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The map label for this gene is gcvT [H]

Identifier: 121610875

GI number: 121610875

Start: 4342974

End: 4344200

Strand: Direct

Name: gcvT [H]

Synonym: Veis_3957

Alternate gene names: 121610875

Gene position: 4342974-4344200 (Clockwise)

Preceding gene: 121610874

Following gene: 121610876

Centisome position: 78.02

GC content: 69.93

Gene sequence:

>1227_bases
GTGAATCTCTCAGGTAAAGTGGACAGCAGGGCAAATTCCGTCGCGGCCTGCCCGGTCGCGCAACCCCATTTGCCCCGGAG
CCTCGTCTTGACCGCCATCGCCGCTGCAGCCGCCCCGCTGCGCACCACGCCCCTGAACGCGCTGCACATCGAGCTAGGCG
CCCGCATGGTGCCGTTTGCCGGTTACTCGATGCCGGTGCAATACCCCACCGGCCTGATCGCGGAGCACCTGCACACGCGC
CGGGCCGCCGGGCTGTTCGATGTCTCCCACATGGGCCAACTGCGCCTGCTCGGGCCTGCCGGCGCAGCCGCATTCGAGAC
CCTGATGCCGGTGGATGTGATCGGCCTGCCGGTGGGCAAGCAGCGCTATGGCCTGCTGCTCAGCGATGAAGGCACCATCA
TCGATGACCTGATGTTCTTCAACCAGGGCCATGACGCGATCTTCGTCATCGTCAACGGCGCCTGCAAGGCCGGCGACCTG
GCCCATATCCAGGCGCGCATCGCCCAGCGCTGCGCGGTGGTCGCGCTGCCGGAGCAGGCCCTGCTCGCGCTGCAAGGCCC
GCTGGCCGTCACGGCGCTGGCGCGCTTGGCGCCGGGCGTGGAAAAACTGCGCTTCATGACCGGCGGCAACTACGCCGTCG
CCGGCTGTGACTGCCTGGTGACCCGCAGCGGCTACACCGGCGAGGACGGCTTCGAGCTTTCGCTGCCGGCAGCGCAGGCC
GAGCGCCTGGCGCGGGCCTTGCTGGCGCAGCCCGAGGTCAGGCCCATAGGCTTGGGCGCGCGCAACTCGCTGCGGCTGGA
AGCCGGCCTGTGCCTGTACGGCAACGACATCGACAGCAGCACCACCCCGTCCGAAGCGGCGCTGGACTGGGCGATACAGA
AGGTGCGCCGCAGCGGGGGCGCGCGCGCCGGCGGCTTTCCCGGCGCCGACAAGGTGCTGGCCCAGATCGACAACCCGGCC
AGCCTGCCGCGCAAGCGCGTGGGCCTGGTCGCGCTGGAAGGTGTGCCGGTGCGCGAACACACCGAACTGCAAAGCAGCGA
CGGCCGCAAGATTGGCACCGTCACCAGCGGCCTGCCCGGCCCCACGCTGAACCAGCCCGTGGCCATGGGCTATGTAAGCC
CCGCCTTTGCCGCGCCAGGCACGCGCGTGCAGGCCATCGTGCGCGGCAAGGCCGTGCCGATGCAGGTGTGTGCCATGCCC
TTCGTGCCGGCGAACTACTGCCGCTGA

Upstream 100 bases:

>100_bases
CCGCAGTGATGCGGACGCTCCCTTGCTGGAGAGAGATGGCCCGCGCCATGCGCCGCCATCCACCGAAGGAGCAAACCGCA
GGGTCAGCCAGGGCGCTGCG

Downstream 100 bases:

>100_bases
TGGTCGATTTTTTTCTTTTCCTCCCCGAAAGCCTCCGATGACCGTCAAATTTTCCAAAGACCATGAATGGATCGATGCCG
CCGACGCCACTGCCGCCGTG

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MNLSGKVDSRANSVAACPVAQPHLPRSLVLTAIAAAAAPLRTTPLNALHIELGARMVPFAGYSMPVQYPTGLIAEHLHTR
RAAGLFDVSHMGQLRLLGPAGAAAFETLMPVDVIGLPVGKQRYGLLLSDEGTIIDDLMFFNQGHDAIFVIVNGACKAGDL
AHIQARIAQRCAVVALPEQALLALQGPLAVTALARLAPGVEKLRFMTGGNYAVAGCDCLVTRSGYTGEDGFELSLPAAQA
ERLARALLAQPEVRPIGLGARNSLRLEAGLCLYGNDIDSSTTPSEAALDWAIQKVRRSGGARAGGFPGADKVLAQIDNPA
SLPRKRVGLVALEGVPVREHTELQSSDGRKIGTVTSGLPGPTLNQPVAMGYVSPAFAAPGTRVQAIVRGKAVPMQVCAMP
FVPANYCR

Sequences:

>Translated_408_residues
MNLSGKVDSRANSVAACPVAQPHLPRSLVLTAIAAAAAPLRTTPLNALHIELGARMVPFAGYSMPVQYPTGLIAEHLHTR
RAAGLFDVSHMGQLRLLGPAGAAAFETLMPVDVIGLPVGKQRYGLLLSDEGTIIDDLMFFNQGHDAIFVIVNGACKAGDL
AHIQARIAQRCAVVALPEQALLALQGPLAVTALARLAPGVEKLRFMTGGNYAVAGCDCLVTRSGYTGEDGFELSLPAAQA
ERLARALLAQPEVRPIGLGARNSLRLEAGLCLYGNDIDSSTTPSEAALDWAIQKVRRSGGARAGGFPGADKVLAQIDNPA
SLPRKRVGLVALEGVPVREHTELQSSDGRKIGTVTSGLPGPTLNQPVAMGYVSPAFAAPGTRVQAIVRGKAVPMQVCAMP
FVPANYCR
>Mature_408_residues
MNLSGKVDSRANSVAACPVAQPHLPRSLVLTAIAAAAAPLRTTPLNALHIELGARMVPFAGYSMPVQYPTGLIAEHLHTR
RAAGLFDVSHMGQLRLLGPAGAAAFETLMPVDVIGLPVGKQRYGLLLSDEGTIIDDLMFFNQGHDAIFVIVNGACKAGDL
AHIQARIAQRCAVVALPEQALLALQGPLAVTALARLAPGVEKLRFMTGGNYAVAGCDCLVTRSGYTGEDGFELSLPAAQA
ERLARALLAQPEVRPIGLGARNSLRLEAGLCLYGNDIDSSTTPSEAALDWAIQKVRRSGGARAGGFPGADKVLAQIDNPA
SLPRKRVGLVALEGVPVREHTELQSSDGRKIGTVTSGLPGPTLNQPVAMGYVSPAFAAPGTRVQAIVRGKAVPMQVCAMP
FVPANYCR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=381, Percent_Identity=44.8818897637795, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI257796258, Length=356, Percent_Identity=44.9438202247191, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI257796254, Length=376, Percent_Identity=42.8191489361702, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI257796256, Length=321, Percent_Identity=43.9252336448598, Blast_Score=233, Evalue=3e-61,
Organism=Escherichia coli, GI1789272, Length=371, Percent_Identity=32.3450134770889, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17560118, Length=384, Percent_Identity=39.5833333333333, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6320222, Length=387, Percent_Identity=38.7596899224806, Blast_Score=252, Evalue=9e-68,
Organism=Drosophila melanogaster, GI20129441, Length=388, Percent_Identity=40.2061855670103, Blast_Score=271, Evalue=7e-73,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42678; Mature: 42678

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSGKVDSRANSVAACPVAQPHLPRSLVLTAIAAAAAPLRTTPLNALHIELGARMVPFA
CCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEECCC
GYSMPVQYPTGLIAEHLHTRRAAGLFDVSHMGQLRLLGPAGAAAFETLMPVDVIGLPVGK
CCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCEEEECCCCHHHHHHHCCHHEEECCCCC
QRYGLLLSDEGTIIDDLMFFNQGHDAIFVIVNGACKAGDLAHIQARIAQRCAVVALPEQA
HHCCEEECCCCCEEHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHEEEECCHHH
LLALQGPLAVTALARLAPGVEKLRFMTGGNYAVAGCDCLVTRSGYTGEDGFELSLPAAQA
HHHHCCCHHHHHHHHHCCCHHHEEEEECCCEEEECEEEEEECCCCCCCCCCEEECCHHHH
ERLARALLAQPEVRPIGLGARNSLRLEAGLCLYGNDIDSSTTPSEAALDWAIQKVRRSGG
HHHHHHHHCCCCCEEECCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
ARAGGFPGADKVLAQIDNPASLPRKRVGLVALEGVPVREHTELQSSDGRKIGTVTSGLPG
CCCCCCCCHHHHHHHCCCCHHCCHHHCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCC
PTLNQPVAMGYVSPAFAAPGTRVQAIVRGKAVPMQVCAMPFVPANYCR
CCCCCCEEECCCCHHHCCCCCCEEHHHCCCCCCHHHHCCCCCCHHCCC
>Mature Secondary Structure
MNLSGKVDSRANSVAACPVAQPHLPRSLVLTAIAAAAAPLRTTPLNALHIELGARMVPFA
CCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEECCC
GYSMPVQYPTGLIAEHLHTRRAAGLFDVSHMGQLRLLGPAGAAAFETLMPVDVIGLPVGK
CCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCEEEECCCCHHHHHHHCCHHEEECCCCC
QRYGLLLSDEGTIIDDLMFFNQGHDAIFVIVNGACKAGDLAHIQARIAQRCAVVALPEQA
HHCCEEECCCCCEEHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHEEEECCHHH
LLALQGPLAVTALARLAPGVEKLRFMTGGNYAVAGCDCLVTRSGYTGEDGFELSLPAAQA
HHHHCCCHHHHHHHHHCCCHHHEEEEECCCEEEECEEEEEECCCCCCCCCCEEECCHHHH
ERLARALLAQPEVRPIGLGARNSLRLEAGLCLYGNDIDSSTTPSEAALDWAIQKVRRSGG
HHHHHHHHCCCCCEEECCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
ARAGGFPGADKVLAQIDNPASLPRKRVGLVALEGVPVREHTELQSSDGRKIGTVTSGLPG
CCCCCCCCHHHHHHHCCCCHHCCHHHCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCC
PTLNQPVAMGYVSPAFAAPGTRVQAIVRGKAVPMQVCAMPFVPANYCR
CCCCCCEEECCCCHHHCCCCCCEEHHHCCCCCCHHHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA