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The map label for this gene is clpP

Identifier: 121611285

GI number: 121611285

Start: 4819969

End: 4820577

Strand: Direct

Name: clpP

Synonym: Veis_4371

Alternate gene names: 121611285

Gene position: 4819969-4820577 (Clockwise)

Preceding gene: 121611284

Following gene: 121611286

Centisome position: 86.58

GC content: 62.07

Gene sequence:

>609_bases
ATGAATGCATTGGAAACACAGGGCCTGGGGATGATCCCCATGGTCATCGAGCAGTCGGGCCGTGGCGAGCGGTCCTACGA
CATCTACTCGCGCCTGCTCAAGGAGCGCGTGATTTTTCTGGTCGGACCGGTCAATGACCAGACCGCCAACCTGGTGGTGG
CGCAGTTGCTGTTTCTCGAAAGCGAGAACCCGGACAAGGACATCTCGTTTTACATCAACTCCCCGGGCGGCTCGGTGAGC
GCGGGCATGGCGATCTTCGACACCATGAATTTCATCAAGCCCGATGTCTCGACCCTGTGCACCGGCATGGCGGCCAGCAT
GGGCGCCTTCCTGCTGGCGGCCGGGGCCAAGGGCAAGCGTTTTGCACTGCCCAACTCCAAGGTCATGATCCACCAGCCCC
TGGGCGGCATGCAGGGCCAGGCGACCGAGATCGAGATCCACGCGCGCGAAATCCTCAAGACCCGCGAGCAGCTCAACAAG
ATACTGGCCGAGCGCACCGGCCAGCCGCTGGAGAAGATCCAGCGCGACACCGAGCGCGACTATTTCCTGTCGGCCGACGA
GTCGCGGGAATACGGTCTGGTCGATCAGGTGATCCACCGACGATCCTGA

Upstream 100 bases:

>100_bases
GACCATCTCGGTCGACGAGTTGCTCAATCCAAAGGATCCAAAGGACTGACGCCACGGACCGGTTTCTGACTACAGGCATC
TGCCCGACGGGAGAAAAGAC

Downstream 100 bases:

>100_bases
CGCCCGCCGGGTCACGGCGGCATTGTCCTGTTGGGCAGGGCGCCACTGTCATTTGGTTATCATCCCGACCACTTTCCGTC
ACAAGCAAGGCATTGCCCCC

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MNALETQGLGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVS
AGMAIFDTMNFIKPDVSTLCTGMAASMGAFLLAAGAKGKRFALPNSKVMIHQPLGGMQGQATEIEIHAREILKTREQLNK
ILAERTGQPLEKIQRDTERDYFLSADESREYGLVDQVIHRRS

Sequences:

>Translated_202_residues
MNALETQGLGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVS
AGMAIFDTMNFIKPDVSTLCTGMAASMGAFLLAAGAKGKRFALPNSKVMIHQPLGGMQGQATEIEIHAREILKTREQLNK
ILAERTGQPLEKIQRDTERDYFLSADESREYGLVDQVIHRRS
>Mature_202_residues
MNALETQGLGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDQTANLVVAQLLFLESENPDKDISFYINSPGGSVS
AGMAIFDTMNFIKPDVSTLCTGMAASMGAFLLAAGAKGKRFALPNSKVMIHQPLGGMQGQATEIEIHAREILKTREQLNK
ILAERTGQPLEKIQRDTERDYFLSADESREYGLVDQVIHRRS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=198, Percent_Identity=54.5454545454545, Blast_Score=236, Evalue=7e-63,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=71.6494845360825, Blast_Score=301, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.6881720430108, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=53.5714285714286, Blast_Score=235, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_VEREI (A1WR17)

Other databases:

- EMBL:   CP000542
- RefSeq:   YP_999092.1
- ProteinModelPortal:   A1WR17
- SMR:   A1WR17
- STRING:   A1WR17
- MEROPS:   S14.001
- GeneID:   4693599
- GenomeReviews:   CP000542_GR
- KEGG:   vei:Veis_4371
- NMPDR:   fig|391735.5.peg.4002
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- PhylomeDB:   A1WR17
- ProtClustDB:   CLSK2516737
- BioCyc:   VEIS391735:VEIS_4371-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22365; Mature: 22365

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 106-106 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALETQGLGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDQTANLVVAQLLFLE
CCCCCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHC
SENPDKDISFYINSPGGSVSAGMAIFDTMNFIKPDVSTLCTGMAASMGAFLLAAGAKGKR
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCE
FALPNSKVMIHQPLGGMQGQATEIEIHAREILKTREQLNKILAERTGQPLEKIQRDTERD
EECCCCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
YFLSADESREYGLVDQVIHRRS
EEECCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MNALETQGLGMIPMVIEQSGRGERSYDIYSRLLKERVIFLVGPVNDQTANLVVAQLLFLE
CCCCCCCCCCCHHHHEECCCCCCCHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHC
SENPDKDISFYINSPGGSVSAGMAIFDTMNFIKPDVSTLCTGMAASMGAFLLAAGAKGKR
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCE
FALPNSKVMIHQPLGGMQGQATEIEIHAREILKTREQLNKILAERTGQPLEKIQRDTERD
EECCCCCEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
YFLSADESREYGLVDQVIHRRS
EEECCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA