAGATTCTGGCCATCACCTTCACCAACAAAGCCGCC
GCCGAGATGCGCGAACGGGTGGTGGGCCTGGTTGGGGAGAAGGCCCGGTACATGTGGGTGTCGACGTTTCACTCCACCTG
CGTGCGTATCCTGCGCAACCAGGCGGCGCTGATCGAGGGCCTCAACTCCAACTTTTCGATCTATGACGCCGACGATTCGC
GGCGGTTGCTGCAGATGGTGGGCCGCGACCTGGGCCTAGACATCAAGCGGTACTCGCCGCGACTGCTGGCTAACGCCATC
TCCAACCTGAAGAACGAGTTGATCGACCCGCATCAGGCGCTGGCCGGCTTAACGGAGGACTCCGATGACCTAGCGCGCGC
CGTGGCGTCGGTTTATGACGAATACCAGCGGCGGCTGCGGGCGGCCAACGCGCTGGACTTCGACGACCTGATCGGCGAGA
CCGTCGCGGTGCTGCAGGCCTTCCCGCAGATCGCCCAGTACTACCGTCGGAGGTTCCGGCATGTCCTGGTTGACGAATAC
CAGGACACCAACCACGCCCAGTACGTATTGGTGCGCGAGCTGGTCGGCCGCGACAGCAATGACGGTATTCCCCCCGGCGA
GTTGTGCGTCGTCGGGGATGCCGATCAGTCGATCTATGCGTTCCGCGGCGCCACCATCCGCAACATCGAAGACTTCGAAC
GTGACTACCCCGACACCAGAACCATTCTGCTGGAACAGAATTACCGCTCGACGCAGAACATCCTGTCGGCGGCCAACTCG
GTGATTGCCCGTAACGCGGGGCGCCGGGAGAAGCGGTTGTGGACCGACGCCGGCGCCGGGGAGTTGATCGTTGGCTATGT
CGCCGACAACGAGCACGACGAGGCCCGGTTCGTGGCCGAGGAGATCGATGCGCTCGCCGAGGGTAGCGAGATCACCTACA
ACGATGTCGCCGTCTTCTACCGCACCAACAACTCGTCGCGGTCACTGGAAGAGGTGCTGATCCGCGCCGGTATTCCGTAC
AAGGTCGTTGGGGGAGTGCGCTTTTACGAGCGCAAGGAGATTCGCGACATCGTTGCCTACCTGCGCGTGCTGGACAACCC
GGGCGACGCGGTCAGCCTACGGCGCATCCTTAACACCCCGCGCCGCGGTATCGGGGATCGTGCCGAGGCGTGTGTGGCGG
TGTACGCCGAGAACACCGGCGTCGGCTTCGGTGACGCGCTCGTCGCCGCGGCCCAAGGCAAAGTACCGATGCTGAATACC
CGGGCGGAGAAGGCGATCGCGGGTTTCGTCGAGATGTTCGACGAGCTGCGGGGCCGCCTCGATGACGACCTGGGGGAGCT
GGTCGAGGCGGTGCTGGAACGCACCGGATACCGCCGCGAGCTGGAAGCGTCCACCGATCCACAGGAATTGGCCCGCCTGG
ACAACCTCAACGAATTAGTCAGCGTCGCACACGAATTCAGTACCGACCGGGAGAATGCCGCCGCACTTGGCCCAGACGAC
GAAGACGTCCCCGACACCGGTGTGCTGGCGGATTTTCTGGAACGGGTGTCGCTGGTCGCCGACGCCGATGAGATCCCGGA
GCATGGCGCGGGTGTGGTTACCTTGATGACCTTGCACACCGCCAAGGGTTTGGAGTTCCCGGTGGTGTTTGTGACCGGCT
GGGAGGACGGGATGTTCCCGCACATGCGGGCGTTGGACAACCCGACCGAGTTGTCCGAGGAGCGGCGGCTGGCCTATGTC
GGCATCACCCGCGCCCGGCAGCGGTTGTACGTGAGCCGGGCGATCGTGCGTTCGTCTTGGGGCCAGCCGATGCTCAACCC
GGAGTCGCGGTTTCTGCGGGAAATCCCGCAGGAGCTCATCGACTGGCGGCGCACCGCCCCGAAGCCGTCGTTCAGTGCCC
CGGTGAGTGGCGCCGGTCGGTTCGGTAGCGCGCGTCCATCACCGACCCGCTCGGGGGCGAGCAGGCGCCCGCTGCTGGTG
CTTCAGGTCGGCGACCGCGTGACCCATGACAAATACGGCCTGGGCCGTGTCGAGGAGGTCTCCGGTGTCGGCGAATCGGC
GATGTCGCTGATCGACTTCGGTAGCTCGGGGCGGGTGAAGCTGATGCACAACCACGCCCCTGTCACCAAGCTCTGA

Upstream 100 bases:

>100_bases
GGGTGGTGGCGCCGAAGGACCTGCCGCGTGGCGATGAGCCTGGCCAGGCTATGCCGCGGTCCGCCGACTCGTCGCCGCGC
GGCGGTAAGTTTGGACCGAC

Downstream 100 bases:

>100_bases
GATTTCGCGCCGAGCGTGAAGTCACGGCGGCTATTTCGCGGATTTCTCGCCCTGAGAACACGTTCGGCGTCGTTGCCGGG
TCAACCGGTGTAATTGCCGA

Product: putative ATP dependent DNA helicase uvrD1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 771; Mature: 770

Protein sequence:

>771_residues
MSVHATDAKPPGPSPADQLLDGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAA
AEMRERVVGLVGEKARYMWVSTFHSTCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDLGLDIKRYSPRLLANAI
SNLKNELIDPHQALAGLTEDSDDLARAVASVYDEYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVLVDEY
QDTNHAQYVLVRELVGRDSNDGIPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANS
VIARNAGRREKRLWTDAGAGELIVGYVADNEHDEARFVAEEIDALAEGSEITYNDVAVFYRTNNSSRSLEEVLIRAGIPY
KVVGGVRFYERKEIRDIVAYLRVLDNPGDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPMLNT
RAEKAIAGFVEMFDELRGRLDDDLGELVEAVLERTGYRRELEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGPDD
EDVPDTGVLADFLERVSLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRALDNPTELSEERRLAYV
GITRARQRLYVSRAIVRSSWGQPMLNPESRFLREIPQELIDWRRTAPKPSFSAPVSGAGRFGSARPSPTRSGASRRPLLV
LQVGDRVTHDKYGLGRVEEVSGVGESAMSLIDFGSSGRVKLMHNHAPVTKL

Sequences:

>Translated_771_residues
MSVHATDAKPPGPSPADQLLDGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAA
AEMRERVVGLVGEKARYMWVSTFHSTCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDLGLDIKRYSPRLLANAI
SNLKNELIDPHQALAGLTEDSDDLARAVASVYDEYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVLVDEY
QDTNHAQYVLVRELVGRDSNDGIPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANS
VIARNAGRREKRLWTDAGAGELIVGYVADNEHDEARFVAEEIDALAEGSEITYNDVAVFYRTNNSSRSLEEVLIRAGIPY
KVVGGVRFYERKEIRDIVAYLRVLDNPGDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPMLNT
RAEKAIAGFVEMFDELRGRLDDDLGELVEAVLERTGYRRELEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGPDD
EDVPDTGVLADFLERVSLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRALDNPTELSEERRLAYV
GITRARQRLYVSRAIVRSSWGQPMLNPESRFLREIPQELIDWRRTAPKPSFSAPVSGAGRFGSARPSPTRSGASRRPLLV
LQVGDRVTHDKYGLGRVEEVSGVGESAMSLIDFGSSGRVKLMHNHAPVTKL
>Mature_770_residues
SVHATDAKPPGPSPADQLLDGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAAA
EMRERVVGLVGEKARYMWVSTFHSTCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDLGLDIKRYSPRLLANAIS
NLKNELIDPHQALAGLTEDSDDLARAVASVYDEYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVLVDEYQ
DTNHAQYVLVRELVGRDSNDGIPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANSV
IARNAGRREKRLWTDAGAGELIVGYVADNEHDEARFVAEEIDALAEGSEITYNDVAVFYRTNNSSRSLEEVLIRAGIPYK
VVGGVRFYERKEIRDIVAYLRVLDNPGDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPMLNTR
AEKAIAGFVEMFDELRGRLDDDLGELVEAVLERTGYRRELEASTDPQELARLDNLNELVSVAHEFSTDRENAAALGPDDE
DVPDTGVLADFLERVSLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRALDNPTELSEERRLAYVG
ITRARQRLYVSRAIVRSSWGQPMLNPESRFLREIPQELIDWRRTAPKPSFSAPVSGAGRFGSARPSPTRSGASRRPLLVL
QVGDRVTHDKYGLGRVEEVSGVGESAMSLIDFGSSGRVKLMHNHAPVTKL

Specific function: Has Both Atpase And Helicase Activities. Unwinds DNA Duplexes With 3' To 5' Polarity With Respect To The Bound Strand And Initiates Unwinding Most Effectively When A Single-Stranded Region Is Present. Involved In The Post-Incision Events Of Nucleotide Exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain

Homologues:

Organism=Escherichia coli, GI2367296, Length=740, Percent_Identity=40, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI48994965, Length=671, Percent_Identity=38.8971684053651, Blast_Score=384, Evalue=1e-107,
Organism=Escherichia coli, GI1787196, Length=343, Percent_Identity=27.4052478134111, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322369, Length=762, Percent_Identity=29.6587926509186, Blast_Score=239, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6324477, Length=683, Percent_Identity=22.98682284041, Blast_Score=122, Evalue=2e-28,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): PCRA_MYCBO (P0A5A4)

Other databases:

- EMBL:   BX248337
- RefSeq:   NP_854631.1
- ProteinModelPortal:   P0A5A4
- SMR:   P0A5A4
- EnsemblBacteria:   EBMYCT00000014960
- GeneID:   1093055
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb0974
- GeneTree:   EBGT00050000015808
- HOGENOM:   HBG467281
- OMA:   GIKWLIA
- ProtClustDB:   CLSK799345
- BioCyc:   MBOV233413:MB0974-MONOMER
- GO:   GO:0005737
- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016
- Gene3D:   G3DSA:1.10.10.160
- PANTHER:   PTHR11070
- TIGRFAMs:   TIGR01073

Pfam domain/function: PF00580 UvrD-helicase

EC number: =3.6.4.12

Molecular weight: Translated: 85051; Mature: 84920

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS51198 UVRD_HELICASE_ATP_BIND; PS51217 UVRD_HELICASE_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHATDAKPPGPSPADQLLDGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRIAYLM
CCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHH
AARGVGVGQILAITFTNKAAAEMRERVVGLVGEKARYMWVSTFHSTCVRILRNQAALIEG
HHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
LNSNFSIYDADDSRRLLQMVGRDLGLDIKRYSPRLLANAISNLKNELIDPHQALAGLTED
CCCCCEEEECCHHHHHHHHHCHHHCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCCC
SDDLARAVASVYDEYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVLVDEY
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDTNHAQYVLVRELVGRDSNDGIPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDTR
CCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHCCCCCE
TILLEQNYRSTQNILSAANSVIARNAGRREKRLWTDAGAGELIVGYVADNEHDEARFVAE
EEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
EIDALAEGSEITYNDVAVFYRTNNSSRSLEEVLIRAGIPYKVVGGVRFYERKEIRDIVAY
HHHHHHCCCCEEECCEEEEEEECCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHH
LRVLDNPGDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPMLNT
HHHHCCCCCHHHHHHHHCCCCCCCCCHHHHEEEEEECCCCCCCCHHHHHHCCCCCCCCCC
RAEKAIAGFVEMFDELRGRLDDDLGELVEAVLERTGYRRELEASTDPQELARLDNLNELV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHCHHHHH
SVAHEFSTDRENAAALGPDDEDVPDTGVLADFLERVSLVADADEIPEHGAGVVTLMTLHT
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCEEEEEEEHH
AKGLEFPVVFVTGWEDGMFPHMRALDNPTELSEERRLAYVGITRARQRLYVSRAIVRSSW
CCCCCCCEEEEECCCCCCCHHHHHCCCCHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHCC
GQPMLNPESRFLREIPQELIDWRRTAPKPSFSAPVSGAGRFGSARPSPTRSGASRRPLLV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LQVGDRVTHDKYGLGRVEEVSGVGESAMSLIDFGSSGRVKLMHNHAPVTKL
EEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
SVHATDAKPPGPSPADQLLDGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRIAYLM
CCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHH
AARGVGVGQILAITFTNKAAAEMRERVVGLVGEKARYMWVSTFHSTCVRILRNQAALIEG
HHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
LNSNFSIYDADDSRRLLQMVGRDLGLDIKRYSPRLLANAISNLKNELIDPHQALAGLTED
CCCCCEEEECCHHHHHHHHHCHHHCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCCCC
SDDLARAVASVYDEYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVLVDEY
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDTNHAQYVLVRELVGRDSNDGIPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDTR
CCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCHHHHHHCCCCCE
TILLEQNYRSTQNILSAANSVIARNAGRREKRLWTDAGAGELIVGYVADNEHDEARFVAE
EEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHH
EIDALAEGSEITYNDVAVFYRTNNSSRSLEEVLIRAGIPYKVVGGVRFYERKEIRDIVAY
HHHHHHCCCCEEECCEEEEEEECCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHH
LRVLDNPGDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPMLNT
HHHHCCCCCHHHHHHHHCCCCCCCCCHHHHEEEEEECCCCCCCCHHHHHHCCCCCCCCCC
RAEKAIAGFVEMFDELRGRLDDDLGELVEAVLERTGYRRELEASTDPQELARLDNLNELV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHCHHHHH
SVAHEFSTDRENAAALGPDDEDVPDTGVLADFLERVSLVADADEIPEHGAGVVTLMTLHT
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCEEEEEEEHH
AKGLEFPVVFVTGWEDGMFPHMRALDNPTELSEERRLAYVGITRARQRLYVSRAIVRSSW
CCCCCCCEEEEECCCCCCCHHHHHCCCCHHHHHHHCEEEEEHHHHHHHHHHHHHHHHHCC
GQPMLNPESRFLREIPQELIDWRRTAPKPSFSAPVSGAGRFGSARPSPTRSGASRRPLLV
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LQVGDRVTHDKYGLGRVEEVSGVGESAMSLIDFGSSGRVKLMHNHAPVTKL
EEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972