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The map label for this gene is intA [H]

Identifier: 121611076

GI number: 121611076

Start: 4577297

End: 4578556

Strand: Direct

Name: intA [H]

Synonym: Veis_4160

Alternate gene names: 121611076

Gene position: 4577297-4578556 (Clockwise)

Preceding gene: 121611075

Following gene: 121611077

Centisome position: 82.23

GC content: 66.27

Gene sequence:

>1260_bases
ATGACTGAGACTGAACGCGTCACCGACAAGACGCTGCGGGCCTGGCTCAACACCGGCCCCGTGGACCGTGGCATCGGTGG
CGGCCTGACCTTCGTGGCCACCGCCGCCGGAGCACTCAAGGGCCAAGCTTCCTGGATTCTTCGCTACCGCTTCGGCGGCG
GCGCCCGAGAGAAGGTGCTCGGCCGCTACCCAGACCTGTCGCTCAAGGACGCCCGTGAAGCGACGCGCCAGAACCGGGCA
CGCATCCAGCAGGGCGTGGACGTGGCCGCCGAGAAGCGCGCAGAGCGGCTCAAGGCCCATGAACAGGTCGCCGTGGCCGC
CCTCGCGCAAGCCTGGTATGACCGCCACATCGCCAAGACCTACAAACACCCCGAGGTCGTGCTTCGCGTCATCCGCCGCC
ACATCGAGCCGGCGATCGGCAAGCTGGGCGTGACGGAGGTCCGGCCGCTGCACATCGACAAGGTGCTCACCCGCATCCTC
GATGCAGGCACGCCGACCGTGGCCAACGATGCGCTGCGCCACCTCTTCCGCATGTTCCACTTCGCCGTGAAGCGCCGCTG
GATCGATGCCAACCCGGTCTCTGGCTTCGAGATCTCCGACGCAGGCGGCTTCGAAGTCTCAAGACAGCGCTGGCTGAACC
GCGAGGAACTTGCCGCATTCGCCAAGGCCATGCAGGACACGCCCAACTTCGGTCGCCAGAACGAGCTGGCCGTGTGGCTG
CTGCTCGCCCTGTGCGTGCGCAAGATGGAGTTGCTGTCGGCCCGGTGGACCGAGTTCGACCTGGAGCGTGGCGTCTGGTC
GCTGCACCCGTCGCGCACGAAGATGAACCAGTCCATCGACATCCCGCTCGCGGCGCCGGTCCTGCGGTGGCTGGAGGAGG
TCCAAGTGTTCTCGTGCAACAGCGAGTACCTGTTCCCGCCGCGCCGGCTGATCCACATGAAGGGAGGTGTGCCGAGGCGG
AACCGCTTCGGCCACATCAGCCCGGACACGCTGAACGTCGCGTTGCTCCGCCTGCCGCTGGACGACATCGAGCACTTCAC
CGTGCATGACATGCGCCGCACGGCTCGCACCCACATGGCCGCACTGGGCGTGGACCGCTTCGTCGCGGAGCGGGCGCTGA
ACCACAAGGTCCGCGATGTCGAGGGCGTCTACAACCAGTACGACTACTTCGACGAGCGCAAGGTGGCGTTGGATCGATGG
GCGCAACTGCTGGAGAAAGTCTCCTCCTCTTTCAAAGAGTGCGGCACCACCGCCAGGTAA

Upstream 100 bases:

>100_bases
GGGGTAAATCGTGGGGTAAATGGACTGCCCCCACGACTTCGGGACAGCGCCCGAATTTTTACCCCACAGGTTCCTCGTAA
ATCGCTGTGGAGATCGCGCT

Downstream 100 bases:

>100_bases
GTACCAAAGTAGTGTCACTTACTTGGCAGAAGACGCGTTGAGGACCAGAAAAATGACTTTTGCACTGGCGACCGCCAACG
ATATCCTCCTGACCGTGGGC

Product: phage integrase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MTETERVTDKTLRAWLNTGPVDRGIGGGLTFVATAAGALKGQASWILRYRFGGGAREKVLGRYPDLSLKDAREATRQNRA
RIQQGVDVAAEKRAERLKAHEQVAVAALAQAWYDRHIAKTYKHPEVVLRVIRRHIEPAIGKLGVTEVRPLHIDKVLTRIL
DAGTPTVANDALRHLFRMFHFAVKRRWIDANPVSGFEISDAGGFEVSRQRWLNREELAAFAKAMQDTPNFGRQNELAVWL
LLALCVRKMELLSARWTEFDLERGVWSLHPSRTKMNQSIDIPLAAPVLRWLEEVQVFSCNSEYLFPPRRLIHMKGGVPRR
NRFGHISPDTLNVALLRLPLDDIEHFTVHDMRRTARTHMAALGVDRFVAERALNHKVRDVEGVYNQYDYFDERKVALDRW
AQLLEKVSSSFKECGTTAR

Sequences:

>Translated_419_residues
MTETERVTDKTLRAWLNTGPVDRGIGGGLTFVATAAGALKGQASWILRYRFGGGAREKVLGRYPDLSLKDAREATRQNRA
RIQQGVDVAAEKRAERLKAHEQVAVAALAQAWYDRHIAKTYKHPEVVLRVIRRHIEPAIGKLGVTEVRPLHIDKVLTRIL
DAGTPTVANDALRHLFRMFHFAVKRRWIDANPVSGFEISDAGGFEVSRQRWLNREELAAFAKAMQDTPNFGRQNELAVWL
LLALCVRKMELLSARWTEFDLERGVWSLHPSRTKMNQSIDIPLAAPVLRWLEEVQVFSCNSEYLFPPRRLIHMKGGVPRR
NRFGHISPDTLNVALLRLPLDDIEHFTVHDMRRTARTHMAALGVDRFVAERALNHKVRDVEGVYNQYDYFDERKVALDRW
AQLLEKVSSSFKECGTTAR
>Mature_418_residues
TETERVTDKTLRAWLNTGPVDRGIGGGLTFVATAAGALKGQASWILRYRFGGGAREKVLGRYPDLSLKDAREATRQNRAR
IQQGVDVAAEKRAERLKAHEQVAVAALAQAWYDRHIAKTYKHPEVVLRVIRRHIEPAIGKLGVTEVRPLHIDKVLTRILD
AGTPTVANDALRHLFRMFHFAVKRRWIDANPVSGFEISDAGGFEVSRQRWLNREELAAFAKAMQDTPNFGRQNELAVWLL
LALCVRKMELLSARWTEFDLERGVWSLHPSRTKMNQSIDIPLAAPVLRWLEEVQVFSCNSEYLFPPRRLIHMKGGVPRRN
RFGHISPDTLNVALLRLPLDDIEHFTVHDMRRTARTHMAALGVDRFVAERALNHKVRDVEGVYNQYDYFDERKVALDRWA
QLLEKVSSSFKECGTTAR

Specific function: Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1788974, Length=394, Percent_Identity=24.3654822335025, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788690, Length=386, Percent_Identity=23.0569948186528, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI145693166, Length=375, Percent_Identity=23.2, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR023109 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 47839; Mature: 47707

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETERVTDKTLRAWLNTGPVDRGIGGGLTFVATAAGALKGQASWILRYRFGGGAREKVL
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
GRYPDLSLKDAREATRQNRARIQQGVDVAAEKRAERLKAHEQVAVAALAQAWYDRHIAKT
HCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YKHPEVVLRVIRRHIEPAIGKLGVTEVRPLHIDKVLTRILDAGTPTVANDALRHLFRMFH
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FAVKRRWIDANPVSGFEISDAGGFEVSRQRWLNREELAAFAKAMQDTPNFGRQNELAVWL
HHHHHHCCCCCCCCCCEECCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHH
LLALCVRKMELLSARWTEFDLERGVWSLHPSRTKMNQSIDIPLAAPVLRWLEEVQVFSCN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
SEYLFPPRRLIHMKGGVPRRNRFGHISPDTLNVALLRLPLDDIEHFTVHDMRRTARTHMA
CCCCCCHHHHEEECCCCCCCCCCCCCCCCHHHHEEEECCHHHHHHHHHHHHHHHHHHHHH
ALGVDRFVAERALNHKVRDVEGVYNQYDYFDERKVALDRWAQLLEKVSSSFKECGTTAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TETERVTDKTLRAWLNTGPVDRGIGGGLTFVATAAGALKGQASWILRYRFGGGAREKVL
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
GRYPDLSLKDAREATRQNRARIQQGVDVAAEKRAERLKAHEQVAVAALAQAWYDRHIAKT
HCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YKHPEVVLRVIRRHIEPAIGKLGVTEVRPLHIDKVLTRILDAGTPTVANDALRHLFRMFH
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
FAVKRRWIDANPVSGFEISDAGGFEVSRQRWLNREELAAFAKAMQDTPNFGRQNELAVWL
HHHHHHCCCCCCCCCCEECCCCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHH
LLALCVRKMELLSARWTEFDLERGVWSLHPSRTKMNQSIDIPLAAPVLRWLEEVQVFSCN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCC
SEYLFPPRRLIHMKGGVPRRNRFGHISPDTLNVALLRLPLDDIEHFTVHDMRRTARTHMA
CCCCCCHHHHEEECCCCCCCCCCCCCCCCHHHHEEEECCHHHHHHHHHHHHHHHHHHHHH
ALGVDRFVAERALNHKVRDVEGVYNQYDYFDERKVALDRWAQLLEKVSSSFKECGTTAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7511583; 9278503; 9205837; 7524073 [H]