Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 121610907

GI number: 121610907

Start: 4377366

End: 4378295

Strand: Direct

Name: gyaR [H]

Synonym: Veis_3989

Alternate gene names: 121610907

Gene position: 4377366-4378295 (Clockwise)

Preceding gene: 121610906

Following gene: 121610908

Centisome position: 78.63

GC content: 69.57

Gene sequence:

>930_bases
GTGAGCGCCACCATCCTGGTCACCGGCGCAGACCTTGCGCCGCAGGCGCTGGCCCTGCTCGCAGACTTCAAGATCGTCTA
TGCCGGCCCGGCGCCCGCCGAGCAAGACCTGGTGGCGCTGTGCCGCGCGCACGACCCGGTGGCCATCATCGTGCGCTATG
GCATGGTCGGCGCTGCCGTGATGGATGCTGCGCCGGCGCTGAAAGTCATCTCCAAACATGGCAGTGGCAGCGACACCATC
GACAAGCAGGCAGCCCAGGCGCGCGGCATCGCCGTGGTGGCTGCGGTCGGGGCCAATGCGCCTGCGGTGGCCGAGCAAGC
CCTGGCGCTGCTGCTGGCCTGTGCCAAGTCGGTAGTGGCGCTCGATGCGCGCATGCACGCCGGCCACTGGGACAAGGCCA
CGCACAAAAGCCTGGAACTGCGCGGGCGCAGCATCGGCGTGGTGGGGCTGGGGGCCATCGGCCAGCGCTTTGCGCTGCTG
GCCGCTGCGCTGGGCATGCGGGTGCTGGGTTTCGATCCCCATGCCGGCGCACTCCCGGCTTGCGTGCAGCGCGTGAGTCT
GGAGACCCTCTGGCGCACATCGGATGCGATCTCGCTGCACTGCCCGCTGACCGACGACAACCGGGGCCTGCTCAACGCCC
GCACCCTGGCGCAGTGCAAGCGCGGCGTGCTGCTGATCAACACGGCGCGCGGCGGTCTGATCGACGAGGCCGCATTGCTG
GCCGCCGTGCGCAGCGGCCAGGTGGGCATGGCCGGTCTGGACAGCTTTGCGCTCGAACCCATGGCGGCGGGGCATCCGTT
CCAAGGTGAAAAGAACTTCATCCTCAGCCCGCATATCGGCGGGGTGACCGACACCGCCTATGTCAGCATGGGCGTCGGCG
CGGCCAGAAACCTGCTGGCGGTGCTCGATGGGCGGGTGGCTGCGCCGTGA

Upstream 100 bases:

>100_bases
GCAGCCGGGGTGATACAGCAGGGGCAGGAAGGGCAGTTCCCGTGAGCGCTGCACGGCCGCCCGAAGGCGCCCGCACCGCA
GCCGAAGCGAAGGTACCCCG

Downstream 100 bases:

>100_bases
GATGGCCAGTGCCGGGATCGGGATCATTTGCCGCAAACTGCCGCATCGAATTCCAGCGATGGCTAGTGTCGCGTCACCGA
TCAGATGTCGTAGGCTGCGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSATILVTGADLAPQALALLADFKIVYAGPAPAEQDLVALCRAHDPVAIIVRYGMVGAAVMDAAPALKVISKHGSGSDTI
DKQAAQARGIAVVAAVGANAPAVAEQALALLLACAKSVVALDARMHAGHWDKATHKSLELRGRSIGVVGLGAIGQRFALL
AAALGMRVLGFDPHAGALPACVQRVSLETLWRTSDAISLHCPLTDDNRGLLNARTLAQCKRGVLLINTARGGLIDEAALL
AAVRSGQVGMAGLDSFALEPMAAGHPFQGEKNFILSPHIGGVTDTAYVSMGVGAARNLLAVLDGRVAAP

Sequences:

>Translated_309_residues
MSATILVTGADLAPQALALLADFKIVYAGPAPAEQDLVALCRAHDPVAIIVRYGMVGAAVMDAAPALKVISKHGSGSDTI
DKQAAQARGIAVVAAVGANAPAVAEQALALLLACAKSVVALDARMHAGHWDKATHKSLELRGRSIGVVGLGAIGQRFALL
AAALGMRVLGFDPHAGALPACVQRVSLETLWRTSDAISLHCPLTDDNRGLLNARTLAQCKRGVLLINTARGGLIDEAALL
AAVRSGQVGMAGLDSFALEPMAAGHPFQGEKNFILSPHIGGVTDTAYVSMGVGAARNLLAVLDGRVAAP
>Mature_308_residues
SATILVTGADLAPQALALLADFKIVYAGPAPAEQDLVALCRAHDPVAIIVRYGMVGAAVMDAAPALKVISKHGSGSDTID
KQAAQARGIAVVAAVGANAPAVAEQALALLLACAKSVVALDARMHAGHWDKATHKSLELRGRSIGVVGLGAIGQRFALLA
AALGMRVLGFDPHAGALPACVQRVSLETLWRTSDAISLHCPLTDDNRGLLNARTLAQCKRGVLLINTARGGLIDEAALLA
AVRSGQVGMAGLDSFALEPMAAGHPFQGEKNFILSPHIGGVTDTAYVSMGVGAARNLLAVLDGRVAAP

Specific function: Serine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=277, Percent_Identity=34.6570397111913, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=34.4961240310078, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=34.4961240310078, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=32.5581395348837, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=32.5581395348837, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI145580575, Length=253, Percent_Identity=33.201581027668, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI6912396, Length=286, Percent_Identity=31.4685314685315, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1789279, Length=251, Percent_Identity=34.6613545816733, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1787645, Length=205, Percent_Identity=34.6341463414634, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=32.5581395348837, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17532191, Length=316, Percent_Identity=33.2278481012658, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=255, Percent_Identity=34.9019607843137, Blast_Score=127, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=287, Percent_Identity=30.6620209059233, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=233, Percent_Identity=32.618025751073, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=240, Percent_Identity=31.6666666666667, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=197, Percent_Identity=31.4720812182741, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=165, Percent_Identity=30.9090909090909, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325144, Length=153, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921140, Length=287, Percent_Identity=34.1463414634146, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24646446, Length=264, Percent_Identity=32.5757575757576, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646448, Length=264, Percent_Identity=32.5757575757576, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646452, Length=264, Percent_Identity=32.5757575757576, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646450, Length=264, Percent_Identity=32.5757575757576, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI62472511, Length=264, Percent_Identity=32.5757575757576, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI28574286, Length=333, Percent_Identity=27.6276276276276, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24585516, Length=262, Percent_Identity=29.7709923664122, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571528, Length=266, Percent_Identity=31.9548872180451, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24585514, Length=319, Percent_Identity=26.9592476489028, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574282, Length=319, Percent_Identity=26.9592476489028, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574284, Length=319, Percent_Identity=26.9592476489028, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551003, Length=319, Percent_Identity=26.9592476489028, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45552429, Length=319, Percent_Identity=26.9592476489028, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 31570; Mature: 31439

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATILVTGADLAPQALALLADFKIVYAGPAPAEQDLVALCRAHDPVAIIVRYGMVGAAV
CCEEEEEECCCCCHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHH
MDAAPALKVISKHGSGSDTIDKQAAQARGIAVVAAVGANAPAVAEQALALLLACAKSVVA
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LDARMHAGHWDKATHKSLELRGRSIGVVGLGAIGQRFALLAAALGMRVLGFDPHAGALPA
HHHHHCCCCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCEEECCCCCCHHHH
CVQRVSLETLWRTSDAISLHCPLTDDNRGLLNARTLAQCKRGVLLINTARGGLIDEAALL
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHH
AAVRSGQVGMAGLDSFALEPMAAGHPFQGEKNFILSPHIGGVTDTAYVSMGVGAARNLLA
HHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHCCHHHHHHHH
VLDGRVAAP
HHCCCCCCC
>Mature Secondary Structure 
SATILVTGADLAPQALALLADFKIVYAGPAPAEQDLVALCRAHDPVAIIVRYGMVGAAV
CEEEEEECCCCCHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHH
MDAAPALKVISKHGSGSDTIDKQAAQARGIAVVAAVGANAPAVAEQALALLLACAKSVVA
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LDARMHAGHWDKATHKSLELRGRSIGVVGLGAIGQRFALLAAALGMRVLGFDPHAGALPA
HHHHHCCCCCCHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHCCCEEECCCCCCHHHH
CVQRVSLETLWRTSDAISLHCPLTDDNRGLLNARTLAQCKRGVLLINTARGGLIDEAALL
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCHHHHHHH
AAVRSGQVGMAGLDSFALEPMAAGHPFQGEKNFILSPHIGGVTDTAYVSMGVGAARNLLA
HHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHCCHHHHHHHH
VLDGRVAAP
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA