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The map label for this gene is prpC [H]

Identifier: 121611364

GI number: 121611364

Start: 4919133

End: 4920287

Strand: Direct

Name: prpC [H]

Synonym: Veis_4451

Alternate gene names: 121611364

Gene position: 4919133-4920287 (Clockwise)

Preceding gene: 121611362

Following gene: 121611372

Centisome position: 88.37

GC content: 68.83

Gene sequence:

>1155_bases
ATGAACGACATGACCCGCGCCGGCGCGAAGCCGAAAAAATCCGTCGCCCTTTCGGGCGTCACCGCCGGCAACACCGCGCT
GTGCAGCGTGGGCCGCACCGGCTGCGACCTGCACTACCGCGGCTACGACATCCTGGACATCGCCGAGGTCTGCGAATTCG
AGGAGATCGCCCACCTGCTGGTGCACGGCAAGCTGCCCACCGTTGCCGGGTTGCGCACCTACAAAGCCAGGCTCCGGGCC
ATGCGCGGCGTGCCCGCCAGCGTCAAGTCGGCGCTGGAACAAATCCCTGCCAGCGCGCACCCGATGGACGTGCTGCGCAG
CGGCGTGTCGGCGCTGGGCTGCGCGCTGCCGGAAAAGGACGGGCACCACGCGCCGGGCGCGCGCGACATCGCCGACCGGC
TGCTGGCCTCGCTCGGCTCCATGCTGCTGTACTGGTACCACTGGTCCACCCAGGGCAGGCGCATCGAGCCGGAGACCGAC
GACGACTCCATCGGCGCGCATTTCCTGCACCTGCTGCACGGCAGCAAGCCCTGTGCCGCGTGGGAACGCGCGATGCACAC
CTCGCTGAACCTGTACGCCGAGCACGAGTTCAACGCCTCGACCTTCGCCGCGCGCGTGATCGCCGGCACCGGCAGCGACA
TGCACTCGGCCATCGTCGGCGCCATCGGCGCACTGCGCGGCCCCAAGCACGGCGGCGCCAACGAGATGGCGTTCGAGATC
CAAAAGCGCTACGACGACCCCGATCAGGCCGAGGCCGACATCCGCCGCCGCGTGGCGGCCAAGGAAGTGGTGACCGGCTT
CGGCCACCCGGTCTACACCGTCAGCGACCCGCGCAGCGCGGTCATCAAAGGCGTGGCCCGGGCGCTGGCGCAACGGGCCG
GCTCGACCAGGATGTTCGACATTGCCGAGCGGCTGGAGTCGGTGATGTGGCAGGCCAGGAAGATGTTCCCCAACCTCGAC
TGGTTCAGCGCCGTCAGCTACCACATGATGGGCGTGCCGACGGCCATGTTCACGCCCTTGTTCGTGATCGCGCGCACCAG
CGGCTGGGCGGCCCACATCATCGAGCAGCGCATCGACGACAAGATCATCCGCCCCGGCGCCCACTACACCGGGCCAGAGA
ACCTGGCGTTCCTGCCCATCCAGGAGCGCAAGTGA

Upstream 100 bases:

>100_bases
CCAGGGGTGCCACGAGGCAGGCCCTGGACGCCCGTTTCGGGATGCTGGCGCTGGATGCCCACGGGCGGCCCAGGCGCCAC
ACGACTTTCAAGGAGCCACG

Downstream 100 bases:

>100_bases
GCCGCCAGGCAGGCCCCGGGCCGGCTCCGTGCACACCGGGCGCCGGCCGATCGCGCGTCGCGGGCCAGGCCCCGGCTGCA
CACAAAAGCCGGCGGAAAAC

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MNDMTRAGAKPKKSVALSGVTAGNTALCSVGRTGCDLHYRGYDILDIAEVCEFEEIAHLLVHGKLPTVAGLRTYKARLRA
MRGVPASVKSALEQIPASAHPMDVLRSGVSALGCALPEKDGHHAPGARDIADRLLASLGSMLLYWYHWSTQGRRIEPETD
DDSIGAHFLHLLHGSKPCAAWERAMHTSLNLYAEHEFNASTFAARVIAGTGSDMHSAIVGAIGALRGPKHGGANEMAFEI
QKRYDDPDQAEADIRRRVAAKEVVTGFGHPVYTVSDPRSAVIKGVARALAQRAGSTRMFDIAERLESVMWQARKMFPNLD
WFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRIDDKIIRPGAHYTGPENLAFLPIQERK

Sequences:

>Translated_384_residues
MNDMTRAGAKPKKSVALSGVTAGNTALCSVGRTGCDLHYRGYDILDIAEVCEFEEIAHLLVHGKLPTVAGLRTYKARLRA
MRGVPASVKSALEQIPASAHPMDVLRSGVSALGCALPEKDGHHAPGARDIADRLLASLGSMLLYWYHWSTQGRRIEPETD
DDSIGAHFLHLLHGSKPCAAWERAMHTSLNLYAEHEFNASTFAARVIAGTGSDMHSAIVGAIGALRGPKHGGANEMAFEI
QKRYDDPDQAEADIRRRVAAKEVVTGFGHPVYTVSDPRSAVIKGVARALAQRAGSTRMFDIAERLESVMWQARKMFPNLD
WFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRIDDKIIRPGAHYTGPENLAFLPIQERK
>Mature_384_residues
MNDMTRAGAKPKKSVALSGVTAGNTALCSVGRTGCDLHYRGYDILDIAEVCEFEEIAHLLVHGKLPTVAGLRTYKARLRA
MRGVPASVKSALEQIPASAHPMDVLRSGVSALGCALPEKDGHHAPGARDIADRLLASLGSMLLYWYHWSTQGRRIEPETD
DDSIGAHFLHLLHGSKPCAAWERAMHTSLNLYAEHEFNASTFAARVIAGTGSDMHSAIVGAIGALRGPKHGGANEMAFEI
QKRYDDPDQAEADIRRRVAAKEVVTGFGHPVYTVSDPRSAVIKGVARALAQRAGSTRMFDIAERLESVMWQARKMFPNLD
WFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRIDDKIIRPGAHYTGPENLAFLPIQERK

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786527, Length=375, Percent_Identity=72.5333333333333, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1786939, Length=375, Percent_Identity=30.1333333333333, Blast_Score=158, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24640124, Length=343, Percent_Identity=22.7405247813411, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24640126, Length=343, Percent_Identity=22.7405247813411, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 41957; Mature: 41957

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDMTRAGAKPKKSVALSGVTAGNTALCSVGRTGCDLHYRGYDILDIAEVCEFEEIAHLL
CCCCCCCCCCCCHHEEEECCCCCCHHHEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
VHGKLPTVAGLRTYKARLRAMRGVPASVKSALEQIPASAHPMDVLRSGVSALGCALPEKD
HHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
GHHAPGARDIADRLLASLGSMLLYWYHWSTQGRRIEPETDDDSIGAHFLHLLHGSKPCAA
CCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
WERAMHTSLNLYAEHEFNASTFAARVIAGTGSDMHSAIVGAIGALRGPKHGGANEMAFEI
HHHHHHHHHEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
QKRYDDPDQAEADIRRRVAAKEVVTGFGHPVYTVSDPRSAVIKGVARALAQRAGSTRMFD
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHH
IAERLESVMWQARKMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRIDD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHH
KIIRPGAHYTGPENLAFLPIQERK
HHCCCCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MNDMTRAGAKPKKSVALSGVTAGNTALCSVGRTGCDLHYRGYDILDIAEVCEFEEIAHLL
CCCCCCCCCCCCHHEEEECCCCCCHHHEECCCCCCCEEECCCCHHHHHHHHHHHHHHHHH
VHGKLPTVAGLRTYKARLRAMRGVPASVKSALEQIPASAHPMDVLRSGVSALGCALPEKD
HHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCC
GHHAPGARDIADRLLASLGSMLLYWYHWSTQGRRIEPETDDDSIGAHFLHLLHGSKPCAA
CCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHH
WERAMHTSLNLYAEHEFNASTFAARVIAGTGSDMHSAIVGAIGALRGPKHGGANEMAFEI
HHHHHHHHHEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHH
QKRYDDPDQAEADIRRRVAAKEVVTGFGHPVYTVSDPRSAVIKGVARALAQRAGSTRMFD
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCHHHH
IAERLESVMWQARKMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTSGWAAHIIEQRIDD
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHH
KIIRPGAHYTGPENLAFLPIQERK
HHCCCCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]