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The map label for this gene is betA [H]

Identifier: 121611198

GI number: 121611198

Start: 4722561

End: 4724186

Strand: Direct

Name: betA [H]

Synonym: Veis_4282

Alternate gene names: 121611198

Gene position: 4722561-4724186 (Clockwise)

Preceding gene: 121611197

Following gene: 121611199

Centisome position: 84.84

GC content: 69.74

Gene sequence:

>1626_bases
ATGTGTGACGAAGAGTTCGACTACATCGTCGTCGGCGCCGGATCGGCCGGCTGCGTGCTCGCCGGCCGGTTGAGCGAAGA
CCCGGCGCTGCAGGTGCTGCTGCTCGAAGCCGGGCCGCCCGACAGGTCACTGTGGCTGCACCTGCCGATCGGCTACGGCA
AGACGATGTGGAACCCGGCCTACAACTGGCGCTTCAGCACCGACCCCGACCCGAACCTGCATGGCCGCCGCATCTACTGG
CCGCGCGGCAAGACGCTGGGCGGCTCCAGCGCGATCAACGGGCTGATCTACATCCGTGGCCAGCGCCAGGACTACGACCA
CTGGGCCGCGCTCGGCAACCAGGGCTGGGGCTACGACGATGTGCTGCCCTACTTCATCCGCTCCGAAGGCAACCAGCGCG
GCGCAAACGCCTGGCACGGCGGCGCCGGGCCGCTGAGGGTGTCGGACATCGCGGCCAGGCACGAACTCATCGAAGCCTTC
ATCGCCGGCGCGCAGCAGACCGGCGTGCCGCGCACCCGGGACTTCAACGGCGCCACGCAGGAAGGCGCCGGCTACTACCA
ACTGACGACGCACGAGGGCTGGCGCTGCAGCACGGCCACGGCCTACCTGACACCGGCCAAGCGCCGCCCCAACCTGCGCA
TGCTCACCGGGGCGCTGGCCTGCCAACTGGTGTTCGAGGGCCGGCGCGCCGTCGGCGTCAGCTATCGGCACGGCGGCCGG
ATCAAGACCGCGCGCTGCCGGGCCGAACTGCTGCTGTCGGCCGGGGCCATACAGTCGCCTCAATTGCTGCAGTTATCGGG
CATAGGGCCGCGCGCGCTGCTCGAGCGCTCGGGGCTCCCGGTGGTGCACGAATTGCCCGGCGTCGGCGAGAACCTGCAAG
ATCACCTGCAGATTCGTCTCGGCTACGAGTGCACCAAGCCCATCACCACCAACGACCAGCTCAATGGCTGGTTCGGCCGG
TTGGGCATGGGCCTGGCCTGGCTGCTGCGACGCGCTGGCCCGCTGGCCGTCGGCATCAACCAGGGCGGCTGCTTCATGCG
CGCCCTCAAGGATGCCAACGGCCAACCGGCGGCGGCCAGGCCCGACATACAGTTTCACGTCGCCACGCTCTCGGCCGACA
TGGCCGGCGGCAAGGTGCATCCGTATTCGGGCTTCACGATGTCGGTGTGCCAGTTGCGGCCCGAGTCGCGCGGCCATGTC
CGCATCCGCTCGCCCGACGCCGCCGAGCCGCCCGCGATACAGCCGAACTACCTGGCCACCGCGCTCGACCGCGCAACCAC
CGTGGCCGGCGTGCAGGCTGCGCGCGCGATTGCCGAGACGCCCGCGCTCGCCCCCTATGTCAAGCGTGAAGTGCAGCCCG
GGCCGCAGGCCGCGAGCGCCGCCGAGTTGCTCGATTTCTGCCGCCACCACGGCGCCACCATCTTCCATCCCGTCGGCACC
TGCCGCATGGGCAATGACCCGCTGGCCGTGGTCGATGCGCGCCTGCGCGTGCACGGCATCGCGGGCCTGCGGGTGATCGA
TGGTTCGGCGATGCCGACGCTGGTCTCGGGCAACACCAATGCGCCCATCGTGATGATGGCCGAGAAGGCCGTCGACCTGA
TCCGGCAAGACGCCAGGGCACTTTAG

Upstream 100 bases:

>100_bases
GCATCCGGGTAATCACTGAAAATGGAACATTGAGTTCCAAAAAATAACAACCTAAGATGCACACTATCGGAACGAAAGGT
TCCACTTTCAGGTTGCTTTC

Downstream 100 bases:

>100_bases
TGTCGCGTCACTGGCCGCCGGTTTTTCCTGCCCCGCTTCACCCCGACCGCGAGCGCCCGCAGAGGCGGCGGCCACGACAA
CCGATCGACAACCGATCATC

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MCDEEFDYIVVGAGSAGCVLAGRLSEDPALQVLLLEAGPPDRSLWLHLPIGYGKTMWNPAYNWRFSTDPDPNLHGRRIYW
PRGKTLGGSSAINGLIYIRGQRQDYDHWAALGNQGWGYDDVLPYFIRSEGNQRGANAWHGGAGPLRVSDIAARHELIEAF
IAGAQQTGVPRTRDFNGATQEGAGYYQLTTHEGWRCSTATAYLTPAKRRPNLRMLTGALACQLVFEGRRAVGVSYRHGGR
IKTARCRAELLLSAGAIQSPQLLQLSGIGPRALLERSGLPVVHELPGVGENLQDHLQIRLGYECTKPITTNDQLNGWFGR
LGMGLAWLLRRAGPLAVGINQGGCFMRALKDANGQPAAARPDIQFHVATLSADMAGGKVHPYSGFTMSVCQLRPESRGHV
RIRSPDAAEPPAIQPNYLATALDRATTVAGVQAARAIAETPALAPYVKREVQPGPQAASAAELLDFCRHHGATIFHPVGT
CRMGNDPLAVVDARLRVHGIAGLRVIDGSAMPTLVSGNTNAPIVMMAEKAVDLIRQDARAL

Sequences:

>Translated_541_residues
MCDEEFDYIVVGAGSAGCVLAGRLSEDPALQVLLLEAGPPDRSLWLHLPIGYGKTMWNPAYNWRFSTDPDPNLHGRRIYW
PRGKTLGGSSAINGLIYIRGQRQDYDHWAALGNQGWGYDDVLPYFIRSEGNQRGANAWHGGAGPLRVSDIAARHELIEAF
IAGAQQTGVPRTRDFNGATQEGAGYYQLTTHEGWRCSTATAYLTPAKRRPNLRMLTGALACQLVFEGRRAVGVSYRHGGR
IKTARCRAELLLSAGAIQSPQLLQLSGIGPRALLERSGLPVVHELPGVGENLQDHLQIRLGYECTKPITTNDQLNGWFGR
LGMGLAWLLRRAGPLAVGINQGGCFMRALKDANGQPAAARPDIQFHVATLSADMAGGKVHPYSGFTMSVCQLRPESRGHV
RIRSPDAAEPPAIQPNYLATALDRATTVAGVQAARAIAETPALAPYVKREVQPGPQAASAAELLDFCRHHGATIFHPVGT
CRMGNDPLAVVDARLRVHGIAGLRVIDGSAMPTLVSGNTNAPIVMMAEKAVDLIRQDARAL
>Mature_541_residues
MCDEEFDYIVVGAGSAGCVLAGRLSEDPALQVLLLEAGPPDRSLWLHLPIGYGKTMWNPAYNWRFSTDPDPNLHGRRIYW
PRGKTLGGSSAINGLIYIRGQRQDYDHWAALGNQGWGYDDVLPYFIRSEGNQRGANAWHGGAGPLRVSDIAARHELIEAF
IAGAQQTGVPRTRDFNGATQEGAGYYQLTTHEGWRCSTATAYLTPAKRRPNLRMLTGALACQLVFEGRRAVGVSYRHGGR
IKTARCRAELLLSAGAIQSPQLLQLSGIGPRALLERSGLPVVHELPGVGENLQDHLQIRLGYECTKPITTNDQLNGWFGR
LGMGLAWLLRRAGPLAVGINQGGCFMRALKDANGQPAAARPDIQFHVATLSADMAGGKVHPYSGFTMSVCQLRPESRGHV
RIRSPDAAEPPAIQPNYLATALDRATTVAGVQAARAIAETPALAPYVKREVQPGPQAASAAELLDFCRHHGATIFHPVGT
CRMGNDPLAVVDARLRVHGIAGLRVIDGSAMPTLVSGNTNAPIVMMAEKAVDLIRQDARAL

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=541, Percent_Identity=44.362292051756, Blast_Score=436, Evalue=1e-122,
Organism=Escherichia coli, GI1786503, Length=538, Percent_Identity=43.8661710037175, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17532301, Length=558, Percent_Identity=36.7383512544803, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24642042, Length=575, Percent_Identity=39.1304347826087, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI45551458, Length=571, Percent_Identity=37.1278458844133, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI45549471, Length=571, Percent_Identity=37.1278458844133, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24642055, Length=582, Percent_Identity=36.7697594501718, Blast_Score=337, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24642059, Length=570, Percent_Identity=37.719298245614, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24642048, Length=582, Percent_Identity=36.426116838488, Blast_Score=326, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24642039, Length=586, Percent_Identity=36.518771331058, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI18859995, Length=570, Percent_Identity=36.6666666666667, Blast_Score=321, Evalue=9e-88,
Organism=Drosophila melanogaster, GI17137792, Length=559, Percent_Identity=36.4937388193202, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24642037, Length=574, Percent_Identity=36.2369337979094, Blast_Score=296, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24650267, Length=575, Percent_Identity=34.4347826086956, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24642051, Length=574, Percent_Identity=32.9268292682927, Blast_Score=285, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24642035, Length=572, Percent_Identity=34.6153846153846, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI18859993, Length=571, Percent_Identity=33.2749562171629, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24642057, Length=587, Percent_Identity=31.6865417376491, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24645930, Length=576, Percent_Identity=28.2986111111111, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 58394; Mature: 58394

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCDEEFDYIVVGAGSAGCVLAGRLSEDPALQVLLLEAGPPDRSLWLHLPIGYGKTMWNPA
CCCCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCC
YNWRFSTDPDPNLHGRRIYWPRGKTLGGSSAINGLIYIRGQRQDYDHWAALGNQGWGYDD
CCCEECCCCCCCCCCCEEECCCCCCCCCCHHCCEEEEEEECCCCCHHHHHHCCCCCCHHH
VLPYFIRSEGNQRGANAWHGGAGPLRVSDIAARHELIEAFIAGAQQTGVPRTRDFNGATQ
HHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCC
EGAGYYQLTTHEGWRCSTATAYLTPAKRRPNLRMLTGALACQLVFEGRRAVGVSYRHGGR
CCCCEEEEECCCCEEECCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCE
IKTARCRAELLLSAGAIQSPQLLQLSGIGPRALLERSGLPVVHELPGVGENLQDHLQIRL
EEHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHCCCCCEEECCCCCCCCCHHCEEEEE
GYECTKPITTNDQLNGWFGRLGMGLAWLLRRAGPLAVGINQGGCFMRALKDANGQPAAAR
CCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCCCC
PDIQFHVATLSADMAGGKVHPYSGFTMSVCQLRPESRGHVRIRSPDAAEPPAIQPNYLAT
CCCEEEEEEEEECCCCCEECCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCHHHH
ALDRATTVAGVQAARAIAETPALAPYVKREVQPGPQAASAAELLDFCRHHGATIFHPVGT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCE
CRMGNDPLAVVDARLRVHGIAGLRVIDGSAMPTLVSGNTNAPIVMMAEKAVDLIRQDARA
EEECCCCEEEEEEEEEEEEECEEEEECCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure
MCDEEFDYIVVGAGSAGCVLAGRLSEDPALQVLLLEAGPPDRSLWLHLPIGYGKTMWNPA
CCCCCCCEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCC
YNWRFSTDPDPNLHGRRIYWPRGKTLGGSSAINGLIYIRGQRQDYDHWAALGNQGWGYDD
CCCEECCCCCCCCCCCEEECCCCCCCCCCHHCCEEEEEEECCCCCHHHHHHCCCCCCHHH
VLPYFIRSEGNQRGANAWHGGAGPLRVSDIAARHELIEAFIAGAQQTGVPRTRDFNGATQ
HHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCC
EGAGYYQLTTHEGWRCSTATAYLTPAKRRPNLRMLTGALACQLVFEGRRAVGVSYRHGGR
CCCCEEEEECCCCEEECCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCE
IKTARCRAELLLSAGAIQSPQLLQLSGIGPRALLERSGLPVVHELPGVGENLQDHLQIRL
EEHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHCCCCCEEECCCCCCCCCHHCEEEEE
GYECTKPITTNDQLNGWFGRLGMGLAWLLRRAGPLAVGINQGGCFMRALKDANGQPAAAR
CCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCCCCC
PDIQFHVATLSADMAGGKVHPYSGFTMSVCQLRPESRGHVRIRSPDAAEPPAIQPNYLAT
CCCEEEEEEEEECCCCCEECCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCCCHHHH
ALDRATTVAGVQAARAIAETPALAPYVKREVQPGPQAASAAELLDFCRHHGATIFHPVGT
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEECCCE
CRMGNDPLAVVDARLRVHGIAGLRVIDGSAMPTLVSGNTNAPIVMMAEKAVDLIRQDARA
EEECCCCEEEEEEEEEEEEECEEEEECCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA