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The map label for this gene is echA12 [H]

Identifier: 121611101

GI number: 121611101

Start: 4607829

End: 4608632

Strand: Direct

Name: echA12 [H]

Synonym: Veis_4185

Alternate gene names: 121611101

Gene position: 4607829-4608632 (Clockwise)

Preceding gene: 121611100

Following gene: 121611102

Centisome position: 82.77

GC content: 67.29

Gene sequence:

>804_bases
ATGTCATTCGCCTACACATCGCTGTCGTTCGAGGTCGTCGAAGACCGCATCGGCCTGCTCACGCTGCGCTGCCCGGCGCA
ACACAACAGCCTGAGCGAAACGCTCAAGACCGAGTTGCGGCGCCTGCTGGCCGAGCTGTCGCACGACCGCGAGCTCGGCG
CGCTGGTCATCACCGGCGAAGGCCGCTCCTTCTGCAGCGGCGGCGACCTGCGGCACCTGAAGAACGCCGAGCGCAGCGCC
GACTTCGACCGGCGCCGCATCTACCAGTTGCACGACTGGGTGCAGCCGCTGATGAACCTGGAGATGCCGGTGATCGCCGC
GGTCAACGGACCGGCGATCGGCGCAGGCTTCGGCCTGGCACTGGCTGCCGACTTCATCCTGTGCGCGCCCGAGGCGTACT
TTCGCACCTCGTTCAGCCGCGTCGGCCTGGTGCCCGACACCGGCCTGTTCTTCACGCTGCCGCGCATCGTCGGCCTGCAA
TCGGCCAAGGAAATCACCTTCACGGGCCGCAAGGTCGATGCGGCCGAAGCCCTCGCCTTGCGCATCGCACTCGCCGTCCA
TGCGGGCGAACGGCTGATGGACGAAGCCATGGCACTCGCACGCCGGCTCGCGCAGGGGCCAACCGCCGCCATCGGTGCGA
GCAAACGCATCCTGAACCAGTCCTTCCACCTCGATGCGCGGGCACTGGTCGAGATGGAAGCCGCAGCGCAGGCCATCTTC
TTCCACTCCAGCTTCCACCAGCAGGCCATCGACGACTTCGCGAGCGGCACGCCCTTTCGCTACGACTGGGAGCGGCCACA
CTGA

Upstream 100 bases:

>100_bases
CCCGAGGCGCTGCGCACGCTGCAGCAGCGCGAGACGCTGCGCTGGGGCCAGGCGATCAGGGCCGCGCAGATGGTCGCCAA
CTGAACGCGCGACGCACGAG

Downstream 100 bases:

>100_bases
ACGGCCGCCCTCTACCTTCCTTCTTTTCATCCACCCTTTTTCTTCTGCCTCACGACCATGCTGACTCCTGAACACATCGC
CCTCCAAGACAGCGTTCGCC

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSFAYTSLSFEVVEDRIGLLTLRCPAQHNSLSETLKTELRRLLAELSHDRELGALVITGEGRSFCSGGDLRHLKNAERSA
DFDRRRIYQLHDWVQPLMNLEMPVIAAVNGPAIGAGFGLALAADFILCAPEAYFRTSFSRVGLVPDTGLFFTLPRIVGLQ
SAKEITFTGRKVDAAEALALRIALAVHAGERLMDEAMALARRLAQGPTAAIGASKRILNQSFHLDARALVEMEAAAQAIF
FHSSFHQQAIDDFASGTPFRYDWERPH

Sequences:

>Translated_267_residues
MSFAYTSLSFEVVEDRIGLLTLRCPAQHNSLSETLKTELRRLLAELSHDRELGALVITGEGRSFCSGGDLRHLKNAERSA
DFDRRRIYQLHDWVQPLMNLEMPVIAAVNGPAIGAGFGLALAADFILCAPEAYFRTSFSRVGLVPDTGLFFTLPRIVGLQ
SAKEITFTGRKVDAAEALALRIALAVHAGERLMDEAMALARRLAQGPTAAIGASKRILNQSFHLDARALVEMEAAAQAIF
FHSSFHQQAIDDFASGTPFRYDWERPH
>Mature_266_residues
SFAYTSLSFEVVEDRIGLLTLRCPAQHNSLSETLKTELRRLLAELSHDRELGALVITGEGRSFCSGGDLRHLKNAERSAD
FDRRRIYQLHDWVQPLMNLEMPVIAAVNGPAIGAGFGLALAADFILCAPEAYFRTSFSRVGLVPDTGLFFTLPRIVGLQS
AKEITFTGRKVDAAEALALRIALAVHAGERLMDEAMALARRLAQGPTAAIGASKRILNQSFHLDARALVEMEAAAQAIFF
HSSFHQQAIDDFASGTPFRYDWERPH

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=255, Percent_Identity=28.2352941176471, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI70995211, Length=185, Percent_Identity=30.8108108108108, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4757968, Length=247, Percent_Identity=25.1012145748988, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI49355787, Length=247, Percent_Identity=25.1012145748988, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI25453481, Length=247, Percent_Identity=24.6963562753036, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI51538573, Length=247, Percent_Identity=24.6963562753036, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI116235487, Length=195, Percent_Identity=28.7179487179487, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI221136756, Length=241, Percent_Identity=26.1410788381743, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI221136753, Length=241, Percent_Identity=26.1410788381743, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI221307494, Length=241, Percent_Identity=26.1410788381743, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI45643119, Length=223, Percent_Identity=27.3542600896861, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI260275230, Length=223, Percent_Identity=27.3542600896861, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=26.7942583732057, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI4757966, Length=190, Percent_Identity=26.8421052631579, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI51538581, Length=190, Percent_Identity=26.8421052631579, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI31542718, Length=231, Percent_Identity=29.4372294372294, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI157694516, Length=217, Percent_Identity=26.7281105990783, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI213417737, Length=217, Percent_Identity=26.7281105990783, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4502327, Length=243, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI68989263, Length=211, Percent_Identity=28.9099526066351, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI37594469, Length=146, Percent_Identity=29.4520547945205, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI37594471, Length=146, Percent_Identity=29.4520547945205, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI221142681, Length=200, Percent_Identity=38.5, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1787660, Length=245, Percent_Identity=32.6530612244898, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787659, Length=208, Percent_Identity=32.2115384615385, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788597, Length=255, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788682, Length=201, Percent_Identity=26.3681592039801, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790281, Length=213, Percent_Identity=27.2300469483568, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082183, Length=261, Percent_Identity=22.2222222222222, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=232, Percent_Identity=29.7413793103448, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25145438, Length=231, Percent_Identity=29.8701298701299, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17540714, Length=233, Percent_Identity=28.3261802575107, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17535521, Length=215, Percent_Identity=26.046511627907, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=194, Percent_Identity=30.4123711340206, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17536985, Length=234, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=232, Percent_Identity=28.0172413793103, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=166, Percent_Identity=29.5180722891566, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=27.3092369477912, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=27.3092369477912, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24654903, Length=231, Percent_Identity=29.4372294372294, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19920382, Length=212, Percent_Identity=30.188679245283, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653139, Length=218, Percent_Identity=29.8165137614679, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29427; Mature: 29296

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFAYTSLSFEVVEDRIGLLTLRCPAQHNSLSETLKTELRRLLAELSHDRELGALVITGE
CCEEEHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
GRSFCSGGDLRHLKNAERSADFDRRRIYQLHDWVQPLMNLEMPVIAAVNGPAIGAGFGLA
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHH
LAADFILCAPEAYFRTSFSRVGLVPDTGLFFTLPRIVGLQSAKEITFTGRKVDAAEALAL
HHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
RIALAVHAGERLMDEAMALARRLAQGPTAAIGASKRILNQSFHLDARALVEMEAAAQAIF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FHSSFHQQAIDDFASGTPFRYDWERPH
HHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SFAYTSLSFEVVEDRIGLLTLRCPAQHNSLSETLKTELRRLLAELSHDRELGALVITGE
CEEEHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
GRSFCSGGDLRHLKNAERSADFDRRRIYQLHDWVQPLMNLEMPVIAAVNGPAIGAGFGLA
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHH
LAADFILCAPEAYFRTSFSRVGLVPDTGLFFTLPRIVGLQSAKEITFTGRKVDAAEALAL
HHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
RIALAVHAGERLMDEAMALARRLAQGPTAAIGASKRILNQSFHLDARALVEMEAAAQAIF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FHSSFHQQAIDDFASGTPFRYDWERPH
HHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]