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The map label for this gene is dppA [H]

Identifier: 121611404

GI number: 121611404

Start: 4970760

End: 4972493

Strand: Direct

Name: dppA [H]

Synonym: Veis_4493

Alternate gene names: 121611404

Gene position: 4970760-4972493 (Clockwise)

Preceding gene: 121611403

Following gene: 121611405

Centisome position: 89.29

GC content: 65.92

Gene sequence:

>1734_bases
ATGGGCAAGCGATGCGCCTTGCGCTGCGCTCCGATGGCTGCGCGCAGCCTACGACATCTGATCCGTGACGCGACACCAGG
TCGCACCACGCACCACCGCTGCGCGACGGTTCGCACTCCCCTTCACCCGGAAGAGAAATGCACCATGACAGATTTCCAGT
TCCCGCGCCCCCGGGATGCCGAACTCCAGCGGGCGTTGCAGGACCCGGCCCGACGCCATCTGCTGCTCGGCGCACTGGCT
GCCGGTGCGGGCGCGCTCCTGCCGTGGCAGATGGCCGGCGCGCAGACCGTGGGCAAGTCGACCCTGGCGATCGCCTACCC
GGTGGATGTGCCGACATGGGATCCGAACGCGCTGTCCATTCCCGCCATCCAGAGCCTGTATCAGTCGGTATTCGATTCGC
CGTTGCGCTACTCACCGCAGTTGAAGCTCGAACCGCGCCAGGTCAAGGAGTGGAAGTGGCTTGACAACCAGGCCACCCGT
CTCGCGATCACCCTGCGCGACGACATCCTGTTCCACGACGGCACGCGCATGACGATGGCCGACGTCCGCTACAGCTTGGC
CGAGCGCGCGCAGGCCGACAAAAAGCTGCTGGTCGGCGGCATGCTCAACACCCTCAGCGATATCGAGCTGAGCTCGCCGA
CCAAGGGCGTCATCGTGTTCAACCGGCCGACACCGGCCGCCCCGATCTACCTGGCCTTTCTTGCCGTCTACGTGGTGCCC
AGGGCCTACATGGAGAAGGTGGGAGCCGAGGGCTTCAACGCCAAGCCGATCGGCGCCGGCCCCTACCGGATGGTGGAGCA
CCAGCGCGGCTCGCGCATCGTGCTGGAAGGCTTCGACAAGTACTGGGGCGGCGCGCCCCCGATCAGGCAGGCGGTGTTCC
AGATCGTGCCGGAAGGCTCGGCGCGCGTCGCGCTGGCCGAGTCCGGGCGGGTCGGGATGGCCACGCAACTGCCGATGCGC
GAAGTGCATCGGCTGGCGTCGAAGACCGGCATCGTGACCAAGGCCTATCCCGTCTCGGAGGTCTACATGATCCGGATTCC
CAACTACGTCAAGCCGATGGACAACGATCACGTGCGTGCGGCCATGCACCTGTCCATCGACAAGGCGGCCCTGTCCAAGG
CGTTCTACGACGGCGTCGCCAAGCCGCTGTCGGTCATGGCGCCCGAAGGCACGCCCTCCCATGTGCCCGATTTCCACTTC
CCCCACGACAAGAACAAGGCCATCGATGAACTGAAGGCTGCCGGCTTCAGCCCTGCCAACCCGGTGTCCTTCACGCTGCT
GTCCACCAACGGCGTGTTCCCGAACGACTACGACATGGCGCGCGCCATCTCTGGCATGTGGAAGGCGGTGGGCATCAACG
CCACCATCGAGGAAACCACGCCGGCCAAACTGGTCGAGGCGGCGCAGAACGGCAAGCTCGCGGGCCCGCTCCTCTACAAC
TGGGTCAACAGCACCGGCGACCCGGAGAACTATGCCGGCCGCATCTTCGACCCGCGTCTGCGCTTCTCGACCTGGAAGGA
CATGTCGCTGGCCCCGCGCATCGATGCCCTGATGACCGAAGTCGACGAGGCCAAGCGCATGGCCGGCTACAAGGCCCTCA
ACGTCGAATCATCGCGGCAATCCTGGGCCATCCCGCTGCTGCAGGCCGTCGCCACGGCGGCGTATTCGTCGGCGCTGCAG
CCCACCCTGTTCGACAACGGCTACATCCTGCCGGCTGACATGAAGTACCGCTGA

Upstream 100 bases:

>100_bases
ATGAACGCCGTCCCTAGTGTCGCGTCACCGATCATCTGTCGGTCTGCGCTGGCCATCGAAGCGCATCGCGGCGTTGCATC
GCTTGCCAATACAGCTCGGT

Downstream 100 bases:

>100_bases
ACCGGCCTCGCCCACTGACAGGCCGCGCGCAGGATCCACCACATGTTCCCGCTCATTTCCGCGATCGTCCTGCGCCGGCT
GCTGCTGGCCATCCCGACCC

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MGKRCALRCAPMAARSLRHLIRDATPGRTTHHRCATVRTPLHPEEKCTMTDFQFPRPRDAELQRALQDPARRHLLLGALA
AGAGALLPWQMAGAQTVGKSTLAIAYPVDVPTWDPNALSIPAIQSLYQSVFDSPLRYSPQLKLEPRQVKEWKWLDNQATR
LAITLRDDILFHDGTRMTMADVRYSLAERAQADKKLLVGGMLNTLSDIELSSPTKGVIVFNRPTPAAPIYLAFLAVYVVP
RAYMEKVGAEGFNAKPIGAGPYRMVEHQRGSRIVLEGFDKYWGGAPPIRQAVFQIVPEGSARVALAESGRVGMATQLPMR
EVHRLASKTGIVTKAYPVSEVYMIRIPNYVKPMDNDHVRAAMHLSIDKAALSKAFYDGVAKPLSVMAPEGTPSHVPDFHF
PHDKNKAIDELKAAGFSPANPVSFTLLSTNGVFPNDYDMARAISGMWKAVGINATIEETTPAKLVEAAQNGKLAGPLLYN
WVNSTGDPENYAGRIFDPRLRFSTWKDMSLAPRIDALMTEVDEAKRMAGYKALNVESSRQSWAIPLLQAVATAAYSSALQ
PTLFDNGYILPADMKYR

Sequences:

>Translated_577_residues
MGKRCALRCAPMAARSLRHLIRDATPGRTTHHRCATVRTPLHPEEKCTMTDFQFPRPRDAELQRALQDPARRHLLLGALA
AGAGALLPWQMAGAQTVGKSTLAIAYPVDVPTWDPNALSIPAIQSLYQSVFDSPLRYSPQLKLEPRQVKEWKWLDNQATR
LAITLRDDILFHDGTRMTMADVRYSLAERAQADKKLLVGGMLNTLSDIELSSPTKGVIVFNRPTPAAPIYLAFLAVYVVP
RAYMEKVGAEGFNAKPIGAGPYRMVEHQRGSRIVLEGFDKYWGGAPPIRQAVFQIVPEGSARVALAESGRVGMATQLPMR
EVHRLASKTGIVTKAYPVSEVYMIRIPNYVKPMDNDHVRAAMHLSIDKAALSKAFYDGVAKPLSVMAPEGTPSHVPDFHF
PHDKNKAIDELKAAGFSPANPVSFTLLSTNGVFPNDYDMARAISGMWKAVGINATIEETTPAKLVEAAQNGKLAGPLLYN
WVNSTGDPENYAGRIFDPRLRFSTWKDMSLAPRIDALMTEVDEAKRMAGYKALNVESSRQSWAIPLLQAVATAAYSSALQ
PTLFDNGYILPADMKYR
>Mature_576_residues
GKRCALRCAPMAARSLRHLIRDATPGRTTHHRCATVRTPLHPEEKCTMTDFQFPRPRDAELQRALQDPARRHLLLGALAA
GAGALLPWQMAGAQTVGKSTLAIAYPVDVPTWDPNALSIPAIQSLYQSVFDSPLRYSPQLKLEPRQVKEWKWLDNQATRL
AITLRDDILFHDGTRMTMADVRYSLAERAQADKKLLVGGMLNTLSDIELSSPTKGVIVFNRPTPAAPIYLAFLAVYVVPR
AYMEKVGAEGFNAKPIGAGPYRMVEHQRGSRIVLEGFDKYWGGAPPIRQAVFQIVPEGSARVALAESGRVGMATQLPMRE
VHRLASKTGIVTKAYPVSEVYMIRIPNYVKPMDNDHVRAAMHLSIDKAALSKAFYDGVAKPLSVMAPEGTPSHVPDFHFP
HDKNKAIDELKAAGFSPANPVSFTLLSTNGVFPNDYDMARAISGMWKAVGINATIEETTPAKLVEAAQNGKLAGPLLYNW
VNSTGDPENYAGRIFDPRLRFSTWKDMSLAPRIDALMTEVDEAKRMAGYKALNVESSRQSWAIPLLQAVATAAYSSALQP
TLFDNGYILPADMKYR

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=444, Percent_Identity=25.6756756756757, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1787052, Length=336, Percent_Identity=26.7857142857143, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787762, Length=404, Percent_Identity=24.009900990099, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1789887, Length=460, Percent_Identity=21.5217391304348, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081878, Length=409, Percent_Identity=23.2273838630807, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 63591; Mature: 63460

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRCALRCAPMAARSLRHLIRDATPGRTTHHRCATVRTPLHPEEKCTMTDFQFPRPRDA
CCCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCH
ELQRALQDPARRHLLLGALAAGAGALLPWQMAGAQTVGKSTLAIAYPVDVPTWDPNALSI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHCCCCEEEEEEECCCCCCCCCCEEC
PAIQSLYQSVFDSPLRYSPQLKLEPRQVKEWKWLDNQATRLAITLRDDILFHDGTRMTMA
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCEEEECCCEEEHH
DVRYSLAERAQADKKLLVGGMLNTLSDIELSSPTKGVIVFNRPTPAAPIYLAFLAVYVVP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
RAYMEKVGAEGFNAKPIGAGPYRMVEHQRGSRIVLEGFDKYWGGAPPIRQAVFQIVPEGS
HHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCHHHCCCCCHHHHHHHHHCCCCC
ARVALAESGRVGMATQLPMREVHRLASKTGIVTKAYPVSEVYMIRIPNYVKPMDNDHVRA
CEEEEECCCCCCCEECCCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCCCCCEEE
AMHLSIDKAALSKAFYDGVAKPLSVMAPEGTPSHVPDFHFPHDKNKAIDELKAAGFSPAN
EEEEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
PVSFTLLSTNGVFPNDYDMARAISGMWKAVGINATIEETTPAKLVEAAQNGKLAGPLLYN
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCCCCHHHHH
WVNSTGDPENYAGRIFDPRLRFSTWKDMSLAPRIDALMTEVDEAKRMAGYKALNVESSRQ
HHCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCC
SWAIPLLQAVATAAYSSALQPTLFDNGYILPADMKYR
HHHHHHHHHHHHHHHHHCCCCEECCCCEEECCCCCCC
>Mature Secondary Structure 
GKRCALRCAPMAARSLRHLIRDATPGRTTHHRCATVRTPLHPEEKCTMTDFQFPRPRDA
CCCCEEEECHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCH
ELQRALQDPARRHLLLGALAAGAGALLPWQMAGAQTVGKSTLAIAYPVDVPTWDPNALSI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCHHCCCCEEEEEEECCCCCCCCCCEEC
PAIQSLYQSVFDSPLRYSPQLKLEPRQVKEWKWLDNQATRLAITLRDDILFHDGTRMTMA
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEEECCEEEECCCEEEHH
DVRYSLAERAQADKKLLVGGMLNTLSDIELSSPTKGVIVFNRPTPAAPIYLAFLAVYVVP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
RAYMEKVGAEGFNAKPIGAGPYRMVEHQRGSRIVLEGFDKYWGGAPPIRQAVFQIVPEGS
HHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCHHHCCCCCHHHHHHHHHCCCCC
ARVALAESGRVGMATQLPMREVHRLASKTGIVTKAYPVSEVYMIRIPNYVKPMDNDHVRA
CEEEEECCCCCCCEECCCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCCCCCCCCEEE
AMHLSIDKAALSKAFYDGVAKPLSVMAPEGTPSHVPDFHFPHDKNKAIDELKAAGFSPAN
EEEEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
PVSFTLLSTNGVFPNDYDMARAISGMWKAVGINATIEETTPAKLVEAAQNGKLAGPLLYN
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCCCCHHHHH
WVNSTGDPENYAGRIFDPRLRFSTWKDMSLAPRIDALMTEVDEAKRMAGYKALNVESSRQ
HHCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCCCCCC
SWAIPLLQAVATAAYSSALQPTLFDNGYILPADMKYR
HHHHHHHHHHHHHHHHHCCCCEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]