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The map label for this gene is metR [H]

Identifier: 121611362

GI number: 121611362

Start: 4916076

End: 4917011

Strand: Direct

Name: metR [H]

Synonym: Veis_4448

Alternate gene names: 121611362

Gene position: 4916076-4917011 (Clockwise)

Preceding gene: 121611358

Following gene: 121611364

Centisome position: 88.31

GC content: 65.6

Gene sequence:

>936_bases
ATGGTTTTATCGGTACTGGAAATGCGCCATCTGCGCACGCTGGCCGCTTTGCGCGCCACGGGAAGCCTGGTGCGCGCGGC
GCAACTGCTCAACCTCACGCAATCGGCGCTATCGCACCAGATCAAGCTGCTGGAAGATCATTTCGGCGCCGCGTTGTTCG
AGCGCAAGTCCGTGCCGCCGCAGTTCAGCCATGCGGGCCTGCGCCTGCTCGAACTGGCCGACGCTGCGCTGCCCCTGGTC
GAGGCTGCCGAGCGCGACCTGGCGCGGCTGTCCTCGGGCAAGTCGGGGCAGTTGCGCATCGTCGTCGAATGCCACACCTG
CTTTGACTGGCTGATGCCGGCGATGGATGCTTTTCGCCAGCGCTGGCCCGAGGTCGAACTGGACATCGTCTCGGGCTTTC
ATGCCGACCCGATTGCGCTGGTGCTGCAAGGCCGTGCCGAGGTCGCGATCGTCTCCGAACGGGACCCGGCCGAGACGGTG
GACTACCACGCGCTGTTTCGCTTCGAGATCGTGGCGCTGCTGGCCAACGGCCATGCGCTGACCAGGCACAGCCACCTCGC
GGCAGAGCACTTTGCCGATCAGACCCTGATCACCTACCCGGTGCCTGACGAAATGCTGGACATCGTGCGCCAGGTGTTGC
AGCCTGCGGGCGTGCAGCCGGCACAGCGGCGCACCACCGAACTGACCATTGCGATGCTGCAACTGGTGGCCAGCGGACGC
GGCATTGCCGCGCTGCCGCTGTGGGCGGTTCAAGGCTATCTGGAGCGCGGCTATGTCAGCGCCAGACCGATAAGGACCAC
GGGCAGCGCAAGGCTTACCGGCGAGTTGCACCTGGCCTGCAGCGCCGCCACATCAGGCCAGAGCTGGCTGGCGGACTTTG
TGCACAGCACCCGGCACAGCTGCTTTACCAGCCTGCCGGAGATCGAATTGCTGTAG

Upstream 100 bases:

>100_bases
CGGAAAGCCAAGGATATGTGTGCAGGTCATTGCCCGATGATCCCGGCTGCCCTGTTATTATTCAAACGAAATATTTTGCC
TTTCAACTTGAATAGTATTC

Downstream 100 bases:

>100_bases
TGGCGCCAGCGCGGTTTTTCATGCCGGGTCACGGGCCATTGGCGCCACTCGGGCCACTCGGGCCATTGGCGCTACTTACG
CCATTGGCGCCACTCCCCGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MVLSVLEMRHLRTLAALRATGSLVRAAQLLNLTQSALSHQIKLLEDHFGAALFERKSVPPQFSHAGLRLLELADAALPLV
EAAERDLARLSSGKSGQLRIVVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADPIALVLQGRAEVAIVSERDPAETV
DYHALFRFEIVALLANGHALTRHSHLAAEHFADQTLITYPVPDEMLDIVRQVLQPAGVQPAQRRTTELTIAMLQLVASGR
GIAALPLWAVQGYLERGYVSARPIRTTGSARLTGELHLACSAATSGQSWLADFVHSTRHSCFTSLPEIELL

Sequences:

>Translated_311_residues
MVLSVLEMRHLRTLAALRATGSLVRAAQLLNLTQSALSHQIKLLEDHFGAALFERKSVPPQFSHAGLRLLELADAALPLV
EAAERDLARLSSGKSGQLRIVVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADPIALVLQGRAEVAIVSERDPAETV
DYHALFRFEIVALLANGHALTRHSHLAAEHFADQTLITYPVPDEMLDIVRQVLQPAGVQPAQRRTTELTIAMLQLVASGR
GIAALPLWAVQGYLERGYVSARPIRTTGSARLTGELHLACSAATSGQSWLADFVHSTRHSCFTSLPEIELL
>Mature_311_residues
MVLSVLEMRHLRTLAALRATGSLVRAAQLLNLTQSALSHQIKLLEDHFGAALFERKSVPPQFSHAGLRLLELADAALPLV
EAAERDLARLSSGKSGQLRIVVECHTCFDWLMPAMDAFRQRWPEVELDIVSGFHADPIALVLQGRAEVAIVSERDPAETV
DYHALFRFEIVALLANGHALTRHSHLAAEHFADQTLITYPVPDEMLDIVRQVLQPAGVQPAQRRTTELTIAMLQLVASGR
GIAALPLWAVQGYLERGYVSARPIRTTGSARLTGELHLACSAATSGQSWLADFVHSTRHSCFTSLPEIELL

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=305, Percent_Identity=37.7049180327869, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1787879, Length=244, Percent_Identity=23.7704918032787, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788296, Length=197, Percent_Identity=30.9644670050761, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1786401, Length=250, Percent_Identity=25.2, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788887, Length=264, Percent_Identity=26.5151515151515, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790208, Length=148, Percent_Identity=28.3783783783784, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI157672245, Length=212, Percent_Identity=24.5283018867925, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34179; Mature: 34179

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSVLEMRHLRTLAALRATGSLVRAAQLLNLTQSALSHQIKLLEDHFGAALFERKSVPP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QFSHAGLRLLELADAALPLVEAAERDLARLSSGKSGQLRIVVECHTCFDWLMPAMDAFRQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
RWPEVELDIVSGFHADPIALVLQGRAEVAIVSERDPAETVDYHALFRFEIVALLANGHAL
HCCCCEEEEECCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHH
TRHSHLAAEHFADQTLITYPVPDEMLDIVRQVLQPAGVQPAQRRTTELTIAMLQLVASGR
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
GIAALPLWAVQGYLERGYVSARPIRTTGSARLTGELHLACSAATSGQSWLADFVHSTRHS
CCEEHHHHHHHHHHHCCCCCCCCEECCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHH
CFTSLPEIELL
HHHCCCCEECC
>Mature Secondary Structure
MVLSVLEMRHLRTLAALRATGSLVRAAQLLNLTQSALSHQIKLLEDHFGAALFERKSVPP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QFSHAGLRLLELADAALPLVEAAERDLARLSSGKSGQLRIVVECHTCFDWLMPAMDAFRQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
RWPEVELDIVSGFHADPIALVLQGRAEVAIVSERDPAETVDYHALFRFEIVALLANGHAL
HCCCCEEEEECCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHH
TRHSHLAAEHFADQTLITYPVPDEMLDIVRQVLQPAGVQPAQRRTTELTIAMLQLVASGR
HHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
GIAALPLWAVQGYLERGYVSARPIRTTGSARLTGELHLACSAATSGQSWLADFVHSTRHS
CCEEHHHHHHHHHHHCCCCCCCCEECCCCEEEEEEEEEEEECCCCCHHHHHHHHHHHHHH
CFTSLPEIELL
HHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]