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The map label for this gene is hemL [H]

Identifier: 121611039

GI number: 121611039

Start: 4523036

End: 4523740

Strand: Direct

Name: hemL [H]

Synonym: Veis_4123

Alternate gene names: 121611039

Gene position: 4523036-4523740 (Clockwise)

Preceding gene: 121611031

Following gene: 121611043

Centisome position: 81.25

GC content: 71.63

Gene sequence:

>705_bases
ATGCCGCCCGTTGCCGCGCAAGCACTGTCCAACCGCCAGGACGCCCGGTGGCGCCAACGCGCAGCCAAGGTGCTGCCAGG
CGGAATGACGGGCCATCTGAACGCGGCGGCGCTGCCGGCGGGCTACCCGCAGTTCTTCGAGCACGGGCAGGGCTGCCGGG
TTTGGGATGTGGACGGCAATGCCTACATCGACTTCATGTGCAGTTGGGGCCCGAACCTGCTGGGCCACCACCATCCGCAG
GTCGATGCGGCGGCGCGGCGCCAGCAGGCGCTGGGCGACTGCCTCAACGGCCCGACCCCGCGCCTGGTCGAACTGGCCGA
GCGCTTCGTGGCGCGCAGCGCGCACGCCGACTGGGTGCTGTTCCAGAAGAACGGCACCGACGCCACCACCGTCAGCCTGA
TGGTGGCGCGCGCCGCCAGCGGCAAGCGCAAGGTGCTGGTCGCCGCCAGGGCCTACCACGGCTCCGACCCATGGTGCACG
CCGGTGTCGGCCGGCGTCACGCCCGAGGACCGCGCCCACCTGATCCGCTACGGCTACAACGATGTCGCCAGCCTCGACGC
TGCAGCCGACGCCGCAGGCAACGACCTGGCGGCCATCGTCTGCGCGGCCTTCAATGCTGTGGATTGCGCAACTGCCCGAC
GGCACCGAACTGCGCGCGCGGCTGCCCGAGCCGAGCCGCGTCACGGTGTCCGCCGGCGACCGTAA

Upstream 100 bases:

>100_bases
ACTTCGGGTGATGGCCTCGGGCGATGCCCCGGGCGATGGTTGTGCGCAAGATAAAATATGATATATCATGCAGCGCATCG
CCAACCGCCAAGGATTCCGA

Downstream 100 bases:

>100_bases
TAGCGCGGGGTCAGTCCGCTATTTTTTGGAAAGGTGCCTGTCAATGTGGTTTTGGCAACGTAATTCCAGATACCAAGGGC
GTCCAAGCATGCCCGATGCA

Product: class III aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MPPVAAQALSNRQDARWRQRAAKVLPGGMTGHLNAAALPAGYPQFFEHGQGCRVWDVDGNAYIDFMCSWGPNLLGHHHPQ
VDAAARRQQALGDCLNGPTPRLVELAERFVARSAHADWVLFQKNGTDATTVSLMVARAASGKRKVLVAARAYHGSDPWCT
PVSAGVTPEDRAHLIRYGYNDVASLDAAADAAGNDLAAIVCAAFNAVDCATARRHRTARAAARAEPRHGVRRRP

Sequences:

>Translated_234_residues
MPPVAAQALSNRQDARWRQRAAKVLPGGMTGHLNAAALPAGYPQFFEHGQGCRVWDVDGNAYIDFMCSWGPNLLGHHHPQ
VDAAARRQQALGDCLNGPTPRLVELAERFVARSAHADWVLFQKNGTDATTVSLMVARAASGKRKVLVAARAYHGSDPWCT
PVSAGVTPEDRAHLIRYGYNDVASLDAAADAAGNDLAAIVCAAFNAVDCATARRHRTARAAARAEPRHGVRRRP
>Mature_233_residues
PPVAAQALSNRQDARWRQRAAKVLPGGMTGHLNAAALPAGYPQFFEHGQGCRVWDVDGNAYIDFMCSWGPNLLGHHHPQV
DAAARRQQALGDCLNGPTPRLVELAERFVARSAHADWVLFQKNGTDATTVSLMVARAASGKRKVLVAARAYHGSDPWCTP
VSAGVTPEDRAHLIRYGYNDVASLDAAADAAGNDLAAIVCAAFNAVDCATARRHRTARAAARAEPRHGVRRRP

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786349, Length=192, Percent_Identity=30.7291666666667, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 25174; Mature: 25042

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPVAAQALSNRQDARWRQRAAKVLPGGMTGHLNAAALPAGYPQFFEHGQGCRVWDVDGN
CCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCC
AYIDFMCSWGPNLLGHHHPQVDAAARRQQALGDCLNGPTPRLVELAERFVARSAHADWVL
EEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEE
FQKNGTDATTVSLMVARAASGKRKVLVAARAYHGSDPWCTPVSAGVTPEDRAHLIRYGYN
EECCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCC
DVASLDAAADAAGNDLAAIVCAAFNAVDCATARRHRTARAAARAEPRHGVRRRP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PPVAAQALSNRQDARWRQRAAKVLPGGMTGHLNAAALPAGYPQFFEHGQGCRVWDVDGN
CCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEECCCC
AYIDFMCSWGPNLLGHHHPQVDAAARRQQALGDCLNGPTPRLVELAERFVARSAHADWVL
EEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEE
FQKNGTDATTVSLMVARAASGKRKVLVAARAYHGSDPWCTPVSAGVTPEDRAHLIRYGYN
EECCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCC
DVASLDAAADAAGNDLAAIVCAAFNAVDCATARRHRTARAAARAEPRHGVRRRP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA